Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Search for bottom-type, vectorlike quark pair production in a fully hadronic final state in proton-proton collisions at s=13 TeV

A search is described for the production of a pair of bottom-type vectorlike quarks (VLQs), each decaying into a b or ¯ b quark and either a Higgs or a Z boson, with a mass greater than 1000 GeV. The analysis is based on data from proton-proton collisions at a 13 TeV center-of-mass energy recorded at the CERN LHC, corresponding to a total integrated luminosity of 137     fb − 1 . As the predominant decay modes of the Higgs and Z bosons are to a pair of quarks, the analysis focuses on final states consisting of jets resulting from the six quarks produced in the events. Since the two jets produced in the decay of a highly Lorentz-boosted Higgs or Z boson can merge to form a single jet, nine independent analyses are performed, categorized by the number of observed jets and the reconstructed event mode. No signal in excess of the expected background is observed. Lower limits are set on the VLQ mass at 95% confidence level equal to 1570 GeV in the case where the VLQ decays exclusively to a b quark and a Higgs boson, 1390 GeV for when it decays exclusively to a b quark and a Z boson, and 1450 GeV for when it decays equally in these two modes. These limits represent significant improvements over the previously published VLQ limits

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field