151 research outputs found
Evidence of a new state in Be observed in the Li -decay
Coincidences between charged particles emitted in the -decay of
Li were observed using highly segmented detectors. The breakup channels
involving three particles were studied in full kinematics allowing for the
reconstruction of the excitation energy of the Be states participating
in the decay. In particular, the contribution of a previously unobserved state
at 16.3 MeV in Be has been identified selecting the +
He + He+n channel. The angular correlations between the
particle and the center of mass of the He+n system favors spin and
parity assignment of 3/2 for this state as well as for the previously known
state at 18 MeV.Comment: 13 pages, 6 figure
Study of beta-delayed 3-body and 5-body breakup channels observed in the decay of ^11Li
The beta-delayed charged particle emission from ^11Li has been studied with
emphasis on the three-body n+alpha+^6He and five-body 2alpha+3n channels from
the 10.59 and 18.15 MeV states in ^11Be. Monte Carlo simulations using an
R-matrix formalism lead to the conclusion that the ^AHe resonance states play a
significant role in the break-up of these states. The results exclude an
earlier assumption of a phase-space description of the break-up process of the
18.15 MeV state. Evidence for extra sequential decay paths is found for both
states.Comment: 16 pages, 9 figures. Submitted to Nuclear Physics
A patient-derived explant (PDE) model of hormone-dependent cancer
Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize patient-derived material; however, issues related to low take rate, long duration of establishment, and the associated costs constrain use of these models. This study demonstrates that ex vivo culture of freshly resected breast and prostate tumor specimens obtained from surgery, termed patient-derived explants (PDEs), provides a high-throughput and cost-effective model that retains the native tissue architecture, microenvironment, cell viability, and key oncogenic drivers. The PDE model provides a unique approach for direct evaluation of drug responses on an individual patient's tumor, which is amenable to analysis using contemporary genomic technologies. The ability to rapidly evaluate drug efficacy in patient-derived material has high potential to facilitate implementation of personalized medicine approaches.Margaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tille
Measurement of CP observables in B± â D(â)K± and B± â D(â)ϱ decays
Measurements of CP observables in B ± âD (â) K ± and B ± âD (â) Ï Â± decays are presented, where D (â) indicates a neutral D or D â meson that is an admixture of D (â)0 and DÂŻ (â)0 states. Decays of the D â meson to the DÏ 0 and DÎł final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± Ï â , K + K â and Ï + Ï â final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb â1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± âD â K ± and B ± âD â Ï Â± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± âDK ± and B ± âDÏ Â± decays is an update of previous LHCb measurements. The B ± âDK ± results are the most precise to date
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