Diseño estructural del edificio multifamiliar residencial alayo de 9 niveles empleando aisladores de energía (lead rubber bearing)

El propósito de esta tesis fue analizar y diseñar estructuralmente un edificio de concreto armado de nueve pisos con aisladores de energía en la base tipo LRB elastoméricos ubicado en Trujillo. El terreno en el que se construirá tiene forma rectangular y una superficie neta de 258.75m2, con un área techada de 234.50m2 por nivel, y se encuentra en un suelo de tipo S2 con capacidad portante de Qadm = 1 kg/cm2. El diseño arquitectónico del proyecto se contempla un primer piso para estacionamientos, con una caseta de vigilancia, escalera y ascensor, y los siguientes ocho niveles son pisos típicos destinados a departamentos, uno por piso. La distribución de los elementos estructurales se realizó respetando la arquitectura y uso de la edificación, con el objetivo de lograr una rigidez adecuada en ambas direcciones y evitar problemas de torsión. Para el predimensionamiento de los elementos estructurales, como: losa, vigas, columnas, escaleras, cimientos y muros de concreto armado; se siguieron los criterios y recomendaciones de las referencias bibliográficas mencionadas en la tesis. Luego se modeló la estructura en el programa ETABS para realizar un análisis modal-espectral y comprender la respuesta y comportamiento de la estructura ante esfuerzos producidos durante un sismo. Las cargas de diseño se obtuvieron mediante un sistema de cargas por gravedad (cargas muertas y cargas vivas) siguiendo la norma E.020 CARGAS, y se aplicaron las fuerzas sísmicas según lo recomendado por la norma E.030 DISEÑO SISMO RESISTENTE, mientras que la norma E.031 AISLAMIENTO estipula el diseño de aisladores en basales. Después de realizar el análisis sísmico y verificar el cumplimiento de los requisitos, se procedió con el diseño de los elementos estructurales según lo establecido en la norma E.060 CONCRETO ARMADOThe purpose of this thesis was to structurally analyze and design a nine-story reinforced concrete building with elastomeric LRB base isolators located in Trujillo. The land on which it will be built is rectangular with a net area of 258.75m2, a roofed area of 234.50m2 per level, and is located on an S2 type soil with a bearing capacity of Qadm = 1 kg/cm2. The architectural design of the project includes a first floor for parking, with a guardhouse, stairs, and elevator, and the following eight levels are typical floors intended for apartments, one per floor. The distribution of structural elements was carried out respecting the architecture and use of the building, with the aim of achieving adequate stiffness in both directions and avoiding torsion problems. For the pre-dimensioning of the structural elements, such as: slabs, beams, columns, stairs, foundations, and reinforced concrete walls; the criteria and recommendations of the bibliographic references mentioned in the thesis were followed. The structure was then modeled in the ETABS program to perform a modal-spectral analysis and understand the response and behavior of the structure under stresses produced during an earthquake. The design loads were obtained through a gravity load system (dead loads and live loads) following the E.020 LOADS standard, and seismic forces were applied according to the recommendations of the E.030 SEISMIC DESIGN standard, while the E.031 ISOLATION standard stipulates the design of base isolators. After performing the seismic analysis and verifying compliance with requirements, the design of structural elements proceeded according to the provisions of the E.060 REINFORCED CONCRETE standard.Tesi

Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha

Neuropathological aging is associated with memory impairment and cognitive decline, affecting several brain areas including the neurogenic niche of the dentate gyrus of the hippocampus (DG). In the healthy brain, homeostatic mechanisms regulate neurogenesis within the DG to facilitate the continuous generation of neurons from neural stem cells (NSC). Nevertheless, aging reduces the number of activated neural stem cells and diminishes the number of newly generated neurons. Strategies that promote neurogenesis in the DG may improve cognitive performance in the elderly resulting in the development of treatments to prevent the progression of neurological disorders in the aged population. Our work is aimed at discovering targeting molecules to be used in the design of pharmacological agents that prevent the neurological effects of brain aging. We study the effect of age on hippocampal neurogenesis using the SAMP8 mouse as a model of neuropathological aging. We show that in 6-month-old SAMP8 mice, episodic and spatial memory are impaired; concomitantly, the generation of neuroblasts and neurons is reduced and the generation of astrocytes is increased in this model. The novelty of our work resides in the fact that treatment of SAMP8 mice with a transforming growth factor-alpha (TGFα) targeting molecule prevents the observed defects, positively regulating neurogenesis and improving cognitive performance. This compound facilitates the release of TGFα in vitro and in vivo and activates signaling pathways initiated by this growth factor. We conclude that compounds of this kind that stimulate neurogenesis may be useful to counteract the neurological effects of pathological aging.19 página

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

The Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.

This article contains supplemental material online at http://cjasn. asnjournals.org/lookup/suppl/doi:10.2215/CJN.07730814/-/ DCSupplemental.BACKGROUND AND OBJECTIVES: The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥65 years, n=1005) and younger (3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. CONCLUSIONS: In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial was funded by Amgen

ПОЯСНЮВАЛЬНА ЗАПИСКА кваліфікаційної роботи бакалавра студента Варганова_Дмитра_Дмитровича напряму підготовки 124 Системний аналіз

Об’єкт дослідження – підприємство КПШНЗ «СДЮСШОР з кінного спорту» ДМР. Предмет дослідження – приготування кормів для годування тренованих і спортивних коней. Мета дослідження: оптимізація витрат підприємства шляхом удосконалення технологій виробництва і рецептів кормів для тренованих і спортивних коней, підвищення їх якості та зниження питомих витрат на виробництво. Методи дослідження: методи багатокритеріальної та нечіткої оптимізації Економічна ефективність: очікується позитивною завдяки розробці оптимальних кормових сумішей, які дозволяють отримувати більше користі для коней та знизити витрати на компоненти, це дозволяє збільшити прибуток підприємства.Кваліфікаційна робота ступеня бакалавр напряму підготовки 124 Системний аналіз, НТУ "Дніпровська політехніка", м. Дніпро, 2020 р. Практична цінність роботи полягає у розробці математичних моделей, які дозволяють визначити оптимальну суміш корму, котра буде відповідати необхідним умовам