A PoincarCLDulac Approach to a Nonlinear Beurling-Lax-Halmos Theorem

This paper presents a local nonlinear Beurling-Lax-Halmos type representation for a shift-invariant germ of a complex-analytic manifold embedded in a separable Hilbert space. We represent the manifold locally (near 0) by an asymptotic series (which commutes with the shift) and we discuss the possible convergence of this series. The techniques that we employ are heavily influenced by the classical Poincare-Dulac theory in nonlinear ordinary differential equations, combined with the commutant lifting theorem. 0 1989 Academic Press, Inc

Searching for Gravitational Waves from Binary Inspirals with LIGO

We describe the current status of the search for gravitational waves from inspiralling compact binary systems in LIGO data. We review the result from the first scientific run of LIGO (S1). We present the goals of the search of data taken in the second scientific run (S2) and describe the differences between the methods used in S1 and S2.Comment: 9 pages, 2 figures. Published in proceedings of the 8th Gravitational Wave Data Analysis Workshop, Milwaukee, WI, USA, 17-20 December 200

Development and Test of Highly Autonomous Unmanned Aerial Vehicles

Published in Journal of Aerospace Computing, Information, and Communication, Vol. 1, Issue 12, December 2004.This paper describes the design, development, and testing of Unmanned Aerial Vehicles (UAV) with highly automated search capabilities. Here, systems are able to respond on their own in the presence of considerable uncertainty utilizing an image processor, tracker/mapper, mission manager, and trajectory generation; and are used to complete a realistic benchmark reconnaissance mission. Subsequent to the selection of the search area, all functions are automated and human operator assistance is not required. The applications of these capabilities include reduction of operator workload in operational UAV systems, new UAV or guided-munition missions conducted without the assistance or availability of human operators, or the enhancement/augmentation of human search capabilities. The resulting system was able to search the 15-building village automatically with speed comparable to a human operator searching on foot or with a conventional remotely piloted vehicle. It was successful in 6 of 7 actual flights over the McKenna Military Operations in Urban Terrain test site over two different days and a variety of lighting conditions and choice of desired building

Donald J. Jamison Sr. v. Utah Home Fire Insurance Company : Brief of Respondent

Appeal from the Judgment of the Third Judicial District Court, Salt Lake County- Honorable Stewart M. Hanson, Jr

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions

All pharmaceutical companies are required to assess pharmacokinetic drug-drug interactions (DDIs) of new chemical entities (NCEs) and mathematical prediction helps to select the best NCE candidate with regard to adverse effects resulting from a DDI before any costly clinical studies. Most current models assume that the liver is a homogeneous organ where the majority of the metabolism occurs. However, the circulatory system of the liver has a complex hierarchical geometry which distributes xenobiotics throughout the organ. Nevertheless, the lobule (liver unit), located at the end of each branch, is composed of many sinusoids where the blood flow can vary and therefore creates heterogeneity (e.g. drug concentration, enzyme level). A liver model was constructed by describing the geometry of a lobule, where the blood velocity increases toward the central vein, and by modeling the exchange mechanisms between the blood and hepatocytes. Moreover, the three major DDI mechanisms of metabolic enzymes; competitive inhibition, mechanism based inhibition and induction, were accounted for with an undefined number of drugs and/or enzymes. The liver model was incorporated into a physiological-based pharmacokinetic (PBPK) model and simulations produced, that in turn were compared to ten clinical results. The liver model generated a hierarchy of 5 sinusoidal levels and estimated a blood volume of 283 mL and a cell density of 193 × 106 cells/g in the liver. The overall PBPK model predicted the pharmacokinetics of midazolam and the magnitude of the clinical DDI with perpetrator drug(s) including spatial and temporal enzyme levels changes. The model presented herein may reduce costs and the use of laboratory animals and give the opportunity to explore different clinical scenarios, which reduce the risk of adverse events, prior to costly human clinical studies

The origin of multicellularity in cyanobacteria

Background: Cyanobacteria are one of the oldest and morphologically most diverse prokaryotic phyla on our planet. The early development of an oxygen-containing atmosphere approximately 2.45 - 2.22 billion years ago is attributed to the photosynthetic activity of cyanobacteria. Furthermore, they are one of the few prokaryotic phyla where multicellularity has evolved. Understanding when and how multicellularity evolved in these ancient organisms would provide fundamental information on the early history of life and further our knowledge of complex life forms. Results: We conducted and compared phylogenetic analyses of 16S rDNA sequences from a large sample of taxa representing the morphological and genetic diversity of cyanobacteria. We reconstructed ancestral character states on 10,000 phylogenetic trees. The results suggest that the majority of extant cyanobacteria descend from multicellular ancestors. Reversals to unicellularity occurred at least 5 times. Multicellularity was established again at least once within a single-celled clade. Comparison to the fossil record supports an early origin of multicellularity, possibly as early as the “Great Oxygenation Event” that occurred 2.45 - 2.22 billion years ago. Conclusions: The results indicate that a multicellular morphotype evolved early in the cyanobacterial lineage and was regained at least once after a previous loss. Most of the morphological diversity exhibited in cyanobacteria today —including the majority of single-celled species— arose from ancient multicellular lineages. Multicellularity could have conferred a considerable advantage for exploring new niches and hence facilitated the diversification of new lineages

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Measurement of the mass difference m(D-s(+))-m(D+) at CDF II

We present a measurement of the mass difference m(D-s(+))-m(D+), where both the D-s(+) and D+ are reconstructed in the phipi(+) decay channel. This measurement uses 11.6 pb(-1) of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be m(D-s(+))-m(D+)=99.41+/-0.38(stat)+/-0.21(syst) MeV/c(2)