Density-of-states picture and stability of ferromagnetism in the highly-correlated Hubbard model

The problem of stability of saturated and non-saturated ferromagnetism in the Hubbard model is considered in terms of the one-particle Green's functions. Approximations by Edwards and Hertz and some versions of the self-consistent approximations based on the 1/z-expansion are considered. The account of longitudinal fluctuations turns out to be essential for description of the non-saturated state. The corresponding pictures of density of states are obtained. "Kondo" density-of-states singularities owing to spin-flip processes are analyzed. The critical electron concentrations for instabilities of saturated ferromagnetism and paramagnetic state are calculated for various lattices. Drawbacks of various approximations are discussed. A comparison with the results of previous works is performed.Comment: 16 pages, 7 eps figure

Планирование регистрационной программы исследований препаратов базисной противовоспалительной терапии ревматоидного артрита

Rheumatoid arthritis (RA) is an autoimmune rheumatic disease of unknown etiology which manifests itself in chronic erosive arthritis (synovitis) and systemic lesions affecting internal organs. The main emphasis in the RA treatment is placed on the pharmacological therapy: non-steroidal anti-inflammatory drugs, ordinary analgesics, glucocorticoids, basic synthetic anti-inflammatory drugs, and targeted therapy drugs which are now represented by genetically engineered biologicals. The choice of rational treatment options for this severe disease is an important challenge facing modern medicine. The study reported in this paper analysed the clinical data registry for basic anti-inflammatory drugs for RA treatment, which was elaborated based on RA classification and diagnostic criteria. It was revealed that a product’s indications for use are formulated in the clinical data registry based on the product’s pharmacological properties and are accompanied with the description of the target population. It is necessary to provide a list of clinical parameters that will be monitored in the study to demonstrate the efficacy of treatment. The main efficacy endpoint may be chosen based on the product’s pharmacological properties. The efficacy is assessed using integrated indicators. Expected endpoints should be in line with the declared indication for use. Trials that confirm efficacy of a product should assess its therapeutic potential to the fullest extent possible. Before a medicinal product is authorised, it is necessary to obtain sufficient data on its safety, taking into account potential risks of long-term use. Ревматоидный артрит – аутоиммунное ревматическое заболевание неизвестной этиологии, характеризующееся хроническим эрозивным артритом (синовитом) и системным поражением внутренних органов. Основное место в лечении ревматоидного артрита занимает медикаментозная терапия: нестероидные противовоспалительные препараты, простые анальгетики, глюкокортикоиды, синтетические базисные противовоспалительные препараты и средства таргетной терапии, которые в настоящее время представлены генно-инженерными биологическими препаратами. Выбор рациональных методов лечения этого тяжелого заболевания является актуальной задачей для современной медицины. Был проведен анализ регистрационной программы исследований препаратов базисной противовоспалительной терапии ревматоидного артрита, разработанной в соответствии с классификационными и диагностическими критериями заболевания. Отмечено, что при составлении регистрационной программы исследования  определение показаний для применения препарата проводится на основании информации о его фармакологических свойствах с описанием целевой популяции пациентов. Должен быть представлен перечень клинических показателей, которые будут контролироваться в исследовании для подтверждения эффективности терапии. В зависимости от фармакологических особенностей препарата может быть выбран основной критерий эффективности. Для оценки эффективности используются интегральные показатели. Ожидаемые результаты лечения должны быть согласованы с заявленным показанием. В исследованиях, подтверждающих эффективность препарата, должен максимально полно оцениваться его терапевтический потенциал. До момента регистрации препарата должно быть получено достаточно данных по его безопасности с учетом возможной длительности его применения

Spherical model of the Stark effect in external scalar and vector fields

The Bohr-Sommerfeld quantization rule and the Gamow formula for the width of quasistationary level are generalized by taking into account the relativistic effects, spin and Lorentz structure of interaction potentials. The relativistic quasi-classical theory of ionization of the Coulomb system (V_{Coul}=-\xi/r) by radial-constant long-range scalar (S_{l.r.}=(1-\lambda)(\sigma r+V_0)) and vector (V_{l.r.}=\lambda(\sigma r+V_0)) fields is constructed. In the limiting cases the approximated analytical expressions for the position E_r and width \Gamma of below-barrier resonances are obtained. The strong dependence of the width \Gamma of below-barrier resonances on both the bound level energy and the mixing constant \lambda is detected. The simple analytical formulae for asymptotic coefficients of the Dirac radial wave functions at zero and infinity are also obtained.Comment: 25 pages, 4 figures. Submitted to Int. J. Mod. Phys.

First Results from The GlueX Experiment

The GlueX experiment at Jefferson Lab ran with its first commissioning beam in late 2014 and the spring of 2015. Data were collected on both plastic and liquid hydrogen targets, and much of the detector has been commissioned. All of the detector systems are now performing at or near design specifications and events are being fully reconstructed, including exclusive production of $\pi^{0}$, $\eta$ and $\omega$ mesons. Linearly-polarized photons were successfully produced through coherent bremsstrahlung and polarization transfer to the $\rho$ has been observed.Comment: 8 pages, 6 figures, Invited contribution to the Hadron 2015 Conference, Newport News VA, September 201

Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets

This document is the Technical Design Report covering the two large spectrometer magnets of the PANDA detector set-up. It shows the conceptual design of the magnets and their anticipated performance. It precedes the tender and procurement of the magnets and, hence, is subject to possible modifications arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski, Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy), Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy

Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR

Simulation results for future measurements of electromagnetic proton form factors at \PANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel $\bar p p \to e^+ e^-$ is studied on the basis of two different but consistent procedures. The suppression of the main background channel, $\textit{i.e.}$ $\bar p p \to \pi^+ \pi^-$, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. However, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN