947 research outputs found
Precision high voltage divider for the KATRIN experiment
The Karlsruhe Tritium Neutrino Experiment (KATRIN) aims to determine the
absolute mass of the electron antineutrino from a precise measurement of the
tritium beta-spectrum near its endpoint at 18.6 keV with a sensitivity of 0.2
eV. KATRIN uses an electrostatic retardation spectrometer of MAC-E filter type
for which it is crucial to monitor high voltages of up to 35 kV with a
precision and long-term stability at the ppm level. Since devices capable of
this precision are not commercially available, a new high voltage divider for
direct voltages of up to 35 kV has been designed, following the new concept of
the standard divider for direct voltages of up to 100 kV developed at the
Physikalisch-Technische Bundesanstalt (PTB). The electrical and mechanical
design of the divider, the screening procedure for the selection of the
precision resistors, and the results of the investigation and calibration at
PTB are reported here. During the latter, uncertainties at the low ppm level
have been deduced for the new divider, thus qualifying it for the precision
measurements of the KATRIN experiment.Comment: 22 pages, 12 figure
Observation of Bound Surface States in Grain Boundary Junctions of High Temperature Superconductors
We have performed a detailed study of the tunneling spectra of bicrystal
grain boundary junctions (GBJs) fabricated from the HTS YBCO, BSCCO, LSCO, and
NCCO. In all experiments the tunneling direction was along the CuO planes. With
the exception of NCCO, for all materials a pronounced zero bias conductance
peak was observed which decreases with increasing temperature and disappears at
the critical temperature. These results can be explained by the presence of a
dominating d-wave symmetry of the order parameter resulting in the formation of
zero energy Andreev bound states at surfaces and interfaces of HTS. The absence
of a ZBCP for NCCO is consistent with a dominating s-wave symmetry of the pair
potential in this material. The observed nonlinear shift of spectral weight to
finite energies by applying a magnetic field is in qualitative agreement with
recent theoretical predictions.Comment: 4 pages, 4 figures, to be published in Phys. Rev.
From State Socialist to Neoliberal Productivism:Disability Policy and Invalidation of Disabled People in the Postsocialist Region
GASKAP -- The Galactic ASKAP Survey
A survey of the Milky Way disk and the Magellanic System at the wavelengths
of the 21-cm atomic hydrogen (HI) line and three 18-cm lines of the OH molecule
will be carried out with the Australian Square Kilometre Array Pathfinder
telescope. The survey will study the distribution of HI emission and absorption
with unprecedented angular and velocity resolution, as well as molecular line
thermal emission, absorption, and maser lines. The area to be covered includes
the Galactic plane (|b|< 10deg) at all declinations south of delta = +40deg,
spanning longitudes 167deg through 360deg to 79deg at b=0deg, plus the entire
area of the Magellanic Stream and Clouds, a total of 13,020 square degrees. The
brightness temperature sensitivity will be very good, typically sigma_T ~ 1 K
at resolution 30arcsec and 1 km/s. The survey has a wide spectrum of scientific
goals, from studies of galaxy evolution to star formation, with particular
contributions to understanding stellar wind kinematics, the thermal phases of
the interstellar medium, the interaction between gas in the disk and halo, and
the dynamical and thermal states of gas at various positions along the
Magellanic Stream.Comment: 45 pages, 8 figures, Pub. Astron. Soc. Australia (in press
Differential gene expression mediated by 15-hydroxyeicosatetraenoic acid in LPS-stimulated RAW 264.7 cells
<p>Abstract</p> <p>Background</p> <p>Given the immuno-modulatory activity of native haemozoin (Hz), the effects of constitutive Hz components on immune response are of interest. Recently, gene expression changes mediated by HNE and the synthetic analogue of Hz, beta-haematin (BH), were identified and implicated a significant role for lipid peroxidation products in Hz's activity. The study presented herein examines gene expression changes in response to 15(S)-hydroxyeicosatetraenoic acid (HETE) in a model macrophage cell line.</p> <p>Methods</p> <p>LPS-stimulated RAW 264.7 macrophage-like cells were treated with 40 ΌM 15(S)-HETE for 24 h, and microarray analysis was used to identify global gene expression alterations. Fold changes were calculated relative to LPS-stimulated cells and those genes altered at least 1.8-fold (<it>p </it>value †0.025) were considered to be differentially expressed. Expression levels of a subset of genes were assessed by qRT-PCR and used to confirm the microarray results.</p> <p>Results</p> <p>Network analysis revealed that altered genes were primarily associated with "lipid metabolism" and "small molecule biochemistry". While several genes associated with PPAR-gamma receptor-mediated signaling were differentially expressed, a number of genes indicated the activation of secondary signaling cascades. Genes related to cytoadherence (cell-cell and cell-matrix), leukocyte extravasation, and inflammatory response were also differentially regulated by treatment, supporting a potential role for 15(S)-HETE in malaria pathogenesis.</p> <p>Conclusion</p> <p>These results add insight and detail to 15-HETE's effects on gene expression in macrophage-like cells. Data indicate that while 15-HETE exerts biological activity and may participate in Hz-mediated immuno-modulation, the gene expression changes are modest relative to those altered by the lipid peroxidation product HNE.</p
Knowledge Management and Organisational Culture
This international Handbook provides a comprehensive overview of key topics, debates and issues within the now well-established field of Knowledge Management (KM)
Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study
Research articl
The value of health care â a matter of discussion in Germany
BACKGROUND: Interest in assessing the value of health-care services in Germany has considerably increased since the foundation of the Institut fĂŒr QualitĂ€t und Wirtschaftlichkeit im Gesundheitswesen, IQWiG (Institute for Quality and Efficiency in Health Care). The practical application of value assessment illustrates how problematic the process can be. In all decisions made for the provision of health care, data concerning the measurable dimensions (quantity and quality of efficacy and effectiveness, validity of the results and costs) flow into a complex and not yet standardized decision-making process concerning public financing. Some of these decisions are based on data of uncertain validity, unknown reproducibility and unclear appropriateness. DISCUSSION: In this paper we describe the theoretical aspects of value from psychological and economic viewpoints and discuss national and international approaches. Methodic details and difficulties in assessing the value of health-care services are analysed. A definition of the intangible value of health-care services will be proposed which contains only three factors: the absolute risk reduction (usually a measure of efficacy), the validity of the scientific papers examined and the type of the expected effectiveness (prevention of death and disability, restitution of well-being). The intangible value describes the additional benefit when comparing two possible actions, like treatment or observation only. CONCLUSION: The description of intangible value from the viewpoint of different stakeholders is a useful measure for subsequent steps (not discussed here) â the evaluation of costs and of patient benefit. A standardised, transparent, fair and democratic evaluation is essential for the definition of a basic benefit package
A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007
We present the results of the first search for gravitational wave bursts
associated with high energy neutrinos. Together, these messengers could reveal
new, hidden sources that are not observed by conventional photon astronomy,
particularly at high energy. Our search uses neutrinos detected by the
underwater neutrino telescope ANTARES in its 5 line configuration during the
period January - September 2007, which coincided with the fifth and first
science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed
for candidate gravitational-wave signals coincident in time and direction with
the neutrino events. No significant coincident events were observed. We place
limits on the density of joint high energy neutrino - gravitational wave
emission events in the local universe, and compare them with densities of
merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at
http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access
area to figures, tables at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000
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