HIV and AIDS in the Russian Federation : prisons as a case study of risk environments and agency

This thesis explores Russian prisons as risk environments for the spread of HIV through intravenous drug use. The Russian HIV epidemic is extremely fast growing, and though exact prevalence rates are unknown, the epidemic is now considered generalized as estimated prevalence rates exceed one percent of the Russian population. After decades of foreign-aid and interventions in African nations have largely failed to address the HIV epidemic, social scientists now attribute HIV infection to risk environments created by low levels of social cohesion and a lack of agency. Within my research, I explore Russian male prisons and the role risk environments and agency play in the spread of HIV. I review recently published literature, government statistics, as well as reports published by non-governmental organizations. I then analyze and interpret these data, draw conclusions and inferences regarding the spread of HIV within Russian prison risk environments.Russian, East European, and Eurasian Studie

Love, Will, and the Intellectual Ascents

Augustine’s accounts of his so-called mystical experiences in conf. 7.10.16, 17.23, and 9.10.24 are puzzling. The primary problem is that, although in all three accounts he claims to have seen “that which is,” we have no satisfactory account of what “that which is” is supposed to be. I shall be arguing that, contrary to a common interpretation, Augustine’s intellectual “seeing” of “being” in Books 7 and 9 was not a vision of the Christian God as a whole, nor of one of the divine persons, each of whom is equally God, according to Augustine. This becomes clear when we attend to the fact that Augustine is appropriating a specific meaning of “that which is” or “being” used by Plotinus in his account of the lover of Beauty. This resolution, however, leads to a second question. Is there anything distinctively Christian about any, or all, of Augustine’s ascents? On the one hand, it would be odd if there were not, given that the Confessions are addressed to the Christian God. On the other hand, upon close inspection we find that the allegedly specific “Christian” characteristics that modern commentators have identified in the ascents of conf. 7 and 9 also occur in the Neoplatonists. I will argue that there is in fact one important difference between Augustine and the Neoplatonists here that has not been pointed out in these prior interpretations

Phylogenetic patterns recover known HIV epidemiological relationships and reveal common transmission of multiple variants.

The growth of human immunodeficiency virus (HIV) sequence databases resulting from drug resistance testing has motivated efforts using phylogenetic methods to assess how HIV spreads1-4. Such inference is potentially both powerful and useful for tracking the epidemiology of HIV and the allocation of resources to prevention campaigns. We recently used simulation and a small number of illustrative cases to show that certain phylogenetic patterns are associated with different types of epidemiological linkage5. Our original approach was later generalized for large next-generation sequencing datasets and implemented as a free computational pipeline6. Previous work has claimed that direction and directness of transmission could not be established from phylogeny because one could not be sure that there were no intervening or missing links involved7-9. Here, we address this issue by investigating phylogenetic patterns from 272 previously identified HIV transmission chains with 955 transmission pairs representing diverse geography, risk groups, subtypes, and genomic regions. These HIV transmissions had known linkage based on epidemiological information such as partner studies, mother-to-child transmission, pairs identified by contact tracing, and criminal cases. We show that the resulting phylogeny inferred from real HIV genetic sequences indeed reveals distinct patterns associated with direct transmission contra transmissions from a common source. Thus, our results establish how to interpret phylogenetic trees based on HIV sequences when tracking who-infected-whom, when and how genetic information can be used for improved tracking of HIV spread. We also investigate limitations that stem from limited sampling and genetic time-trends in the donor and recipient HIV populations

Composable computation in discrete chemical reaction networks

We study the composability of discrete chemical reaction networks (CRNs) that stably compute (i.e., with probability 0 of error) integer-valued functions $f:\mathbb{N}^d\to\mathbb{N}$. We consider output-oblivious CRNs in which the output species is never a reactant (input) to any reaction. The class of output-oblivious CRNs is fundamental, appearing in earlier studies of CRN computation, because it is precisely the class of CRNs that can be composed by simply renaming the output of the upstream CRN to match the input of the downstream CRN. Our main theorem precisely characterizes the functions $f$ stably computable by output-oblivious CRNs with an initial leader. The key necessary condition is that for sufficiently large inputs, $f$ is the minimum of a finite number of nondecreasing quilt-affine functions. (An affine function is linear with a constant offset; a quilt-affine function is linear with a periodic offset)

Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number

An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R 0 , is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples

The Effects Of Dieldrin On Chickens

In this study, insecticide residues in chicken eggs, livers, and fats were monitored in a flock of chickens for seventy-nine days. The test group was fed dieldrin in their drinking water for eighteen days and then was returned to normal water for forty-two more days. The sacrificed birds of the test group showed a 0.39 ppm average increase in dieldrin residue in the eggs, 0 .14 ppm in the livers and 9.54ppm in the fats when compared with the control eggs. livers and fats respectively. The I-test calculations showed these results to be significant. Observations of the embryos from the incubated eggs of each group showed abnormalities in the test birds\u27 embryos compared to normal development in the control embryos. There were no significant differences in the eggshell thicknesses in either the test or control groups. Behavioral changes were noted in the test birds after the dieldrin feedings that were not present in the control birds activities. They had become very nervous and leg reflex excitability was evident