192 research outputs found
Communication to the World Food Conference: Plant Nutrients
27 September 1974 letter from CGIAR Chairman Warren C. Baum to World Food Conference Secretary General Sayed Marei on the work being done on plant nutrients at CGIAR centers and proposals being considered by the CGIAR and its TAC. Agenda document presented at CGIAR meeting, October 1974
CGIAR: How it all Began
This report is a brief summary of events leading to the formation of the CGIAR in 1971, as extracted from the the first two chapters of "Partners Against Hunger" by Warren Baum. This summary is also included in the CGIAR's 1985 annual report
Object Classification in Astronomical Multi-Color Surveys
We present a photometric method for identifying stars, galaxies and quasars
in multi-color surveys, which uses a library of >65000 color templates. The
method aims for extracting the information content of object colors in a
statistically correct way and performs a classification as well as a redshift
estimation for galaxies and quasars in a unified approach. For the redshift
estimation, we use an advanced version of the MEV estimator which determines
the redshift error from the redshift dependent probability density function.
The method was originally developed for the CADIS survey, where we checked
its performance by spectroscopy. The method provides high reliability (6 errors
among 151 objects with R<24), especially for quasar selection, and redshifts
accurate within sigma ~ 0.03 for galaxies and sigma ~ 0.1 for quasars.
We compare a few model surveys using the same telescope time but different
sets of broad-band and medium-band filters. Their performance is investigated
by Monte-Carlo simulations as well as by analytic evaluation in terms of
classification and redshift estimation. In practice, medium-band surveys show
superior performance. Finally, we discuss the relevance of color calibration
and derive important conclusions for the issues of library design and choice of
filters. The calibration accuracy poses strong constraints on an accurate
classification, and is most critical for surveys with few, broad and deeply
exposed filters, but less severe for many, narrow and less deep filters.Comment: 21 pages including 10 figures. Accepted for publication in Astronomy
& Astrophysic
The multiple quantum NMR dynamics in systems of equivalent spins with the dipolar ordered initial state
The multiple quantum (MQ) NMR dynamics in the system of equivalent spins with
the dipolar ordered initial state is considered. The high symmetry of the MQ
Hamiltonian is used in order to develop the analytical and numerical methods
for an investigation of the MQ NMR dynamics in the systems consisting of
hundreds of spins from "the first principles". We obtain the dependence of the
intensities of the MQ NMR coherences on their orders (profiles of the MQ NMR
coherences) for the systems of spins. It is shown that these
profiles may be well approximated by the exponential distribution functions. We
also compare the MQ NMR dynamics in the systems of equivalent spins having two
different initial states, namely the dipolar ordered state and the thermal
equilibrium state in the strong external magnetic field.Comment: 11 pages 4 figure
The evolution of faint AGN between z~1 and z~5 from the COMBO-17 survey
We present a determination of the optical/UV AGN luminosity function and its
evolution, based on a large sample of faint (R<24) QSOs identified in the
COMBO-17 survey. Using multi-band photometry in 17 filters within 350nm <
lambda_obs < 930nm, we could simultaneously determine photometric redshifts
with an accuracy of sigma_z<0.03 and obtain spectral energy distributions. The
redshift range covered by the sample is 1.2<z<4.8, which implies that even at
z~3, the sample reaches below luminosities corresponding to M_B = -23,
conventionally employed to distinguish between Seyfert galaxies and quasars. We
clearly detect a broad plateau-like maximum of quasar activity around z~2 and
map out the smooth turnover between z~1 and z~4. The shape of the LF is
characterised by some mild curvature, but no sharp `break' is present within
the range of luminosities covered. Using only the COMBO-17 data, the evolving
LF can be adequately described by either a pure density evolution (PDE) or a
pure luminosity evolution (PLE) model. However, the absence of a strong L*-like
feature in the shape of the LF inhibits a robust distinction between these
modes. We present a robust estimate for the integrated UV luminosity generation
by AGN as a function of redshift. We find that the LF continues to rise even at
the lowest luminosities probed by our survey, but that the slope is
sufficiently shallow that the contribution of low-luminosity AGN to the UV
luminosity density is negligible. Although our sample reaches much fainter flux
levels than previous data sets, our results on space densities and LF slopes
are completely consistent with extrapolations from recent major surveys such as
SDSS and 2QZ.Comment: 17 pages, 14 figures, Astronomy & Astrophysics, in print, revised
versio
Ultrashort-pulse laser with an intracavity phase shaping element
A novel ultrashort-pulse laser cavity configuration that incorporates an intracavity deformable mirror as a phase control element is reported. A user-defined spectral phase relation of 0.7 radians relative shift could be produced at around 1035 nm. Phase shaping as well as pulse duration optimization was achieved via a computer-controlled feedback loop
Coherent Control of Multiphoton Transitions with Femtosecond pulse shaping
We explore the effects of ultrafast shaped pulses for two-level systems that
do not have a single photon resonance by developing a multiphoton
density-matrix approach. We take advantage of the fact that the dynamics of the
intermediate virtual states are absent within our laser pulse timescales. Under
these conditions, the multiphoton results are similar to the single photon and
that it is possible to extend the single photon coherent control ideas to
develop multiphoton coherent control.Comment: 13 pages, 7 figures. submitted to PR
Mobility, Expansion and Management of a Multi-Species Scuba Diving Fishery in East Africa
Background: Scuba diving fishing, predominantly targeting sea cucumbers, has been documented to occur in an uncontrolled manner in the Western Indian Ocean and in other tropical regions. Although this type of fishing generally indicates a destructive activity, little attention has been directed towards this category of fishery, a major knowledge gap and barrier to management. Methodology and Principal Findings: With the aim to capture geographic scales, fishing processes and social aspects the scuba diving fishery that operate out of Zanzibar was studied using interviews, discussions, participant observations and catch monitoring. The diving fishery was resilient to resource declines and had expanded to new species, new depths and new fishing grounds, sometimes operating approximately 250 km away from Zanzibar at depths down to 50 meters, as a result of depleted easy-access stock. The diving operations were embedded in a regional and global trade network, and its actors operated in a roving manner on multiple spatial levels, taking advantage of unfair patron-client relationships and of the insufficient management in Zanzibar. Conclusions and Significance: This study illustrates that roving dynamics in fisheries, which have been predominantly addressed on a global scale, also take place at a considerably smaller spatial scale. Importantly, while proposed management of the sea cucumber fishery is often generic to a simplified fishery situation, this study illustrates
A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis
\ua9 2024 The AuthorsBackground: Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manifests with painful pustular eruptions on the palms and soles. Although the disease can present with concurrent plaque psoriasis, TNF and IL-17/IL-23 inhibitors show limited efficacy. There is therefore a pressing need to uncover PPP disease drivers and therapeutic targets. Objectives: We sought to identify genetic determinants of PPP and investigate whether cigarette smoking contributes to disease pathogenesis. Methods: We performed a genome-wide association meta-analysis of 3 North-European cohorts (n = 1,456 PPP cases and 402,050 controls). We then used the scGWAS program to investigate the cell-type specificity of the association signals. We also undertook genetic correlation analyses to examine the similarities between PPP and other immune-mediated diseases. Finally, we applied Mendelian randomization to analyze the causal relationship between cigarette smoking and PPP. Results: We found that PPP is not associated with the main genetic determinants of plaque psoriasis. Conversely, we identified genome-wide significant associations with the FCGR3A/FCGR3B and CCHCR1 loci. We also observed 13 suggestive (P < 5
7 10−6) susceptibility regions, including the IL4/IL13 interval. Accordingly, we demonstrated a significant genetic correlation between PPP and TH2-mediated diseases such as atopic dermatitis and ulcerative colitis. We also found that genes mapping to PPP-associated intervals were preferentially expressed in dendritic cells and often implicated in T-cell activation pathways. Finally, we undertook a Mendelian randomization analysis, which supported a causal role of cigarette smoking in PPP. Conclusions: The first genome-wide association study of PPP points to a pathogenic role for deregulated TH2 responses and cigarette smoking
Burden of disease from inadequate water, sanitation and hygiene for selected adverse health outcomes: An updated analysis with a focus on low- and middle-income countries
Background
To develop updated estimates in response to new exposure and exposure-response data of the burden of diarrhoea, respiratory infections, malnutrition, schistosomiasis, malaria, soil-transmitted helminth infections and trachoma from exposure to inadequate drinking-water, sanitation and hygiene behaviours (WASH) with a focus on low- and middle-income countries.
Methods
For each of the analysed diseases, exposure levels with both sufficient global exposure data for 2016 and a matching exposure-response relationship were combined into population-attributable fractions. Attributable deaths and disability-adjusted life years (DALYs) were estimated for each disease and, for most of the diseases, by country, age and sex group separately for inadequate water, sanitation and hygiene behaviours and for the cluster of risk factors. Uncertainty estimates were computed on the basis of uncertainty surrounding exposure estimates and relative risks.
Findings
An estimated 829,000 WASH-attributable deaths and 49.8 million DALYs occurred from diarrhoeal diseases in 2016, equivalent to 60% of all diarrhoeal deaths. In children under 5 years, 297,000 WASH-attributable diarrhoea deaths occurred, representing 5.3% of all deaths in this age group. If the global disease burden from different diseases and several counterfactual exposure distributions was combined it would amount to 1.6 million deaths, representing 2.8% of all deaths, and 104.6 million DALYs in 2016.
Conclusions
Despite recent declines in attributable mortality, inadequate WASH remains an important determinant of global disease burden, especially among young children. These estimates contribute to global monitoring such as for the Sustainable Development Goal indicator on mortality from inadequate WASH
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