Exploring Perceptions and Practices in Organizing University Scientific Research

he development of transdisciplinary projects, crucial in the context of the complex challenges facing society. The organization of scientific research must prioritize the human factor and involve establishing the departments involved in university scientific research and the connections between them. This paper presents the perceptions of academic staff at a medical university regarding the organization and implementation of research within the university and the sources of research funding. The results highlight a clear orientation towards interdisciplinary research, albeit conducted within the organization itself, and a weak prioritization of fundamental research. Additionally, funding through international grants is seen as less accessible than national funding, despite the medical field being considered a priority in the funding programs. The research findings are relevant for decision-makers in the field of research funding at both the national and organizational levels

¿Cuántos cubos de Rubik hay?

Este trabajo se centra en explicar la teoría de enumeración de Pólya y todos los conceptos relativos a teoría de grupos necesarios para entenderla. Dicha teoría es luego aplicada para resolver un problema concreto: queremos contar el número de cubos de Rubik (libres en el espacio pero no articulados) distinguibles al colorearlos con 6 colores, de manera que cada color aparezca 9 veces exactamente.<br /

Fluid identities and gendered intimacies : the indeterminate narrator in Jeanette Winterson's Written on the Body

Winterson's Written on the Body (1992) deals with a brief but passionate relationship between its narrator and a beautiful, married woman called Louise. The novel tackles romantic relationships, love, loss and sexuality from an experimental point of view and presents an interesting, challenging feature: a genderless narrator. Winterson has created a narrative where every reference to the gender of the narrative voice has been carefully omitted, thus engaging the reader to participate in the construction of both the novel and the narrator's identity. For this reason, I would like to argue that this deliberate play on gender ambiguity places the reader in a situation where he or she is induced to deconstruct perceptions about sexuality.La novel·la de la Jeanette Winterson "Written on the Body"(1992) retrata la breva però apassionada relació entre el seu narrador i la seva amant Louise, una dona casada. La novel·la aborda temes com les relacions romàntiques, l'amor, la pèrdua i la sexualitat d'un punt de vista experimental. A més presenta una característica interessant, desafiant: un narrador indeterminat. Winterson crea una narrativa on cada referència al gènere de la veu narrativa ha estat omesa, i per això convida al lector a participar en la construcció de la novel·la i la identitat del narrador. Per aquesta raó, es pot argumentar que aquest joc deliberat sobre l'ambigüitat de gènere col·loca el lector en una situació on ell o ella és induït a desconstruir percepcions sobre la sexualitat

Enterobacteria in the hospital environment and their antimicrobial resistance

CHU Reunion, France, Vasile Goldis Western University of Arad, Romania, Arad County Clinical Hospital, Romania, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania, The 5th International Congress of the Society of Anesthesiology and Reanimatology of the Republic of Moldova, 16th Edition of the International Course of Guidelines and Protocols in Anesthesia, Intensive Care and Emergency Medicine, 28th Meeting of the European Society for Computing and Technology in Anesthesia and Intensive Care September 27-29, 2018, Chisinau, the Republic of MoldovaBackground: Enterobacteria can produce enzymes (ESBLs) to inactivate beta-lactamins and can also be resistant to carbapenems (CRE), as superbugs. Objective: To evaluate the superbacteria frequency in the last two years in Arad County Clinical Hospital. Material and methods: The multidrug criteria described in Clinical Microbiology and Infection Volume 18, Issue 3, 2011 were used. VITEK and E-test for ESBLs and diffusometric anti-biograms methods for CRE were used, interpreted according to EUCAST and CLSI. Results: Were identified 5093 isolates, 67.85% were Gram negative (n = 3456), 2905 were enterobacteria (57.03% of total, 84.05% of Gram negatives). ESBLs represent 19.53% (n = 995), 15.2% (n = 151) in Surgical wards, 14.94% (n = 149) on ICU and 12.8% (n = 127) in Internal Medicine departments; they were present in all 24 hospital wards, colonizing even ambulatory patients (n = 32; 3.2%). Superbugs were 117 of these, most of which were present on ICUs (n = 57; 48.7%), Neurology (n = 15; 12.8%), Surgery (n=15; 12.8%) and Palliative (n = 12; 10.3%). Most multidrug resistant organisms were Klebsiella pneumoniae (n = 58; 49.6%), Proteus spp (n = 28; 23.91%) and Providencia stuartti (n = 19; 16.2%). Conclusions: Enterobacteria with extended resistance to cephalosporins and carbapenems were identified in the last two years in this hospital, especially in the ICU, Surgical and Internal Medicine departments, colonizing ambulatory patients as well. They are in the WHO alert, along with other Gram negative species, as Acinetobacter baumannii and Pseudomonas aeruginosa

Charming and bewitching : considering the Harry Potter series

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Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

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Comparative Studies concerning Bioactive Peptides Obtained from Fish By-Products

Fish byproducts (bone, scale, or skin) contain a wide range of nutritional components, especially proteins and lipids, the most important of all being collagen [...

CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction

Atherosclerosis is the main cause of cardiovascular diseases with high prevalence worldwide. A promising therapeutic strategy to reverse atherosclerotic process is to improve the athero-protective potential of high-density lipoproteins (HDL). Since the small intestine is a source of HDL, we aimed to activate transcription of the endogenous HDL major proteins, apolipoprotein AI (ApoAI) and paraoxonase 1 (PON1), in enterocytes, and to evaluate their potential to correct the pro-inflammatory status of endothelial cells (EC). Caco-2 enterocytes were transfected with CRISPR activation plasmids targeting ApoAI or PON1, and their gene and protein expression were measured in cells and conditioned medium (CM). ATP binding cassette A1 and G8 transporters (ABCA1, ABCG8), scavenger receptor BI (SR-BI), and transcription regulators peroxisome proliferator-activated receptor &gamma; (PPAR&gamma;), liver X receptors (LXRs), and sirtuin-1 (SIRT1) were assessed. Anti-inflammatory effects of CM from transfected enterocytes were estimated through its ability to inhibit tumor necrosis factor &alpha; (TNF&alpha;) activation of EC. Transcriptional activation of ApoAI or PON1 in enterocytes induces: (i) increase of their gene and protein expression, and secretion in CM; (ii) stimulation of ABCA1/G8 and SR-BI; (iii) upregulation of PPAR&gamma;, LXRs, and SIRT1. CM from transfected enterocytes attenuated the TNF&alpha;-induced inflammatory and oxidative stress in EC, by decreasing TNF receptor 1, monocyte chemoattractant protein-1, and p22phox. In conclusion, transcriptional activation of endogenous ApoAI or PON1 in enterocytes by CRISPR/dCas9 system is a realistic approach to stimulate biogenesis and function of major HDL proteins which can regulate cholesterol efflux transporters and reduce the inflammatory stress in activated EC