Handout: You Too Can Help...

Statistic and information on how people can help the Women\u27s Rape Crisis Center. Major local projects: Founding of Women\u27s Rape Crisis Center

Pamphlet: Stop Rape

Pamphlet providing information about the Women\u27s Rape Crisis Center Jacksonville with identification card for Women\u27s Rape Crisis Center Advocate taped to cover. Major local projects: Founding of Women\u27s Rape Crisis Center

Press Release: Women\u27s Rape Crisis Center

News release announcing the 24 hour rape hotline working in conjunction with the Suicide Prevention and Crisis Intervention hotline and organization of the Women\u27s Rape Crisis Center in Jacksonville Florida. NOW major local projects: Founding of Women\u27s Rape Crisis Center

Fact Sheet: Rape in Jacksonville

Informational handout with statistics for rape in Jacksonville Florida and the nation for 1973-74. Major local projects: Founding of Women\u27s Rape Crisis Center

Minutes: Meeting of the Board of Directors WRCC

Minutes taken at Women\u27s Rape Crisis Center Board meeting, June 16, 1974. Major local projects: Founding of Women\u27s Rape Crisis Center

Bibliography

List of books, resources and preventative tips. Major local projects: Founding of Women\u27s Rape Crisis Center

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.

Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome dynamics. We show that PRP31, a component of U4 snRNP, is modified with K63-linked ubiquitin chains by the PRP19 complex and deubiquitinated by USP15 and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 and this ternary complex serves as a platform to deubiquitinate PRP31 and PRP3. The ubiquitination and deubiquitination status of PRP31 regulates its interaction with the U5 snRNP component PRP8, which is required for the efficient splicing of chromosome segregation related genes, probably by stabilizing the U4/U6.U5 tri-snRNP complex. Collectively, our data suggest that USP15 plays a key role in the regulation of dynamic protein-protein interactions of the spliceosome