252 research outputs found
Finding hidden knowledge in WASH: effective methods for exploring the needs of perimenopausal women in Ghana
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
As increased urbanisation brings the challenges of providing sustainable
and equitable WASH provision for all, a globally ageing population will bring more women in low income countries passing through the perimenopause, the transition to menopause , with various hidden WASH
needs. A lack of knowledge upon these needs also means that effective methods to work with perimenopausal women
are not well established. Drawing on field experiences from Accra and Kumasi in Ghana, this paper reflects upon the methodological lessons learned in researching the WASH needs of perimenopausal women in two low income communities. An effective methodology to explore perimenopausal women’s WASH needs encourages participation
and engagement with the topic through use of appropriate tools , and effective
community mobilisation. A collaboration of different people in a team, group reflection and adaptation of tools which consider practical aspects and local cultural values
are needed to understand such needs
Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Arnaldi Roberta
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
- Barile Francesco
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
- Bashir Butt Jamila
- Basile Maurizio
- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Berceanu Ionela
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berenyi Daniel
- Bertens Redmer Alexander
- Berzano Dario
- Betev Latchezar
- Bhasin Anju
- Bhat Inayat Rasool
- Bhati Ashok Kumar
- Bhattacharjee Buddhadeb
- Bhom Jihyun
- Bianchi Livio
- Bianchi Nicola
- Bianchin Chiara
- Bielcik Jaroslav
- Bielcikova Jana
- Bilandzic Ante
- Biswas Rathijit
- Biswas Saikat
- Bjelogrlic Sandro
- Blair Justin Thomas
- Blau Dmitry
- Blume Christoph
- Bock Friederike
- Boettger Stefan
- Bogdanov Alexey
- Boggild Hans
- Boldizsar Laszlo
- Bombara Marek
- Book Julian Heinz
- Borel Herve
- Borissov Alexander
- Borri Marcello
- Bossu Francesco
- Botta Elena
- Bourjau Christian
- Braun-Munzinger Peter
- Bregant Marco
- Breitner Timo Gunther
- Broker Theo Alexander
- Browning Tyler Allen
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- Brucken Erik Jens
- Bruna Elena
- Bruno Giuseppe Eugenio
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Buncic Predrag
- Busch Oliver
- Buthelezi Edith Zinhle
- Buxton Jesse Thomas
- Cabanillas Noris Juan Carlos
- Caffarri Davide
- Cai Xu
- Caines Helen Louise
- Calero Diaz Liliet
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carena Francesco
- Carena Wisla
- Carnesecchi Francesca
- Castillo Castellanos Javier Ernesto
- Castro Andrew John
- Casula Ester Anna Rita
- Ceballos Sanchez Cesar
- Cepila Jan
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- Chang Beomsu
- Chapeland Sylvain
- Chartier Marielle
- Charvet Jean-Luc Fernand
- Chattopadhyay Subhasis
- Chattopadhyay Sukalyan
- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Cho Soyeon
- Chochula Peter
- Choi Kyungeon
- Chojnacki Marek
- Choudhury Subikash
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
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- Chung Suh-Urk
- Chunhui Zhang
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
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- Colella Domenico
- Collu Alberto
- Colocci Manuel
- Conesa Balbastre Gustavo
- Conesa Del Valle Zaida
- Connors Megan Elizabeth
- Contreras Nuno Jesus Guillermo
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- Corrales Morales Yasser
- Correia Zanoli Henrique Jose
- Cortes Maldonado Ismael
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- Costa Filippo
- Crochet Philippe
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- Cuautle Flores Eleazar
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- Das Supriya
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- Dash Sadhana
- De Caro Annalisa
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- De Conti Camila
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- De Falco Alessandro
- De Gruttola Daniele
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- De Sudipan
- Deisting Alexander
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- Deplano Caterina
- Dhankher Preeti
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- Di Mauro Antonio
- Di Nezza Pasquale
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- Dietel Thomas
- Dillenseger Pascal
- Diozcora Vargas Trevino Aurora
- Divia Roberto
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- Dobrigkeit Chinellato David
- Dobrin Alexandru Florin
- Domenicis Gimenez Diogenes
- Donigus Benjamin
- Dordic Olja
- Drozhzhova Tatiana
- Dubey Anand Kumar
- Dubla Andrea
- Ducroux Laurent
- Dupieux Pascal
- Ehlers Iii Raymond James
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- Engel Heiko
- Epple Eliane
- Erazmus Barbara Ewa
- Erdemir Irem
- Erhardt Filip
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- Feofilov Grigorii
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- Figiel Jan
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- Finogeev Dmitry
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- Williams Crispin
- Windelband Bernd Stefan
- Winn Michael Andreas
- Yaldo Chris G
- Yang Hongyan
- Yang Ping
- Yano Satoshi
- Yasar Cigdem
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yoon Jin Hee
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zaporozhets Sergey
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 14/09/2015
- Field of study
We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe
Long-range angular correlations on the near and away side in p–Pb collisions at
- Author
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Adam Szczepankiewicz
- Adela Kravcakova
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Alberica Toia
- Alberto Baldisseri
- Alberto Collu
- Alberto Gago
- Alberto Masoni
- Alejandro Szanto de Toledo
- Alessandra Maria Mazzoni
- Alessandra Fantoni
- Alessandro De Falco
- Alessandro Feliciello
- Alessandro Grelli
- Alessandro Pesci
- Alexander Philipp Kalweit
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Florin Dobrin
- Alexandru Bercuci
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean Michel Mas
- Alfonso Tarazona Martinez
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alis Rodriguez Manso
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anais Annick Erica Bergognon
- Anand Kumar Dubey
- Anatoly Kolojvari
- Anders Garritt Knospe
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea Dubla
- Andrea Festanti
- Andrea Francescon
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei Geae Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Reshetin
- Andrey Vasiliev
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- Andry Malala Rakotozafindrabe
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- Andrzej Rybicki
- Andzhey Asryan
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- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
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- Antoine Xavier Lardeux
- Anton Alkin
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- Antonin Maire
- Antonino Zichichi
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- Antonio Juan Rubio Montero
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- Ara Grigoryan
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- Arnaldi Roberta
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- Beomsu Chang
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- Uwe Westerhoff
- Valentina Zaccolo
- Valeria Muccifora
- Valerie Barret
- Valerio Altini
- Valery Kondratiev
- Valery Punin
- Vardanush Papikyan
- Vasco Miguel Chibante Barroso
- Vasile Catanescu
- Vasily Kushpil
- Vedran Nikolic
- Venelin Anguelov
- Vera Loggins
- Vercellin Ermanno
- Veronica Canoa Roman
- Victor Trubnikov
- Vikas Singhal
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
- Vito Manzari
- Vladimir Ivanov
- Vladimir Kaplin
- Vladimir Kovalenko
- Vladimir Nikulin
- Vladimir Peskov
- Vladimir Pospisil
- Vladimir Samsonov
- Vladimir Vechernin
- Vladimir Wagner
- Vladislav Grigoriev
- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Yaldo Chris G.
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- Yorito Yamaguchi
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adolfsson Jonatan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Al-turany Mohammad
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfaro Molina Jose Ruben
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkamper Lucas
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andreou Dimitra
- Andrews Harry Arthur
- Andronic Anton
- Anguelov Venelin
- Anson Christopher Daniel
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Arnaldi Roberta
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Ball Markus
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
- Barile Francesco
- Barioglio Luca
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartsch Esther
- Bashir Butt Jamila
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Batyunya Boris
- Batzing Paul Christoph
- Bautista Guzman Irais
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
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- Yang Ping
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-kwon
- Yoon Jin Hee
- Yun Eungyu
- Yurchenko Volodymyr
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zhalov Mikhail
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zhu Ya
- Zichichi Antonino
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zmeskal Johann
- Zou Shuguang
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe
Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aimo Ilaria
- Aiola Salvatore
- Ajaz Muhammad
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
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- Bastid Nicole
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- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
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- Yaldo Chris G
- Yang Hongyan
- Yang Ping
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- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
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- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
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- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Chunhui
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
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- Zhu Jianhui
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- Publication venue
- Publication date
- 26/06/2015
- Field of study
Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe
Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aimo Ilaria
- Aiola Salvatore
- Ajaz Muhammad
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Baltasar Dos Santos Pedrosa Fernando
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- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
- Bashir Butt Jamila
- Basile Maurizio
- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
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- Shigaki Kenta
- Shtejer Diaz Katherin
- Sibiryak Yury
- Siddhanta Sabyasachi
- Sielewicz Krzysztof Marek
- Siemiarczuk Teodor
- Silvermyr David Olle Rickard
- Silvestre Catherine Micaela
- Simatovic Goran
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- Singaraju Rama Narayana
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- Terasaki Kohei
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- Tieulent Raphael Noel
- Timmins Anthony Robert
- Toia Alberica
- Trogolo Stefano
- Trubnikov Victor
- Trzaska Wladyslaw Henryk
- Tsuji Tomoya
- Tumkin Alexandr
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- Tveter Trine Spedstad
- Ullaland Kjetil
- Uras Antonio
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- Utrobicic Antonija
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- Wang Yifei
- Watanabe Daisuke
- Watanabe Yosuke
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- Westerhoff Uwe
- Wiechula Jens
- Wikne Jon
- Wilde Martin Rudolf
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Williams Crispin
- Windelband Bernd Stefan
- Winn Michael Andreas
- Yaldo Chris G
- Yang Hongyan
- Yang Ping
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zaporozhets Sergey
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Chunhui
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zhu Xiangrong
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 22/07/2015
- Field of study
Peer reviewe
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
- Avery Alison
- Avis Joanne
- Aya Viviana
- Azirar Hanna
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- Bahl Amit
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- Barnett Debra
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- Bashir Faheem
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- Bauman Glenn
- Baumber Shelley
- Baxter Matt
- Bayley Andrew J
- Beamish Neal
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- Beaney Ronald
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- Bech-Nielsen Nanette
- Bedoya Luis Diaz de
- Beech Darren
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- Christensen Anne Juel
- Christensen Tine
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- Crossley Lin
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- Dalton-Short Ross
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- De Silva-Minor Shiroma
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- Guerrero-Urbano Teresa
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- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
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- Anyamene Nicola
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- Appleby Rowan
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- Archer Denise
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- Archer Simon
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- Catton Charles N
- Caumont Tom
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- Chadwick David
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- Chakraborti Prabir
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- Choudhury Ananya
- Chowdhury Amitava D
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- Cole David J
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- Drachenberg Darrel E
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- Flynn-Batham Marian
- Fode Kirsten
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- Gao Annie
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- Gardiner Fiona
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- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
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- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
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- Giovannini Julia
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- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
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- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
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- Griffiths Dorothy
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- Griffiths Theresa
- Gruschy Lisa
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- Gudelis Susan O
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- Gujral Sandeep
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- Hargreaves Carolyn
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- Hargreaves Jeanette
- Harinarayanan Sathish
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- Haydock Helen
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- Hayes Jill A
- Hayward Lesley
- Healey Gail
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- Heath Catherine
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- Ibrahim Azman
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- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
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- Jackman Dee
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- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- James Nicholas D
- Jamieson Ceri
- Jampana Raj
- Janke Susan
- Jannapureddy Revanth
- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
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- Jelski Joseph
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- Jepson Debbie
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- Jeyasanger Ganesan
- Joe Howard
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- Jones Stephanie
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- Jonnada Sai
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- Jose Sanal
- Joseph Joji
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- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
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- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
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- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
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- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
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- Khoury Ghassan
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- Kilmartin John
- Kilroy Stephen
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- Kiltie Anne
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- Kim David
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- Kim-Sing Charmaine
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- King Amy
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- Kirkbride Peter
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- Klapp Kathi
- Klotz Laurence
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- Kockelbergh Roger
- Kodavatiganti Ravi
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- Lacey Cathy
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- Laing Robert
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- Lalani Nafisha
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- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
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- Larson Beverly
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- Lau Maurice
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- Liau Joy
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- Lipsham Margaret
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- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
- Lomax Laurie
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- Loughlin Kate
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- Love Sally
- Lowe Amelia
- Lowi Suzy
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- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
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- Macavoy Tina
- Macdonald Alison
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- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
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- Marineau Line
- Mark Ian
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- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
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- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
- Martinou Maria
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- Marty Janet
- Mashegede Beverley
- Mason Jessica
- Mason Malcolm
- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Matkins Ellen
- Matthews Laura
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- Mayer Heather
- Mayne Barbara
- Mazhar Danish
- McAleese Jonathan
- McAlister Judy
- McAllister Jo
- McAuliffe Sarah
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- McBride Julia
- McCabe Alastair
- McCadden Angela
- McCarth Fiona
- McCartin Fiona
- McCaul Damian
- McClelland Marie
- McClements Jane
- McClurey Sister Patricia
- McCormack Anne
- McCormick Marian
- McCracken Jillian
- McCrisken Lauren
- McCrudden Sylvia
- McCully Ruby
- McCurrie Marilyn
- McFarlane Jonathan
- McFarlane Victoria
- McGarry Karen
- McGinley Shannon
- McGlynn Brian
- McGrath John
- McGrath Katherine
- McIndoe Sue
- McInerney Paul
- McInerney Sue
- McInerney Veronica
- Mcintosh Gregor
- McKee Dianne
- McKenna Karen
- McKenzie Michael
- McKernan Margaret
- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
- McLaren Duncan
- McLarty Esther
- Mcleod Nick
- McMeekin Faith
- McMenemin Rhona
- McNally Morag
- McNish Jennifer
- McNulty Dawn
- McPhail Neil
- McWilliam Donna
- McWilliam Marie
- Meadows Lorna
- Medisetti Aruna
- Meidhal Petersen Peter
- Melcher Lucinda
- Melcher Lucinda
- Menard Cynthia
- Menard Cynthia
- Mendoza Edeliza
- Merante Pat
- Mercer Lily
- Mercier Barbara
- Merrick Richard
- Metcalf Karen
- Meyer Ralph
- Michael Elena
- Michaelidou Andriana
- Michels Jorg
- Middleton Sharon
- Mikropoulos Christos
- Mikropoulos Christos
- Millage Helen
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- Mills Laurie
- Mills-Baldock Tina
- Milner Jessica
- Milosevic Michael
- Mirmooji Ramesh
- Mirza Arafat
- Mislang Albert
- Mistry Heena
- Mistry Leena
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- Mithal Natasha
- Mitra Anita
- Moelker Yvonne
- Moffatt Emily
- Mohamed Fatima
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- Moir Rachel
- Mojidra Chintan
- Mole Lisa
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- Money-Kyrle Julian
- Montebello Joseph
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- Moody Emma
- Mooney Matthew
- Moore Eleanor
- Moore Eleanor
- Moore Sally
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- Morales Maria
- Morales-Azofra Fabiola
- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
- Morrow Hugh
- Morton Gerard
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- Morton Susan
- Moss Sarah
- Mthethwa Thobekile
- Mui Jimmy
- Mukkath Sandra
- Mumin Anissa
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- Murad Fatima
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- Musunuru Hima Bindu
- Muthu Kumar Dakshinamoorthy
- Myatt Alison
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- Nabid Abdenour
- Nabid Abdenour
- Nagar Yoodhvir
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- Nakashima Lynne
- Nallathambi Chandran
- Nam Robert K
- Narahari Krishna
- Naraine Nicky
- Nash Dominic
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- Nathan Kannon
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- Ngumo Alice
- Ngumo Alice
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- Ngwenya Su
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- Nicholson Alastair
- Nicholson Alastair
- Nieforth Joan
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- Nikapota Ashok
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- Oliverio Carmela
- Ong Aldrich D
- Ong Aldrich Dixon
- Oni Titilayo
- Onoge Ekugbe
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- Ouelette Ashley
- Overend Aldyn
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- Pach Jackie
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- Page Nancy
- Pai Howard H
- Paisey Sangeeta
- Palmer Debbie
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- Pamphlett Ian
- Pan Siew Siew
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- Parker Chris
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- Parmar Mahesh K B
- Parmar Max
- Parr Stephen
- Partington Lillian
- Partridge Kerena
- Parulekar Wendy
- Parulekar Wendy R
- Paschalis Alec
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- Patel Anup
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- Pathmanathan Byiravey
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- Perkins Lauren
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- Persad Raj
- Persad Rajendra A
- Pervez Nadeem
- Peterkin Zhane
- Peters John
- Petersen Peter M
- Peterson Jane
- Petroff Avi
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- Petsa Maria
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- Philp Timothy
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- Pickering Holly
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- Pigott Katherine
- Pilkington Pauline
- Pillai Sijy
- Pineda Sandra
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- Plataniotis George
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- Pugh Cheryl
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- Rezkallah Sarah
- Rezkallah Sarah
- Rezkallah Sarah
- Ribeiro Helena
- Ribers Kristine
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- Richardson Karen
- Richardson Karen
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- Riley Karen
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- Rodda Sree
- Rodrigues George B
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- Thomas Carys
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- Thompson Catherine
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- Thoms John
- Thomson Alastair H
- Thomson Sister Jane
- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
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- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
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- Townley Luke
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- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
- Venkitaraman Ramachandran
- Vermette Tracy
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- Vigneault Eric
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- Walton Sharon
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- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
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- Whitehouse James
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- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
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- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
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- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
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- Worthington Hannah
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- Wright Seonaid
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- Wu Min
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- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at root s(NN)=2.76TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Baltasar Dos Santos Pedrosa Fernando
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
- Barile Francesco
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
- Bashir Butt Jamila
- Basile Maurizio
- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Berceanu Ionela
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berenyi Daniel
- Bertens Redmer Alexander
- Berzano Dario
- Betev Latchezar
- Bhasin Anju
- Bhat Inayat Rasool
- Bhati Ashok Kumar
- Bhattacharjee Buddhadeb
- Bhom Jihyun
- Bianchi Livio
- Bianchi Nicola
- Bianchin Chiara
- Bielcik Jaroslav
- Bielcikova Jana
- Bilandzic Ante
- Biswas Rathijit
- Biswas Saikat
- Bjelogrlic Sandro
- Blair Justin Thomas
- Blanco Fernando
- Blau Dmitry
- Blume Christoph
- Bock Friederike
- Boettger Stefan
- Bogdanov Alexey
- Boggild Hans
- Boldizsar Laszlo
- Bombara Marek
- Book Julian Heinz
- Borel Herve
- Borissov Alexander
- Borri Marcello
- Bossu Francesco
- Botta Elena
- Braun-Munzinger Peter
- Bregant Marco
- Breitner Timo Gunther
- Broker Theo Alexander
- Browning Tyler Allen
- Broz Michal
- Brucken Erik Jens
- Bruna Elena
- Bruno Giuseppe Eugenio
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Buncic Predrag
- Busch Oliver
- Buthelezi Edith Zinhle
- Buxton Jesse Thomas
- Cabanillas Noris Juan Carlos
- Caffarri Davide
- Cai Xu
- Caines Helen Louise
- Calero Diaz Liliet
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carena Francesco
- Carena Wisla
- Carnesecchi Francesca
- Castillo Castellanos Javier Ernesto
- Castro Andrew John
- Casula Ester Anna Rita
- Cavicchioli Costanza
- Ceballos Sanchez Cesar
- Cepila Jan
- Cerello Piergiorgio
- Cerkala Jakub
- Chang Beomsu
- Chapeland Sylvain
- Chartier Marielle
- Charvet Jean-Luc Fernand
- Chattopadhyay Subhasis
- Chattopadhyay Sukalyan
- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Chochula Peter
- Choi Kyungeon
- Chojnacki Marek
- Choudhury Subikash
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Chung Suh-Urk
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
- Cleymans Jean Willy Andre
- Colamaria Fabio Filippo
- Colella Domenico
- Collu Alberto
- Colocci Manuel
- Conesa Balbastre Gustavo
- Conesa Del Valle Zaida
- Connors Megan Elizabeth
- Contreras Nuno Jesus Guillermo
- Cormier Thomas Michael
- Corrales Morales Yasser
- Correia Zanoli Henrique Jose
- Cortes Maldonado Ismael
- Cortese Pietro
- Cosentino Mauro Rogerio
- Costa Filippo
- Crochet Philippe
- Cruz Albino Rigoberto
- Cuautle Flores Eleazar
- Cunqueiro Mendez Leticia
- D'Erasmo Ginevra
- Dahms Torsten
- Dainese Andrea
- Danu Andrea
- Das Debasish
- Das Indranil
- Das Supriya
- Dash Ajay Kumar
- Dash Sadhana
- De Caro Annalisa
- De Cataldo Giacinto
- De Cuveland Jan
- De Falco Alessandro
- De Gruttola Daniele
- De Marco Nora
- De Pasquale Salvatore
- De Sudipan
- Deisting Alexander
- Deloff Andrzej
- Denes Ervin Sandor
- Di Bari Domenico
- Di Mauro Antonio
- Di Nezza Pasquale
- Diaz Corchero Miguel Angel
- Dietel Thomas
- Dillenseger Pascal
- Diozcora Vargas Trevino Aurora
- Divia Roberto
- Djuvsland Oeystein
- Dobrigkeit Chinellato David
- Dobrin Alexandru Florin
- Dobrowolski Tadeusz Antoni
- Domenicis Gimenez Diogenes
- Donigus Benjamin
- Dordic Olja
- Drozhzhova Tatiana
- Dubey Anand Kumar
- Dubla Andrea
- Ducroux Laurent
- Dupieux Pascal
- Ehlers Iii Raymond James
- Elia Domenico
- Engel Heiko
- Epple Eliane
- Erazmus Barbara Ewa
- Erdemir Irem
- Erhardt Filip
- Espagnon Bruno
- Estienne Magali Danielle
- Esumi Shinichi
- Eum Jongsik
- Evans David
- Evdokimov Sergey
- Eyyubova Gyulnara
- Fabbietti Laura
- Fabris Daniela
- Faivre Julien
- Fantoni Alessandra
- Fasel Markus
- Feldkamp Linus
- Felea Daniel
- Feliciello Alessandro
- Feofilov Grigorii
- Ferencei Jozef
- Fernandez Tellez Arturo
- Ferreira Natal Da Luz Pedro Hugo
- Ferretti Alessandro
- Festanti Andrea
- Feuillard Victor Jose Gaston
- Figiel Jan
- Filchagin Sergey
- Finogeev Dmitry
- Fionda Fiorella
- Fiore Enrichetta Maria
- Fleck Martin Gabriel
- Floris Michele
- Foertsch Siegfried Valentin
- Foka Panagiota
- Fokin Sergey
- Fragiacomo Enrico
- Francescon Andrea
- Frankenfeld Ulrich Michael
- Fuchs Ulrich
- Furget Christophe
- Furs Artur
- Fusco Girard Mario
- Gaardhoeje Jens Joergen
- Gagliardi Martino
- Gago Medina Alberto Martin
- Gallio Mauro
- Gameiro Munhoz Marcelo
- Gangadharan Dhevan Raja
- Ganoti Paraskevi
- Gao Chaosong
- Garabatos Cuadrado Jose
- Garcia-Solis Edmundo Javier
- Gargiulo Corrado
- Gasik Piotr Jan
- Germain Marie
- Gheata Andrei George
- Gheata Mihaela
- Ghosh Premomoy
- Ghosh Sanjay Kumar
- Gianotti Paola
- Giubellino Paolo
- Giubilato Piero
- Gladysz-Dziadus Ewa
- Glassel Peter
- Gomez Coral Diego Mauricio
- Gomez Ramirez Andres
- Gonzalez Ferreiro Elena
- Gonzalez Zamora Pedro
- Gorbunov Sergey
- Gorlich Lidia Maria
- Gotovac Sven
- Grabski Varlen
- Graczykowski Lukasz Kamil
- Graham Katie Leanne
- Grelli Alessandro
- Grigoras Alina Gabriela
- Grigoras Costin
- Grigoryan Ara
- Grigoryan Smbat
- Grigoryev Vladislav
- Grion Nevio
- Grosse-Oetringhaus Jan Fiete
- Grossiord Jean-Yves
- Grosso Raffaele
- Grynyov Borys
- Guber Fedor
- Guernane Rachid
- Guerzoni Barbara
- Gulbrandsen Kristjan Herlache
- Gulkanyan Hrant
- Gunji Taku
- Gupta Anik
- Gupta Ramni
- Haake Rudiger
- Haaland Oystein Senneset
- Hadjidakis Cynthia Marie
- Haiduc Maria
- Hamagaki Hideki
- Hamar Gergoe
- Harris John William
- Harton Austin Vincent
- Hatzifotiadou Despina
- Hayashi Shinichi
- Heckel Stefan Thomas
- Heide Markus Ansgar
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- Wilde Martin Rudolf
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- Winn Michael Andreas
- Yaldo Chris G
- Yang Hongyan
- Yang Ping
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zaporozhets Sergey
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Chunhui
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 11/07/2015
- Field of study
The elliptic flow, v(2), of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4) is measured in Pb-Pb collisions at root s(NN)= 2.76TeVwith the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee-Yang zeros methods are used. The dependence of the v(2) of muons from heavy-flavour hadron decays on the collision centrality, in the range 0-40%, and on transverse momentum, p(T), is studied in the interval 3 <p(T)<10 GeV/c. A positive v(2) is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10-20% and 20-40% centrality classes) for the p(T) interval from 3 to about 5GeV/c with a significance larger than 3 sigma, based on the combination of statistical and systematic uncertainties. The v(2) magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6 <p(T)<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe
Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Arnaldi Roberta
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Balasubramanian Supraja
- Baldisseri Alberto
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
- Barile Francesco
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
- Bashir Butt Jamila
- Basile Maurizio
- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Berceanu Ionela
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berenyi Daniel
- Bertens Redmer Alexander
- Berzano Dario
- Betev Latchezar
- Bhasin Anju
- Bhat Inayat Rasool
- Bhati Ashok Kumar
- Bhattacharjee Buddhadeb
- Bhom Jihyun
- Bianchi Livio
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- Bianchin Chiara
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- Bielcikova Jana
- Bilandzic Ante
- Biswas Rathijit
- Biswas Saikat
- Bjelogrlic Sandro
- Blair Justin Thomas
- Blau Dmitry
- Blume Christoph
- Bock Friederike
- Boettger Stefan
- Bogdanov Alexey
- Boggild Hans
- Boldizsar Laszlo
- Bombara Marek
- Book Julian Heinz
- Borel Herve
- Borissov Alexander
- Borri Marcello
- Bossu Francesco
- Botta Elena
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- Braun-Munzinger Peter
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- Breitner Timo Gunther
- Broker Theo Alexander
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- Broz Michal
- Brucken Erik Jens
- Bruna Elena
- Bruno Giuseppe Eugenio
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Buncic Predrag
- Busch Oliver
- Buthelezi Edith Zinhle
- Buxton Jesse Thomas
- Cabanillas Noris Juan Carlos
- Caffarri Davide
- Cai Xu
- Caines Helen Louise
- Calero Diaz Liliet
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carena Francesco
- Carena Wisla
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- Castro Andrew John
- Casula Ester Anna Rita
- Ceballos Sanchez Cesar
- Cepila Jan
- Cerello Piergiorgio
- Cerkala Jakub
- Chang Beomsu
- Chapeland Sylvain
- Chartier Marielle
- Charvet Jean-Luc Fernand
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- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
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- Chibante Barroso Vasco Miguel
- Cho Soyeon
- Chochula Peter
- Choi Kyungeon
- Chojnacki Marek
- Choudhury Subikash
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Chung Suh-Urk
- Chunhui Zhang
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
- Cleymans Jean Willy Andre
- Colamaria Fabio Filippo
- Colella Domenico
- Collu Alberto
- Colocci Manuel
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- Wilde Martin Rudolf
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- Winn Michael Andreas
- Yaldo Chris G
- Yang Hongyan
- Yang Ping
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- Yasar Cigdem
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yoon Jin Hee
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
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- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 29/09/2015
- Field of study
The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe
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