ABORDAGENS METODOLÓGICAS DA PESQUISA EM BRANDING NO CAMPO DO TURISMO: análise das produções científicas (teses e dissertações) no Brasil

Este estudo analisa a produção científica das pesquisas em Branding no campo do turismo, a partir de teses e dissertações publicadas no Brasil, para identificar as suas principais características quanto a metodologia. Do exame de 39 trabalhos no banco de dados da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) foi possível conhecer e enquadrar as abordagens metodológicas adotadas pelos pesquisadores nesse específico campo. Entre os principais resultados: foi identificado a hegemonia da postura epistêmica empírico-analítica na fundamentação dos estudos; o uso de métodos essencialmente positivistas; a primazia de abordagens qualitativas, e, de caráter exploratório; e a adoção indiscriminada da estratégia do estudo de caso (único) combinado a outros delineamentos.  Conclui-se que as pesquisas em Branding no turismo têm seguido uma agenda de pesquisa positivista, essencialmente empírica, e, pouco reflexiva.  Espera-se que estimule a discussão sobre novas e distintas possibilidades metodológicas para esse campo específico de pesquisa, bem como a extensão para outros estudos que ampliem a compreensão sobre seus modos de investigação

Quantitative analysis of bone marrow in pancytopenic dogs

The pancytopenia can be associated with intra and extra medullary disorders. When the etiology is not obvious, the examination of bone marrow is necessary. The study aims to report and discuss quantitative amendments in bone marrow and their causes in dogs with pancytopenia. Bone marrow aspirate was obtained from 65 dogs with pancytopenia over a period of 13 consecutive months for preparation of smears stained by Giemsa and observed in light microscopy. Five hundred cells differential count was held; and assessed myeloid:erythroid ratio, cellularity, megakaryocytes and direct parasitological examination. The data were evaluated by the Chi-square statistical test. Blood tests of 3120 canines with several clinical changes were analyzed to identify pancytopenia, which accounted for 167 (5.4%) dogs. Interpretation of quantitative characteristics was carried out from the bone marrow smear in 65 pancytopenic dogs and the etiology was established in 40 (61.5%) of these, which included infection by E. canis and L. chagasi, idiopathic aplastic anemia, chronic renal failure and co-infections. In 17 (26.2%) animals were not observed medullary changes. The most bone marrow change was observed myeloid and erythroid hypoplasia in 17 (26.2%) dogs, followed by myeloid and erythroid hyperplasia (24.6%). The myelogram association to the blood cell count allowed the identification of medullary findings and its participation on the occurrence of pancytopenia cases. The number of cases resulting from infectious diseases was 38 (58.5%) in canine assessed: significant number due to its endemic characteristic of the study region

The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital

<p>Abstract</p> <p>Background</p> <p>Vancomycin is an antibiotic of growing importance in the treatment of hospital infections, with particular emphasis on its value in the fight against methicillin-resistant <it>Staphylococcus aureus</it>. However its usage profile must be evaluated to assure maximum benefit and minimum risk.</p> <p>Findings</p> <p>A cross-sectional retrospective study was carried out among inpatients that received vancomycin in a Brazilian quaternary hospital. The occurrence of adverse reactions reported was evaluated in medical records relating to patients taking vancomycin during a one year period. Males comprised 52% (95% CI: 41.7-60.2%) of the sample population, with a mean age of 50.6 (95% CI: 47.2-54.0) years and mean treatment period of 9.7 (95% CI: 8.0-11.5) Days. It was verified that nephrotoxicity occurred in 18.4% (95% CI: 11.3-27.5) of patients, Red man syndrome occurred in 2% (95% CI 0.2-7.2), while the occurrence of thrombocytopenia was 7.1% (95% CI: 2.9-14.2).</p> <p>Conclusions</p> <p>It may be noted that even after 50 years of use, adverse reactions associated with vancomycin continue with high frequency, presenting a public health problem, especially considering its current use in cases of multidrug resistant infections. In this context, we emphasize the importance of intensive pharmacovigilance in hospital as a surveillance tool after drug approval by the sanitary authority.</p

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation

The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking studies of a novel series of 2-(pyridin-2-yl)-1,3- thiazoles derived from 2-pyridine thiosemicarbazone. The majority of these compounds are potent cruzain inhibitors and showed excellent inhibition on the trypomastigote form of the parasite, and the resulting structure-activity relationships are discussed. Together, these data present a novel series of thiazolyl hydrazones with potential effects against Chagas disease and they could be important leads in continuing development against Chagas disease

Cuidados de enfermagem para prevenção da Enterocolite necrosante: Nursing care to prevent necrotizing Enterocolitis

Introdução: A enterocolite necrosante é definida por manifestações gastrointestinais e sistêmicas de intensidades variáveis e progressivas, decorrente à necrose de coagulação do trato gastrintestinal. Objetivo: Analisar na literatura a importância dos cuidados de enfermagem para prevenção da enterocolite necrosante Método: Revisão integrativa de literatura, coletadas as informações em bases de dados que contemplem o tema proposto. Foi instituída a pergunta norteadora “Quais as condutas de enfermagem podem ser adotadas para prevenção da enterocolite necrosante?”. 05 publicações foram selecionadas para leitura integral. Utilizados critérios de inclusão: ano e período de publicação (2017 a 2021), artigos na íntegra disponíveis e disponíveis nos idiomas português e inglês.&nbsp; Critérios de exclusão: trabalhos de conclusão de curso, artigos repetidos nas bases de dados e os que não respondiam a pergunta norteadora. Resultados: a identificação dos fatores de riscos para desenvolvimento da doença pode prevenir complicações, e ainda em alguns casos evitar o desencadear da patologia. A ECN atinge com maior frequência nascidos pré-termo com peso inferior à 1500g, sabendo disso a equipe de enfermagem deve estabelecer cuidados rigorosos específicos. Apesar de a doença apresentar sinais e sintomas inespecíficos os profissionais devem estar prontamente treinados para identificação precoce da patologia, corroborando para sobrevida dos bebês. Conclusões: Por meio da compreensão sobre a ECN, sua fisiopatologia e suas manifestações, é possível traçar medidas de prevenção através do cuidado de enfermagem, resultando na redução da morbimortalidade em decorrência da doença

Long-term thermal sensitivity of Earth’s tropical forests

The sensitivity of tropical forest carbon to climate is a key uncertainty in predicting global climate change. Although short-term drying and warming are known to affect forests, it is unknown if such effects translate into long-term responses. Here, we analyze 590 permanent plots measured across the tropics to derive the equilibrium climate controls on forest carbon. Maximum temperature is the most important predictor of aboveground biomass (−9.1 megagrams of carbon per hectare per degree Celsius), primarily by reducing woody productivity, and has a greater impact per °C in the hottest forests (>32.2°C). Our results nevertheless reveal greater thermal resilience than observations of short-term variation imply. To realize the long-term climate adaptation potential of tropical forests requires both protecting them and stabilizing Earth’s climate

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P &lt; 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P &lt; 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223