Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Heat transfer optimisation through viscous ternary nanofluid flow over a stretching/shrinking thin needle

The current investigation interprets the flow and the thermal characteristics of the ternary nanofluid composed of MoS2, ZnO, and SiO2 spherical nanoparticles and water. The resulting nanofluid is MoS2−ZnO−SiO2−(H2O+EG) where (H2O+EG) act as the base fluid which help in the flow and the nanoparticles contribute to enhancing the heat conductivity. The flow is assumed to occur across a thin needle whose surface is maintained at a higher temperature than the surroundings. The mathematical model is framed by incorporating radiation introduced by Rosseland in terms of partial differential equations (PDE). This system of equations governs the flow and thermal properties of fluid which are converted to a system of ordinary differential equations (ODE). The major outcomes of the study indicated that the increase in the amount of molybdenum disulfide enhanced the heat conducted by the nanofluid whereas it reduced the flow speed. The positive values of the heat source/sink parameter caused the heat conduction of the nanofluid to go high

Heat transfer optimisation through viscous ternary nanofluid flow over a stretching/shrinking thin needle

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through large group Research Project Project under the grant number RGP2/107/44.The current investigation interprets the flow and the thermal characteristics of the ternary nanofluid composed of MoS2, ZnO, and SiO2 spherical nanoparticles and water. The resulting nanofluid is MoS2−ZnO−SiO2−(H2O+EG) where (H2O+EG) act as the base fluid which help in the flow and the nanoparticles contribute to enhancing the heat conductivity. The flow is assumed to occur across a thin needle whose surface is maintained at a higher temperature than the surroundings. The mathematical model is framed by incorporating radiation introduced by Rosseland in terms of partial differential equations (PDE). This system of equations governs the flow and thermal properties of fluid which are converted to a system of ordinary differential equations (ODE). The major outcomes of the study indicated that the increase in the amount of molybdenum disulfide enhanced the heat conducted by the nanofluid whereas it reduced the flow speed. The positive values of the heat source/sink parameter caused the heat conduction of the nanofluid to go high.Publisher PDFPeer reviewe

Possibilities for the Flow of Water and Blood through a Graphene Layer in a Geometry Analogous to Human Arterioles: An Observational Study

Atherosclerosis and aneurysm are two non-communicable diseases that affect the human arterial network. The arterioles undergo dimensional changes that prominently influence the flow of oxygen and nutrients to distal organs and organ systems. Several studies have emerged discussing the various possibilities for the circumstances surrounding the existence of these pathologies. In the present work, we analyze the flow of blood across the stenosis and the aneurysmic sac in contrast with the flow of water to explore alterations in the flow characteristics caused by introduction of the graphene layer. We investigate the blood flow past the graphene layer with varying porosity. The study is undertaken to replace usage of a stent along a blocked artery by inserting a thin layer of graphene along the flow channel in the post-pathological section of the geometry. To explain the flow, a 2D mathematical model is constructed, and the validity and exclusivity of the model&rsquo;s solution are examined. When the artery wall is assumed to be inelastic, the computation of the mathematical system is evaluated using a finite element method (FEM) solver. We define a new parameter called critical porosity C&epsilon;p to explore the flow possibilities through the graphene layer. The findings indicate that the flow pattern was adversely affected by the graphene layer that was added to the flow field. The negative impact on the flow could be due to the position of the graphene layer placed. The C&epsilon;p values for the flow of blood across healthy arteriole, stenosed arteriole, and aneurysmic arteriole segments were 5.7%,&nbsp;3.5%, and 3.5% respectively. The critical porosity values were achieved with precision in terms of linear errors 8.1&times;10&minus;12, 7.7&times;10&minus;12, and 3.9&times;10&minus;12, respectively. The consequences of the present study disclose various possible ways to utilize graphene and its compounds in the medical and clinical arena, with a prior exploration of the chemical properties of the compound. The idea and the methodology applied for the present study are novel as there have been no previous research works available in this direction of the research field

Possibilities for the Flow of Water and Blood through a Graphene Layer in a Geometry Analogous to Human Arterioles: An Observational Study

Atherosclerosis and aneurysm are two non-communicable diseases that affect the human arterial network. The arterioles undergo dimensional changes that prominently influence the flow of oxygen and nutrients to distal organs and organ systems. Several studies have emerged discussing the various possibilities for the circumstances surrounding the existence of these pathologies. In the present work, we analyze the flow of blood across the stenosis and the aneurysmic sac in contrast with the flow of water to explore alterations in the flow characteristics caused by introduction of the graphene layer. We investigate the blood flow past the graphene layer with varying porosity. The study is undertaken to replace usage of a stent along a blocked artery by inserting a thin layer of graphene along the flow channel in the post-pathological section of the geometry. To explain the flow, a 2D mathematical model is constructed, and the validity and exclusivity of the model’s solution are examined. When the artery wall is assumed to be inelastic, the computation of the mathematical system is evaluated using a finite element method (FEM) solver. We define a new parameter called critical porosity Cεp to explore the flow possibilities through the graphene layer. The findings indicate that the flow pattern was adversely affected by the graphene layer that was added to the flow field. The negative impact on the flow could be due to the position of the graphene layer placed. The Cεp values for the flow of blood across healthy arteriole, stenosed arteriole, and aneurysmic arteriole segments were 5.7%, 3.5%, and 3.5% respectively. The critical porosity values were achieved with precision in terms of linear errors 8.1×10−12, 7.7×10−12, and 3.9×10−12, respectively. The consequences of the present study disclose various possible ways to utilize graphene and its compounds in the medical and clinical arena, with a prior exploration of the chemical properties of the compound. The idea and the methodology applied for the present study are novel as there have been no previous research works available in this direction of the research field

Not Available

Not AvailableAndaman and Nicobar Islands are pristine in nature and blessed with a variety of species diversity in general as well as aquatic resources in specific. The three facets of aquatic environment namely, freshwater, brackishwater and marine resources are not fully tapped to the potential and therefore have further scope for improvement. At present, only freshwater carp farming is being practiced in the Bay Islands while brackishwater aquaculture and mariculture are the identified areas for development. Diseases are the major constraints for the development in aquaculture sector. The present study reviews the work carried out till date on the disease aspects of aquatic animals. Abdominal dropsy from freshwater fishes, pop-eye disease, trematode and cestode infestations from marine fishes, White Spot Syndrome Virus (WSSV) and luminescent vibriosis from crustaceans and necrotic patches, yellow spot disease, pink line syndrome, white line syndrome, white plague, black band disease, tissue lesion, ring line syndrome and abnormal growth from corals have been reported from Andaman and Nicobar Islands. It is interesting to find that the pathogens like virus, bacteria, fungi and parasites were reported from these aquatic animals in the Island ecosystem. This is in contrast to our perception considering the virgin status of the Island. The scanty information available at present on the aquatic animal diseases itself has listed out all the possible diseases which would serve as a base for further studies in future. Therefore, it is the need of the hour to carry out a systematic study on the aquatic animal diseases of Bay Islands. Early detection of the diseases and rapid response to the identified diseases are critical for the effective management of aquatic animal disease emergencies in the Island ecosystem.Not Availabl

Search for narrow resonances using the dijet mass spectrum in pp collisions at s√=8 TeV

Results are presented of a search for the production of new particles decaying to pairs of partons (quarks, antiquarks, or gluons), in the dijet mass spectrum in proton-proton collisions at s√=8  TeV. The data sample corresponds to an integrated luminosity of 4.0  fb−1, collected with the CMS detector at the LHC in 2012. No significant evidence for narrow resonance production is observed. Upper limits are set at the 95% confidence level on the production cross section of hypothetical new particles decaying to quark-quark, quark-gluon, or gluon-gluon final states. These limits are then translated into lower limits on the masses of new resonances in specific scenarios of physics beyond the standard model. The limits reach up to 4.8 TeV, depending on the model, and extend previous exclusions from similar searches performed at lower collision energies. For the first time mass limits are set for the Randall–Sundrum graviton model in the dijet channel

Measurement of the charge ratio of atmospheric muons with the CMS detector

We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/ c to 1 TeV/ c . The surface flux ratio is measured to be 1.2766±0.0032(stat.)±0.0032(syst.) , independent of the muon momentum, below 100 GeV/ c . This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments.We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/c to 1 TeV/c. The surface flux ratio is measured to be 1.2766 \pm 0.0032(stat.) \pm 0.0032 (syst.), independent of the muon momentum, below 100 GeV/c. This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments