Comparison of hadronic rescattering calculations of elliptic flow and HBT with measurements from RHIC

Results from the data obtained in the first physics run of the Relativistic Heavy Ion Collider (RHIC) have shown suprisingly large elliptic flow and suprisingly small HBT radii. Attempts to explain both results in a consistant picture have so far been unsuccessful. The present work shows that a simple thermal-like initial state model coupled to a hadronic rescattering calculation can explain reasonably well both elliptic flow and HBT results from RHIC. The calculation suggests a very early hadronization time of about 1 fm/c after the initial collision of the nuclei.Comment: 6 pages, 6 figure

Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B

Item does not contain fulltextSince its introduction in the 1990s, liposomal amphotericin B (LAmB) continues to be an important agent for the treatment of invasive fungal diseases caused by a wide variety of yeasts and molds. This liposomal formulation was developed to improve the tolerability of intravenous amphotericin B, while optimizing its clinical efficacy. Since then, numerous clinical studies have been conducted, collecting a comprehensive body of evidence on its efficacy, safety, and tolerability in the preclinical and clinical setting. Nevertheless, insights into the pharmacokinetics and pharmacodynamics of LAmB continue to evolve and can be utilized to develop strategies that optimize efficacy while maintaining the compound's safety. In this article, we review the clinical pharmacokinetics, pharmacodynamics, safety, and efficacy of LAmB in a wide variety of patient populations and in different indications, and provide an assessment of areas with a need for further clinical research

Elliptic flow from color strings

It is shown that the elliptic flow can be successfully described in the color string picture with fusion and percolation provided anisotropy of particle emission from the fused string is taken into account. Two possible sources of this anisotropy are considered, propagation of the string in the transverse plane and quenching of produced particles in the strong color field of the string. Calculations show that the second source gives an overwhelming contribution to the flow at accessible energies.Comment: 23 pages, 11 figure

Intersection theory from duality and replica

Kontsevich's work on Airy matrix integrals has led to explicit results for the intersection numbers of the moduli space of curves. In this article we show that a duality between k-point functions on $N\times N$ matrices and N-point functions of $k\times k$ matrices, plus the replica method, familiar in the theory of disordered systems, allows one to recover Kontsevich's results on the intersection numbers, and to generalize them to other models. This provides an alternative and simple way to compute intersection numbers with one marked point, and leads also to some new results

Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration

Extensive experimental data from high-energy nucleus-nucleus collisions were recorded using the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). The comprehensive set of measurements from the first three years of RHIC operation includes charged particle multiplicities, transverse energy, yield ratios and spectra of identified hadrons in a wide range of transverse momenta (p_T), elliptic flow, two-particle correlations, non-statistical fluctuations, and suppression of particle production at high p_T. The results are examined with an emphasis on implications for the formation of a new state of dense matter. We find that the state of matter created at RHIC cannot be described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted to Nuclear Physics A as a regular article; v3 has minor changes in response to referee comments. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Decoherence and CPT Violation in a Stringy Model of Space-Time Foam

I discuss a model inspired from the string/brane framework, in which our Universe is represented as a three brane, propagating in a bulk space time punctured by D0-brane (D-particle) defects. As the D3-brane world moves in the bulk, the D-particles cross it, and from an effective observer on D3 the situation looks like a ``space-time foam'' with the defects ``flashing'' on and off (``D-particle foam''). The open strings, with their ends attached on the brane, which represent matter in this scenario, can interact with the D-particles on the D3-brane universe in a topologically non-trivial manner, involving splitting and capture of the strings by the D0-brane defects. Such processes are described by logarithmic conformal field theories on the world-sheet. Physically, they result in effective decoherence of the string matter on the D3 brane, and as a result, of CPT Violation, but of a type that implies an ill-defined nature of the effective CPT operator. Due to electric charge conservation, only electrically neutral (string) matter can exhibit such interactions with the D-particle foam. This may have unique, experimentally detectable, consequences for electrically-neutral entangled quantum matter states on the brane world, in particular the modification of the pertinent EPR Correlation of neutral mesons in a meson factory.Comment: 41 pages Latex, five eps figures incorporated. Uses special macro

Differential geometry construction of anomalies and topological invariants in various dimensions

In the model of extended non-Abelian tensor gauge fields we have found new metric-independent densities: the exact (2n+3)-forms and their secondary characteristics, the (2n+2)-forms as well as the exact 6n-forms and the corresponding secondary (6n-1)-forms. These forms are the analogs of the Pontryagin densities: the exact 2n-forms and Chern-Simons secondary characteristics, the (2n-1)-forms. The (2n+3)- and 6n-forms are gauge invariant densities, while the (2n+2)- and (6n-1)-forms transform non-trivially under gauge transformations, that we compare with the corresponding transformations of the Chern-Simons secondary characteristics. This construction allows to identify new potential gauge anomalies in various dimensions.Comment: 27 pages, references added, matches published versio

Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B

The improved safety profile and antifungal efficacy of liposomal amphotericin B (LAmB) compared to conventional amphotericin B deoxycholate (DAmB) is due to several factors including, its chemical composition, rigorous manufacturing standards, and ability to target and transit through the fungal cell wall. Numerous preclinical studies have shown that LAmB administered intravenously distributes to tissues frequently infected by fungi at levels above the minimum inhibitory concentration (MIC) for many fungi. These concentrations can be maintained from one day to a few weeks, depending upon the tissue. Tissue accumulation is dose-dependent with drug clearance occurring most rapidly from the brain and slowest from the liver and spleen. LAmB localizes in lung epithelial lining fluid, within liver and splenic macrophages and in kidney distal tubules. LAmB has been used successfully in therapeutic and prophylactic animal models to treat many different fungal pathogens, significantly increasin

Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B

Since its introduction in the 1990s, liposomal amphotericin B (LAmB) continues to be an important agent for the treatment of invasive fungal diseases caused by a wide variety of yeasts and molds. This liposomal formulation was developed to improve the tolerability of intravenous amphotericin B, while optimizing its clinical efficacy. Since then, numerous clinical studies have been conducted, collecting a comprehensive body of evidence on its efficacy, safety, and tolerability in the preclinical and clinical setting. Nevertheless, insights into the pharmacokinetics and pharmacodynamics of LAmB continue to evolve and can be utilized to develop strategies that optimize efficacy while maintaining the compound's safety. In this article, we review the clinical pharmacokinetics, pharmacodynamics, safety, and efficacy of LAmB in a wide variety of patient populations and in different indications, and provide an assessment of areas with a need for further clinical research

Comparison of the h-index for different fields of research using bootstrap methodology

An important disadvantage of the h-index is that typically it cannot take into account the specific field of research of a researcher. Usually sample point estimates of the average and median h-index values for the various fields are reported that are highly variable and dependent of the specific samples and it would be useful to provide confidence intervals of prediction accuracy. In this paper we apply the non-parametric bootstrap technique for constructing confidence intervals for the h-index for different fields of research. In this way no specific assumptions about the distribution of the empirical h-index are required as well as no large samples since that the methodology is based on resampling from the initial sample. The results of the analysis showed important differences between the various fields. The performance of the bootstrap intervals for the mean and median h-index for most fields seems to be rather satisfactory as revealed by the performed simulation