Circadian Cell-Cycle Progression: Cracking Open the Gate

In cyanobacteria cell division is intimately linked with the circadian cycle. Dong et al. (2010) now identify components of the circadian clock that regulate the formation of the midcell ring for cytokinesis, revealing a critical link between the circadian cycle and the control of cell division

K-Dominance in Multidimensional Data: Theory and Applications

We study the problem of k-dominance in a set of d-dimensional vectors, prove bounds on the number of maxima (skyline vectors), under both worst-case and average-case models, perform experimental evaluation using synthetic and real-world data, and explore an application of k-dominant skyline for extracting a small set of top-ranked vectors in high dimensions where the full skylines can be unmanageably large

Future Challenges in Nocturia: Relevance to Voiding Clock?

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Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes.

ObjectiveChorioamnionitis (inflammation of the placenta and fetal membranes) and abnormal gastrointestinal colonization have been associated with an increased risk of sepsis and death in preterm infants, but whether chorioamnionitis causes abnormal pioneering gastrointestinal colonization in infants is not known. We determined the relationship between chorioamnionitis, altered infant fecal microbiome indicating abnormal gastrointestinal colonization, and adverse outcomes.Study designPreterm infants ≤ 28 weeks at birth were enrolled from 3 level III NICUs in Cincinnati, Ohio and Birmingham, Alabama. Sequencing for 16S microbial gene was performed on stool samples in the first 3 weeks of life. Chorioamnionitis was diagnosed by placental histology. Late onset sepsis and death outcomes were analyzed in relation to fecal microbiota and chorioamnionitis with or without funisitis (inflammation of the umbilical cord).ResultsOf the 106 enrolled infants, 48 infants had no chorioamnionitis, 32 infants had chorioamnionitis but no funisitis (AC), and 26 infants had chorioamnionitis with funisitis (ACF). The fecal samples from ACF infants collected by day of life 7 had higher relative abundance of family Mycoplasmataceae (phylum Tenericutes), genus Prevotella (phylum Bacteroidetes) and genus Sneathia (phylum Fusobacteria). Further, AC and ACF infants had higher incidence of late-onset sepsis/death as a combined outcome. Presence of specific clades in fecal samples, specifically, order Fusobacteria, genus Sneathia or family Mycoplasmataceae, were significantly associated with higher risk of sepsis or death.ConclusionThe results support the hypothesis that specific alterations in the pioneering infant gastrointestinal microbiota induced by chorioamnionitis predispose to neonatal sepsis or death

Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults

Our understanding of regional filling of the lung and regional ventilation distribution is based on studies using stepwise inhalation of radiolabelled tracer gases, magnetic resonance imaging and positron emission tomography. We aimed to investigate whether these differences in ventilation distribution at different end-expiratory levels (EELs) and tidal volumes (V Ts) held also true during tidal breathing. Electrical impedance tomography (EIT) measurements were performed in ten healthy adults in the right lateral position. Five different EELs with four different V Ts at each EEL were tested in random order, resulting in 19 combinations. There were no measurements for the combination of the highest EEL/highest V T. EEL and V T were controlled by visual feedback based on airflow. The fraction of ventilation directed to different slices of the lung (VENTRL1−VENTRL8) and the rate of the regional filling of each slice versus the total lung were analysed. With increasing EEL but normal tidal volume, ventilation was preferentially distributed to the dependent lung and the filling of the right and left lung was more homogeneous. With increasing V T and maintained normal EEL (FRC), ventilation was preferentially distributed to the dependent lung and regional filling became more inhomogeneous (p<0.05). We could demonstrate that regional and temporal ventilation distribution during tidal breathing was highly influenced by EEL and V

The significance of climate fluctuations for lake level changes and shifts in subsistence economy during the late Neolithic (4300-2400 b.c. ) in central Europe

In the last decades, data on the economy and environment of the Neolithic period of lake dwellings (4300-2400 b.c.) in central Europe has increased considerably and also palaeoecological data on lake level fluctuations has been thoroughly elaborated. Lake shores were mainly settled during warm and rather dry climate periods which caused a fall in the lake levels. Nevertheless, there were strong and partly very short-term shifts in the economy during the lake-dwelling period. These can be recognised only because the settlement layers can be very precisely dated by dendrochronology. In this article we discuss in an interdisciplinary way the possible interrelations between climatic and economic changes. To explain the latter, we assume crop failures as the main reason, which caused intensified hunting and gathering. There are three different possibilities which might explain this: cold and wet summers, severe droughts during spring and summer, or local over-exploitation of soils in densely settled area