26 research outputs found
MiCASA is a new method for quantifying cellular organization
While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using the mouse thymus as a test organ. The thymus is the primary lymphoid organ responsible for generating T cells in vertebrates, and its proper structure and organization is essential for optimal function. Our method, Multitaper Circularly Averaged Spectral Analysis (MiCASA), identifies differences in the tissue-level organization with high sensitivity, including defining a novel type of phenotype by measuring variability as a specific parameter. MiCASA provides a novel and easily implemented quantitative tool for assessing cellular organization
Different paths to the modern state in Europe: the interaction between domestic political economy and interstate competition
Theoretical work on state formation and capacity has focused mostly on early modern Europe and on the experience of western European states during this period. While a number of European states monopolized domestic tax collection and achieved gains in state capacity during the early modern era, for others revenues stagnated or even declined, and these variations motivated alternative hypotheses for determinants of fiscal and state capacity. In this study we test the basic hypotheses in the existing literature making use of the large date set we have compiled for all of the leading states across the continent. We find strong empirical support for two prevailing threads in the literature, arguing respectively that interstate wars and changes in economic structure towards an urbanized economy had positive fiscal impact. Regarding the main point of contention in the theoretical literature, whether it was representative or authoritarian political regimes that facilitated the gains in fiscal capacity, we do not find conclusive evidence that one performed better than the other. Instead, the empirical evidence we have gathered lends supports to the hypothesis that when under pressure of war, the fiscal performance of representative regimes was better in the more urbanized-commercial economies and the fiscal performance of authoritarian regimes was better in rural-agrarian economie
Different Paths to the Modern State in Europe: The Interaction between Domestic Political Economy and Interstate Competition
Months backward test: a review of its use in clinical studies
To review the use of the Months Backwards Test
(MBT) in clinical and research contexts.
METHODS: We conducted a systematic review of
reports relating to the MBT based upon a search of
PsychINFO and MEDLINE between January 1980 and
December 2014. Only reports that specifically described
findings pertaining to the MBT were included. Findings
were considered in terms of rating procedures, testing
performance, psychometric properties, neuropsychological
studies and use in clinical populations.
RESULTS: We identified 22 data reports. The MBT is
administered and rated in a variety of ways with very
little consistency across studies. It has been used to
assess various cognitive functions including focused
and sustained attention as well as central processing
speed. Performance can be assessed in terms of the
ability to accurately complete the test without errors
(âMB accuracyâ), and time taken to complete the test
(âMB durationâ). Completion time in cognitively intact
subjects is usually < 20 s with upper limits of 60-90 s
typically applied in studies. The majority of cognitively
intact adults can complete the test without error such
that any errors of omission are strongly suggestive of
cognitive dysfunction. Coverage of clinical populations,
including those with significant cognitive difficulties is
high with the majority of subjects able to engage with
MBT procedures. Performance correlates highly with
other cognitive tests, especially of attention, including
the digit span backwards, trailmaking test B, serial
threes and sevens, tests of simple and complex choice
reaction time, delayed story recall and standardized list
learning measures. Test-retest and inter-rater reliability
are high (both > 0.90). Functional magnetic resonance
imaging studies comparing the months forward test
and MBT indicate greater involvement of more complex
networks (bilateral middle and inferior frontal gyri, the
posterior parietal cortex and the left anterior cingulate
gyrus) for backwards cognitive processing. The MBT
has been usefully applied to the study of a variety of
clinical presentations, for both cognitive and functional
assessment. In addition to the assessment of major
neuropsychiatric conditions such as delirium, dementia
and Mild Cognitive Impairment, the MBT has been
used in the assessment of concussion, profiling of
neurocognitive impairments in organic brain disorders
and Parkinsonâs disease, prediction of delirium risk in
surgical patients and medication compliance in diabetes.
The reported sensitivity for acute neurocognitive
disturbance/delirium in hospitalised patients is estimated
at 83%-93%. Repeated testing can be used to identify
deteriorating cognitive function over time.
CONCLUSION: The MBT is a simple, versatile tool
that is sensitive to significant cognitive impairment.
Performance can be assessed according to accuracy and
speed of performance. However, greater consistency in
administration and rating is needed. We suggest two
approaches to assessing performance - a simple (pass/
fail) method as well as a ten point scale for rating test
performance (467)