35 research outputs found
Multi-Decadal Decline of Mercury in the North Atlantic Atmosphere Explained by Changing Subsurface Seawater Concentrations
- Author
- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- 17/03/2014
- Field of study
[1] We analyze 1977–2010 trends in atmospheric mercury (Hg) from 21 ship cruises over the North Atlantic (NA) and 15 over the South Atlantic (SA). We find a steep 1990–2009 decline of −0.046 ± 0.010 ng m−3 a−1 (−2.5% a−1) over the NA (steeper than at Northern Hemispheric land sites) but no significant decline over the SA. Surface water Hg0 measurements in the NA show a decline of −5.7% a−1since 1999, and limited subsurface ocean data show an ∼80% decline from 1980 to present. We use a coupled global atmosphere-ocean model to show that the decline in NA atmospheric concentrations can be explained by decreasing oceanic evasion from the NA driven by declining subsurface water Hg concentrations. We speculate that this large historical decline of Hg in the NA Ocean could have been caused by decreasing Hg inputs from rivers and wastewater and by changes in the oxidant chemistry of the atmospheric marine boundary layer.Engineering and Applied Science
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Abrantes Katya
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia A.
- Block Barbara A.
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Camrin D.
- Brooks Edward J.
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron
- Castleton Michael
- Chapple Taylor K.
- Clarke Maurice
- Coelho Rui
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark
- Farrugia Thomas J.
- Ferreira Luciana C.
- Ferretti Francesco
- Filmalter John D.
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galvan-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J.
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio
- Heard Matthew
- Hearn Alex
- Hedges Kevin J.
- Henderson Suzanne M.
- Holdsworth John
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicholas E.
- Hussey Nigel E.
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M. P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim C. D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G.
- Mendonca Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa J.
- O'Sullivan John B.
- Oliveira Paulo
- Papastamtiou Yannis P.
- Patterson Toby A.
- Phillips Sophy R. McCully
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A.
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M.
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George L.
- Shipley Oliver N.
- Shivji Mahmood S.
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B.
- Sousa Lara L.
- Southall Emily J.
- Spaet Julia L. Y.
- Stehfest Kilian M.
- Stewart Joshua D.
- Sulikowski James A.
- Syakurachman Ismail
- Thorrold Simon R.
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P.
- Vaudo Jeremy J.
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R. J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia A.
- Block Barbara A.
- Bonfil Ramon
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Camrin D.
- Brooks Edward J.
- Brown Judith
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron
- Castleton Michael
- Chapple Taylor K.
- Chateau Olivier
- Clarke Maurice
- Coelho Rui
- Coffey Daniel M.
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- dos Santos Abrantes Katya
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark
- Farrugia Thomas J.
- Ferreira Luciana C.
- Ferretti Francesco
- Filmalter John D.
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galvan-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J.
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher A.
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio
- Heard Matthew
- Hearn Alex
- Hedges Kevin J.
- Henderson Suzanne M.
- Holdsworth John
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicholas E.
- Hussey Nigel E.
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M.P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim. C.D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G.
- Mendonca Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa J.
- O'Sullivan John B.
- Oliveira Paulo
- Papastamtiou Yannis P.
- Patterson Toby A.
- Peel Lauren R.
- Phillips Sophy R. McCully
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Andy J.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A.
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M.
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George L.
- Shipley Oliver N.
- Shivji Mahmood S.
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B.
- Sousa Lara L.
- Southall Emily J.
- Spaet Julia L. Y.
- Stehfest Kilian M.
- Stevens Guy
- Stewart Joshua D.
- Sulikowski James A.
- Syakurachman Ismail
- Thorrold Simon R.
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P.
- Vaudo Jeremy J.
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R. J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Almeida Marcio A. A.
- Alnaes Dag
- Alvim Marina K. M.
- Ames David
- Amlien Inge K.
- Anderson Tim J.
- Andersson Micael
- Andreassen Ole A.
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J.
- Artiges Eric
- Ashley-Koch Allison
- Assareh Amelia A.
- Atkins Joshua R.
- Ayesa-Arriola Rosa
- Bastin Mark E.
- Baune Bernhard T.
- Beckham Jean C.
- Belger Aysenil
- Bernard Manon
- Bis Joshua C.
- Blangero John
- Boomsma Dorret I.
- Bralten Janita
- Brandt Christine L.
- Brodaty Henry
- Brouwer Rachel M.
- Brown Gregory G.
- Brunner Han G.
- Buckner Randy L.
- Buimer Elizabeth E. L.
- Buitelaar Jan K.
- Bulow Robin
- Burger Christian
- Bustillo Juan R.
- Cahn Wiepke
- Cairns Murray J.
- Calhoun Vince
- Cannon Dara M.
- Carr Vaughan J.
- Caseras Xavier
- Caspers Svenja
- Cavalleri Gianpiero L.
- Cendes Fernando
- Chakravarty Mallar
- Chen Qiang
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Colodro-Conde Lucia
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crespo-Facorro Benedicto
- Curran Joanne E.
- Dale Anders M.
- Dalrymple-Alford John C.
- Dalvie Shareefa
- Dannlowski Udo
- Davies Gareth E.
- de Araujo Tania K.
- de Geus Eco J. C.
- de Zubicaray Greig I.
- de Zwarte Sonja M. C.
- Deary Ian J.
- Debette Stephanie
- Decarli Charles
- Degenhardt Franziska
- Delanty Norman
- den Braber Anouk
- Dennis Michelle F.
- Depondt Chantal
- Desrivieres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doherty Colin P.
- Dohm Katharina
- Donohoe Gary
- Ehrlich Stefan
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espeseth Thomas
- Espiritu Ryan
- Fan Chun Chieh
- Fedko Iryna O.
- Fernandez Guillen
- Fisher Simon E.
- Flor Herta
- Foley Sonya F.
- Ford Judith M.
- Fornage Myriam
- Forstner Andreas J.
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Garijo Daniel
- Garrett Melanie E.
- Ge Tian
- Giddaluru Sudheer
- Gil Yolanda
- Glahn David C.
- Goldman Aaron L.
- Gollub Randy L.
- Gowland Penny A.
- Grabe Hans J.
- Grasby Katrina L.
- Green Melissa J.
- Green Robert C.
- Groenewold Nynke A.
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gurholt Tiril P.
- Gutman Boris A.
- Haberg Asta K.
- Hansell Narelle K.
- Hariri Ahmad R.
- Harris Mathew A.
- Harrison Marc B.
- Hartman Catharina A.
- Hashimoto Ryota
- Haswell Courtney C.
- Hauser Michael
- Hausler Alexander N.
- Heindel Walter
- Heinz Andreas
- Henskens Frans A.
- Herms Stefan
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hillegers Manon H. J.
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U.
- Holleran Laurena
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hong L. Elliot
- Hoogman Martine
- Hopkins William D.
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M. Arfan
- Jack Clifford R.
- Jahanshad Neda
- Jang MiHyun
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E.
- Jernigan Terry L.
- Jia Tianye
- Jockwitz Christiane
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Karama Sherif
- Kasperaviciute Dalia
- Kaufmann Tobias
- Kelly Sinead
- Kennedy Martin A.
- Kikuchi Masataka
- Kimbrel Nathan A.
- Kircher Tilo T. J.
- Klein Marieke
- Knapp Michael
- Knodt Annchen R.
- Kochunov Peter
- Kolskar Knut
- Koops Sanne
- Kramer Bernd
- Krug Axel
- Kwok John B. J.
- Lam Max
- Lancaster Thomas M.
- Launer Lenore
- Le Hellard Stephanie
- Lee Phil H.
- Lett Tristram A.
- Lewis Lindsay B.
- Lim Kelvin O.
- Lind Penelope A.
- Longstreth W. T.
- Loohuis Loes M. Olde
- Lopes-Cendes Iscia
- Lopez Oscar L.
- Loughland Carmel M.
- Luciano Michelle
- Luykx Jurjen J.
- Macciardi Fabio
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Martinot Marie-Laure Paillere
- Mathalon Daniel H.
- Mather Karen A.
- Mathias Samuel R.
- Mattay Venkata S.
- Matthews Sarah
- Mazoyer Bernard
- McDonald Colm
- McEwen Sarah C.
- McMahon Katie L.
- McMahon Mary Agnes B.
- Medland Sarah E.
- Melle Ingrid
- Melzer Tracy R.
- Meyer-Lindenberg Andreas
- Michie Patricia T.
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Moreira Jose C. V.
- Morey Rajendra A.
- Morris Derek W.
- Mosley Thomas H.
- Mota Nina R.
- Mowry Bryan
- Mueller Bryon A.
- Mueller-Myhsok Bertram
- Muhleisen Thomas W.
- Najt Pablo
- Nakahara Soichiro
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Noethen Markus M.
- Nordvik Jan E.
- Nyberg Lars
- O'Leary Daniel S.
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A.
- Orfanos Dimitri Papadopoulos
- Painter Jodie N.
- Pantelis Christos
- Paus Tomas
- Pausova Zdenka
- Pearson John F.
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pitcher Toni L.
- Pizzagalli Fabrizio
- Pol Hilleke E. Hulshoff
- Polderman Tinca J. C.
- Posthuma Danielle
- Preda Adrian
- Putz Benno
- Quide Yann
- Quinlan Erin B.
- Ragothaman Anjanibhargavi
- Rashid Faisal M.
- Rasser Paul E.
- Ratnakar Varun
- Reay William R.
- Redlich Ronny
- Reinbold Celine S.
- Reppermund Simone
- Repple Jonathan
- Richard Genevieve
- Riedel Brandalyn C.
- Rietschel Marcella
- Risacher Shannon L.
- Rocha Cristiane S.
- Roffman Joshua L.
- Roshchupkin Gennady V.
- Rowland Laura M.
- Sachdev Perminder S.
- Salminen Lauren
- Samann Philipp G.
- Saremi Arvin
- Satizabal Claudia L.
- Saykin Andrew J.
- Schall Ulrich
- Schlag Fenja
- Schmaal Lianne
- Schmidt Reinhold
- Schofield Peter R.
- Schumann Gunter
- Scott Rodney J.
- Secolin Rodrigo
- Seshadri Sudha
- Shapland Chin Yang
- Shatokhina Natalia
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sim Kang
- Sisodiya Sanjay M.
- Smoller Jordan W.
- Sommer Iris E.
- Sonderby Ida E.
- Sprooten Emma
- St Pourcain Beate
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Strike Lachlan T.
- Tansey Katherine E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomopoulos Sophia I.
- Thompson Paul M.
- Toga Arthur W.
- Tooney Paul A.
- Tordesillas-Gutierrez Diana
- Torres Fabio R.
- Trollor Julian N.
- Turner Jessica A.
- Uhlmann Anne
- Vallerga Costanza L.
- van der Meer Dennis
- Van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Eijk Liza
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- Van Son Jaqueline Mayoral
- van Tol Marie-Jose
- van't Ent Dennis
- Veldink Jan H.
- Veltman Dick J.
- Verhoef Ellen
- Volzke Henry
- Voyvodic James T.
- Walter Henrik
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Wardlaw Joanna M.
- Weber Bernd
- Weinberger Daniel R.
- Wen Wei
- Westlye Lars T.
- Whelan Christopher D.
- Whelan Robert
- White Tonya
- Witt Stephanie H.
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wright Margaret J.
- Wu Jing Qin
- Yamamori Hidenaga
- Yang Qiong
- Yasuda Clarissa L.
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H.
- Zsembik Leo C. P.
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Abrantes Katya
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia P. A.
- Block Barbara A.
- Bonfil Ramon
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Carmin D.
- Brooks Edward J.
- Brown Judith
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron B
- Castleton Michael
- Chapple Taylor K
- Chateau Olivier
- Clarke Maurice
- Coelho Rui
- Coffey Daniel M.
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark V.
- Farrugia Thomas J.
- Ferreira Luciana C
- Ferretti Francesco
- Filmalter John D
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galva-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher A.
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio H.V.
- Heard Matthew
- Hearn Alex
- Henderson Suzanne M.
- Holdsworth John C
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicolas E.
- Hussey Nigel E
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M. P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim C. D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D
- McCully Phillips Sophy R.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G
- Mendonça Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa
- O\u27Sullivan John B.
- Oliveira Paulo
- Papastamatiou Yannis P
- Patterson Toby A.
- Peel Lauren R.
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Andy J.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George
- Shipley Oliver N.
- Shivji Mahmood
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B
- Sousa Lara L.
- Southall Emily J
- Spaet Julia L. Y.
- Stehfest Killian M.
- Stevens Guy
- Stewart Joshua D.
- Sulikowski James
- Syakurachman Ismail
- Thorrold Simon R
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P
- Vaudo Jeremy
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R.J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- NSUWorks
- Publication date
- 19/08/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
- Author
- Adams Mark James
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Alda Martin
- Alfredsson Lars
- Andreassen Ole a.
- Appadurai Vivek
- Artigas María soler
- Ashley-Koch Allison e.
- Awasthi Swapnil
- Azevedo M. helena
- Bakian Amanda v.
- Bass Nicholas
- Bau Claiton h.d.
- Baune Bernhard t.
- Beckham Jean c.
- Behera Chittaranjan
- Bellivier Frank
- Berger Klaus
- Berrettini Wade h.
- Biernacka Joanna m.
- Bigdeli Tim b.
- Binder Elisabeth b.
- Boehnke Michael
- Bohus Martin
- Boks Marco p.
- Braff David l.
- Breen Gerome
- Bryant Richard
- Budde Monika
- Bulik Cynthia m.
- Byrne Enda m.
- Børglum Anders d.
- Cahn Wiepke
- Campos Adrian i.
- Castelao Enrique
- Cervilla Jorge a.
- Chang Xiao
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei j.
- Christensen Erik d.
- Coleman Jonathan r.i.
- Coon Hilary
- Corvin Aiden
- Craddock Nicholas
- Crow Scott
- Demontis Ditte
- Dennis Michelle
- Diblasi Emily
- Djurovic Srdjan
- Docherty Anna r.
- Duriez Philibert
- Edenberg Howard j.
- Edwards Alexis c.
- Erlangsen Annette
- Fernández-Aranda Fernando
- Foo Jerome c.
- Forstner Andreas j.
- Frye Mark
- Fullerton Janice m.
- Galfalvy Hanga
- Gandal Michael
- Garrett Melanie
- Gatt Justine m.
- Gelernter Joel
- Giegling Ina
- Glatt Stephen j.
- Gorwood Philip
- Grabe Hans j.
- Green Melissa j.
- Grevet Eugenio h.
- Grigoroiu-Serbanescu Maria
- Guo Yiran
- Gutierrez Blanca
- Guzman-Parra Jose
- Hafferty Jonathan d.
- Hair Lauren
- Hakonarson Hakon
- Halmi Katherine a.
- Hamshere Marian l.
- Hartmann Annette m.
- Harvey Philip
- Hauser Elizabeth r.
- Hauser Joanna
- Hauser Michael a.
- Heilmann-Heimbach Stefanie
- Hishimoto Akitoyo
- Hoffmann Per
- Hougaard David m.
- Huffman Jennifer
- Hwu Hai-Gwo
- Ising Marcus
- Jacobson Daniel
- Jain Sonia
- Jamain Stéphane
- Jiménez-Murcia Susana
- Johnson Craig
- Jones Ian
- Jones Lisa a.
- Jonsson Lina
- Kahn René s.
- Kang Jooeun
- Kaplan Allan s.
- Kaye Walter h.
- Keel Pamela k.
- Kelsoe John r.
- Kendler Kenneth s.
- Kennedy James l.
- Kessler Ronald c.
- Kim Minsoo
- Kimbrel Nathan a.
- Kloiber Stefan
- Klump Kelly l.
- Koenen Karestan c.
- Kogevinas Manolis
- Kranzler Henry r.
- Krebs Marie-Odile
- Kuo Po-Hsiu
- Landén Mikael
- Leboyer Marion
- Lee Phil h.
- Levey Daniel f.
- Levinson Douglas f.
- Lewis Cathryn m.
- Li Dong
- Li Qingqin s.
- Liao Calwing
- Liao Shih-Cheng
- Lieb Klaus
- Lilenfeld Lisa
- Lissowska Jolanta
- Liu Chih-Min
- Madduri Ravi
- Mann J. john
- Marshall Christian r.
- Martin Nicholas g.
- Mayoral Fermin
- Mcelroy Susan l.
- Mcgrath Patrick
- Mcguffin Peter
- Mcintosh Andrew m.
- Mcmahon Benjamin
- Mcquillin Andrew
- Medland Sarah e.
- Mehta Divya
- Melle Ingrid
- Mitchell James e.
- Mitchell Philip b.
- Molina Esther
- Monson Eric t.
- Morken Gunnar
- Mors Ole
- Mullins Niamh
- Murnyak Balasz
- Nievergelt Caroline
- Nordentoft Merete
- Nurnberger John i.
- Nöthen Markus m.
- Okazaki Satoshi
- Olsen Catherine m.
- Ophoff Roel a.
- Oslin David w.
- Otsuka Ikuo
- Owen Michael j.
- O’donovan Michael c.
- Pato Carlos
- Pato Michele t.
- Penninx Brenda w.j.h.
- Pinto Dalila
- Pistis Giorgio
- Polimanti Renato
- Porteous David
- Potash James b.
- Power Robert a.
- Powers Abigail
- Preisig Martin
- Qin Xuejun
- Quested Digby
- Ramos-Quiroga Josep antoni
- Ramoz Nicolas
- Reif Andreas
- Rentería Miguel e.
- Ribasés Marta
- Richarte Vanesa
- Rietschel Marcella
- Ripke Stephan
- Rivera Margarita
- Roberts Andrea
- Roberts Gloria
- Roepke Stefan
- Rouleau Guy a.
- Rovaris Diego l.
- Rozanov Vsevolod
- Ruderfer Douglas m.
- Sanders Alan r.
- Scherer Stephen w.
- Schmahl Christian
- Schofield Peter r.
- Schulze Thomas g.
- Scott Laura j.
- Serretti Alessandro
- Shabalin Andrey
- Shi Jianxin
- Sirignano Lea
- Sklar Pamela
- Smeland Olav b.
- Smith Daniel j.
- Smoller Jordan w.
- Sokolowski Marcus
- Sonuga-Barke Edmund j.s.
- Stahl Eli a.
- Starnawska Anna
- Stein Murray b.
- Streit Fabian
- Strober Michael
- Su Mei-Hsin
- Thornton Laura m.
- Trafton Jodie
- Treasure Janet
- Trzaskowski Maciej
- Tsuang Ming t.
- Turecki Gustavo
- Ursano Robert j.
- Van der auwera Sandra
- Vilar-Ribó Laura
- Vincent John b.
- Völzke Henry
- Walss-Bass Consuelo
- Walters James t.r.
- Ware Erin b.
- Wasserman Danuta
- Watson Hunna j.
- Weickert Cynthia shannon
- Weickert Thomas w.
- Weissman Myrna m.
- Wendt Frank
- Werge Thomas
- Whiteman David c.
- Williams Leanne m.
- Willour Virginia
- Witt Stephanie h.
- Woodside D. blake
- Wray Naomi r.
- Yilmaz Zeynep
- Zai Clement c.
- Zillich Lea
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and crossvalidated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS metaanalysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. Methods: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. Results: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10-8. These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10-80). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors. Conclusions: This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.</p
Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies
- Author
- Adams Mark J.
- Adan Roger A.H.
- Adkins Amy E.
- Adkins Daniel E.
- Agrawal Arpana
- Alfredsson Lars
- Aliev Fazil
- Ando Tetsuya
- Andreassen Ole A.
- Bacanu Silviu-Alin
- Baker Jessica H.
- Batzler Anthony
- Bergen Andrew W.
- Berrettini Wade H.
- Bertelsen Sarah
- Biernacka Joanna M.
- Bierut Laura J.
- Bigdeli Tim B.
- Birgegård Andreas
- Boardman Jason D.
- Boden Joseph M.
- Boehm Ilka
- Boni Claudette
- Boomsma Dorret I.
- Brandt Harry
- Breen Gerome
- Brown Sandra A.
- Bryois Julien
- Bucholz Kathleen K.
- Buehren Katharina
- Bulik Cynthia M.
- Burghardt Roland
- Cassina Matgteo
- Chen Danfeng
- Chen Li-Shiun
- Choi Doo-Sup
- Chou Yi-Ling
- Cichon Sven
- Clarke Toni-Kim
- Clementi Maurizio
- Coleman Jonathan R.I.
- Cone Roger D.
- Copeland William E.
- Costello E. Jane
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James J.
- Culverhouse Robert C.
- Dahmen Norbert
- Danner Unna N.
- Davis Oliver S.P.
- de Wit Harriet
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Louisa
- Degortes Daniela
- DeSocio Janiece E.
- Diazgranados Nancy
- Dick Danielle M.
- Dikeos Dimitris
- Dina Christian
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Docherty Anna R.
- Domingue Benjamin W.
- Duncan Laramie E.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eriksson Johan G.
- Escaramís Geòrgia
- Esko Tõnu
- Estivill Xavier
- Farmer Anne
- Farrer Lindsay A.
- Favaro Angela
- Fernández-Aranda Fernando
- Fichter Manfred M.
- Fischer Krista
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forzan Monica
- Fox Louis
- Frank Josef
- Franklin Christopher S.
- Frye Mark A.
- Föcker Manuel
- Gallinger Steven
- Gaspar Héléna A.
- Gelernter Joel
- Giegling Ina
- Gillespie Nathan A.
- Giuranna Johanna
- Giusti-Rodríguez Paola
- Goate Alison M.
- Goldman David
- Gonidakis Fragiskos
- Gordon Scott
- Gorwood Philip
- Grove Jakob
- Grucza Richard A.
- Guillaume Sébastien
- Guo Yiran
- Gäbel Wolfgang
- Hack Laura M.
- Hakonarson Hakon
- Halmi Katherine A.
- Hancock Dana B.
- Hanscombe Ken B.
- Harris Kathleen Mullan
- Hartmann Annette M.
- Hartz Sarah M.
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Henders Anjali K.
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hesselbrock Victor
- Hewitt John K.
- Hinney Anke
- Hodgkinson Colin
- Hoffmann Per
- Hopfer Christian
- Horwood L. John
- Hottenga Jouke-Jan
- Huckins Laura M.
- Hudson James I.
- Hübel Christopher
- Iacono William G.
- Imgart Hartmut
- Inoko Hidetoshi
- Ising Marcus
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Emma C.
- Johnson Eric O.
- Jordan Jennifer
- Julià Antonio
- Kalsi Gursharan
- Kaminská Deborah
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karpyak Victor M.
- Karwautz Andreas
- Kas Martien J.H.
- Kaye Walter H.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Keyes Margaret
- Kiefer Falk
- Kiezebrink Kirsty
- Kim Youl-Ri
- Klump Kelly L.
- Knudsen Gun Peggy S.
- Koller Gabrielle
- Konte Bettina
- Kramer John
- Kranzler Henry R.
- Krauter Kenneth
- Kuperman Samuel
- La Via Maria C.
- Lahti Jari
- Lahti-Pulkkinen Marius
- Lai Dongbing
- Landén Mikael
- Larsen Janne T.
- Le Hellard Stephanie
- Leppä Virpi M.
- Levitan Robert D.
- Li Dong
- Lichtenstein Paul
- Ligthart Lannie
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lissowska Jolanta
- Loukola Anu
- Lucae Susanne
- Luykx Jurjen
- Lynskey Michael T.
- MacKillop James
- Madden Pamela A.F.
- Maes Hermine H.
- Magistretti Pierre J.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Maj Mario
- Mann Karl
- Mannik Katrin
- Marsal Sara
- Marshall Christian R.
- Martin Nicholas G.
- Mattheisen Manuel
- Mattingsdal Morten
- Mayora Monica Gratacos
- Mbarek Hamdi
- McClintick Jeanette N.
- McDevitt Sara
- McGue Matt
- McGuffin Peter
- McIntosh Andrew M.
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meulenbelt Ingrid
- Meyers Jacquelyn L.
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Mortensen Preben Bo
- Munn-Chernoff Melissa A.
- Murray Alison D.
- Männistö Satu
- Müller-Myhsok Bertram
- Nacmias Benedetta
- Navratilova Marie
- Neale Benjamin M.
- Nelson Elliot C.
- Norring Claes
- Ntalla Ioanna
- Nurnberger John I.
- Nöthen Markus M.
- Olsen Catherine M.
- Ophoff Roel A.
- O’Toole Julie K.
- Padyukov Leonid
- Palmer Abraham A.
- Palotie Aarno
- Palviainen Teemu
- Pantel Jacques
- Papezova Hana
- Parker Richard
- Pearson John F.
- Pedersen Nancy L.
- Penninx Brenda W.J.H.
- Perica Vesna Boraska
- Petersen Liselotte V.
- Peterson Roseann E.
- Pinto Dalila
- Polimanti Renato
- Porjesz Bernice
- Preuss Ulrich
- Rabionet Raquel
- Raevuori Anu
- Ramoz Nicolas
- Reichborn-Kjennerud Ted
- Reynolds Maureen D.
- Ricca Valdo
- Rice John P.
- Ridinger Monika
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rose Richard J.
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Ryu Euijung
- Räikkönen Katri
- Saccone Nancy L.
- Salvatore Jessica E.
- Sanchez-Roige Sandra
- Santonastaso Paolo
- Scherag André
- Scherbaum Norbert
- Scherer Stephen W.
- Schmidt Ulrike
- Schork Nicholas J.
- Schosser Alexandra
- Schuckit Marc A.
- Schwandt Melanie
- Seitz Jochen
- Shen Pei-Hong
- Sherva Richard
- Silberg Judy
- Slachtova Lenka
- Slagboom P. Eline
- Slof-Op’t Landt Margarita C.T.
- Slopien Agnieszka
- Sorbi Sandro
- Soyka Michael
- Stallings Michael C.
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuber Garret D.
- Sullivan Patrick F.
- Szatkiewicz Jin P.
- Tachmazidou Ioanna
- Tarter Ralph E.
- Tenconi Elena
- Thomas Nathaniel
- Thornton Laura M.
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tsitsika Artemis
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- van Elburg Annemarie A.
- van Furth Eric F.
- Vanyukov Michael M.
- Vrieze Scott
- Wade Tracey D.
- Wagner Gudrun
- Wall Tamara L.
- Walters Raymond K.
- Walton Esther
- Wang Jen-Chyong
- Watson Hunna J.
- Webb Bradley T.
- Wedow Robbee
- Werge Thomas
- Wetherill Leah
- Whiteman David C.
- Whitfield John B.
- Widen Elisabeth
- Wills Amanda G.
- Witt Stephanie H.
- Wodarz Norbert
- Woodside D. Blake
- Yao Shuyang
- Yilmaz Zeynep
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhao Hongyu
- Zhou Hang
- Zill Peter
- Zipfel Stephan
- Świątkowska Beata
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
First published: 16 February 202
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
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- Ittermann Bernd
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- Wardlaw Joanna M
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- Weinberger Daniel R
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- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
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- Willeke Diana
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- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
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- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
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- Banerjee Ruby
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- Barbe Valérie
- Bardill Simon
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- Barker Darren
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- Barlow Karen
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- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
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- Bituin Aleksandr
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- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
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- Chillingworth Neil
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- Collings Simon
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- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
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- Copeland Alex
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- Cordes Matt
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- Danganan Linda
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- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
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- Davis Matthew
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- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
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- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
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- Delgado Oliver
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- Dennis Janet
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- Denys Mirian
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- Desai Anu
- Detter John C.
- Devlin Laurie
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- Ding Hao
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- Dinh Huyen H.
- Dixon Kami
- Do Long
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- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
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- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
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- Du Hui
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- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
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- Edwards Carol
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- Emelianenko Natalia
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- Endrizzi Matthew
- Engh Ger van den
- Engle David
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- Eugene Craig S.
- Evans Gareth
- Evans John
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- Footman Simon
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- Fuller Liam
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- Fulton Lucinda A.
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- Garnes Jeffrey A.
- Garnett Jane
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- Gatland Leigh
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- Gibbs Ben
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- Gonzales Eidelyn
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- Gordon Catherine
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- Grady Michelle L.
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- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
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- Hammon Nancy
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- Hamza Khalid
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- Hanak Vincent A.
- Hancock Julie
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- Harding Adam
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- Hawes Alicia C.
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- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
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- Hitchens Matthew Edward
- Ho Issac
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- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
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- Idlebird Devincent G.
- Iliev Ilian
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- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Inoue Shuuji
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jia Jia
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- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
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- Kube Michael
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- Lowenstein Michael G.
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- McNinch Jenny
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- Mesirov Jill P.
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- Nakato Eriko
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- Nandkeshwar Richard
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- Naranjo Cleo M.
- Nash William
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- Nwokenkwo Stanley
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- O\u27Neill Keith
- Obayashi Izumi
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- Wyatt Julia
- Wycoff-Montenegro Melissa
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- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
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- Yamamoto Yuko
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- Zembeck Lisa
- Zeng Yixin
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
- Author
- A Auton
- A Boyd
- A Fraser
- A Fry
- Aarno Palotie
- AB Hart
- Abraham A. Palmer
- AD Skol
- Alexis C. Edwards
- Alison D. Murray
- Alison M. Goate
- AM Andersen
- Amanda G. Wills
- American Psychiatric Association.
- American Psychiatric Association.
- Amy E. Adkins
- Andrew C. Heath
- Andrew M. McIntosh
- Anna R. Docherty
- Annette M. Hartmann
- Anthony Batzler
- Anu Loukola
- AP Morris
- Arpana Agrawal
- B Bulik-Sullivan
- B Han
- B Howie
- B Verhulst
- Benjamin M. Neale
- Benjamin W. Domingue
- Bernice Porjesz
- Bertram Müller-Myhsok
- Bettina Konte
- BF Grant
- BH Smith
- BK Bulik-Sullivan
- BN Howie
- Bradley T. Webb
- Brenda W. J. H. Penninx
- Brien P. Riley
- Brion S. Maher
- CA de Leeuw
- CA Prescott
- Caroline Hayward
- Christian J. Hopfer
- CJ Willer
- Colin Hodgkinson
- D B Hancock
- D Firth
- D Li
- D Li
- DA Dawson
- Dan Rujescu
- Dana B. Hancock
- Danfeng Chen
- Daniel E. Adkins
- Danielle M. Dick
- David Goldman
- DB Hancock
- Dongbing Lai
- Doo-Sup Choi
- Dorret I. Boomsma
- DP Hibar
- DR Zerbino
- DS Hasin
- DS Pratt
- E. Jane Costello
- Elliot C. Nelson
- EM Derks
- Emma C. Johnson
- Eric O. Johnson
- Euijung Ryu
- F Dudbridge
- Fabian Streit
- Falk Kiefer
- Fazil Aliev
- Franziska Degenhardt
- G Schumann
- G Traversy
- GF Koob
- Grant W. Montgomery
- H Mbarek
- H Zhou
- Hamdi Mbarek
- Harriet de Wit
- Henry R. Kranzler
- Hermine H. Maes
- Hongyu Zhao
- Howard J. Edenberg
- I Pe’er
- Ina Giegling
- J Frank
- J Lonsdale
- J Martin
- J O’Connell
- J Zheng
- Jaakko A. Kaprio
- Jacquelyn L. Meyers
- James MacKillop
- Jana Strohmaier
- Jari Lahti
- Jason D. Boardman
- JC Chambers
- Jeanette N. McClintick
- Jen-Chyong Wang
- Jens Treutlein
- Jerome C. Foo
- Jessica E. Salvatore
- Joanna M. Biernacka
- Joel Gelernter
- Johan G. Eriksson
- John B. Whitfield
- John F. Pearson
- John Horwood
- John I. Nurnberger
- John K. Hewitt
- John Kramer
- John P. Rice
- Josef Frank
- Joseph M. Boden
- Jouke Jan Hottenga
- Judy Silberg
- Karl Mann
- Kathleen K. Bucholz
- Kathleen Mullan Harris
- Katri Räikkönen
- Kenneth Krauter
- Kenneth S. Kendler
- KS Kendler
- L Duncan
- Lannie Ligthart
- Laura J. Bierut
- Laura M. Hack
- LE Duncan
- Leah Wetherill
- Li-Shiun Chen
- Lindsay A. Farrer
- LJ Bierut
- LM Evans
- Louis Fox
- Louisa Degenhardt
- Marc A. Schuckit
- Marcella Rietschel
- Marcus Ising
- Margaret Keyes
- Marius Lahti-Pulkkinen
- Mark A. Frye
- Mark J. Adams
- Markus M. Nöthen
- Martin A. Kennedy
- Matt McGue
- Matthew B. McQueen
- Maureen D Reynolds
- Melanie Schwandt
- Mervi Alanne-Kinnunen
- MH Chen
- Michael C. Stallings
- Michael M. Vanyukov
- Michael Soyka
- Michael T. Lynskey
- MJ Kreek
- Monika Ridinger
- MR Munafò
- Nancy Diazgranados
- Nancy L. Pedersen
- Nancy L. Saccone
- Nathan A. Gillespie
- Nathaniel Thomas
- Nicholas G. Martin
- Norbert Dahmen
- Norbert Scherbaum
- Norbert Wodarz
- NR Wray
- NR Wray
- Pamela A. F. Madden
- Patrik Magnusson
- Paul Lichtenstein
- Pei-Hong Shen
- Penelope A. Lind
- Per Hoffmann
- Peter Zill
- PF Sullivan
- Pierre Fontanillas
- R Polimanti
- R Polimanti
- Ralph E. Tarter
- Raymond K. Walters
- Renato Polimanti
- RHC Palmer
- Richard A. Grucza
- Richard Rose
- Richard Sherva
- RJL Anney
- Robbee Wedow
- Robert C. Culverhouse
- Roseann E. Peterson
- S Jaffee
- S Sanchez-Roige
- S Stringer
- Samuel Kuperman
- Samuli Ripatti
- Sandra A. Brown
- Sandra Sanchez-Roige
- Sarah Bertelsen
- Sarah E. Medland
- Sarah L. Elson
- Sarah M. Hartz
- Satu Männistö
- Schizophrenia Working Group of the Psychiatric Genomics Consortium.
- Scott Gordon
- Scott Vrieze
- SE Luczak
- SH Lee
- SI Berndt
- Silviu-Alin Bacanu
- Stefan Herms
- Stefanie Heilmann-Heimbach
- Stephanie Witt
- Susanne Lucae
- Sven Cichon
- Tamara L. Wall
- Tatiana M. Foroud
- TD Hurley
- Teemu Palviainen
- Tim B. Bigdeli
- TK Clarke
- Toni-Kim Clarke
- Ulrich Preuss
- Victor Hesselbrock
- Victor M. Karpyak
- William E. Copeland
- William Iacono
- Wolfgang Gäbel
- Wolfgang Maier
- World Health Organization.
- Yi-Ling Chou
- Yuri Milaneschi
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 x 10(-13)) and African ancestries (rs2066702; P = 2.2 x 10(-9)). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.Peer reviewe