224 research outputs found
Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells
- Author
- A Albini
- A Matsumoto
- A Musacchio
- A Rapraeger
- B Agerberth
- B Agerberth
- B Agerberth
- BF Liebersbach
- C Yeaman
- E Martin
- G Albrecht-Buehler
- H Yu
- HG Boman
- HG Boman
- I Doi
- I Gout
- J Shi
- JE Koda
- K Elenius
- K Elenius
- M Bernfield
- M Solursh
- MT Hinkes
- N Huh
- P Storici
- PJ Effert
- RB Dickson
- RD Sanderson
- RD Sanderson
- RL Gallo
- RS Aycock
- S Saunders
- S Saunders
- S Vainio
- S Vanio
- T Pawson
- T Stossel
- YR Chan
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
PR-39 is an endogenous proline-rich antimicrobial peptide which induces the synthesis of syndecan-1, a transmembrane heparan sulphate proteoglycan involved in cell-to-matrix interactions and wound healing. Previously, we revealed that the expression of syndecan-1 was reduced in human hepatocellular carcinomas with high metastatic potential and speculated that syndecan-1 played an important role in inhibition of invasion and metastasis. It is assumed that a modification of this process with PR-39 and syndecan-1 may result in a new strategy by which it can inhibit the invasion and metastasis. Therefore, we transduced a gene of PR-39 into human hepatocellular carcinoma cell line HLF, which shows a low expression of syndecan-1 and a high in vitro invasive activity, and examined whether this procedure could reduce the invasive activity of tumour cells. In two transfectants with PR-39 gene, the syndecan-1 expression was induced and the invasive activity in type I collagen-coated chamber was inhibited. Moreover, these transfectants showed the suppression of motile activity assayed by phagokinetic tracks in addition to the disorganization of actin filaments observed by a confocal imaging system. In contrast, five transfectants with syndecan-1 gene in the HLF cells revealed suppression of invasive activity but did not alter the motile activity and actin structures of the cell. These results suggest that PR-39 has functions involved in the suppression of motile activity and alteration of actin structure on human hepatocellular carcinoma cells in addition to the suppression of invasive activity which might result from the induction of syndecan-1 expression. © 1999 Cancer Research Campaig
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
- Author
- Adolfsson Jan
- Aguado Miguel
- Aitken Joanne
- Albanes Demetrius
- Alcaraz Antonio
- Aly Markus
- Andriole Gerald
- Aukim-Hastie Claire
- Auvinen Anssi
- Bangma Christopher
- Barnett Gill
- Batra Jyotsna
- Beane Freeman Laura E.
- Benlloch Sara
- Bensen Jeanette T.
- Bentzen Søren
- Berndt Sonja I.
- Berry Clare
- Bisbjerg Rasmus
- Bohnert Philipp
- Borre Michael
- Brenner Hermann
- Broms Michael
- Brook Mark N.
- Brown Paul
- Burnet Neil
- Bustamante Mariona
- Butler Lisa
- Calvo Patricia
- Cancel-Tassin Géraldine
- Cannon-Albright Lisa A.
- Canzian Federico
- Cao Guangwen
- Carballo Ana
- Cardoso Marta
- Carracedo Angel
- Carter Brian D.
- Castaño-Vinyals Gemma
- Castelao Jose Esteban
- Cavalli-Bjoerkman Carin
- Cecchini Lluís
- Cenee Sylvie
- Chambers Suzanne
- Chanock Stephen J.
- Christova Svetlana
- Claessens Frank
- Clements Judith
- Conti David V.
- Cook Margaret
- Cox Angela
- Cuk Katarina
- Cussenot Olivier
- Cybulski Cezary
- Dadaev Tokhir
- Davis Michael
- De Langhe Sofie
- De Meerleer Gert
- De Ruyck Kim
- Dearnaley David
- Dierssen-Sotos Trinidad
- Dikov Tihomir
- Ding Yuan Chun
- Donovan Jenny L.
- Drake Bettina F.
- Dunning Alison M.
- Easton Douglas F.
- Eckert Allison
- Eeles Rosalind A.
- Eklund Martin
- Elliott Rebecca
- Evans Andrew
- Fachal Laura
- Feng Ninghan
- Finelli Antonio
- Fisher Cyril
- Fitzgerald Liesel M.
- Fleshner Neil E.
- Freedman Matthew
- Gago-Dominguez Manuela
- Gamulin Marija
- Gapstur Susan M.
- Gardiner Robert
- George Anne
- Geybels Milan S.
- Giles Graham G.
- Giovannucci Edward
- Goodman Phyllis J.
- Govindasami Koveela
- Gracia-Lavedan Esther
- Grindedal Eli M.
- Grönberg Henrik
- Guo Jianming
- Guo Xin
- Guy Michelle
- Gómez Acebo Inés
- Gómez-Caamaño Antonio
- Haiman Christopher A.
- Hakansson Niclas
- Hamdy Freddie C.
- Hamilton Robert J.
- Hayes Vanessa
- Haynes Anne-Maree
- Hazel Steve
- He Weiyang
- Henderson Brian E.
- Herkommer Kathleen
- Hicks Belynda
- Holleczek Bernd
- Hoover Robert N.
- Hopper John L.
- Horvath Lisa
- Hunter David J.
- Hutchinson Amy
- Imai Takashi
- Ingles Sue A.
- Iversen Peter
- Jenster Guido
- Johansson Jan-Erik
- John Esther M.
- Joniau Steven
- Kachakova Darina
- Kaneva Radka
- Karlsson Ami
- Kastelan Zeljko
- Kedda Mary-Anne
- Kerns Sarah
- Key Tim J.
- Khaw Kay-Tee
- Kibel Adam S.
- Kierzek Andrzej
- Kim Jeri
- Klarskov Peter
- Klim Aleksandra
- Kluzniak Wojciech
- Kogevinas Manolis
- Kolb Suzanne
- Kolonel Laurence N.
- Kote-Jarai Zsofia
- Koudou Yves Akoli
- Koutros Stella
- Kraft Peter
- Kujala Paula
- Kulis Tomislav
- Kulkarni Girish S.
- Lane Athene
- Larkin Samantha
- Le Marchand Loic
- Lessel Davor
- Lewis Sarah J.
- Li Jie
- Li Meiling
- Lim Jasmine
- Lin Daniel W.
- Lin Hui-Yi
- Lin Ji
- Lindström Sara
- Ling Jin
- Livni Naomi
- Llorca Javier
- Lobato-Busto Ramón
- Logothetis Christopher J. J.
- Lophatananon Artitaya
- Lu Yong-Jie
- Lubinski Jan
- Luedeke Manuel
- Ma Jing
- Machiela Mitchell J.
- MacInnis Robert J.
- Maehle Lovise
- Maia Sofia
- Maier Christiane
- Mao Xueying
- Marsden Gemma
- Martin Richard M.
- Martinez Maria Elena
- Marzec Jacek
- Matejcic Marco
- McDonnell Shannon K.
- Menegaux Florence
- Mengual Lourdes
- Michael Agnieszka
- Milne Roger
- Mitev Vanio
- Mitkova Atanaska
- Morgan Angela
- Moya Leire
- Mucci Lorelei
- Muir Kenneth
- Mulot Claire
- Murtola Teemu
- Neal David E.
- Neuhausen Susan L.
- Newcomb Lisa F.
- Nielsen Sune F.
- Nordestgaard Børge G.
- Nordström Tobias
- Olama Ali Amin Al
- Ong Aik T.
- Orntoft Torben Falck
- Ost Piet
- Ostrander Elaine A.
- Ostrer Harry
- Pandha Hardev
- Papargiris Melissa
- Park Hyun
- Park Jong Y.
- Parliament Matthew
- Pashayan Nora
- Paulo Paula
- Pedersen John
- Peleteiro Paula
- Penney Kathryn L.
- Pharoah Paul
- Popov Elenko
- Pow-Sang Julio
- Ranu Hardeep
- Razack Azad
- Rebillard Xavier
- Ren Guoping
- Riboli Elio
- Risbridger Gail
- Riska Shaun
- Roobol Monique J.
- Rosenstein Barry
- Ruiz-Dominguez José Manuel
- Røder Martin Andreas
- Saito Shiro
- Sanchez Marie
- Saunders Edward J.
- Saunders Pamela
- Schaid Daniel J.
- Schleutker Johanna
- Schnoeller Thomas
- Schroder F. H.
- Schumacher Fredrick R.
- Sellers Thomas A.
- Sheng Xin
- Siddiq Afshan
- Silva Maria P.
- Sipeky Csilla
- Slavov Chavdar
- Sorensen Karina D.
- Southey Melissa C.
- Spurdle Amanda
- Srinivasan Srilakshmi
- Stampfer Meir
- Stanford Janet L.
- Stattin Par
- Steele Linda
- Stegmaier Christa
- Stern Mariana C.
- Stevens Victoria L.
- Strom Sara S.
- Sun Zan
- Szulkin Robert
- Taari Kimmo
- Talala Kirsi
- Tammela Teuvo L. J.
- Tan Meng H.
- Tangen Catherine M.
- Taylor Renea
- Teixeira Manuel R.
- Teo Soo-Hwang
- Thibodeau Stephen N.
- Thierens Hubert
- Thompson Ian M.
- Thwaites Alison
- Tilley Wayne
- Tillmans Lori
- Toi Ants
- Townsend Paul A.
- Travis Ruth C.
- Tretarre Brigitte
- Truong Thérèse
- Turman Constance
- Usmani Nawaid
- Van den Broeck Thomas
- van der Kwast Theodorus H.
- van Schaik Ron H. N.
- Vega Ana
- Vlahova Aleksandrina
- Vogel Walther
- Vogt Aurelie
- Wang Guomin
- Wang Kan
- Weinstein Stephanie
- Weisher Maren
- West Catharine
- Whitmore Ian
- Wiklund Fredrik
- Wokolorczyk Dominika
- Wolk Alicja
- Wu Huihai
- Wu Ji
- Wu Yudong
- Xu Jianfeng
- Yeadon Trina
- Yu Yongwei
- Zachariah Babu
- Zhang Hong-Wei
- Zhang Yangling
- Zhao Shan-Chao
- Zhou Bo
- Zlotta Alexandre R.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Characterizing Prostate Cancer Risk Through Multi-Ancestry Genome-Wide Discovery of 187 Novel Risk Variants
- Author
- Abraham Aswin
- Adebiyi Akindele O
- Adjei Andrew A
- Adusei Ben
- Aisuodionoe-Shadrach Oseremen I
- Ajibola Hafees O
- Albanes Demetrius
- Aldrich Melinda C
- Aly Markus
- Ambs Stefan
- Amodu Olukemi
- Andrews Caroline
- Andriole Gerald L
- Aukim-Hastie Claire
- Auvinen Anssi
- Barnett Gill
- Batra Jyotsna
- Beane Freeman Laura E
- Benlloch Sara
- Bensen Jeannette T
- Berndt Sonja I
- Biritwum Richard B
- Blanchet Pascal
- Blot William J
- Bohlender Ryan J
- Bojesen Stig E
- Borre Michael
- Brandão Andreia
- Brenner Hermann
- Brook Mark N
- Brureau Laurent
- Bush William S
- Butler Ebonee N
- Cancel-Tassin Geraldine
- Cannon-Albright Lisa
- Carpten John
- Casey Graham
- Castaño-Vinyals Gemma
- Castelao Jose Esteban
- Chambers Suzanne
- Chanock Stephen J
- Chen Fei
- Chen Xuechen
- Cho Kelly
- Chokkalingam Anand P
- Chou Alisha J
- Choudhury Parichoy P
- Claessens Frank
- Clark Peter E
- Clements Judith A
- Conti David V
- Cook Michael B
- Crawford Dana C
- Cullen Jennifer
- Cussenot Olivier
- Cybulski Cezary
- Dadaev Tokhir
- Darkwa-Abrahams Afua
- Darst Burcu F
- De Meerleer Gert
- De Ruyck Kim
- Dierssen-Sotos Trinidad
- Ding Yuan Chun
- Diop Halimatou
- Donovan Jenny L
- Drake Bettina F
- Dunning Alison M
- Easton Douglas F
- Edwards Todd L
- Eeles Rosalind A
- Eklund Martin
- Fachal Laura
- Feng Ninghan
- Figuerêdo Jéssica
- Finelli Antonio
- Fleshner Neil E
- Fowke Jay H
- Fritsche Lars
- Fujita Masashi
- Gago-Dominguez Manuela
- Gamulin Marija
- Gaziano J Michael
- Ghoussaini Maya
- Giles Graham G
- Giovannucci Edward
- Goodman Phyllis J
- Govindasami Koveela
- Grindedal Eli Marie
- Gronberg Henrik
- Gu Jian
- Gueye Serigne M
- Gundell Susan M
- Gómez-Caamaño Antonio
- Haiman Christopher A
- Hamdy Freddie C
- Hamilton Robert J
- Hellwege Jacklyn N
- Hennis Anselm J M
- Hoffman Thomas J
- Holleczek Bernd
- Hoover Robert N
- Horvath Lisa
- Hsing Ann W
- Hu Jennifer J
- Huff Chad D
- Hunter David J
- Håkansson Niclas
- Ingles Sue A
- Isaacs William B
- Ito Shuji
- Jalloh Mohamed
- Jamda Mustapha A
- Janivara Rohini
- Jenster Guido
- John Esther M
- Joniau Steven
- Justice Amy C
- Kachuri Linda
- Kamatani Yoichiro
- Kaneva Radka
- Keaton Jacob M
- Kerns Sarah L
- Key Tim J
- Khaw Kay-Tee
- Kibel Adam S
- Kim Jeri
- Kittles Rick A
- Klein Eric A
- Kogevinas Manolis
- Kote-Jarai Zsofia
- Koudou Yves Akoli
- Koutros Stella
- Kraft Peter
- Kubo Michiaki
- Kulis Tomislav
- Lachance Joseph
- Laisk Triin
- Larkin Samantha
- Leach Robin J
- Lessel Davor
- Lim Jasmine
- Lin Daniel W
- Lin Hui-Yi
- Lindstrom Sara
- Liu Xiaoxi
- Logothetis Christopher J
- Loos Ruth J F
- Lophatananon Artitaya
- Lori Adriana
- Lu Yong-Jie
- Lu Zeyun
- Lubinski Jan
- Lubwama Alexander
- Luedeke Manuel
- Machiela Mitchell J
- MacInnis Robert J
- Madduri Ravi K
- Maehle Lovise
- Maier Christiane
- Mancuso Nick
- Mante Sunny
- Mao Xueying
- Martin Richard M
- Martinez Maria Elena
- Matsuda Koichi
- McDonnell Shannon K
- McKean-Cowdin Roberta
- Mcmahon Benjamin H
- Menegaux Florence
- Mensah James E
- Michael Agnieszka
- Mitev Vanio
- Mohler James L
- Momozawa Yukihide
- Mucci Lorelei A
- Muir Kenneth
- Multigner Luc
- Murphy Adam B
- Mägi Reedik
- Nakagawa Hidewaki
- Neal David E
- Nemesure Barbara
- Neslund-Dudas Christine M
- Neuhausen Susan L
- Newcomb Lisa F
- Niang Lamine
- Nielsen Sune F
- Niwa Shelley
- Nordestgaard Borge G
- Nordstrom Tobias
- Nwegbu Maxwell
- Ogunbiyi Olufemi
- Oluwole Olabode P
- Ost Piet
- Ostrander Elaine A
- Ostrer Harry
- Pandha Hardev
- Parent Marie-Élise
- Park Jong Y
- Parliament Matthew
- Pashayan Nora
- Paulo Paula
- Penney Kathryn L
- Petrovics Gyorgy
- Pilie Patrick
- Plym Anna
- Preuss Michael H
- Razack Azad
- Rebbeck Timothy R
- Rentsch Christopher T
- Riboli Elio
- Risbridger Gail P
- Rodriguez Alex A
- Roobol Monique J
- Rosenstein Barry S
- Rybicki Benjamin A
- Røder Andreas
- Sahimi Ali
- Sanderson Maureen
- Saunders Edward J
- Schaid Daniel J
- Schleutker Johanna
- Schnoeller Thomas
- Schöttker Ben
- Sellers Thomas A
- Shen Jiayi
- Sheng Xin
- Shittu Olayiwola
- Singhal Sandeep
- Sipeky Csilla
- Slavov Chavdar
- Southey Melissa C
- Srivastava Shiv
- Stampfer Meir
- Stanford Janet L
- Steele Linda
- Stern Mariana C
- Strom Sara S
- Stroomberg Hein V
- Sun Zan
- Szulkin Robert
- Sørensen Karina Dalsgaard
- Takahashi Atushi
- Tammela Teuvo L J
- Tang Wei
- Tangen Catherine M
- Tay Evelyn
- Taylor Jack A
- Teerlink Craig C
- Teixeira Manuel R
- Teo Soo-Hwang
- Terao Chikashi
- Tettey Yao
- Thibodeau Stephen N
- Thompson Ian M
- Tilly Wayne
- Torres Mina
- Townsend Paul A
- Travis Ruth C
- Truelove Ann
- Truong Thérèse
- Turman Constance
- Uchio Yuji
- Usmani Nawaid
- Van den Broeck Thomas
- Van Den Eeden Stephen K
- van Schaik Ron H N
- Varma Rohit
- Vega Ana
- Wan Peggy
- Wang Anqi
- Wang Ying
- Watya Stephen
- Weinstein Stephanie
- Weischer Maren
- West Catharine M L
- Wiklund Fredrik
- Witte John S
- Wokolorczyk Dominika
- Wolk Alicja
- Wu Yudong
- Xu Jianfeng
- Xu Yili
- Yamoah Kosj
- Yeboah Edward D
- Yu Yao
- Zawistowski Matthew
- Zhang Hong-Wei
- Zhao Shan-Chao
- Zheng Wei
- Zöllner Sebastian
- Publication venue
- DigitalCommons@TMC
- Publication date
- 01/12/2023
- Field of study
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
- Author
- Adam S. Kibel
- Afshan Siddiq
- Agnieszka Michael
- Aik T. Ong
- Aleksandra Klim
- Aleksandrina Vlahova
- Alexandre R. Zlotta
- Ali Amin Al Olama
- Alicja Wolk
- Alison M. Dunning
- Alison Thwaites
- Allison Eckert
- Amanda Spurdle
- Ami Karlsson
- Amy Hutchinson
- Ana Carballo
- Ana Vega
- Andrew Evans
- Andrzej Kierzek
- Angel Carracedo
- Angela Cox
- Angela Morgan
- Anne George
- Anne-Maree Haynes
- Anssi Auvinen
- Antonio Alcaraz
- Antonio Finelli
- Antonio Gómez-Caamaño
- Ants Toi
- Artitaya Lophatananon
- Atanaska Mitkova
- Athene Lane
- Aurelie Vogt
- Azad Razack
- Babu Zachariah
- Barry Rosenstein
- Belynda Hicks
- Bernd Holleczek
- Bettina F. Drake
- Bo Zhou
- Brian D. Carter
- Brian E. Henderson
- Brigitte Tretarre
- Børge G. Nordestgaard
- Carin Cavalli-Bjoerkman
- Catharine West
- Catherine M. Tangen
- Cezary Cybulski
- Chavdar Slavov
- Chee Goh
- Christa Stegmaier
- Christiane Maier
- Christopher A. Haiman
- Christopher Bangma
- Christopher J. Logothetis
- Claire Aukim-Hastie
- Claire Mulot
- Clara Cieza-Borrella
- Clare Berry
- Constance Turman
- Csilla Sipeky
- Cyril Fisher
- Daniel A. Leongamornlert
- Daniel J. Schaid
- Daniel W. Lin
- Darina Kachakova
- David Dearnaley
- David E. Neal
- David J. Hunter
- David V. Conti
- Davor Lessel
- Demetrius Albanes
- Dominika Wokolorczyk
- Douglas F. Easton
- Edward Giovannucci
- Edward J. Saunders
- Elaine A. Ostrander
- Elenko Popov
- Eli Marie Grindedal
- Elio Riboli
- Esther Gracia-Lavedan
- Esther M. John
- Ezequiel Anokian
- F. H. Schroder
- Federico Canzian
- Florence Menegaux
- Frank Claessens
- Freddie C. Hamdy
- Fredrick R. Schumacher
- Fredrik Wiklund
- Gail Risbridger
- Gemma Castaño-Vinyals
- Gemma Marsden
- Gerald Andriole
- Gert De Meerleer
- Gill Barnett
- Girish S. Kulkarni
- Graham G. Giles
- Guangwen Cao
- Guido Jenster
- Guomin Wang
- Guoping Ren
- Géraldine Cancel-Tassin
- Hardeep Ranu
- Hardev Pandha
- Harry Ostrer
- Henrik Gronberg
- Hermann Brenner
- Hong-Wei Zhang
- Hubert Thierens
- Hui-Yi Lin
- Huihai Wu
- Hyun Park
- Ian M. Thompson
- Ian Whitmore
- Ines Gomez-Acebo
- Jacek Marzec
- Jan Adolfsson
- Jan Lubinski
- Jan-Erik Johansson
- Janet L. Stanford
- Jasmine Lim
- Javier Llorca
- Jenny L. Donovan
- Jeri Kim
- Ji Lin
- Ji Wu
- Jianfeng Xu
- Jianming Guo
- Jie Li
- Jin Ling
- Jing Ma
- Joanne Aitken
- Johanna Schleutker
- John L. Hopper
- John Pedersen
- Jong Y. Park
- Jose Esteban Castelao
- José Manuel Ruiz-Dominguez
- Judith Clements
- Julio Pow-Sang
- Jyotsna Batra
- Karina Dalsgaard Sorensen
- Katarina Cuk
- Kathleen Herkommer
- Kathryn L. Penney
- Kay-Tee Khaw
- Kenneth Muir
- Kim De Ruyck
- Kimmo Taari
- Kirsi Talala
- Koveela Govindasami
- Laura E. Beane Freeman
- Laura Fachal
- Laurence N. Kolonel
- Leire Moya
- Liesel M. FitzGerald
- Linda Steele
- Lisa Butler
- Lisa Cannon-Albright
- Lisa F. Newcomb
- Lisa Horvath
- Lluís Cecchini
- Loic Le Marchand
- Lorelei Mucci
- Lori Tillmans
- Lourdes Mengual
- Lovise Maehle
- Mahbubl Ahmed
- Manolis Kogevinas
- Manuel Luedeke
- Manuel R. Teixeira
- Manuela Gago-Dominguez
- Maren Weisher
- Margaret Cook
- Maria Elena Martinez
- Maria P. Silva
- Mariana C. Stern
- Marie Sanchez
- Marija Gamulin
- Mariona Bustamante
- Mark N. Brook
- Markus Aly
- Marta Cardoso
- Martin Andreas Røder
- Martin Eklund
- Martina Mijuskovic
- Mary-Anne Kedda
- Matthew Freedman
- Matthew Parliament
- Meiling Li
- Meir Stampfer
- Melissa C. Southey
- Melissa Papargiris
- Meng H. Tan
- Michael Borre
- Michael Broms
- Michael Davis
- Michelle Guy
- Miguel Aguado
- Milan S. Geybels
- Mitchell J. Machiela
- Monique J. Roobol
- Naomi Livni
- Nawaid Usmani
- Neil Burnet
- Neil E. Fleshner
- Niclas Hakansson
- Ninghan Feng
- Nora Pashayan
- null null
- Olivier Cussenot
- Pamela Saunders
- Par Stattin
- Patricia Calvo
- Paul A. Townsend
- Paul Brown
- Paul J. Newcombe
- Paul Pharoah
- Paula Kujala
- Paula Paulo
- Paula Peleteiro
- Peter Iversen
- Peter Klarskov
- Peter Kraft
- Philipp Bohnert
- Phyllis Goodman
- Piet Ost
- Radka Kaneva
- Ramón Lobato-Busto
- Rasmus Bisbjerg
- Rebecca Elliott
- Renea Taylor
- Richard M. Martin
- Robert Gardiner
- Robert J. Hamilton
- Robert J. MacInnis
- Robert N. Hoover
- Robert Szulkin
- Roger Milne
- Ron H. N. van Schaik
- Rosalind A. Eeles
- Ruth C. Travis
- Samantha Larkin
- Sandeep Singhal
- Sara Benlloch
- Sara Lindstrom
- Sarah J. Lewis
- Sarah Kerns
- Sarah Wakerell
- Shan-Chao Zhao
- Shannon K. McDonnell
- Shaun Riska
- Shiro Saito
- Sofia Maia
- Sofie De Langhe
- Sonja I. Berndt
- Soo-Hwang Teo
- Srilakshmi Srinivasan
- Stella Koutros
- Stephanie Weinstein
- Stephen Chanock
- Stephen N. Thibodeau
- Steve Hazel
- Steven Joniau
- Sue Ann Ingles
- Sune F. Nielsen
- Susan L. Neuhausen
- Susan M. Gapstur
- Suzanne Chambers
- Suzanne Kolb
- Svetlana Christova
- Sylvie Cenee
- Søren Bentzen
- Takashi Imai
- Teemu Murtola
- Teuvo L. J. Tammela
- Theodorus H. van der Kwast
- Thomas A. Sellers
- Thomas Schnoeller
- Thomas Van den Broeck
- Thérèse Truong
- Tihomir Dikov
- Tim J. Key
- Tobias Nordström
- Tokhir Dadaev
- Tomislav Kulis
- Torben Falck Orntoft
- Trina Yeadon
- Trinidad Dierssen-Sotos
- Vanessa Hayes
- Vanio Mitev
- Victoria L. Stevens
- Walther Vogel
- Wayne Tilley
- Weiyang He
- Wojciech Kluzniak
- Xavier Rebillard
- Xin Guo
- Xin Sheng
- Xueying Mao
- Yangling Zhang
- Yong-Jie Lu
- Yongwei Yu
- Yuan Chun Ding
- Yudong Wu
- Yves Akoli Koudou
- Zan Sun
- Zeljko Kastelan
- Zhuo Zhang
- Zsofia Kote-Jarai
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
- Author
- Albanes Demetrius
- Aldrich Melinda C
- Aly Markus
- Andriole Gerald L
- Aukim-Hastie Claire
- Auvinen Anssi
- Barnett Gill
- Batra Jyotsna
- Benlloch Sara
- Bensen Jeannette T
- Berndt Sonja I
- Blanchet Pascal
- Blot William J
- Bojesen Stig E
- Borre Michael
- Brandão Andreia
- Brenner Hermann
- Brook Mark N
- Brureau Laurent
- Burnet Neil
- Bush William S
- Cancel-Tassin Géraldine
- Cannon-Albright Lisa
- Carpten John
- Carter Brian D
- Casey Graham
- Castaño-Vinyals Gemma
- Castelao Jose Esteban
- Chambers Suzanne
- Chanock Stephen J
- Chou Alisha
- Claessens Frank
- Clements Judith A
- Conti David V
- Cook Michael B
- Crawford Dana C
- Cuk Katarina
- Cullen Jennifer C
- Cussenot Olivier
- Cybulski Cezary
- Dadaev Tokhir
- Darst Burcu F
- De Meerleer Gert
- De Ruyck Kim
- Ding Yuan Chun
- Donovan Jenny L
- Drake Bettina F
- Dunning Alison M
- Easton Douglas F
- Eeles Rosalind A
- Eklund Martin
- Fachal Laura
- Feng Ninghan
- Finelli Antonio
- Fleshner Neil E
- Fontham Elizabeth TH
- Fowke Jay H
- Freeman Laura E Beane
- Fujita Masashi
- Gago-Dominguez Manuela
- Gamulin Marija
- Gapstur Susan M
- Geybels Milan S
- Ghoussaini Maya
- Giles Graham G
- Giovannucci Edward
- Goodman Phyllis J
- Grindedal Eli Marie
- Gronberg Henrik
- Gómez-Caamaño Antonio
- Haiman Christopher A
- Hamdy Freddie C
- Hamilton Robert J
- Hennis Anselm JM
- Hoffmann Thomas J
- Holleczek Bernd
- Hoover Robert N
- Horvath Lisa
- Hsing Ann W
- Hu Jennifer J
- Huff Chad D
- Hunter David J
- Håkansson Niclas
- Ingles Sue A
- Isaacs William B
- Iversen Peter
- Jenster Guido
- John Esther M
- Joniau Steven
- Kaneva Radka
- Kerns Sarah L
- Key Tim J
- Khaw Kay-Tee
- Kibel Adam S
- Kim Jeri
- Kittles Rick A
- Klein Eric A
- Kogevinas Manolis
- Kote-Jarai Zsofia
- Koudou Yves Akoli
- Koutros Stella
- Kraft Peter
- Kulis Tomislav
- Larkin Samantha
- Le Marchand Loic
- Leach Robin J
- Lessel Davor
- Lim Jasmine
- Lin Daniel W
- Lin Hui-Yi
- Lindstrom Sara
- Llorca Javier
- Logothetis Christopher J
- Lophatananon Artitaya
- Lu Yong-Jie
- Lubiński Jan
- Lubwama Alexander
- Luedeke Manuel
- Machiela Mitchell J
- MacInnis Robert J
- Maehle Lovise
- Maier Christiane
- Mancuso Nicholas
- Mao Xueying
- Martin Richard M
- Martinez Maria Elena
- Matsuda Koichi
- McDonnell Shannon K
- McKean-Cowdin Roberta
- Menegaux Florence
- Mensah James E
- Michael Agnieszka
- Mitev Vanio
- Mohler James
- Momozawa Yukihide
- Moss Lilit C
- Moya Leire
- Mucci Lorelei A
- Muir Kenneth
- Multigner Luc
- Murphy Adam B
- Nakagawa Hidewaki
- Neal David E
- Nemesure Barbara
- Neslund-Dudas Christine
- Neuhausen Susan L
- Newcomb Lisa F
- Nielsen Sune F
- Nordestgaard Børge G
- Nordström Tobias
- Olama Ali Amin Al
- Ost Piet
- Ostrander Elaine A
- Ostrer Harry
- Pandha Hardev
- Parent Marie-Élise
- Park Jong Y
- Parliament Matthew
- Pashayan Nora
- Paulo Paula
- Penney Kathryn L
- Petrovics Gyorgy
- Razack Azad
- Riboli Elio
- Risbridger Gail P
- Roobol Monique J
- Rosenstein Barry S
- Rybicki Benjamin A
- Røder Martin Andreas
- Sahimi Ali
- Sanderson Maureen
- Saum Kai-Uwe
- Saunders Edward J
- Schaid Daniel J
- Schleutker Johanna
- Schnoeller Thomas
- Schumacher Fredrick R
- Sellers Thomas A
- Sheng Xin
- Singhal Sandeep
- Sipeky Csilla
- Slavov Chavdar
- Southey Melissa C
- Srivastava Shiv
- Stampfer Meir
- Stanford Janet L
- Steele Linda
- Stern Mariana C
- Stevens Victoria L
- Strom Sara S
- Sun Zan
- Szulkin Robert
- Sørensen Karina Dalsgaard
- Takahashi Atushi
- Tammela Teuvo LJ
- Tangen Catherine M
- Taylor Jack A
- Teerlink Craig C
- Teixeira Manuel R
- Teo Soo-Hwang
- Thibodeau Stephen N
- Thompson Ian M
- Tilley Wayne
- Torres Mina
- Townsend Paul A
- Travis Ruth C
- Truong Thérèse
- Turman Constance
- Usmani Nawaid
- Van den Broeck Thomas
- Van Den Eeden Stephen K
- van Schaik Ron HN
- Varma Rohit
- Vega Ana
- Wan Peggy
- Watya Stephen
- Weaver Brandi
- Weinstein Stephanie J
- Weischer Maren
- West Catharine ML
- Wiklund Fredrik
- Wilkens Lynne R
- Witte John S
- Wokołorczyk Dominika
- Wolk Alicja
- Wu Yudong
- Xu Jianfeng
- Yeboah Edward D
- Zhang Hong-Wei
- Zhao Shan-Chao
- Zheng Wei
- Publication venue
- Nat Genet
- Publication date
- 01/01/2021
- Field of study
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.
- Author
- A Takeuchi
- AA Al Olama
- AA Al Olama
- AA Al Olama
- AE Norrish
- Aida K Dieffenbach
- Ali Amin Al Olama
- Amanda Spurdle
- Artitaya Lophatananon
- AS Dressen
- AW Hsing
- B Mukherjee
- BC Wallace
- BP McEvoy
- Chavdar Slavov
- D Gunnell
- D Gunnell
- David E Neal
- Douglas Easton
- E Giovannucci
- EE Calle
- Emerging Risk Factors Collaboration
- F Gu
- Freddie C Hamdy
- Fredrik Wiklund
- G Lettre
- GB Chen
- Graham G Giles
- H Chial
- H Lango Allen
- H Zhao
- Henrik Gronberg
- Hermann Brenner
- Hui-Yi Lin
- I Cheng
- J Qian
- JA Ellis
- Janet L Stanford
- Jenny L Donovan
- Jong Y Park
- Judith A Clements
- Jyotsna Batra
- Kenneth Muir
- KK Tsilidis
- L Zuccolo
- Liesel M Fitzgerald
- M Johansson
- Markus Aly
- Melissa C Southey
- MN Weedon
- NM Davies
- Nora Pashayan
- P Stattin
- Paul Pharoah
- PJ Villeneuve
- RA Eeles
- RA Eeles
- RA Eeles
- Radka Kaneva
- RB Hayes
- RC Travis
- Rosalind A Eeles
- S Lindstrom
- S Purcell
- Sara Benlloch Garcia
- Sarah Stewart-Brown
- Thomas Sellers
- TJ Key
- Vanio Mitev
- VL Freeman
- Volker Arndt
- WC Willett
- WR Farwell
- XY Lou
- Y Cao
- Y Gan
- Zsofia Kote-Jarai
- Publication venue
- Br J Cancer
- Publication date
- 01/08/2017
- Field of study
This corrects the article DOI: 10.1038/bjc.2017.231
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
- Author
- Aittomaki Kristiina
- Al Olama Ali Amin
- Al Olama Ali Amin
- Aly Markus
- Aly Markus
- Ambrosone Christine B.
- Anton-Culver Hoda
- Arndt Volker
- Arndt Volker
- Bandera Elisa V.
- Batra Jyotsna
- Batra Jyotsna
- Beckmann Matthias W.
- Beesley Jonathan
- Benitez Javier
- Benlloch Sara
- Benlloch Sara
- Berchuck Andrew
- Berndt Sonja
- Blomqvist Carl
- Blot William J.
- Bogdanova Natalia
- Bojesen Stig E.
- Bolla Manjeet K.
- Brauch Hiltrud
- Brennan Paul
- Brenner Hermann
- Brenner Hermann
- Broberg Per
- Bruinsma Fiona
- Bruning Thomas
- Burwinkel Barbara
- Butzow Ralf
- Cai Qiuyin
- Campbell Ian
- Cannon-Albright Lisa
- Cannon-Albright Lisa
- Chang-Claude Jenny
- Chanock Stephen J.
- Chen Kexin
- Chenevix-Trench Georgia
- Clements Judith A.
- Cook Linda S.
- Couch Fergus J.
- Cox Angela
- Cramer Daniel W.
- Cunningham Julie M.
- Cybulski Cezary
- Cybulski Cezary
- Czene Kamila
- Dansonka-Mieszkowska Agnieszka
- Darabi Hatef
- Dennis Joe
- Devilee Peter
- Dieffenbach Aida K.
- Dieffenbach Aida K.
- Doherty Jennifer A.
- Donovan Jenny L.
- Donovan Jenny L.
- Dork Thilo
- Dunning Alison M.
- Easton Douglas
- Easton Douglas F.
- Eccles Diana
- Edwards Todd L.
- Eeles A.
- Eeles Rosalind
- Ekici Arif B.
- Fasching Peter A.
- Figueroa Jonine
- Fitzgerald Liesel M.
- Fitzgerald Liesel M.
- Flesch-Janys Dieter
- Freedman Matthew L.
- Gao Yu Tang
- Gapstur Susan M.
- Garcia-Closas Montserrat
- Gayther Simon A.
- Gentry-Maharaj Aleksandra
- Giles Graham G.
- Giles Graham G.
- Gonzalez-Neira Anna
- Goode Ellen L.
- Goodman Marc T.
- Gronberg Henrik
- Gronberg Henrik
- Gronwald Jacek
- Guenel Pascal
- Haiman Christopher A.
- Haiman Christopher A.
- Hall Per
- Hamann Ute
- Hamdy Freddie C.
- Hamdy Freddie C.
- Heitz Florian
- Henderson Brian E.
- Henderson Brian E.
- Herkommer Kathleen
- Herkommer Kathleen
- Hildebrandt Michelle A T
- Hogdall Claus K.
- Hogdall Estrid
- Hooning Maartje J.
- Hoover Robert N.
- Hopper John L.
- Hou Ming Feng
- Hunter David J.
- Jones Michael
- Kaneva Radka
- Kaneva Radka
- Kang Daehee
- Kar Siddhartha P.
- Karlan Beth Y.
- Key Tim J.
- Key Tim J.
- Khaw Kay Tee
- Khaw Kay Tee
- Khusnutdinova Elza
- Kibel Adam S.
- Kibel Adam S.
- Kiemeney Lambertus A.
- Kierzek Andrzej
- Kierzek Andrzej
- Kjar Susanne Kruger
- Kluzniak Wojciech
- Kluzniak Wojciech
- Knight Julia A.
- Kopperud Reidun Kristin
- Kosma Veli Matti
- Kote-Jarai Z. Sofia
- Kote-Jarai Zsofi A.
- Kraft Peter
- Kristensen Vessela
- Kupryjanczyk Jolanta
- Lambrechts Diether
- Lawrenson Kate
- Le Nhu D.
- Lee Soo Chin
- Levine Douglas A.
- Li Qiyuan
- Lim Hui Yi
- Lim Hui Yi
- Lindblom Annika
- Lindstrom Sara
- Lu Karen H.
- Lubiński Jan
- Luedeke Manuel
- Luedeke Manuel
- Lush Michael
- Macinnis Robert J.
- Maia Sofia
- Maia Sofia
- Maier Christiane
- Maier Christiane
- Massuger Leon F A G
- Matsuo Keitaro
- McDonnell Shannon K.
- McDonnell Shannon K.
- McLean Catriona
- McNeish Iain
- Menon Usha
- Michael Agnieszka
- Michael Agnieszka
- Michailidou Kyriaki
- Milne Roger L.
- Mitev Vanio
- Mitev Vanio
- Modugno Francesmary
- Moisse Matthieu
- Monteiro Alvaro
- Moysich Kirsten B.
- Muir Kenneth
- Muir Kenneth
- Neal David E.
- Neal David E.
- Ness Roberta
- Nevanlinna Heli
- Nordestgaard Borge G.
- Nordestgaard Børge G.
- Odunsi Kunle
- Offitt Kenneth
- Olson Sara H.
- Olsson Hakan
- Orr Nick
- Pandha Hardev
- Pandha Hardev
- Park Jong Y.
- Park Jong Y.
- Pashayan Nora
- Pashayan Nora
- Paulo Paula
- Paulo Paula
- Pearce Celeste Leigh
- Peixoto Ana
- Pejovic Tanja
- Permuth Jennifer B.
- Peterlongo Paolo
- Peto Julian
- Pharoah Paul
- Pharoah Paul D P
- Phelan Catherine
- Pike Malcolm C.
- Poole Elizabeth M.
- Pow-Sang Julio
- Rahman Nazneen
- Ramus Susan J.
- Riggan Marjorie
- Risch Harvey A.
- Rossing Mary Anne
- Rudolph Anja
- Salvesen Helga B.
- Sanderson Maureen
- Sawyer Elinor J.
- Schaid Daniel J.
- Schaid Daniel J.
- Schildkraut Joellen M.
- Schleutker Johanna
- Schleutker Johanna
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Schoemaker Minouk J.
- Schumacher Fredrick
- Schumacher Fredrick
- Sellers Thomas
- Sellers Thomas A.
- Setiawan Veronica Wendy
- Shu Xiao Ou
- Sieh Weiva
- Simard Jacques
- Slavov Chavdar
- Slavov Chavdar
- Song Fengju
- Song Honglin
- Southey Melissa C.
- Southey Melissa C.
- Spurdle Amanda
- Spurdle Amanda
- Stanford Janet L.
- Stanford Janet L.
- Stegmaier Christa
- Stephenson Robert A.
- Stram Daniel O.
- Swerdlow Anthony
- Tammela Teuvo L J
- Tammela Teuvo L J
- Teerlink Craig C.
- Teixeira Manuel R.
- Teixeira Manuel R.
- Teo Soo Hwang
- Tessier Daniel C.
- Thibodeau Stephen N.
- Thibodeau Stephen N.
- Thompson Deborah J.
- Travis Ruth C.
- Travis Ruth C.
- Tworoger Shelley S.
- Tyrer Jonathan
- Ulmer Hans Ulrich
- Vachon Celine
- Velez Edwards Digna R.
- Vergote Ignace
- Vogel Walther
- Vogel Walther
- Wahlfors Tiina
- Wahlfors Tiina
- Wang Qin
- Webb Penelope M.
- Wentzensen Nicolas
- Whittemore Alice S.
- Wiklund Fredrik
- Wiklund Fredrik
- Wildiers Hans
- Winqvist Robert
- Wokozorczyk Dominika
- Wokozorczyk Dominika
- Wolk Alicja
- Wu Anna H.
- Yannoukakos Drakoulis
- Zheng Wei
- Ziogas Argyrios
- Publication venue
- Cancer Discov
- Publication date
- 01/01/2016
- Field of study
UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932.The Breast Cancer Association Consortium (BCAC), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), and the Ovarian Cancer Association Consortium (OCAC) that contributed breast, prostate, and ovarian cancer data analyzed in this study were in part funded by Cancer Research UK [C1287/A10118 and C1287/A12014 for BCAC; C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, and C16913/A6135 for PRACTICAL; and C490/A6187, C490/A10119, C490/A10124, C536/A13086, and C536/A6689 for OCAC]. Funding for the Collaborative Oncological Gene-environment Study (COGS) infrastructure came from: the European Community's Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, and C8197/A16565), the US National Institutes of Health (CA128978) and the Post-Cancer GWAS Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112), the US Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund [with donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07)]. Additional financial support for contributing studies is documented under Supplementary Financial Support.This is the author accepted manuscript. The final version is available from the American Association for Cancer Research via http://dx.doi.org/10.1158/2159-8290.CD-15-122
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belyaev Alexander
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Bender Walter
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beretvas Andrew
- Bergauer Thomas
- Bergholz Matthias
- Beri Suman Bala
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boeriu Oana
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bona Marcella
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Borcherding Frederick
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmuller Oliver
- Buege Volker
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Callner Jeremy
- Calvo Enrique
- Camanzi Barbara
- Caminada Lea
- Campagnari Claudio
- Campbell Alan
- Camporesi Tiziano
- Capiluppi Paolo
- Caponeri Benedetta
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casimiro Linares Edgar
- Cassel David
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Castro Elena
- Caudron Julien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerizza Giordano
- Cerminara Gianluca
- Ceron Cristobal
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chandra Avdhesh
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cheng Teh Lee
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Conway John
- Cooper Seth
- Cooper William
- Cortina Gil Eduardo
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
- Curé Benoît
- Cushman Priscilla
- Cussans David
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Darmenov Nikolay
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- David Tinoco Mendes Andre
- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
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- Vitulo Paolo
- Viviani Claudio
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- Vogel Helmut
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- Wardrope David
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- Weber Martin
- Weber Matthias
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- Weiler Thomas
- Weinberg Marc
- Weinberger Michael
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- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
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- Willmott Carlos
- Wimpenny Stephen
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- Winstrom Lucas
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- Wittmer Bruno
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Jing-Han
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yan Ming
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yiu Chun Hin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
stairs and fire
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biasotto Massimo
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boimska Bozena
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Callner Jeremy
- Calvert Brian
- Calvo Enrique
- Campagnari Claudio
- Campbell Alan
- Camporesi Tiziano
- Capiluppi Paolo
- Caponeri Benedetta
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casal Bruno
- Casimiro Linares Edgar
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Castro Elena
- Caudron Julien
- Caulfield Matthew
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerizza Giordano
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
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- Mitselmakher Guenakh
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- Moeller Anthony
- Mohammadi Najafabadi Mojtaba
- Mohammadi Abdollah
- Mohanty Ajit Kumar
- Mohanty Gagan Bihari
- Mohapatra Ajit
- Mohr Niklas
- Moisenz Petr
- Molnar Jozsef
- Monaco Vincenzo
- Mondal Naba Kumar
- Montalvo Roy
- Montanari Alessandro
- Montanino Damiana
- Moon Dong Ho
- Mooney Michael
- Moortgat Filip
- Morelos Pineda Antonio
- Moroni Luigi
- Morovic Srecko
- Morse David Michael
- Moser Roland
- Mossolov Vladimir
- Mott Alexander
- Mousa Jehad
- Mozer Matthias Ulrich
- Mrenna Stephen
- Mucia Nicholas
- Mucibello Luca
- Mueller Steffen
- Mulders Martijn
- Mundim Luiz
- Muniz Lana
- Munoz Sanchez Francisca Javiela
- Mura Benedikt
- Murray Michael
- Murzin Victor
- Musella Pasquale
- Musenich Riccardo
- Musich Marco
- Musienko Yuri
- Mussgiller Andreas
- My Salvatore
- Mäenpää Teppo
- Müller Thomas
- Müntel Mait
- Nachtman Jane
- Nahn Steve
- Naimuddin Md
- Nam Soon-Kwon
- Nandi Robin
- Nappi Aniello
- Narain Meenakshi
- Nash Jordan
- Nauenberg Uriel
- Naumann-Emme Sebastian
- Navarria Francesco
- Nawrocki Krzysztof
- Nayak Aruna
- Nef Pascal
- Nelson Randy
- Nespolo Massimo
- Nessi-Tedaldi Francesca
- Nesvold Erik
- Neu Christopher
- Neumeister Norbert
- Newbold Dave M.
- Newman Harvey B.
- Newman-Holmes Catherine
- Newsom Charles Ray
- Nguyen Duong
- Nguyen Harold
- Nguyen Matthew
- Nicolaou Charalambos
- Nicolas Kaufman Gala
- Niegel Martin
- Nikitenko Alexander
- Nirunpong Kachanon
- Nishu Nishu
- Nogima Helio
- Noonan Daniel
- Norbeck Edwin
- Nourbakhsh Shervin
- Novaes Sergio F.
- Nowack Andreas
- Nowak Friederike
- Ntomari Eleni
- Nuttens Claude
- Nuzzo Salvatore
- Nägeli Christoph
- Nürnberg Andreas
- O'Brien Christine
- O'Dell Vivian
- Oberst Oliver
- Obertino Maria Margherita
- Obraztsov Stepan
- Ocalan Kadir
- Ocampo Rios Alberto Andres
- Ochando Christophe
- Ochesanu Silvia
- Odell Nathaniel
- Odorici Fabrizio
- Oehler Andreas
- Ofierzynski Radoslaw Adrian
- Oguri Vitor
- Ojalvo Isabel
- Olaiya Emmanuel
- Olbrechts Annik
- Oliveros Sandra
- Olschewski Mark
- Olsen James
- Olson Jonathan
- Olzem Jan
- Onel Yasar
- Onengut Gulsen
- Oreshkin Vadim
- Organtini Giovanni
- Orimoto Toyoko
- Orsini Luciano
- Osipenkov Ilya
- Osorio Oliveros Andres Felipe
- Ostapchuk Andrey
- Otiougova Polina
- Ott Jochen
- Ozdemir Kadri
- Ozkorucuklu Suat
- Ozok Ferhat
- Ozpineci Altug
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- Padley Brian Paul
- Padula Sandra
- Paganini Pascal
- Pagano Davide
- Paganoni Marco
- Pakhotin Yuriy
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- Palencia Cortezon Enrique
- Palichik Vladimir
- Palinkas Jozsef
- Palla Fabrizio
- Palmer Christopher
- Palmonari Francesco
- Panagiotou Apostolos
- Pandolfi Francesco
- Pant Lalit Mohan
- Panwalkar Shruti
- Paoletti Simone
- Paolucci Pierluigi
- Papacz Paul Jakob
- Papadopoulos Ioannis
- Papageorgiou Anastasios
- Pape Luc
- Paramatti Riccardo
- Paramesvaran Sudarshan
- Parashar Neeti
- Parida Bibhuti
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- Park Hyangkyu
- Park Inkyu
- Park Michael
- Park Sangnam
- Park Sung Keun
- Pashenkov Anatoli
- Pastika Nathaniel
- Pastrone Nadia
- Patel Rishi
- Patras Vaios
- Patterson Juliet Ritchie
- Paulini Manfred
- Paus Christoph
- Pauss Felicitas
- Pavlov Borislav
- Pavlunin Viktor
- Pearson Tessa
- Pedrini Daniele
- Pegoraro Matteo
- Peiffer Thomas
- Pela Joao
- Pellett Dave
- Pelliccioni Mario
- Peltola Timo
- Penzo Aldo
- Perchalla Lars
- Perelygin Victor
- Perera Lalith
- Perez Emmanuelle
- Perfilov Maxim
- Perieanu Adrian
- Perloff Alexx
- Pernicka Manfred
- Perries Stephane
- Perrotta Andrea
- Perrozzi Luca
- Peruzzi Marco
- Pesaresi Mark
- Peterman Alison
- Petkov Peicho
- Petrakou Eleni
- Petridis Konstantinos
- Petrilli Achille
- Petrillo Gianluca
- Petrov Vladimir
- Petrucciani Giovanni
- Petrukhin Alexey
- Petrushanko Sergey
- Petyt David
- Pfeiffer Andreas
- Pi Haifeng
- Piccolo Davide
- Piedra Gomez Jonatan
- Pieri Marco
- Pierini Maurizio
- Pierro Giuseppe Antonio
- Pieta Holger
- Pietsch Niklas
- Pimiä Martti
- Pin Arnaud
- Pioppi Michele
- Piotrzkowski Krzysztof
- Piparo Danilo
- Piperov Stefan
- Piroué Pierre
- Pitzl Daniel
- Pivarski James
- Plager Charles
- Plestina Roko
- Pol Maria Elena
- Polatoz Ayse
- Polese Giovanni
- Polic Dunja
- Poll Anthony
- Pollack Brian
- Pompili Alexis
- Pooth Oliver
- Popov Vladimir
- Pordes Ruth
- Potenza Alberto
- Potenza Renato
- Pozdnyakov Andrey
- Pozzobon Nicola
- Prado Da Silva Wanda Lucia
- Primavera Federica
- Prokofyev Oleg
- Prosper Harrison
- Ptochos Fotios
- Puerta Pelayo Jesus
- Pugliese Gabriella
- Puigh Darren
- Puljak Ivica
- Qazi Shamona
- Qian Si-Jin
- Quan Xiaohang
- Quast Gunter
- Quertenmont Loic
- Rabbertz Klaus
- Racz Attila
- Radburn-Smith Benjamin Charles
- Radi Amr
- Ragazzi Stefano
- Rahatlou Shahram
- Rahbaran Babak
- Rahmat Rahmat
- Raics Peter
- Raidal Martti
- Rakness Gregory
- Ralph Duncan
- Ramirez Vargas Juan Eduardo
- Rander John
- Ranieri Riccardo
- Ranjan Kirti
- Rappoccio Salvatore
- Raspereza Alexei
- Ratnikov Fedor
- Ratnikova Natalia
- Ratti Sergio P.
- Raupach Frank Arthur
- Raval Amita
- Raymond David Mark
- Razis Panos A.
- Rebane Liis
- Rebassoo Finn
- Redaelli Nicola
- Redjimi Radia
- Redondo Ignacio
- Reece William
- Reid Ivan
- Reithler Hans
- Rekovic Vladimir
- Remington Ronald
- Renker Dieter
- Rennefeld Jörg
- Renz Manuel
- Reucroft Steve
- Reyes-Santos Marco A.
- Ribeiro Cipriano Pedro M.
- Ribeiro Pedro Quinaz
- Ribnik Jacob
- Riccardi Cristina
- Richards Alan
- Richman Jeffrey
- Rinkevicius Aurelijus
- Rizzi Andrea
- Ro Sang-Ryul
- Roberts Jay
- Robles Jorge
- Robmann Peter
- Rodenburg Marissa
- Rodozov Mircho
- Rodrigo Teresa
- Rodrigues Antunes Joao
- Rodriguez Jorge Luis
- Rodríguez-Marrero Ana Yaiza
- Roe Jeffrey
- Rogan Christopher
- Rogerson Samuel
- Roh Youn
- Rohe Tilman
- Rohlf James
- Rohringer Christine
- Rohringer Herbert
- Roland Benoit
- Roland Christof
- Roland Gunther
- Rolandi Gigi
- Romano Francesco
- Romanowska-Rybinska Katarzyna
- Romeo Francesco
- Romero Alessandra
- Romero Luciano
- Rommerskirchen Tanja
- Rompotis Nikolaos
- Ronchese Paolo
- Ronga Frederic Jean
- Rose Andrew
- Rose Keith
- Rosin Michele
- Rosowsky André
- Ross Ian
- Rossato Kenneth
- Rossi Antonio
- Rossin Roberto
- Rossini Marco
- Rougny Romain
- Rovelli Chiara
- Rovelli Tiziano
- Rovere Marco
- Ruchti Randy
- Rudolph Matthew
- Ruiz-Jimeno Alberto
- Rumerio Paolo
- Rusack Roger
- Rusakov Sergey V.
- Ruspa Marta
- Russ James
- Rutherford Britney
- Ryan Matthew John
- Ryckbosch Dirk
- Ryd Anders
- Ryu Geonmo
- Ryutin Roman
- Röcker Steffen
- Sabes David
- Sacchi Roberto
- Safarzadeh Batool
- Safonov Alexei
- Safronov Grigory
- Saha Anirban
- Saini Lovedeep Kaur
- Saka Halil
- Sakharov Alexandre
- Sakulin Hannes
- Sakuma Tai
- Sakumoto Willis
- Sala Leonardo
- Sala Silvano
- Salazar Ibarguen Humberto Antonio
- Salerno Roberto
- Salfeld-Nebgen Jakob
- Salur Sevil
- Salvati Emmanuele
- Sammet Jan
- Sanabria Juan Carlos
- Sanchez Ann - Karin
- Sander Christian
- Sanders David A.
- Sanders Stephen
- Sani Matteo
- Santanastasio Francesco
- Santaolalla Javier
- Santocchia Attilio
- Santoro Alberto
- Saoulidou Niki
- Saout Christophe
- Sarkar Subir
- Sarycheva Ludmila
- Sasseville Michael
- Sauerland Philip
- Savin Alexander
- Savrin Viktor
- Sawley Marie-Christine
- Scarborough Tara
- Schael Stefan
- Schettler Hannes
- Scheurer Armin
- Schieferdecker Philipp
- Schilling Frank-Peter
- Schlein Peter
- Schleper Peter
- Schlieckau Eike
- Schmanau Mike
- Schmidt Alexander
- Schmidt Ringo
- Schmitt Michael Henry
- Schmitt Michael Houston
- Schmitz Stefan Antonius
- Schnetzer Steve
- Schoerner-Sadenius Thomas
- Schott Gregory
- Schröder Matthias
- Schul Nicolas
- Schum Torben
- Schwarz Thomas
- Schwick Christoph
- Schäfer Christoph
- Schöfbeck Robert
- Scodellaro Luca
- Scurlock Bobby
- Searle Matthew
- Seez Christopher
- Segala Michael
- Segoni Ilaria
- Seitz Claudia
- Seixas Joao
- Sekmen Sezen
- Sellers Paul
- Selvaggi Giovanna
- Selvaggi Michele
- Semenov Sergey
- Sen Niladri
- Sen Sercan
- Senghi Soares Mara
- Sengupta Sinjini
- Senkin Sergey
- Seo Eunsung
- Seo Hyunkwan
- Serban Alin Titus
- Serin Meltem
- Sever Ramazan
- Sexton-Kennedy Elizabeth
- Sfiligoi Igor
- Sguazzoni Giacomo
- Shah Mehar Ali
- Sharma Archana
- Sharma Archana
- Sharma Seema
- Sharma Varun
- Sharma Vivek
- Sheldon Paul
- Shepherd-Themistocleous Claire H.
- Shi Xin
- Shipkowski Simon Peter
- Shipsey Ian
- Shiu Jing-Ge
- Shivpuri Ram Krishen
- Shmatov Sergey
- Shoaib Muhammad
- Shrestha Shruti
- Shreyber Irina
- Shukla Prashant
- Shumeiko Nikolai
- Sibille Jennifer
- Siegrist Patrice
- Sigamani Michael
- Sikler Ferenc
- Silkworth Christopher
- Sill Alan
- Sillou Daniel
- Silva Do Amaral Sheila Mara
- Silva Pedro
- Silvers David
- Silverwood Hamish
- Silvestre Catherine
- Silvestris Lucia
- Sim Kwang Souk
- Simon Michal
- Simon Sean
- Simonetto Franco
- Simonis Hans-Jürgen
- Singh Anil
- Singh Gurpreet
- Singh Jasbir
- Singh Supreet Pal
- Singovsky Alexander
- Sinthuprasith Tutanon
- Sirois Yves
- Siroli Gianni
- Sirunyan Albert M.
- Skhirtladze Nikoloz
- Skuja Andris
- Slaunwhite Jason
- Smirnov Igor
- Smirnov Vitaly
- Smith James
- Smith John
- Smith Kenneth
- Smith Vincent J.
- Smith Wesley H.
- Snigirev Alexander
- Snoek Hella
- Snook Benjamin
- Snow Gregory R.
- Snowball Matthew
- Soares Jorge Luana
- Sobol Andrei
- Sobron Sanudo Mar
- Soffi Livia
- Sogut Kenan
- Solano Ada
- Somalwar Sunil
- Son Dong-Chul
- Song Sanghyeon
- Sonmez Nasuf
- Sonnenschein Lars
- Sordini Viola
- Souza Dos Anjos Tiago
- Spagnolo Paolo
- Spalding William J.
- Spanier Stefan
- Sparrow Alex
- Speer Thomas
- Sperka David
- Sphicas Paraskevas
- Spiegel Leonard
- Spiga Daniele
- Spiridonov Alexander
- Spiropulu Maria
- Sprenger Daniel
- Squires Michael
- St John Jason
- Stadie Hartmut
- Stahl Achim
- Staiano Amedeo
- Starodumov Andrei
- Steggemann Jan
- Stein Matthias
- Steinbrück Georg
- Stenson Kevin
- Stephans George
- Stickland David
- Stieger Benjamin
- Stiliaris Efstathios
- Stober Fred-Markus Helmut
- Stolin Viatcheslav
- Stone Robert
- Stoye Markus
- Stoykova Stefka
- Stoynev Stoyan
- Strauss Josef
- Stringer Robert
- Strobbe Nadja
- Strom Derek
- Stuart David
- Sturdy Jared
- Stöckli Fabian
- Suarez Gonzalez Juan
- Suarez Indara
- Sudano Elizabeth
- Sudhakar Katta
- Sulak Lawrence
- Sulimov Valentin
- Sultanov Georgi
- Summers Don
- Sumorok Konstanty
- Sumowidagdo Suharyo
- Sun Werner
- Sunar Cerci Deniz
- Sung Kevin
- Surat Ugur Emrah
- Svintradze Irakli
- Svyatkovskiy Alexey
- Swanson Joshua
- Swartz Morris
- Symonds Philip
- Szillasi Zoltan
- Szleper Michal
- Sznajder Andre
- Sánchez Hernández Alberto
- Tabarelli de Fatis Tommaso
- Tadel Matevz
- Takahashi Maiko
- Tali Bayram
- Tambe Norbert
- Tan Ping
- Tao Junquan
- Tapper Alexander
- Taroni Silvia
- Tatarinov Aysen
- Taurok Anton
- Tauscher Ludwig
- Taylor Lucas
- Tcholakov Vanio
- Teischinger Florian
- Temple Jeffrey
- Tenchini Roberto
- Teng Haiyun
- Teo Wee Don
- Teodorescu Liliana
- Teyssier Daniel
- Thea Alessandro
- Theofilatos Konstantinos
- Thiebaux Christophe
- Thom Julia
- Thomas Laurent
- Thomas Scott
- Thompson Joshua
- Thomsen Jan
- Thyssen Filip
- Tiko Andres
- Timciuc Vladlen
- Tinti Gemma
- Tiras Emrah
- Titov Maksym
- Tkaczyk Slawek
- To Wing
- Toback David
- Tomalin Ian R.
- Tomaszewska Justyna
- Tomei Thiago
- Tonelli Guido
- Tonjes Marguerite
- Tonwar Suresh C.
- Topakli Huseyin
- Torassa Ezio
- Toropin Alexander
- Torre Paola
- Tosi Mia
- Tosi Silvano
- Tourneur Stephane
- Tourtchanovitch Leonid
- Traczyk Piotr
- Tran Nhan Viet
- Trapani Pier Paolo
- Travaglini Riccardo
- Trayanov Rumen
- Treille Daniel
- Triantis Frixos A.
- Tricomi Alessia
- Tripathi Mani
- Trocino Daniele
- Trocsanyi Zoltan Laszlo
- Troendle Daniel
- Troitsky Sergey
- Tropiano Antonio
- Troshin Sergey
- Tsang Ka Vang
- Tschudi Yohann
- Tsirou Andromachi
- Tu Yanjun
- Tucker Jordan
- Tully Christopher
- Tumasyan Armen
- Tuo Shengquan
- Tuominen Eija
- Tuominiemi Jorma
- Tuovinen Esa
- Tupputi Salvatore
- Turkewitz Jared
- Turner Mark
- Tuuva Tuure
- Tuve Cristina
- Twedt Elizabeth
- Tytgat Michael
- Tyurin Nikolay
- Tzeng Yeng-Ming
- Ujvari Balazs
- Ulmer Keith
- Ungaro Donatella
- Uplegger Lorenzo
- Urscheler Christina
- Uvarov Lev
- Uzun Dilber
- Uzunian Andrey
- Vaandering Eric Wayne
- Valdata Marisa
- Valls Nil
- Valuev Vyacheslav
- Van Doninck Walter
- Van Haevermaet Hans
- Van Hove Pierre
- Van Mechelen Pierre
- Van Mulders Petra
- Van Onsem Gerrit Patrick
- Van Remortel Nick
- Van Spilbeeck Alex
- Vander Velde Catherine
- Vanelderen Lukas
- Vanini Sara
- Vanlaer Pascal
- Varela Joao
- Varelas Nikos
- Vartak Adish
- Vasquez Sierra Ricardo
- Vaughan Jennifer
- Vavilov Sergey
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veelken Christian
- Veeraraghavan Venkatesh
- Velasco Mayda
- Velicanu Dragos
- Velkovska Julia
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Vergili Latife Nukhet
- Vergili Mehmet
- Verwilligen Piet
- Verzetti Mauro
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vichoudis Paschalis
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Viviani Claudio
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vodopiyanov Igor
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volodko Anton
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Philipp
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Walzel Gerhard
- Wan Zongru
- Wang Dayong
- Wang Jian
- Wang Jian
- Wang Minzu
- Wang Siguang
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickens John
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
- Williams Grayson
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wolf Matthias
- Wolf Roger
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
- …