Fluctuations in measured radioactive decay rates inside a modified Faraday cage: Correlations with space weather

[EN] For several years, reports have been published about fluctuations in measured radioactive decay time-series and in some instances linked to astrophysical as well as classical environmental influences. Anomalous behaviors of radioactive decay measurement and measurement of capacitance inside and outside a modified Faraday cage were documented by our group in previous work. In the present report, we present an in-depth analysis of our measurement with regard to possible correlations with space weather, i.e. the geomagnetic activity (GMA) and cosmic-ray activity (CRA). Our analysis revealed that the decay and capacitance time-series are statistically significantly correlated with GMA and CRA when specific conditions are met. The conditions are explained in detail and an outlook is given on how to further investigate this important finding. Our discovery is relevant for all researchers investigating radioactive decay measurements since they point out that the space weather condition during the measurement is relevant for partially explaining the observed variability.This work has been partially financed by: grant no. 20170764 (Equipos de deteccion, regulacion e informacion en el sector de los sistemas inteligentes de transporte (ITS). Nuevos modelos y ensayos de compatibilidad y verificacion de funcionamiento) (Spain), by grant no. RTI2018-102256-B-I00 (Spain), by the Generalitat Valenciana (Spain) under project Bioingenieria de las Radiaciones Ionizantes. Biorad (PROMETEO/2018/035) and the project MEMO RADION (IDIFEDER/2018/038) co-financed by the Programa Operativo del Fondo Social Europeo 2014-2020", and by grant No.075-00845-20-01 (Russia).Milián-Sánchez, V.; Scholkmann, F.; Fernández De Córdoba, P.; Mocholí Salcedo, A.; Mocholí-Belenguer, F.; Iglesias-Martínez, ME.; Castro-Palacio, JC.... (2020). Fluctuations in measured radioactive decay rates inside a modified Faraday cage: Correlations with space weather. Scientific Reports. 10(1):1-12. https://doi.org/10.1038/s41598-020-64497-0S112101Milián-Sánchez, V., Mocholí-Salcedo, A., Milián, C., Kolombet, V. A. & Verdú, G. Anomalous effects on radiation detectors and capacitance measurements inside a modified Faraday cage. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 828, 210–228 (2016).G. F. Knoll Radiation Detection and Measurement, 4th Edition. (Wiley, 2010).Jenkins, J. H., Mundy, D. W. & Fischbach, E. Analysis of environmental influences in nuclear half-life measurements exhibiting time-dependent decay rates. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 620, 332–342 (2010).Jenkins, J. H. et al. Additional experimental evidence for a solar influence on nuclear decay rates. Astroparticle Physics 37, 81–88 (2012).Falkenberg, E. D. Radioactive Decay Caused by Neutrinos? Apeiron 8, 32–45 (2001).A. G. Parkhomov Influence of Relic Neutrinos on Beta Radioactivity. arXiv:1010.1591v1 [physics.gen-ph], (2010).P. A. Sturrock, E. Fischbach, A. G. Parkhamov, J. D. Scargle, G. Steinitz, Concerning the variability of beta-decay measurements. arXiv:1510.05996 [nucl-ex], (2015).Baurov, Y. A. et al. Experimental Investigations of Changes in β-Decay if 60Co and 137Cs. Modern Physics Letters A 16, 2089–2101 (2001).Baurov, Y. A. Research of Global Anisotropy of Physical Space on Investigation Base of Changes in β and α-decay Rate of Radioactive Elements. Motion of Pulsars and Anisotropy of Cosmic Rays. American Journal of Modern Physics 2, 177–184 (2013).Baurov, Y. A., Sobolev, Y. G., Ryabov, Y. V. & Kushniruk, V. F. Experimental investigations of changes in the rate of beta decay of radioactive elements. Physics of Atomic Nuclei 70, 1825–1835 (2009).Baurov, Y. A. The anisotropic phenomenon in the β decay of radioactive elements and in other processes in nature. Bulletin of the Russian Academy of Sciences: Physics 76, 1076–1080 (2012).Baurov, Y. A., Sobolev, Y. G. & Ryabov, Y. V. New force, global anisotropy and the changes in β-decay rate of radioactive elements. American Journal of Astronomy and Astrophysics 2, 8–19 (2014).Pons, D. J., Pons, A. D. & Pons, A. J. Asymmetrical neutrino induced decay of nucleons. Applied Physics Research 7, 1–13 (2015).Pons, D. J., Pons, A. D. & Pons, A. J. Hidden Variable Theory Supports Variability in Decay Rates of Nuclides. Applied Physics Research 7, 18–29 (2015).Kossert, K. & Nähle, O. J. Long-term measurements of 36Cl to investigate potential solar influence on the decay rate. Astroparticle Physics 55, 33–36 (2014).Schrader, H. Seasonal variations of decay rate measurement data and their interpretation. Applied Radiation and Isotopes 114, 202–213 (2016).Pommé, S. et al. Evidence against solar influence on nuclear decay constants. Physics Letters B 761, 281–286 (2016).Bergeson, S. D., Peatross, J. & Ware, M. J. Precision long-term measurements of beta-decay-rate ratios in a controlled environment. Physics Letters B 767, 171–176 (2017).McKnight, Q., Bergeson, S. D., Peatross, J. & Ware, M. J. 2.7 years of beta-decay-rate ratio measurements in a controlled environment. Applied Radiation and Isotopes 142, 113–119 (2018).Pommé, S. et al. On decay constants and orbital distance to the Sun—part I: alpha decay. Metrologia 54, 1–18 (2017).Pommé, S. et al. On decay constants and orbital distance to the Sun—part III: beta plus and electron capture decay. Metrologia 54, 36–50 (2017).Pommé, S., Lutter, G., Marouli, M., Kossert, K. & Nähle, O. On the claim of modulations in radon decay and their association with solar rotation. Astroparticle Physics 97, 38–45 (2018).S. Pommé, K. Kossert, O. Nähle On the Claim of Modulations in 36Cl Beta Decay and Their Association with Solar Rotation. Solar Physics 292 (2017).Pommé, S. et al. Is decay constant? Applied Radiation and Isotopes 134, 6–12 (2018).Bellotti, E., Broggini, C., Di Carlo, G., Laubenstein, M. & Menegazzo, R. Search for time modulations in the decay constant of 40 K and 226 Ra at the underground Gran Sasso Laboratory. Physics Letters B 780, 61–65 (2018).Borrello, J. A., Wuosmaa, A. & Watts, M. Non-dependence of nuclear decay rates of 123 I and 99m Tc on Earth-Sun distance. Applied Radiation and Isotopes 132, 189–194 (2018).Sturrock, P. A., Steinitz, G., Fischbach, E., Parkhomov, A. & Scargle, J. D. Analysis of beta-decay data acquired at the Physikalisch-Technische Bundesanstalt: Evidence of a solar influence. Astroparticle Physics 84, 8–14 (2016).Stancil, D. D., Balci Yegen, S., Dickey, D. A. & Gould, C. R. Search for possible solar influences in Ra-226 decays. Results in Physics 7, 385–406 (2017).P. A. Sturrock, G. Steinitz & E. Fischbach Analysis of Ten Years of Radon-Chain Decay Measurements: Evidence of Solar Influences and Inferences Concerning Solar Internal Structure and the Role of Neutrinos. arXiv:1705.03010 [astro-ph.SR], (2017).Sturrock, P. A., Steinitz, G. & Fischbach, E. Concerning the variability of nuclear decay rates: Rebuttal of an article by Pomme et al. [1]. Astroparticle Physics 98, 9–12 (2018).Pommé, S., Lutter, G., Marouli, M., Kossert, K. & Nähle, O. A reply to the rebuttal by Sturrock et al. Astroparticle Physics 107, 22–25 (2019).S. Pommé, Solar influence on radon decay rates: irradiance or neutrinos? The European Physical Journal C. 79 (2019).Barnes, V. E. et al. Upper limits on perturbations of nuclear decay rates induced by reactor electron antineutrinos. Applied Radiation and Isotopes 149, 182–199 (2019).Pommé, S., Stroh, H. & Van Ammel, R. The 55Fe half-life measured with a pressurised proportional counter. Applied Radiation and Isotopes 148, 27–34 (2019).Elmaghraby, E. E. Configuration Mixing in Particle Decay and Reaction. Progress in Physics 13, 150–155 (2017).Shnoll, S. E. et al. Realization of discrete states during fluctuations in macroscopic processes. Physics-Uspekhi 41, 1025–1035 (1998).Namiot, V. A. & Shnoll, S. E. On the possible mechanism of periodicity in fine structure of histograms during nuclear decay processes. Physics Letters A 359, 249–251 (2006).Panchelyuga, V. A. & Panchelyuga, M. S. Fractal dimension and histogram method: Algorithm and some preliminary results of noise-like time series analysis. Biophysics 58, 283–289 (2013).Panchelyuga, V. A. & Panchelyuga, M. S. Local fractal analysis of noise-like time series by the all-permutations method for 1–115 min periods. Complex Systems Biophysics 60, 317–330 (2015).T. A. Zenchenko, A. A. Konradov, K. I. Zenchenko In Biophotonics and Coherent Systems in Biology. chap. Chapter 18, pp. 225–233 (2005).Jenkins, J. H. & Fischbach, E. Perturbation of nuclear decay rates during the solar flare of 2006 December 13. Astroparticle Physics 31, 407–411 (2009).F. Scholkmann et al., Anomalous effects of radioactive decay rates and capacitance values measured inside a modified Faraday cage: Correlations with space weather. EPL (Europhysics Letters) 117 (2017).M. E. Iglesias-Martínez et al. Correlations between Background Radiation Inside a Multilayer Interleaving Structure, Geomagnetic Activity, and Cosmic Radiation: A Fourth-Order Cumulant-Based Correlation Analysis. Mathematics 8 (2020).Karinen, A. & Mursula, K. A new reconstruction of the Dst index for 1932-2002. Annales Geophysicae 23, 475–485 (2005).A. Karinen, K. Mursula Correcting the Dst index: Consequences for absolute level and correlations. Journal of Geophysical Research 111 (2006).Nakamura, T., Uwamino, Y., Ohkubo, T. & Hara, A. Altitude Variation of Cosmic-ray Neutrons. Health Physics 53, 509–517 (1987).Hendrick, L. D. & Edge, R. D. Cosmic-Ray Neutrons near the Earth. Physical Review 145, 1023–1025 (1966).Yamashita, M., Stephens, L. D. & Patterson, H. W. Cosmic-ray-produced neutrons at ground level: Neutron production rate and flux distribution. Journal of Geophysical Research 71, 3817–3834 (1966).Mohsinally, T. et al. Evidence for correlations between fluctuations in 54Mn decay rates and solar storms. Astroparticle Physics 75, 29–37 (2016).Snyder, C. W., Neugebauer, M. & Rao, U. R. The solar wind velocity and its correlation with cosmic-ray variations and with solar and geomagnetic activity. Journal of Geophysical Research 68, 6361–6370 (1963).Kharayat, H., Prasad, L., Mathpal, R., Garia, S. & Bhatt, B. Study of Cosmic Ray Intensity in Relation to the Interplanetary Magnetic Field and Geomagnetic Storms for Solar Cycle 23. Solar Physics 291, 603–611 (2016).M. Tsichla, M. Gerontidou, H. Mavromichalaki, Spectral Analysis of Solar and Geomagnetic Parameters in Relation to Cosmic-ray Intensity for the Time Period 1965 – 2018. Solar Physics 294 (2019).Singh, Y. P. Badruddin, Short- and mid-term oscillations of solar, geomagnetic activity and cosmic-ray intensity during the last two solar magnetic cycles. Planetary and Space Science 138, 1–6 (2017).B. Adhikari, N. Sapkota, P. Baruwal, N. P. Chapagain & C. R. Braga Impacts on Cosmic-Ray Intensity Observed During Geomagnetic Disturbances. Solar Physics 292 (2017).Grigoryev, V. G., Starodubtsev, S. A. & Gololobov, P. Y. Monitoring geomagnetic disturbance predictors using data of ground measurements of cosmic rays. Bulletin of the Russian Academy of Sciences: Physics 81, 200–202 (2017).W. Reich Selected Writings: An Introduction to Orgonomy. (Farrar, Straus and Cudahy, 1960).Fischbach, E. et al. Time-Dependent Nuclear Decay Parameters: New Evidence for New Forces? Space Science Reviews 145, 285–335 (2009).Javorsek, D. et al. Power spectrum analyses of nuclear decay rates. Astroparticle Physics 34, 173–178 (2010).Bellotti, E., Broggini, C., Di Carlo, G., Laubenstein, M. & Menegazzo, R. Search for time dependence of the 137Cs decay constant. Physics Letters B 710, 114–117 (2012)

Implementation of exon arrays: alternative splicing during T-cell proliferation as determined by whole genome analysis

<p>Abstract</p> <p>Background</p> <p>The contribution of alternative splicing and isoform expression to cellular response is emerging as an area of considerable interest, and the newly developed exon arrays allow for systematic study of these processes. We use this pilot study to report on the feasibility of exon array implementation looking to replace the 3' <it>in vitro </it>transcription expression arrays in our laboratory.</p> <p>One of the most widely studied models of cellular response is T-cell activation from exogenous stimulation. Microarray studies have contributed to our understanding of key pathways activated during T-cell stimulation. We use this system to examine whole genome transcription and alternate exon usage events that are regulated during lymphocyte proliferation in an attempt to evaluate the exon arrays.</p> <p>Results</p> <p>Peripheral blood mononuclear cells form healthy donors were activated using phytohemagglutinin, IL2 and ionomycin and harvested at 5 points over a 7 day period. Flow cytometry measured cell cycle events and the Affymetrix exon array platform was used to identify the gene expression and alternate exon usage changes. Gene expression changes were noted in a total of 2105 transcripts, and alternate exon usage identified in 472 transcript clusters. There was an overlap of 263 transcripts which showed both differential expression and alternate exon usage over time. Gene ontology enrichment analysis showed a broader range of biological changes in biological processes for the differentially expressed genes, which include cell cycle, cell division, cell proliferation, chromosome segregation, cell death, component organization and biogenesis and metabolic process ontologies. The alternate exon usage ontological enrichments are in metabolism and component organization and biogenesis. We focus on alternate exon usage changes in the transcripts of the spliceosome complex. The real-time PCR validation rates were 86% for transcript expression and 71% for alternate exon usage.</p> <p>Conclusions</p> <p>This study illustrates that the Exon array technology has the potential to provide information on both transcript expression and isoform usage, with very little increase in expense.</p

Structural basis for the recognition and cleavage of histone H3 by cathepsin L

Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation of cell-cycle progression and cellular differentiation. The recruitment of lysosomal cathepsin L to the nucleus where it mediates proteolysis of the mouse histone H3 tail has been described recently. Here, we report the three-dimensional crystal structures of a mature, inactive mutant of human cathepsin L alone and in complex with a peptide derived from histone H3. Canonical substrate–cathepsin L interactions are observed in the complex between the protease and the histone H3 peptide. Systematic analysis of the impact of posttranslational modifications at histone H3 on substrate selectivity suggests cathepsin L to be highly accommodating of all modified peptides. This is the first report of cathepsin L–histone H3 interaction and the first structural description of cathepsin L in complex with a substrate

Advances of genomic science and systems biology in renal transplantation: a review

The diagnosis of rejection in kidney transplant patients is based on histologic classification of a graft biopsy. The current “gold standard” is the Banff 97 criteria; however, there are several limitations in classifying rejection based on biopsy samples. First, a biopsy involves an invasive procedure. Second, there is significant variance among blinded pathologists in the interpretation of a biopsy. And third, there is also variance between the histology and the molecular profiles of a biopsy. To increase the positive predictive value of classifiers of rejection, a Banff committee is developing criteria that integrate histologic and molecular data into a unified classifier that could diagnose and prognose rejection. To develop the most appropriate molecular criteria, there have been studies by multiple groups applying omics technologies in attempts to identify biomarkers of rejection. In this review, we discuss studies using genome-wide data sets of the transcriptome and proteome to investigate acute rejection, chronic allograft dysfunction, and tolerance. We also discuss studies which focus on genetic biomarkers in urine and peripheral blood, which will provide clinicians with minimally invasive methods for monitoring transplant patients. We also discuss emerging technologies, including whole-exome sequencing and RNA-Seq and new bioinformatic and systems biology approaches, which should increase the ability to develop both biomarkers and mechanistic understanding of the rejection process

Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.

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Pure Gauge Configurations and Tachyon Solutions to String Field Theories Equations of Motion

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