477 research outputs found
Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old man with glycogenosis 1b
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Peri-Implant Bone Loss of External Hexagon and Morse Taper in Patients Wearing Immediately Loaded Overdentures
- Author
- Adriana da Fonte Porto Carreiro
- Albrektsson T
- Algraffee H
- Almeida EO
- Attard NJ
- Borges TF
- Castro DS
- Cehreli MC
- Dean AG
- Esposito M
- Geraets WG
- Goodacre CJ
- Gustavo Augusto Seabra Barbosa
- Hermann JS
- Koo KT
- Lang NP
- Laércio Almeida de Melo
- Machado LS
- Mangano C
- Mariana Barbosa Câmara de Souza
- Meijer HJA
- Nkenke E
- Oh TJ
- Peñarrocha-Diago MA
- Ponzoni D
- Roe P
- Schwarz F
- Smith DE
- Song DW
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
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- Anduaga XS
- Angerami A
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- Anh TV
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- Antonaki A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Zhemchugov A
- Zheng S
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- Zhuravlov V
- Zieminska D
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- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
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- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Khalek SA
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles F
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- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MS
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
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- Aloisio A
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- Gonzalez BA
- Alviggi MG
- Amako K
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
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- Zeitnitz C
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- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
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- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
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- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
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- Schroeder TV
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- Schultens MJ
- Schultes J
- Schultz-Coulon H-C
- Schulz H
- Schumacher M
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- Schune P
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- Schwartzman A
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- Schwemling P
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- Schwierz R
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- Searcy J
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- Sekhniaidze G
- Sekula SJ
- Selbach KE
- Seliverstov DM
- Sellden B
- Sellers G
- Seman M
- Semprini-Cesari N
- Serfon C
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- Serkin L
- Seuster R
- Severini H
- Sfyrla A
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- Shamim M
- Shan LY
- Shank JT
- Shao QTQ
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- Shatalov PB
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- Sherwood P
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- Shimojima M
- Shin T
- Shiyakova M
- Shmeleva A
- Shochet MJ
- Short D
- Shrestha S
- Shulga E
- Shupe MA
- Sicho P
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- Simonyan M
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- Sinev NB
- Sipica V
- Siragusa G
- Sircar A
- Sisakyan AN
- Sivoklokov SY
- Sjoelin J
- Sjursen TB
- Skinnari LA
- Skottowe HP
- Skovpen K
- Skubic P
- Slater NM
- Slavicek T
- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smit GVY
- Smith BC
- Smith D
- Smith KM
- Smizanska M
- Smolek K
- Snesarev AA
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- Snow SW
- Snyder S
- Sobie R
- Sodomka J
- Soffer A
- Soh DA
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- Solans CA
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- Soldatov EY
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- Solodkov AA
- Solovyev V
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- Stanitzki MM
- Stapnes S
- Starchenko EA
- Stark J
- Staroba P
- Starovoitov P
- Staszewski R
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- Steinbach P
- Steinberg P
- Stekl I
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- Stoicea G
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- Strachota P
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- Straessner A
- Strandberg J
- Strandberg S
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- Styles NA
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- Subramania HS
- Subramaniam R
- Succurro A
- Sugaya Y
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- Suk M
- Sulin VV
- Sultansoy S
- Sumida T
- Sun X
- Sundermann JE
- Suruliz K
- Susinno G
- Sutton MR
- Suzuki Y
- Suzuki Y
- Svatos M
- Swedish S
- Sykora I
- Sykora T
- Ta D
- Tackmann K
- Taffard A
- Tafirout R
- Taiblum N
- Takahashi Y
- Takai H
- Takashima R
- Takeda H
- Takeshita T
- Takubo Y
- Talby M
- Talyshev A
- Tamsett MC
- Tan KG
- Tanaka J
- Tanaka R
- Tanaka S
- Tanaka S
- Tanasijczuk AJ
- Tani K
- Tannoury N
- Tapprogge S
- Tardif D
- Tarem S
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- Temming KK
- Ten Kate H
- Teng PK
- Terada S
- Terashi K
- Terron J
- Testa M
- Teuscher RJ
- Therhaag JJ
- Theveneaux-Pelzer T
- Thoma S
- Thomas JP
- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
- Thomson E
- Thomson M
- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tic T
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tiouchichine E
- Tipton P
- Tisserant S
- Todorov T
- Todorova-Nova S
- Toggerson B
- Tojo J
- Tokar S
- Tokushuku K
- Tollefson K
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- Trischuk W
- Trocme B
- Troncon C
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- True P
- Trzebinski M
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- Tsarouchas C
- Tseng JC-L
- Tsiakiris M
- Tsiareshka P
- Tsionou D
- Tsipolitis G
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsung J-W
- Tsuno S
- Tsybychev D
- Tua A
- Tudorache A
- Tudorache V
- Tuggle JM
- Tuna AN
- Turala M
- Turecek D
- Turlay E
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Tzanakos G
- Uchida K
- Ueda I
- Ueno R
- Ugland M
- Uhlenbrock M
- Uhrmacher M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Unno Y
- Urbaniec D
- Urquijo P
- Usai G
- Uslenghi M
- Vacavant L
- Vacek V
- Vachon B
- Vague FV
- Vahsen S
- Valenta J
- Valentinetti S
- Valero A
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
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- Van der Deijl PC
- van der Geer R
- van der Graaf H
- van der Leeuw R
- van der Poe E
- van der Ster D
- van Eldik N
- van Gemmeren P
- van Huysduynen LH
- van Vulpen I
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- Vannucci F
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vassilakopoulos VI
- Vazeille F
- Vazquez JGP
- Vegni G
- Veillet JI
- Veloso F
- Veness R
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vest A
- Vetterli MC
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
- Virchaux M
- Virzi J
- Vitells O
- Viti M
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- Volpini G
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorwerk V
- Vos M
- Voss R
- Voss TT
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wahlen H
- Wahrmund S
- Wakabayashi J
- Walch S
- Walder J
- Walker R
- Walkowiak W
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- Waller P
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- Wang C
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- Wang J
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- Wang R
- Wang SM
- Wang T
- Warburton A
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- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watanabe I
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh AT
- Waugh BM
- Weber MS
- Webster JS
- Weidberg AR
- Weigell P
- Weingarten J
- Weiser C
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Wengler T
- Wengu Z
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Wetter J
- Weydert C
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- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocoq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
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- Abolins M
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- Wilson JA
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- Winkelmann S
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- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Evidence and morality in harm-reduction debates: can we use value-neutral arguments to achieve value-driven goals?
- Author
- A Eriksson
- A Hunt
- A Roxburgh
- A Roxburgh
- A Stevens
- A Stevens
- A Stevens
- A Stevens
- A Wodak
- ACMD
- AD Hathaway
- B Pauly
- C Deeming
- C Knill
- C Pedwell
- C Pollitt
- CH Weiss
- CZ Mooney
- D Beirness
- D Evans
- D Layder
- DP Haider-Markel
- G Esping-Andersen
- G Evans
- G Lakoff
- G Roe
- G Zampini
- GA Marlatt
- GF Zampini
- H Keane
- Home Office
- I Engeli
- J Boswell
- J Fischer
- J Germov
- J Graham
- J Haidt
- J Strang
- JJ Ray
- JR Tilley
- K Duke
- K Duke
- K Lancaster
- K Valentine
- KJ Meier
- M Archer
- M Dee
- M Monaghan
- M Monaghan
- M Naughton
- M Petticrew
- MC Nussbaum
- N Ezard
- N Hunt
- N Hunt
- N Skinner
- NP McKeganey
- P Taylor‐Gooby
- R Room
- RA Coutinho
- RA Sayer
- S Heichel
- S Lenton
- S MacGregor
- S MacGregor
- SC Flanagan
- TF Gieryn
- V Berridge
- W Haydock
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/06/2018
- Field of study
It is common to argue that politicians make selective use of evidence to tacitly reinforce their moral positions, but all stakeholders combine facts and values to produce and use research for policy. The drug policy debate has largely been framed in terms of an opposition between evidence and politics. Focusing on harm reduction provides useful ground to discuss a further opposition proposed by evidence advocates, that between evidence and morality. Can evidence sway individuals from their existing moral positions, so as to “neutralise” morality? And if not, then should evidence advocates change the way in which they frame their arguments? To address these questions, analysis of N=27 interviews with stakeholders involved in drug policy and harm reduction research, advocacy, lobbying, implementation and decision-making in England, UK and New South Wales, Australia, was conducted. Participants’ accounts suggest that although evidence can help focus discussions away from values and principles, exposure to evidence does not necessarily change deeply held views. Whether stakeholders decide to go with the evidence or not seems contingent on whether they embrace a view of evidence as secular faith; a view that is shaped by experience, politics, training, and role. And yet, morality, values, and emotions underpin all stakeholders’ views, motivating their commitment to drug policy and harm reduction. Evidence advocates might thus benefit from morally and emotionally engaging audiences. This paper aims to develop better tools for analysing the role of morality in decision-making, starting with moral foundations theory. Using tools from disciplines such as moral psychology is relevant to the study of the politics of evidence-based policymaking
Mitochondrial 2,4-dienoyl-CoA Reductase Deficiency in Mice Results in Severe Hypoglycemia with Stress Intolerance and Unimpaired Ketogenesis
- Author
- A Hirose
- AM Schuler
- Anne Huotari
- B Viollet
- C Handschin
- C Postic
- CR Roe
- DB Jump
- DM Kurtz
- DS Kelley
- E Challet
- EH Hakkola
- EH Hakkola
- EH Hakkola
- Emiel Ver Loren van Themaat
- Ernst Conzelmann
- H Herrema
- H Popper
- H Sampath
- H Sampath
- HJ Kim
- HM Helander
- IJ Miinalainen
- Ilkka J. Miinalainen
- J. Kalervo Hiltunen
- JK Hiltunen
- JM Torkko
- K Shoukry
- K Uyeda
- Kaija J. Autio
- Karl-Heinz Herzig
- KB Cox
- KT Koivuranta
- KW Wahle
- LR Nyman
- M Mizugaki
- MA Griggio
- MJ Luo
- MS Alphey
- Myriam Baes
- P Lefebvre
- P Rinaldo
- PA Wood
- Philip A. Wood
- R Dentin
- Raija Soininen
- RJ Tolwani
- RT Okita
- S Kersten
- S Lo
- TE Smeland
- TF Osborne
- U Janssen
- U Spiekerkoetter
- W Yu
- Werner Schmitz
- WH Kunau
- X Chu
- Y Ren
- Y Saegusa
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
The mitochondrial β-oxidation system is one of the central metabolic pathways of energy metabolism in mammals. Enzyme defects in this pathway cause fatty acid oxidation disorders. To elucidate the role of 2,4-dienoyl-CoA reductase (DECR) as an auxiliary enzyme in the mitochondrial β-oxidation of unsaturated fatty acids, we created a DECR–deficient mouse line. In Decr−/− mice, the mitochondrial β-oxidation of unsaturated fatty acids with double bonds is expected to halt at the level of trans-2, cis/trans-4-dienoyl-CoA intermediates. In line with this expectation, fasted Decr−/− mice displayed increased serum acylcarnitines, especially decadienoylcarnitine, a product of the incomplete oxidation of linoleic acid (C18:2), urinary excretion of unsaturated dicarboxylic acids, and hepatic steatosis, wherein unsaturated fatty acids accumulate in liver triacylglycerols. Metabolically challenged Decr−/− mice turned on ketogenesis, but unexpectedly developed hypoglycemia. Induced expression of peroxisomal β-oxidation and microsomal ω-oxidation enzymes reflect the increased lipid load, whereas reduced mRNA levels of PGC-1α and CREB, as well as enzymes in the gluconeogenetic pathway, can contribute to stress-induced hypoglycemia. Furthermore, the thermogenic response was perturbed, as demonstrated by intolerance to acute cold exposure. This study highlights the necessity of DECR and the breakdown of unsaturated fatty acids in the transition of intermediary metabolism from the fed to the fasted state
Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells
- Author
- A Hinman
- Alexander G. Obukhov
- B Colsoul
- B Nilius
- BF Bessac
- CA Leech
- CR Jan
- DA Andersson
- DA Jacobson
- De-Shou Cao
- DM Bautista
- DM Bautista
- DX Gram
- E Ceppa
- E Hisanaga
- F Li
- F Qian
- FM Ashcroft
- G Drews
- GM Story
- H Cheng
- H Katsura
- H Sakura
- H Wang
- J Pi
- JC Henquin
- K Nagata
- K Obata
- K Togashi
- K Uchida
- KY Kwan
- KY Kwan
- Lauren Hughes
- Linlin Zhong
- LJ Cook
- LJ Macpherson
- Louis S. Premkumar
- M Bandell
- M Barbasa
- M Brownlee
- M Brownlee
- M Ishii
- M Ishii
- M Komatsu
- M Nakazaki
- M Trevisani
- MA Ravier
- Mahendra Bishnoi
- MJ MacDonald
- Mruvil Abooj
- MS Islam
- MW Roe
- P Krippeit-Drews
- P Krippeit-Drews
- PC Kerstein
- R Razavi
- R Vennekens
- S Britsch
- S Casas
- S Numazawa
- SE Jordt
- SG Straub
- TF Wagner
- Tsung-han Hsieh
- Y Akiba
- Y Miura
- Y Sato
- Y Sawada
- Publication venue
- Public Library of Science
- Publication date
- 31/05/2012
- Field of study
<div><h3>Objective</h3><p>Several transient receptor potential (TRP) channels are expressed in pancreatic beta cells and have been proposed to be involved in insulin secretion. However, the endogenous ligands for these channels are far from clear. Here, we demonstrate the expression of the transient receptor potential ankyrin 1 (TRPA1) ion channel in the pancreatic beta cells and its role in insulin release. TRPA1 is an attractive candidate for inducing insulin release because it is calcium permeable and is activated by molecules that are produced during oxidative glycolysis.</p> <h3>Methods</h3><p>Immunohistochemistry, RT-PCR, and Western blot techniques were used to determine the expression of TRPA1 channel. Ca<sup>2+</sup> fluorescence imaging and electrophysiology (voltage- and current-clamp) techniques were used to study the channel properties. TRPA1-mediated insulin release was determined using ELISA.</p> <h3>Results</h3><p>TRPA1 is abundantly expressed in a rat pancreatic beta cell line and freshly isolated rat pancreatic beta cells, but not in pancreatic alpha cells. Activation of TRPA1 by allyl isothiocyanate (AITC), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), 4-hydroxynonenal (4-HNE), and cyclopentenone prostaglandins (PGJ<sub>2</sub>) and a novel agonist methylglyoxal (MG) induces membrane current, depolarization, and Ca<sup>2+</sup> influx leading to generation of action potentials in a pancreatic beta cell line and primary cultured pancreatic beta cells. Activation of TRPA1 by agonists stimulates insulin release in pancreatic beta cells that can be inhibited by TRPA1 antagonists such as HC030031 or AP-18 and by RNA interference. TRPA1-mediated insulin release is also observed in conditions of voltage-gated Na<sup>+</sup> and Ca<sup>2+</sup> channel blockade as well as ATP sensitive potassium (K<sub>ATP</sub>) channel activation.</p> <h3>Conclusions</h3><p>We propose that endogenous and exogenous ligands of TRPA1 cause Ca<sup>2+</sup> influx and induce basal insulin release and that TRPA1-mediated depolarization acts synergistically with K<sub>ATP</sub> channel blockade to facilitate insulin release.</p> </div
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