Age of menarche in girls with cystic fibrosis.

Malnutrition, delayed growth and puberty are commonly observed in children suffering from cystic fibrosis. The aim of this study was to assess the age of menarche in girls with CF using status quo analysis. The relationship between types of CFTR mutations and onset of the first menstruation was also evaluated. Material was based on somatic data gathered from medical history records of 47 girls with cystic fibrosis, aged 11-18 years. All girls were patients of the Mother and Child Institute in Warsaw (Poland). Results: The age of menarche in the girls in the study group was 14.65+/-1.21 years. In comparison with the healthy child population, girls with cystic fibrosis experienced menarche with 2 years' delay. Menstruating girls were found to be statistically older and taller than their non-menstruating consorts. Regarding body mass and BMI, a marked tendency towards higher parameter values was noted in the menstruating group, although the differences did not reach statistical significance. A significant relationship between onset of menarche and type of CFTR mutation was found. Girls with cystic fibrosis enter puberty later than their peers, in spite of intensive medical care. The issue of growth and puberty in children with CF requires further detailed investigation under clinical and auxological aspects

Age of menarche in girls with sight organ diseases

ABSTRACT The paper attempts to clarify the reasons for sooner pubescence of girls with sight defects than that of their normally seeing peers. The age of menarche was considered depending on the degree of the sight impairment and the disease etiology as well as some selected factors of the socio-economic environment in the examined girls' families

Postural stability in patients with cystic fibrosis

Aim of the study: The aim of the study was to evaluate the postural stability in a group of patients with cystic fibrosis. Material and methods: The study included a group of 44 patients with cystic fibrosis with the analysis of parameters in the age groups under 16 years (mean 10,1 ± 3,6) and over 16 years (mean 23,6 ± 7,3). For stabilometric measurements, a two-plate CQ Stab posturograph and for body posture measurements Posturometr-S was used. Results: The mean value of the SP body balance COP index in the measurement with open eyes was 336,1 ± 123 mm in the younger group and 201,3 ± 47 mm in the older age group. The results differed significantly in the measurement with closed eyes in both age groups, similarily to the other indicators of the balance in the assessment for each planes. The indicators associated with the assessment of COP displacement significantly correlated negatively with the age of the subjects, where for the measurement with eyes closed this relationship was the highest in the group up to 16 years and was r = - 0,90 (p <0,0001) and the size of the chest kyphosis angle ( for the whole group: r = - 0,45, p = 0,002) and some indicators of the pulmonary system. The correlation value for FEV1% pred., for the whole group, was r = 0,41 (p = 0,005). It was observed that with the age of the subjects, the kyphosis angle increased (for the group > 16 years: r = 0,77, p <0,0001). Conclusions: The results of the study show that with age of the cf patients, changes in the spine in the sagittal plane, the parameters related to postural stability of the body may be improved

Anatomical variances and dimensions of the superior orbital fissure and foramen ovale in adults

The aim of the study was the retrospective morphological analysis of selected structures of the middle cranial fossa, i.e. foramen ovale and superior orbital fissure, in relation to the external head and cranial diameters in adults from the Lublin region (Poland). The study was performed on data collected during computed tomography examinations of 60 individuals (age 20&#8211;30 years), without any cranial or brain abnormalities. Based on the post-processing reconstructions, 3-dimensional views of the skull and head were obtained. The length and width of both structures, as well as thickness of the frontal, temporal, and occipital squamae, were measured. The morphology of the ovale foramina and superior orbital fissures were checked. The length and width of the skull and head were the only parameters that significantly differed between males and females. The thickness of the frontal and temporal squama was insignificantly lower in males than in females. Almond and oval shapes were the most typical for the foramen ovale. The superior orbital fissure was found as a wide form &#8212; with or without accessory spine originating from its lower margin or as a laterally narrowed form. The length and width of the foramen ovale were insignificantly higher in males than in females. The same results were found for the area of the right superior orbital fissure. The thickness of the frontal and occipital squamae influenced the thickness of the temporal squama. The analysed individuals had asymmetrical, oval, or almond-shape ovale foramina. Unlike the seldom visible laterally narrowed form of the superior orbital fissure, a wide form with or without accessory spine was the most commonly observed. The diameters of both superior orbital fissures and ovale foramina indicated the asymmetry of the neurocranium. (Folia Morphol 2011; 70, 4: 263&#8211;271

Growth And The Growth Hormone-Insulin Like Growth Factor 1 Axis In Children With Chronic Inflammation:Current Evidence, Gaps In Knowledge And Future Directions

Growth failure is frequently encountered in children with chronic inflammatory conditions like juvenile idiopathic arthritis, inflammatory bowel disease and cystic fibrosis. Delayed puberty and attenuated pubertal growth spurt is often seen during adolescence. The underlying inflammatory state mediated by pro-inflammatory cytokines, prolonged use of glucocorticoid and suboptimal nutrition contribute to growth failure and pubertal abnormalities. These factors can impair growth by their effects on the growth hormone-insulin like growth factor axis and also directly at the level of the growth plate via alterations in chondrogenesis and local growth factor signaling. Recent studies on the impact of cytokines and glucocorticoid on the growth plate studies further advanced our understanding of growth failure in chronic disease and provided a biological rationale of growth promotion. Targeting cytokines using biologic therapy may lead to improvement of growth in some of these children but approximately one third continue to grow slowly. There is increasing evidence that the use of relatively high dose recombinant human growth hormone may lead to partial catch up growth in chronic inflammatory conditions, although long term follow-up data is currently limited. In this review, we comprehensively review the growth abnormalities in children with juvenile idiopathic arthritis, inflammatory bowel disease and cystic fibrosis, systemic abnormalities of the growth hormone-insulin like growth factor axis and growth plate perturbations. We also systematically reviewed all the current published studies of recombinant human growth hormone in these conditions and discuss the role of recombinant human insulin like growth factor-1

Age of menarche in girls with sight organ diseases

The paper attempts to clarify the reasons for sooner pubescence of girls with sight defects than that of their normally seeing peers. The age of menarche was considered depending on the degree of the sight impairment and the disease etiology as well as some selected factors of the socio-economic environment in the examined girls' familie

Growth and nutritional status in children and adolescents with cystic fibrosis

Background: Growth retardation, delayed puberty and malnutrition are frequently observed in children suffering from cystic fibrosis. Aim: The aim of this study was to estimate growth and nutritional status in children with cystic fibrosis on the basis of body proportions and body mass index. Subjects and methods: Anthropometric data were collected from the medical histories of 62 patients treated in three cystic fibrosis treatment centers in Poland. Anthropometric parameters were expressed in terms of standard deviations away from age-specific and sex-specific reference means reported for the population of Poland. Two-way analysis of variance was used to determine whether the type of cystic fibrosis transmembrane conductance regulator (CFTR) mutation is correlated with age at the time of diagnosis and with body proportions. Results: The type of mutation was significantly correlated with height, weight and transverse chest width. Growth retardation was greater in subjects diagnosed before they were 3 years old than in subjects diagnosed later. The children had infantile body proportions. Their legs were short and their trunks were long in comparison to their height. Almost 40% of the subjects suffered from malnourishment. Conclusion: Further study is needed to determine how growth in children with cystic fibrosis is affected by clinical practice and socio-economic factors. © 2008 Informa UK Ltd.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

An attempt to evaluate some personality characteristics of Wrocław high school graduates of different pubescence age

An attempt was made to establish the correlation between the time of reaching sexual maturity and the level of physical development. The material consisted of data obtained from schoolgirls of final classes of 6 secondary schools. In a questionnaire, the girls provided retrospective data concerning the age of menarche, and replied to questions being the basis for sexual maturity evaluation