Molecular motion in cell membranes: analytic study of fence-hindered random walks

A theoretical calculation is presented to describe the confined motion of transmembrane molecules in cell membranes. The study is analytic, based on Master equations for the probability of the molecules moving as random walkers, and leads to explicit usable solutions including expressions for the molecular mean square displacement and effective diffusion constants. One outcome is a detailed understanding of the dependence of the time variation of the mean square displacement on the initial placement of the molecule within the confined region. How to use the calculations is illustrated by extracting (confinement) compartment sizes from experimentally reported published observations from single particle tracking experiments on the diffusion of gold-tagged G-protein coupled mu-opioid receptors in the normal rat kidney cell membrane, and by further comparing the analytical results to observations on the diffusion of phospholipids, also in normal rat kidney cells.Comment: 10 pages, 5 figure

Effects of disorder in location and size of fence barriers on molecular motion in cell membranes

The effect of disorder in the energetic heights and in the physical locations of fence barriers encountered by transmembrane molecules such as proteins and lipids in their motion in cell membranes is studied theoretically. The investigation takes as its starting point a recent analysis of a periodic system with constant distances between barriers and constant values of barrier heights, and employs effective medium theory to treat the disorder. The calculations make possible, in principle, the extraction of confinement parameters such as mean compartment sizes and mean intercompartmental transition rates from experimentally reported published observations. The analysis should be helpful both as an unusual application of effective medium theory and as an investigation of observed molecular movements in cell membranes.Comment: 9 pages, 5 figure

Tagging High Energy Photons in the H1 Detector at HERA

Measures taken to extend the acceptance of the H1 detector at HERA for photoproduction events are described. These will enable the measurement of electrons scattered in events in the high y range 0.85 < y < 0.95 in the 1998 and 1999 HERA run period. The improvement is achieved by the installation of an electromagnetic calorimeter, the ET8, in the HERA tunnel close to the electron beam line 8 m downstream of the H1 interaction point in the electron direction. The ET8 will allow the study of tagged gamma p interactions at centre-of-mass energies significantly higher than those previously attainable. The calorimeter design and expected performance are discussed, as are results obtained using a prototype placed as close as possible to the position of the ET8 during the 1996 and 1997 HERA running.Comment: 13 pages, 13 figure

A New High Energy Photon Tagger for the H1 - Detector at HERA

The H1 detector at HERA has been upgraded by the addition of a new electromagnetic calorimeter. This is installed in the HERA tunnel close to the electron beam line at a position 8m from the interaction point in the electron beam direction. The new calorimeter extends the acceptance for tagged photoproduction events to the high y range, 0.85 < y < 0.95, and thus significantly improves the capability of H1 to study high energy gamma-p processes. The calorimeter design, performance and first results obtained during the 1996-1999 HERA running are described.Comment: 17 pages, 16 figure

The changing pattern of domestic cannabis cultivation in the UK and its impact on the cannabis market

With improvements in both technology and information cannabis is being increasingly grown indoors for domestic use, rather than being imported. This study examines 50 cannabis farms detected by an English police force, and examines the characteristics of the 61 suspects associated with them. The study highlights a UK pattern in domestic cultivation, that is moving away from large scale commercial cultivation, at times co-ordinated by South East Asian organised crime groups, to increased cultivation within residential premises by British citizens. Offenders range from those who have no prior criminal history to those who are serious and persistent offenders. The ramifications for law enforcement agencies and policy formers are discussed

Soil methane sink capacity response to a long-term wildfire chronosequence in Northern Sweden

Boreal forests occupy nearly one fifth of the terrestrial land surface and are recognised as globally important regulators of carbon (C) cycling and greenhouse gas emissions. Carbon sequestration processes in these forests include assimilation of CO2 into biomass and subsequently into soil organic matter, and soil microbial oxidation of methane (CH4). In this study we explored how ecosystem retrogression, which drives vegetation change, regulates the important process of soil CH4 oxidation in boreal forests. We measured soil CH4 oxidation processes on a group of 30 forested islands in northern Sweden differing greatly in fire history, and collectively representing a retrogressive chronosequence, spanning 5000 years. Across these islands the build-up of soil organic matter was observed to increase with time since fire disturbance, with a significant correlation between greater humus depth and increased net soil CH4 oxidation rates. We suggest that this increase in net CH4 oxidation rates, in the absence of disturbance, results as deeper humus stores accumulate and provide niches for methanotrophs to thrive. By using this gradient we have discovered important regulatory controls on the stability of soil CH4 oxidation processes that could not have not been explored through shorter-term experiments. Our findings indicate that in the absence of human interventions such as fire suppression, and with increased wildfire frequency, the globally important boreal CH4 sink could be diminished

The Conformal Anomaly of M5-Branes

We show that the conformal anomaly for N M5-branes grows like $N^3$. The method we employ relates Coulomb branch interactions in six dimensions to interactions in four dimensions using supersymmetry. This leads to a relation between the six-dimensional conformal anomaly and the conformal anomaly of N=4 Yang-Mills. Along the way, we determine the structure of the four derivative interactions for the toroidally compactified (2,0) theory, while encountering interesting novelties in the structure of the six derivative interactions.Comment: 38 pages, LaTeX; references adde

The Discovery of a Large Lyman-alpha+HeII Nebula at z~1.67: A Candidate Low Metallicity Region?

We have discovered a ~45 kpc Lya nebula (or Lya ``blob'') at z~1.67 which exhibits strong, spatially-extended HeII emission and very weak CIV and CIII] emission. This is the first spatially-extended Lya+HeII emitter observed and the lowest redshift Lya blob yet found. Strong Lya and HeII-1640 emission in the absence of metal lines has been proposed as a unique observational signature of primordial galaxy formation (e.g., from gravitational cooling radiation or Population III star formation), but no convincing examples of spatially-extended Lya+HeII emitters have surfaced either in Lya-emitting galaxy surveys at high redshifts (z > 4) or in studies of Lya nebulae at lower redshifts. From comparisons with photoionization models, we find that the observed line ratios in this nebula are consistent with low metallicity gas (Z < 10^-2 - 10^-3 Z_sun), but that this conclusion depends on the unknown ionization parameter of the system. The large HeII equivalent width (~37+/-10A) and the large HeII/Lya ratio (0.12+/-0.04) suggest that the cloud is being illuminated by a hard ionizing continuum, either an AGN or very low metallicity stars, or perhaps powered by gravitational cooling radiation. Thus far there is no obvious sign of a powerful AGN in or near the system, so in order to power the nebula while remaining hidden from view even in the mid-infrared, the AGN would need to be heavily obscured. Despite the strong Lya+HeII emission, it is not yet clear what is the dominant power source for this nebula. The system therefore serves as an instructive example of how the complexities of true astrophysical sources will complicate matters when attempting to use a strong Lya+HeII signature as a unique tracer of primordial galaxy formation.Comment: Accepted for publication in ApJ; emulateapj format, 17 pages, 7 figures, 3 tables; updated coordinate

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry