Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully

Background. Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole after T. asahii infection that is known to cause fatal sepsis and invasive fungal infection. Conclusion. There is no conclusive evidence that the antifungal agent voriconazole is effective in the neutropenic patients infected with Trichosporon asahii. Liposomal amphotericin B has also been reported to be inadequate for treatment. We believe that our patients were successfully treated and survived because the antifungal agents were started early and properly, although the infection can be fatal in up to 80% of cases despite treatment

Tectonic history of basins sited along the western section of the North Anatolian Fault System, Turkey

Geological and geomorphological features of basins along the western half of the North Anatolian Fault System (NAFS) are used to constrain the formation of these basins by localization of deformation and the total displacement, and to determine the timing of basin development. In this study, tectonic influence direction of the NAFS on tectonic and hydrologic basins Bolu, Yenicaga, Dortdivan, Cerkes, Ilgaz and Tosya has been investigated to deduce information about the formation stages and interaction between these areas by using the GIS techniques. This research has been carried out by two different approaches; first is the comparison of main tilt directions of the basins determined by means of the basin slope frequency differences on opposite sides of the basin margins, and secondly, orientations of basins with respect to NAFS are investigated

Features of Congenital Hemangiomas

Hemangiomas are the most common benign tumors of childhood. The known risk factors are female gender, prematurity, and low birth weight. In this study, it is planned to investigate prenatal and natal risk factors which may affect hemangioma development in addition to these factors. The study included 114 patients with congenital hemangioma and 100 healthy children as the control group. Age, sex, prenatal characteristics of two groups (use of drugs, diseases, hypo-hypertension and hyperemesis during pregnancy, parental smoking), natal features (type of birth, birth weight, gestation age), parents' age, parents' diseases and medications used were questioned. The most frequent site of congenital hemangiomas was the head and neck region in our study. Female gender and being the first child increased the risk of developing congenital hemangioma. As an important information, hyperemesis during pregnancy increased the risk of congenital hemangioma 1.75 times. Postterm birth and birth weight over 4000 gram were protective against congenital hemangioma development. Apart from the known risk factors, drug use in pregnancy could be a risk factor for the development of congenital hemangioma. We recommend that future studies should be conducted in larger patient groups in order to consider different risk factors

Economic and psychosocial problems experienced by pediatric with cancer patients and their families during the treatment and follow-up process

WOS: 000471597800008PubMed: 31217707Aim: To identify the psychosocial and economic problems of the pediatric patients with cancer who were treated at the Dr. Sami Ulus Obstetrics and Gynecology and Child Health and Diseases Training and Research Hospital's Pediatric Oncology Department and their relatives during this process. Material and Methods: We interviewed a total of 100 patients who were treated at Dr. Sami Ulus Obstetrics and Gynecology and Child Health and Diseases Hospital's Pediatric Oncology Department between 1996 and 2015, and were now followed up without treatment and their relatives using survey questions on the psychosocial and economic problems they experienced. Results: Most of patients were from provinces outside Ankara. The average monthly income was below the level that would meet the family needs in 80% of the families and only 16% had extra income. Additional economic support had been received by 93% of the families in the patient group. Twenty-five families (25%) had been forced to sell property during the treatment. Forty-nine (49%) families had borrowed money from acquaintances and relatives or had taken out a bank loan. Serious psychological problems were experienced during and after the treatment by 46% of the mothers; 41% of the families had used religious procedures more commonly during the treatment period to cope with the psychological problems. Education was subject to a 1-2 year pause in 83% of the patients. Conclusion: Childhood-age patients with cancer and their families experience significant psychosocial and economic problems during and after the treatment process. Providing medical treatment and psychosocial support in harmony is an important factor that increases the success of cancer treatment. The patient and the family will require psychosocial support mechanisms throughout life, starting from the moment they face the disease. Developing national social support programs and legal regulations to form a basis for such programs are required in our country

Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus

Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation

Remembering the Importance of an Old Friend: History Taking in Preoperative Evaluation of Healthy Children: A Single Center Experience

Albayrak, Meryem/0000-0003-2711-5150WOS: 000386045600005Objective: To investigate the consequences of routine laboratory tests that lead to surgical delay or high cost in patients with a normal medical history and physical examination who undergo minor surgical interventions. Patients and Method: Files of 1,322 patients aged between 0-16 years that had undergone elective surgical intervention within six years were reviewed. Results: Of the 1,322 patients, 1,246 (94.3%) had normal physical examination and laboratory findings. Seventy-six children who had abnormalities in laboratory findings and physical examination were referred to pediatrics. Of the 76 pediatric referees, 42 (55.3%) were reevaluated and were diagnosed with upper respiratory tract infection (n=23; 30.2%), iron deficiency anemia (n=5; 6.5%), innocent murmur (n=4; 5.3%), thalassemia minor (n=2; 2.6%), lower respiratory tract infection (n=2; 2.6%), urinary tract infection (n=1; 1.3%), mumps (n=1; 1.3%), acute gastroenteritis (n=1; 1.3%), minimal aortic and tricuspid valve insufficiency (n=1; 1.3%), minimal aortic stenosis (n=1; 1.3%), atrial septal defect (n=1; 1.3%). Surgical interventions were delayed until the recovery of the infectious diseases. In 25 of the patients, repeated tests showed normal ranges after the second test; however nine (n=9) of the patients showed increased or decreased numbers of white blood cell counts and whose medical history and physical examination revealed signs and symptoms related to infection. Conclusion: Routine laboratory tests contribute little to preoperative evaluation of children with normal history and physical examination undergoing low grade surgery

The Renal Problems in X-Ray Based Imaging Techniques Using lodinated Radiographic Contrast Agents

Iodinated radiographic contrast agents (IRCA) are pharmaceuticals commonly used for improving the visibility of internal organs and structures in X-ray based imaging techniques such as radiography, angiography and contrast-enhanced computed tomography scans, and for performing cardiac catheterizations and percutaneous coronary interventions. Like all other pharmaceuticals, however, these agents are not completely devoid of risk. The main risk is their nephrotoxicity. Following the description of Contrast-Induced Nephropathy (CIN) and its pathogenesis, the conditions favoring the development of CIN are discussed in depth. The main predisposing condition is a pre-existing renal impairment, particularly when associated with diabetes mellitus. Then, measures to prevent CIN are suggested. The important rules in CIN prevention are: monitoring renal function, discontinuation of potentially nephrotoxic drugs, use of either iodixanol or iopamidol at the lowest dosage possible. Above all, the main procedure for prevention of CIN is an adequate hydration of the patient with either isotonic sodium chloride or sodium bicarbonate solutions