DOES GOOD CORPORATE GOVERNANCE AND FINANCIAL RATIO ABLE TO PREDICT FINANCIAL DISTRESS? STUDY ON PUBLIC COMPANIES IN ENERGY AND RAW MATERIALS SECTOR

 For investors and creditors, the sustainability of an entity's business is an important matter, so that information about financial distress becomes significant in determining investment decisions and loans. Measuring the effect of good corporate governance mechanisms and financial ratios on business sustainability is the aim of this study. The sample includes 174 data on energy and raw material sector companies listed on the Indonesia Stock Exchange for the 2017-2019 period which are accessed using the refinitive database and the Indonesian stock exchange. Using logistic regression, this study finds that those that have no effect on financial distress are independent commissioners, liquidity ratios, and leverage ratios, while those that have a negative effect on financial distress are managerial ownership, institutional ownership, and profitability ratios. This finding implies the significance of profitability as a predictor of financial distress and institutional ownership and management in determining business sustainability.Bagi investor dan kreditur, keberlangsungan usaha suatu entitas merupakan hal yang penting, sehingga informasi mengenai financial distress menjadi signifikan dalam menentukan keputusan investasi dan pinjaman. Mengukur pengaruh mekanisme tata kelola perusahaan yang baik dan rasio keuangan terhadap kelangsungan usaha adalah tujuan dari penelitian ini. Sampel meliputi 174 data perusahaan sektor energi dan bahan baku yang terdaftar di Bursa Efek Indonesia periode 2017-2019 yang diakses menggunakan database refinitive dan Bursa Efek Indonesia. Dengan menggunakan regresi logistik, penelitian ini menemukan bahwa yang tidak berpengaruh terhadap financial distress adalah komisaris independen, rasio likuiditas, dan rasio leverage, sedangkan yang berpengaruh negatif terhadap financial distress adalah kepemilikan manajerial, kepemilikan institusional, dan rasio profitabilitas. Temuan ini menyiratkan pentingnya profitabilitas sebagai prediktor kesulitan keuangan dan kepemilikan dan manajemen institusional dalam menentukan keberlanjutan bisnis

Investigating quorum-quenching marine bacilli as potential biocontrol agents for protection of shrimps against Early Mortality Syndrome (EMS)

Early Mortality Syndrome (EMS) has been a major problem for shrimp aquaculture in Southeast Asia due to its epizootic prevalence within the region since the first reported case in 2009. This study explores the application of halophilic marine bacilli isolated from coral mucus and their quorum-quenching abilities as potential biocontrol agents in aquaculture systems to combat the causative agent of EMS, Vibrio parahaemolyticus. N-acylhomoserine lactone (AHL)-degrading (AiiA) activity was first screened by PCR then confirmed by bio-reporter assay, and a combination of 16S rDNA sequence analysis and quantitative phenotype assays including biofilm-formation and temperature-growth responses were used to demonstrate diversity amongst these quorum-quenching isolates. Three phenotypically distinct strains showing notable potential were chosen to undergo co-cultivation as a method for strain improvement via long term exposure to the pathogenic V. parahaemolyticus. The novel approach taken led to significant improvements in antagonism and quorum quenching activities as compared to the ancestral wild-type strains and offers a potential solution as well as pathway to improve existing beneficial microbes for one of the most pressing issues in shrimp aquacultures worldwide

HUBUNGAN POLA ASUH DEMOKRATIS DENGAN KECERDASAN EMOSIONAL PADA ANGGOTA KELOMPOK SEL YOUTH HERMON DI GEREJA HERMON

Penelitian ini bertujuan untuk menguji secara empiris mengenai hubungan pola asuh demokratis dan kecerdasan emosional pada anggota kelompok sel Youth Hermon. Hipotesis pada penelitian ini terdapat hubungan positif antara pola asuh demokratis dengan kecerdasan emosional pada anggota kelompok sel Youth Hermon. Penelitian dilakukan di Kelompok Sel Youth Hermon dan didapatkan subyek sebanyak 50 orang. Untuk mengungkapkan kecerdasan emosional Anggota Kelompok Sel Youth Hermon menggunakan skala kecerdasan emosional pada anggota kelompok sel Youth Hermon dan pola asuh demokratis dengan skala pola asuh demokratis. Analisis data dilakukan dengan teknik korelasi Product Moment. Hasil penelitian menunjukkan nilai korelasi rxy= 0,733 (p<0,01) yang menunjukkan bahwa terdapat hubungan yang positif antara pola asuh demokratis dan kecerdasan emosional pada anggota kelompok sel Youth Hermon

Beyond Supervised Classification: Extreme Minimal Supervision with the Graph 1-Laplacian

We consider the task of classifying when an extremely reduced amount of labelled data is available. This problem is of a great interest, in several real-world problems, as obtaining large amounts of labelled data is expensive and time consuming. We present a novel semi-supervised framework for multi-class classification that is based on the normalised and non-smooth graph 1-Laplacian. Our transductive framework is framed under a novel functional with carefully selected class priors - that enforces a sufficiently smooth solution that strengthens the intrinsic relation between the labelled and unlabelled data. We demonstrate through extensive experimental results on large datasets CIFAR-10 and ChestX-ray14, that our method outperforms classic methods and readily competes with recent deep-learning approaches

Investigating quorum-quenching marine bacilli as potential biocontrol agents for protection of shrimps against Early Mortality Syndrome (EMS)

Early Mortality Syndrome (EMS) has been a major problem for shrimp aquaculture in Southeast Asia due to its epizootic prevalence within the region since the first reported case in 2009. This study explores the application of halophilic marine bacilli isolated from coral mucus and their quorum-quenching abilities as potential biocontrol agents in aquaculture systems to combat the causative agent of EMS, Vibrio parahaemolyticus. N-acylhomoserine lactone (AHL)-degrading (AiiA) activity was first screened by PCR then confirmed by bio-reporter assay, and a combination of 16S rDNA sequence analysis and quantitative phenotype assays including biofilm-formation and temperature-growth responses were used to demonstrate diversity amongst these quorum-quenching isolates. Three phenotypically distinct strains showing notable potential were chosen to undergo co-cultivation as a method for strain improvement via long term exposure to the pathogenic V. parahaemolyticus. The novel approach taken led to significant improvements in antagonism and quorum quenching activities as compared to the ancestral wild-type strains and offers a potential solution as well as pathway to improve existing beneficial microbes for one of the most pressing issues in shrimp aquacultures worldwide

The Wnt co-receptor PTK7/Otk and Its Homolog Otk-2 in neurogenesis and patterning

Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interactions with different receptors on the cell membrane. PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion. Here, we examine two roles of Otk-1 and Otk-2 in patterning and neurogenesis. We find that Otk-1 is a positive regulator of signaling and Otk-2 functions as its inhibitor. We propose that PTK7/Otk functions in signaling, cell migration, and polarity contributing to the diversity of cellular responses seen in Wnt-mediated processes

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts