18 research outputs found
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel L.
- Abela L.
- Abelb L.
- Abelc L.
- Abers M.S.
- Agra J.J.C.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O.M.
- Al-Mulla F.
- Alarcon M.G.
- Alavoine L.
- Albert M.L.
- Alcover A.
- Aldave J.C.
- Algera A.G.
- Alkan G.
- Allardet-Servent J.
- Allende L.M.
- Alsina L.
- Alvarez J.T.
- Alyanakian M.A.
- Amador-Borrero B.
- Amat K.K.A.
- Amoura Z.
- Anderson M.S.
- Andrejak C.
- Angoulvant F.
- AntolĂ A.
- Arias A.A.
- Arias A.A.
- Arquero M.F.
- Arranz M.J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S.E.
- Azot A.
- Bachelet D.
- Bajolle F.
- Baldolli A.
- Ballester M.
- Bansal N.
- Barrett K.S.
- Barrou B.
- Basmaci R.
- Bastard P.
- Bax D.
- Behillil S.
- Behillil S.
- Bellani G.
- Belot A.
- Belota A.
- Beluze M.
- Benkerrou D.
- Bettini L.R.
- Beudel M.
- Beurton A.
- Bhavsar K.
- Bielicki J.
- Bigio B.
- Bilbao A.
- Bilguvar K.
- Biondi A.
- Bizien L.
- Blanch G.R.
- Blanchard-Rohner G.
- Blanco I.
- BlandiniĂšres A.
- Blazquez-Gamero D.
- Bloomfield M.
- Bogaard H.J.
- Bogunovic D.
- Boisson B.
- Boisson-Dupuis S.
- Bole-Feysot C.
- Bolivar-Prados Mireia
- Bolze A.
- Bolze A.
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- Bonfanti P.
- Borie R.
- Bos Lieuwe D
- Bosticardo M.
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- Bouadma L.
- Boucherit S.
- Bouscambert M.
- Bousfiha A.A.
- Bousfiha A.A.
- Bousso P.
- Bouvattier C.
- Boyarchuk O.
- Bree G.
- Brodin P.
- Brodin P.
- Brouwer M.C.
- Bruhns P.
- Bruijning P.
- Bryceson Y.
- Bueno M.R.P.
- Bugiani M.
- Bulle E.
- Burbelo P.D.
- Burdet C.
- Bustamante C.D.
- Bustamante J.
- Bustamante J.
- Butte M.
- BĂ©ziat V.
- Calimli S.
- Capra R.
- Caralp M.
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- Casanova J.L.
- Casanovaa J.L.
- Casari G.
- Casasnovas C.
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- Castagnoli R.
- Castelle M.
- Castelli F.
- Castro M.V.
- Catherinot E.
- Catherinot E.
- Caumes E.
- Cazzaniga M.
- Cervantes-Gonzalez M.
- Chair A.
- Chakravorty S.
- Chalumeau M.
- Charbit B.
- Charpentier C.
- Chauvin S.D.
- Chbihi M.
- Chen J.
- Cheng M.P.
- Chouchane O.
- Chrabieh M.
- Christodoulou J.
- Ciceri F.
- Cirulli E.
- Citerio G.
- Clavé P.
- Cloherty A.
- Clotet B.
- Cobat A.
- Codina A.
- Coelho A.
- Cohen J.I.
- Coignard B.
- Colkesen F.
- ColobrĂĄn Oriol Roger
- Comarmond C.
- Condino-Neto A.
- Contro E.
- Cooper M.A.
- Corsico A.G.
- Costa Y.
- Couffignal C.
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- Cumano A.
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- da Silveira C.
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- Elbers P.
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- Enninga J.
- Enouf V.
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- Gorochov G.
- Gregersen P.K.
- Grobusch M.P.
- Gu J.
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- Guerder A.
- Gul Y.
- Guner S.N.
- Gut M.
- Hadjadj J.
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- Haerynck F.
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- Hagin D.
- HaljasmÀgi L.
- Halwani R.
- Halwani R.
- Hamann J.
- Hammarström L.
- Hammarström Q.P.
- Harris V.
- Hasan M.
- Hatipoglu N.
- Heath J.
- Hemke R.
- Henrickson S.E.
- Hercberg S.
- Hermans S.M.
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- Hoffmann H.H.
- Hoffmann I.
- Holanda-Peña M.S.
- Holland S.M.
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- Humbert L.
- Husebye E.S.
- Iglesias A.D.
- Ilic-Habensus E.
- Ilovich A.S.
- Imai K.
- Imberti L.
- Itan Y.
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- Jamme M.
- Joost Wiersinga W.
- Jordan I.
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- Kafif O.
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- Kali S.
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- Kashyap A.
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- Koning R.
- Koroleva G.
- KrĂłl Z.J.
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- Kwan Y.W.M.
- Lagier J.C.
- Lampasona V.
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- Laribi S.
- Lau Y.L.
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- Le Bourgeois F.
- Le Hingrat Q.
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- Le Pen J.
- Le Voyer T.
- Le M.
- Lebeaux D.
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- Li Z.
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- Liu D.
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- Louapre C.
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- Lucas C.L.
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- LĂ©vy R.
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- Mansouri D.
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- Masson C.
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- Uddin F.
- Uddin M.J.
- Ungeheuer M.N.
- Universitat AutĂČnoma de Barcelona
- Ursini M.V.
- Ursini M.V.
- Uzunhan Y.
- Vabres P.
- Valencia-Ramos J.
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- Vatansev H.
- Vazquez S.E.
- Veelo D.
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- Vignali V.
- Vilain C.
- Vilaire M.E.
- Vincent A.
- Vinh D.C.
- Vinh D.C.
- Visseaux B.
- Visseaux B.
- Vlaar A.P.J.
- Vladikine N.
- Vogt G.
- Voiriot G.
- von Bernuth H.
- Vuotto F.
- VĂ©lez-Santamaria V.
- Wang Q.
- Washington N.
- Wiedemann A.
- Woollett M.
- Wouters D.
- Yang R.
- Yasar K.K.
- Yazdanpanah Y.
- Yazdanpanah Y.
- Yosunkaya A.
- Young B.E.
- Yucel F.
- Zannad F.
- Zarhrate M.
- Zatz M.
- Zawadzki P.
- Zhang P.
- Zhang Q.
- Zhang S.Y.
- Zhang Y.
- Zwinderman A.H.
- Ăñigo-Campos A.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-muhsen Saleh
- Al-mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis M.
- Altamirano Luz Torres
- Anderson Mark S.
- Anderson Mark S.
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés A.
- Arroyo-sĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine M.
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed A.
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos D.
- Butte Manish J.
- Calfee Carolyn S.
- Carrillo Sidney A.
- Casanova Jean-laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Comet Consortium
- Condino-neto Antonio
- Constantinescu Stefan N.
- Conti Francesca
- Cooper Megan A.
- Cordel Hugues
- Couffignal Camille
- Couffin-cadiergues Sandrine
- Covid Hge Consortium
- Dalgard Clifton L.
- Danielson Jeffrey
- De Diego Rebeca Perez
- De Montmollin Etienne
- Debard Alexa
- Debray Marie-pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph L.
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth A.
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David J.
- Esperou HĂ©lĂšne
- Espinosa-padilla Sara
- Esposito-farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela K.
- Franco José Luis
- French Covid Study Group
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter K.
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James R.
- Hendrickson Carolyn M.
- Henrickson Sarah E.
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena W.y.
- Hulot Jean-sébastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich D.
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten N.
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew F.
- Ku Cheng-lung
- Laine Fabrice
- Langelier Charles R.
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-lung
- Laurie Matthew T.
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie L.
- Lucet Jean Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua D.
- Mironska Kristina
- Mitchell Anthea M.
- Mogensen Trine H.
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa F. P.
- Ng Lisa F.p.
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-hammarström Qiang
- Pan-hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean W.
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline Caraux
- Peiffer-smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David S.
- Pesole Graziano
- Pession Andrea
- Petrov-sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna M.
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis Felipe
- Rigo-bonnin RaĂșl
- Rocamora-blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-gallego Carlos
- RodrĂguez-gallego Carlos
- Rosa-calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko R.j.
- Shahrooei Mohammed
- Sharif-askari Narjes Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew L.
- Solanich Xavier
- Soler-palacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs N.
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-lambiotte Yacine
- Tang Kevin
- Tangye Stuart G.
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-capucine
- Terrier Olivier
- Thompson Leslie M.
- Timsit Jean-françois
- Trouillet-assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart E.
- Téoulé François
- Uddin K M Furkan
- Uddin Mohammed
- Van Der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald C.
- Visseaux Benoit
- Volokha Alla
- Wang Chung Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael
- Wilson Michael R
- Woodruff Prescott G.
- Yazdanpanah Yazdan
- Ye Chun Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-ying
- Zhang Yu
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 13/04/2023
- Field of study
Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
Plant regeneration from proroplasts of alfalfa (Medicago sativa) via somatic embryogenesis Regeneração de plantas a partir de protoplastos de alfafa (Medicago sativa) via embriogĂȘnese somĂĄtica
- Author
- ARAGĂO F.J.L.
- ATANASSOV A.
- Beatriz Appezzato-da-GlĂłria
- BINGHAM E.T.
- Carlos Alberto de Oliveira
- CHEN T.H.H.
- COELHO Jr. W.
- D'HALLUIN K.
- DICE L.R.
- Dornelas M.C.
- DORNELAS M.C.
- DU S.
- FERNANDO J.A.
- FREARSON E.M.
- GAMBORG O.L.
- GESTEIRA A.S.
- GILMOUR D.M.
- GROSSER J.W.
- HADDAD C.M.
- KAO K.N.
- KAO K.N.
- KARNOVSKY M.J.
- Maria José Valarini
- Maria Lucia Carneiro Vieira
- Mariza Monteiro
- McKERSEI B. D.
- MENDIS M.H.
- MONTEIRO M.
- MURASHIGE T.
- MYERS J.R.
- NENZ E.
- PARROT W.A.
- PICCIONI E.
- POTRYKUS I.
- PUPILLI F.
- QUECINI V.M.
- QUECINI V.M.
- SAKAI W.S.
- SCHROEDER H.E.
- SHENK B.U.
- TĂOULĂ E.
- UCHIMIYA H.
- VIEIRA M.L.C.
- WALKER K.A.
- Publication venue
- Universidade de SĂŁo Paulo
- Publication date
- 01/12/2003
- Field of study
Alfalfa is one of the most frequently studied species from the production of tissue culture-derived embryos point of view. In this study, five alfalfa cultivars were analyzed with reference to their ability to regenerate plants from protoplast cultures via somatic embryogenesis. Plant regeneration from leaf-derived protoplasts isolated from the cultivar Rangelander was achieved using a protocol defined for alfalfa cell suspension-derived embryogenesis. Because of its high efficiency, this procedure is recommended for protoplast electroporation-mediated genetic transformation of alfalfa.<br>A alfafa Ă© uma das espĂ©cies mais freqĂŒentemente estudadas do ponto de vista da produção de embriĂ”es somĂĄticos derivados da cultura de tecidos. Neste trabalho, cinco cultivares de alfafa foram analisados com referĂȘncia Ă capacidade de regenerar plantas a partir de culturas de protoplastos via embriogĂȘnese somĂĄtica. Regeneração de plantas a partir de protoplastos isolados de folhas da cultivar Rangelander foi obtida usando-se um protocolo definido para embriogĂȘnese somĂĄtica derivada de suspensĂ”es celulares de alfafa. Em função da sua alta eficiĂȘncia, recomenda-se o uso deste procedimento para transformação genĂ©tica de alfafa mediada por eletroporação de protoplastos
Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease
- Author
- Agop-Nersesian
- Altan-Bonnet
- Audhya
- Audhya
- Avitzur
- Baird
- Balla
- Balla
- Balla
- BaumlovĂĄ
- Blumental-Perry
- Bojjireddy
- Boura
- Brill
- Brown
- Burke
- Chung
- de Graaf
- Dorobantu
- Flanagan
- Gehrmann
- Gillian L. Dornan
- Godi
- Greninger
- Greninger
- Greninger
- Harak
- Hausser
- Hausser
- Hendricks
- Hsu
- Ishikawa-Sasaki
- Jacob A. McPhail
- John E. Burke
- Klima
- Lamarche
- Lim
- McNamara
- Moravcevic
- Nakagawa
- Nakagawa
- Nakatsu
- Pagnamenta
- Polevoy
- Reiss
- Rodgers
- Sasaki
- Spickler
- Sridhar
- Strahl
- Strahl
- Tai
- Tan
- Téoulé
- TĂłth
- Vadas
- Vaillancourt
- Vaillancourt
- van der Schaar
- Wu
- Yoshida
- Zhao
- Zhou
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Somaclonal Variation in Alfalfa (Medicago sativa L.)
- Author
- A Atanassov
- A Dâhont
- AO Latunde-Dada
- AO Latunde-Dada
- AV Mezentsev
- AVP Santos dos
- AVP Santos dos
- B Reisch
- B Reisch
- B Reisch
- B Reisch
- CL Hartman
- CL Hartman
- CR Edwards
- CR Gunn
- CW Birky Jr
- CY Kramer
- DA Baertlein
- DA Evans
- DA Stuart
- DA Stuart
- DA Stuart
- DA Stuart
- DA Stuart
- DA Stuart
- DCW Brown
- DH Mitten
- DK Barnes
- DM Gilmour
- DY Lu
- DY Lu
- E Lupotto
- E Lupotto
- E Téoulé
- E Téoulé
- EA Shahin
- EGM Meijer
- EGM Meijer
- EGM Meijer
- EGM Meijer
- ET Bingham
- ET Bingham
- ET Bingham
- ET Bingham
- ET Bingham
- F DâAmato
- F Feher
- F Schiavo Lo
- FC Elliott
- FJ NovĂĄk
- G Donn
- G Giuliano
- G Maheswaran
- GC Phillips
- GJ Keyes
- GL Lees
- GR Bauchan
- H Kudo
- J Schaefer
- JD Hamill
- JH Elgin Jr
- JH Graham
- JW Krause
- JW Saunders
- JW Saunders
- JW Wang
- K Redenbaugh
- K Redenbaugh
- K Sukhapinda
- KA Lesins
- KA Walker
- KA Walker
- KA Walker
- KH Beach
- KN Kao
- KN Kao
- KN Kao
- L SpanĂČ
- LA Mroginski
- LB Johnson
- LB Johnson
- LB Johnson
- M Barbier
- M Chabaud
- M Deak
- M Dijak
- M Dijak
- M Dijak
- M Pezzotti
- MH TĂĄrczy
- MHK Seitz
- MK Smith
- ML Skotnicki
- MM Oelck
- N Zagorska
- P BinarovĂĄ
- P Maliga
- P Nagarajan
- P Nagarajan
- PD Walton
- PH Schreier
- PJ Larkin
- R Michaud
- RH Edwards
- RJ Rose
- RK Sree
- RW Groose
- RW Groose
- RW Groose
- S Arcioni
- S Arcioni
- S Arcioni
- S Bianchi
- S Xu
- SA Masoud
- SE Schlarbaum
- SE Smith
- SG Strickland
- SJ Stavarek
- SJ Stavarek
- T McCoy
- TA Skokut
- THH Chen
- THH Chen
- THH Chen
- TJ McCoy
- TJ McCoy
- TJ McCoy
- TJ McCoy
- TJ McCoy
- TJ Reich
- TP Croughan
- TP CroĆłghan
- TW Pfeiffer
- US Department of Agriculture â USDA
- WG Willis
- Y Wan
- Z-H Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1990
- Field of study
Aneusomaty in vivo
- Author
- Babiychuk E.
- Bao P.H.
- Barklay I.R.
- Bennici A.
- Bennici A.
- Bennici A.
- Bodanese-Zanettini M.H.
- Britton D.M.
- Caffaro L.
- Carlson P.S.
- Cavallini A.
- Cavallini A.
- Cavallini A.
- Cavallini A.
- Chulow S.A.
- Chupeau Y.
- Collins G.B.
- Cremonini R.
- Cremonini R.
- Dud Its D.
- Dudits D.
- Duncan R.E.
- Finch R.A.
- Gleba Y.Y.
- Gleba Y.Y.
- Gleba Y.Y.
- Greilhuber J.
- Hegwood M.P.
- Heinz D.J.
- Hidaka T.
- Ho K.M.
- Hoffmann F.
- Hu H.
- Humphreys M.W.
- Jacobsen E.
- Kato Y.
- Krumbiegel G.
- Krumbiegel G.
- Lange W.
- Laurie D.A.
- Lewis W.H.
- Liu M.C.
- Love R.M.
- Lupi M.C.
- Maliga P.
- Melchers G.
- Mix G.
- Natali L.
- NovĂĄk F.J.
- Nuti Ronchi V.
- Ogura H.
- Ogura H.
- Ono H.
- Pickering R.A.
- Pijinacker L.P.
- Pijinacker L.P.
- Putie K.J.
- Ramanna M.S.
- Saalbach G.
- Sachs L.
- Sacristan M.D.
- Schieder O.
- Singh B.D.
- Smith H.H.
- Snoad B.
- Sokolov W.N.N.
- Speckmann G.J.
- Subrahmanyam N.C.
- Thomas K.M.
- Téoulé E.
- Vaarama A.
- Watanabe Y.
- Yurkova G
- Zagorska N.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel Laurent
- Abela L.
- Abelb L.
- Abelc L.
- Abers M. S.
- Agra J. J. C.
- Aguilera-Albesa Sergio
- Aiuti A.
- Akcan O. M.
- Al-Mulla F.
- Alarcon M. G.
- Alavoine L.
- Albert Matthew L
- Alcover A.
- Aldave J. C.
- Algera A. G.
- Alkan G.
- Allardet-Servent J.
- Allende L. M.
- Alsina L.
- Alyanakian M. A.
- Amador-Borrero B.
- Amat K. K. A.
- Amoura Z.
- Anderson M. S.
- Andrejak C.
- Angoulvant F.
- AntolĂ Arnau
- Arias A. A.
- Arias A. A.
- Arquero M. F.
- Arranz M. J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S. E.
- Azot A.
- Bachelet Delphine
- Bajolle F.
- Baldolli A.
- Ballester Devis Maria
- Bansal N.
- Barrett K. S.
- Barrou B.
- Basmaci R.
- Bastard Paul
- Bax D.
- Behillil S.
- Behillil S.
- Bellani G.
- Belot Alexandre
- Belota A.
- Beluze M.
- Benkerrou D.
- Bettini L. R.
- Beudel M.
- Beurton A.
- Bhavsar K.
- Bielicki J.
- Bigio B.
- Bilbao A.
- Bilguvar K.
- Biondi A.
- Bizien L.
- Blanch G. R.
- Blanchard-Rohner G.
- Blanco Guillermo Ignacio
- BlandiniĂšres A.
- Bloomfield M.
- BlĂĄzquez-Gamero Daniel
- Bogaard H. J.
- Bogunovic Dusan
- Boisson Bertrand
- Boisson-Dupuis S.
- Bole-Feysot C.
- Bolivar-Prados Mireia
- Bolze A.
- Bolze A.
- Bomers M.
- Bompart F.
- Bondarenko A.
- Bonfanti Paolo
- Borie R.
- Bos Lieuwe D..
- Bosticardo M.
- Botta Michela
- Bouadma L.
- Boucherit S.
- Bouscambert M.
- Bousfiha A. A.
- Bousfiha A. A.
- Bousso P.
- Bouvattier C.
- Boyarchuk O.
- Bree G.
- Brodin P.
- Brodin P.
- Brouwer M. C.
- Bruhns P.
- Bruijning P.
- Bryceson Y.
- Bueno M. R. P.
- Bugiani Marianna
- Bulle E.
- Burbelo P. D.
- Burdet C.
- Bustamante C. D.
- Bustamante J.
- Bustamante J.
- Butte M.
- BĂ©ziat V.
- Calimli S.
- Capra R.
- Caralp M.
- Carrabba M.
- Casanova Jean-Laurent
- Casanovaa J. L.
- Casari G.
- Casasnovas Carlos
- Caseris M.
- Castagnoli R.
- Castelle M.
- Castelli F.
- Castro M. V.
- Catherinot E.
- Catherinot E.
- Caumes E.
- Cazzaniga M.
- Cervantes-Gonzalez M.
- Chair A.
- Chakravorty S.
- Chalumeau M.
- Charbit B.
- Charpentier C.
- Chauvin S. D.
- Chbihi M.
- Chen J.
- Cheng M. P.
- Chouchane O.
- Chrabieh M.
- Christodoulou J.
- Ciceri F.
- Cirulli E.
- Citerio Giuseppe
- Clavé P.
- Cloherty A.
- Clotet B.
- Cobat A.
- Codina A.
- Coelho A.
- Cohen J. I.
- Coignard B.
- ColobrĂĄn Oriol Roger
- Comarmond C.
- Condino-Neto Antonio
- Contro E.
- Cooper M. A.
- Corsico A. G.
- Costa Y.
- Couffignal C.
- Couffin-Cadiergues S.
- Couffin-Cadiergues S.
- Cuadros E. N.
- Cumano A.
- D'ortenzio E.
- da Silveira C.
- Dalgard C. L.
- Dalgard C. L.
- Dalmau D.
- Dalmau D.
- Damond F.
- Darazam I. A.
- Darley D. R.
- Dauby N.
- Dauger S.
- de Brabander J.
- de Bruin S.
- de Diego R. P.
- de Diego R. P.
- de Jesus A. A.
- de Jong M. D.
- de Pontual L.
- de Vera M. C.
- de Vries H.
- Debray M. P.
- Dechanet A.
- Dehban A.
- del Prado M. Y. R.
- Delmas C.
- Delmonte O. M.
- Delplancq G.
- Demangel C.
- Demirkol Y. K.
- Demoule A.
- Deplanque D.
- Deriano L.
- DeRisi J. L.
- Desai M.
- Descamps D.
- Descamps D.
- Desvallées M.
- Di Sabatino A.
- Diallo A.
- Diehl J. L.
- Ding L.
- Diouf A.
- Dobbelaere S.
- Dobbs K.
- Dorgham Karim
- Dorival C.
- Drolet B. A.
- Dromer F.
- Dubos F.
- Duffy D.
- Duffy D.
- Durand Sophie
- Duval X.
- Duval X.
- Duval X.
- DĂngio M.
- Eberl G.
- Ecobichon J. L.
- Elbers P.
- Eldars W.
- Elgamal M.
- Elnagdy M. H.
- Eloy P.
- Emiroglu M.
- Enninga J.
- Enouf V.
- Enouf V. V. E.
- Erdeniz E. H.
- Espinosa S.
- Esposito-Farese M.
- Espérou H.
- Espérou H.
- Etienne M.
- Ettalhaoui N.
- Euvrard R.
- Evcen R.
- Fabio G.
- Faivre L.
- Falck A.
- Fartoukh M.
- Faure M.
- Feldman H. B.
- Feldman H. B.
- Fellay Jacques
- Fellay Jacques
- Fleuren L.
- Flores Carlos
- Flores Carlos
- Foti Giuseppe
- Franco J. L.
- Francois B.
- Frezouls W.
- FumadĂł Victoria
- Fusco F.
- Fusco F.
- Gault N.
- Gaussem P.
- Gaymard A.
- Geerlings S.
- Geerts B.
- Geijtenbeek T.
- Ghosn J.
- Ghosn J.
- Gigante T.
- Gil-Herrera J.
- Gilardin L.
- Girbes A.
- Girona-AlarcĂłn M.
- Goffard J. C.
- Gok F.
- Goldbach-Mansky R.
- Gomperts-Boneca I.
- Gonzalo Ocejo-Vinyals J.
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis B.
- Gorenne I.
- Gorochov G.
- Gregersen P. K.
- Grobusch M. P.
- Gu J.
- Guedj J.
- Guerder A.
- Gul Y.
- Guner S. N.
- Gut Marta
- Hadjadj J.
- Hadjadj J.
- Haerynck F.
- Haerynck F.
- Haerynck F.
- Hafkamp F.
- Hagens L.
- Hagin D.
- HaljasmÀgi L.
- Halwani R.
- Halwani R.
- Hamann J.
- Hammarström L.
- Hammarström Q. P.
- Harris V.
- Hasan M.
- Hatipoglu N.
- Heath J.
- Hemke R.
- Henrickson S. E.
- Hercberg S.
- Hermans S. M.
- Hernandez-Brito E.
- Heunks L.
- Hoctin A.
- Hoffmann H. H.
- Hoffmann I.
- Holanda-Peña M. S.
- Holland S. M.
- Hollmann M. W.
- Horcajada J. P.
- Horn J.
- Houhou N.
- Hovius J. W.
- Hraiech S.
- Hsieh E.
- Humbert L.
- Husebye E. S.
- Iglesias A. D.
- Ilic-Habensus E.
- Ilovich A. S.
- Imai K.
- Imberti L.
- Itan Y.
- Iuti F.
- Jaafoura S.
- Jamme M.
- Joost Wiersinga W.
- Jordan I.
- Jouanguy E.
- Kafif O.
- Kafif O.
- Kaguelidou F.
- Kali S.
- Kallaste A.
- Kanat F.
- Kapakli H.
- Kara I.
- Karamitros T.
- Karbuz A.
- Kashyap A.
- Keles S.
- Kerner G.
- Khalil A.
- Khan C.
- Kikoine J.
- Kisand K.
- Kisanda K.
- Klocperk A.
- Kochetkov T.
- Koning R.
- Koroleva G.
- KrĂłl Z. J.
- Ku C. L.
- Kuentz P.
- Kwan Y. W. M.
- Lagier J. C.
- Lampasona V.
- Lantz O.
- Laouénan C.
- Laribi S.
- Lau Y. L.
- Lau Y. L.
- Le Bourgeois F.
- Le Hingrat Q.
- Le Hingrat Q.
- Le Mestre S.
- Le Nagard H.
- Le Pen J.
- Le Voyer T.
- Le M.
- Lebeaux D.
- Leclercq A.
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- Toubiana J.
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- Treoux T.
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- Turvey S.
- Téoulé F.
- Uddin F.
- Uddin M. J.
- Ungeheuer M. N.
- Universitat AutĂČnoma de Barcelona
- Ursini M. V.
- Ursini M. V.
- Uzunhan Y.
- Vabres P.
- Valencia-Ramos J.
- Valsecchi M. G.
- van Agtmael M.
- van Baarle F.
- van de Beek D.
- van de Beek D.
- van de Beek D.
- van Den Rym A. M.
- van der Poll T.
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- Vandernoot I.
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- Voiriot Guillaume
- von Bernuth H.
- Vuotto F.
- VĂ©lez-Santamaria V.
- Wang Q.
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- Wiedemann A.
- Woollett M.
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- Yucel F.
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- Ăölkesen F.
- Ăñigo-Campos A.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
International audienceInterindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-Ï (IFN-Ï) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-Jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis, M
- Altamirano Luz, Torres
- Anderson Mark, S
- Anderson Mark, S
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés, A
- Arroyo-SĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine, M
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed, A
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos, D
- Butte Manish, J
- Calfee Carolyn, S
- Carrillo Sidney, A
- Casanova Jean-Laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Condino-Neto Antonio
- Constantinescu Stefan, N
- Conti Francesca
- Cooper Megan, A
- Cordel Hugues
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Dalgard Clifton, L
- Danielson Jeffrey
- de Diego Rebeca, Perez
- de Montmollin Etienne
- Debard Alexa
- Debray Marie-Pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph, L
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-Luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth, A
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David, J
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit, Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela, K
- Franco José, Luis
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter, K
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James, R
- Hendrickson Carolyn, M
- Henrickson Sarah, E
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena, W Y
- Hulot Jean-SĂ©bastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich, D
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten, N
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew, F
- Ku Cheng-Lung
- Laine Fabrice
- Langelier Charles, R
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-Lung
- Laurie Matthew, T
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-Xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie, L
- Lucet Jean, Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-Picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua, D
- Mironska Kristina
- Mitchell Anthea, M
- Mogensen Trine, H
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa, F P
- Ng Lisa, F P
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi, D
- Notarangelo Luigi, D
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'Farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean, W
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline, Caraux
- Peiffer-Smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David, S
- Pesole Graziano
- Pession Andrea
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna, M
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-Murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun, Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis, Felipe
- Rigo-Bonnin RaĂșl
- Rocamora-Blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-Gallego Carlos
- RodrĂguez-Gallego Carlos
- Rosa-Calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-Shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko, R J
- Shahrooei Mohammed
- Sharif-Askari Narjes, Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew, L
- Solanich Xavier
- Soler-PalacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs, N
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tang Kevin
- Tangye Stuart, G
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-Capucine
- Terrier Olivier
- Thompson Leslie, M
- Timsit Jean-François
- Trouillet-Assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart, E
- Téoulé François
- Uddin K, M Furkan
- Uddin Mohammed
- van der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald, C
- Visseaux Benoit
- Volokha Alla
- Wang Chung, Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael, R
- Wilson Michael, R
- Woodruff Prescott, G
- Yazdanpanah Yazdan
- Ye Chun, Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Publication venue
- American Association for the Advancement of Science (AAAS)
- Publication date
- 14/06/2022
- Field of study
International audienceLife-threatening âbreakthroughâ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-Ï, while two neutralized IFN-Ï only. No patient neutralized IFN-ÎČ. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study
- Author
- Ada Ebo
- Adam Ali
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- AgnĂšs Meybeck
- AgnĂšs Sommet
- Aidan Burrell
- Alamin Mustafa
- Albert Sotto
- Aldric Manuel
- Alexa Debard
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amiel A Dror
- Ana da SilvaFilipe
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Tveita
- Andrea Angheben
- Andrea Cortegiani
- Andrea Rossanese
- Andreas Lind
- Andrew Dagens
- André Cabie
- Andy Law
- Anissa Chair
- Ankana Satya
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne-HĂ©lĂšne Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annemarie B Docherty
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonia Ricchiuto
- Antonio Lalueza
- Ariel Bolanga
- Arnaud Scherpereel
- Arne SĂžraas
- ArsĂšne Kpangon
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Barbara Wanjiru Citarella
- Bato Hammarström
- Battaglini Denise
- Beatrice Alex
- Benjamin Bach
- Benjamin LefĂšvre
- Benjamine Sarton
- Benoit Visseaux
- BenoĂźt Roze
- BenoĂźt Thill
- Berline Fotso
- Bernard Cholley
- Bertrand Dussol
- Birgitte Stiksrud
- Blandine Rammaert
- Bouchra Loufti
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Cammandji Damien
- Carine Roy
- Caroline Mudara
- Carrol Gamble
- Catherine A Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Cecile Azoulay
- Cedric Djadda
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Charpentier
- Charlotte Summers
- Chiara Piubelli
- Cho Sung-Min
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Claire Andrejak
- Claire Levy-Marchal
- Clare Jackson
- Clark D Russell
- Claudine Badr
- Clotilde Allavena
- Clément Bihan
- Colin McArthur
- Coralie Tardivon
- Cristina De Rose
- Cyril Bris
- Cyril Cadoz
- CĂ©cile Goujard
- CĂ©cile Mear-Passard
- CĂ©cile Tromeur
- CĂ©cile Yelnik
- CĂ©dric Joseph
- Cédric Laouénan
- CĂ©line Dorival
- CĂ©line Ficko
- CĂ©line Michelanglei
- Damien Bouhour
- Daniel Glikman
- Daniel Perez
- Danielle Jaafar
- Danilo Buonsenso
- Dario Sinatti
- David L Robertson
- David Stuart
- David Zucma
- Debby Bogaert
- Deepjyoti Kalita
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Denis Garot
- Denis Malvy
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Denise Battaglini
- Diana Hernandez
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Dominique Deplanque
- Dominique Luton
- Donald Buri
- Drashti Patel
- Duc Nguyen
- Eder Caceres
- Edouard Soum
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Emma C Thomson
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric Delaveuve
- Eric DâOrtenzio
- Eric Oziol
- Eric Senneville
- Erwan Fourn
- Erwan LâHer
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eve Defous
- Ewen M Harrison
- Eyrun Floerecke Kjetland Kjetland
- Eyvind W Axelsen
- Fabrice Laine
- Fanny Vuotto
- Fara Diop
- Fernanda Dias Da Silva
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- Fouda Atangana
- France Mentré
- François Angoulvant
- François Dubos
- François Goehringer
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Fredrik MĂŒller
- FĂ©lix Djossou
- Gabriel Macheda
- Gail Carson
- Galyna Kutsyna
- Gary Leeming
- Gayatri Vishwanathan
- Geoffrey Liegeon
- Georges Falher
- Georgios Pollakis
- Gervais Eneli
- Gilles Peytavin
- Girish Sindhwani
- Giulia Bertoli
- Grace Assi
- Graham S Cooke
- Grégory Corvaisier
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guylaine Castor-Alexandre
- Gwenaël Moal
- Gwenhaël Colin
- Haider Hirkani
- Hayley Hardwick
- Hervé Nagard
- Hiba Zayyad &
- Hikombo Hitoto
- Hodane Yonis
- Hugo Mouquet
- Hugues Aumaitre
- Hugues Cordel
- Husna Begum
- HĂ©lĂšne Esperou
- HĂ©lĂšne Salvator
- Ikram Houas
- Ilka Engelmann
- Ingrid G Bustos
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- ISARIC Clinical Characterization Group Laurent Abel
- Jade Ghosn
- Jaime Cruz Rojo
- Jake Dunning
- James Lee
- James Scott-Brown
- Janet Harrison
- Janet T Scott
- Jean Baptiste Assie
- Jean-BenoĂźt Arlet
- Jean-Charles Gagnard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-SĂ©bastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jennifer Lee
- Jia Wei
- Jimmy Mullaert
- Jo Dalton
- JoaquĂn Baruch
- Johann Auchabie
- John Arne Dahl
- John Kenneth Baillie
- John Marshall
- Jose Andres Calvache
- José Luis Bernal Sobrino
- Juan Luis Cruz BermĂșdez
- Jules Bauer
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Justine Pages
- Jérémie Guedj
- Jérémie Pasquier
- JĂ©rĂŽme Dimet
- Kalynn Kennon
- Kamal Abu Jabal
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Krish Kherajani
- Krishna Bhavsar
- Kristian Tonby
- Kyle Gomez
- KĂ©vin Alexandre
- KĂ©vin Bouiller
- KĂ©vin Didier
- Laetitia Bodenes
- Lance C. W. Turtle
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Eloundou
- Laurence Bouillet
- Laurence Maulin
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- LaurĂšne Azemar
- Leonard Numfor
- Liem Luong
- Lila Bouadma
- Linda Gail Skeie
- Linn Margrete EggesbĂž
- Lionel Piroth
- Liv Hesstvedt
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Fevre
- Lucille Blumberg
- Lysa Tagherset
- LĂ©o Chenard
- Mahdad Noursadeghi
- Mahendra Singh
- Maire-Laure Casanova
- Malcolm G Semple
- Manuel Etienne
- Manuel Rosa-Calatrava
- Manuella Ademnou
- Marc Fabre
- Marc Lambert
- Marc Leone
- Margaux Isnard
- Maria Zambon
- Mariachiara Ippolito
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marina Esposito-Farese
- Marine Beluze
- Marine Livrozet
- Marion Maréchal
- Marion Schneider
- Marion Zabbe
- Mark G Pritchard
- MarlĂšne Murris
- Marta Alessi
- Martin Guego
- Martin Martinot
- Martine Remy
- Massimo Palmarini
- Mathew Thorpe
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthieu Revest
- Maude Bouscambert
- Maxime Hentzien
- Mayka Mergeay-Fabre
- MaĂŻder Pagadoy
- Meera Chand
- Mehdi Mezidi
- Mercé Jourdain
- Merete Ellingjord-Dale
- Merson Laura
- Michael Edelstein
- Michelle Girvan
- Miles Lunn
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammed ElSanharawi
- Moise Massoma
- MoĂŻse Machado
- Murray Dryden
- Murray Wham
- MylĂšne Maillet
- MĂ©lanie Roriz
- Nadhem Lafhej
- Nadia Ouamara
- Nadia Saidani
- Nadir Hadri
- NadĂšge Neant
- Nastia Medombou
- Natalie Wright
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Nerissa Niba
- Nicholas Sedillot
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Noelia GarcĂa Barrio
- Noémie Mercier
- Noémie Tissot
- Noémie Vanel
- Oana SÄndulescu
- Odile Launay
- Oksana Kruglova
- Olga Martynenko
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ouifiya Kafif
- Palmer Masumbe
- Paola Rodari
- Pascal Granier
- Pasquale Anania
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Loubet
- Paul Otiku
- Pauline Caraux-Paz
- Peter Horby
- Peter Openshaw
- Philippine Eloy
- Piero L Olliaro
- Piero Valentini
- Pierre Delobel
- Pierre Ondobo
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Premraj Lavienraj
- Pulak Kedia
- Quentin Hingrat
- Quentin Lepiller
- Rachael Parke
- Rachel Essaka
- Rachida Ouissa
- Rafael Mahieu
- Raphaël Borie
- Raphaël Favory
- Rebecca Hamidfar
- Renaud Tamisier
- Richa Su
- Riinu Pius
- Roar BĂŠvre-Jensen
- Robba Chiara
- Robert A Fowler
- Roberta Meta
- Rohan Shetty
- Romain Basmaci
- Romain Decours
- Romain Guery
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rupert Higgins
- Ryadh Pokeerbux
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sadie Kelly
- Sakshi Lath
- Salma Jaafoura
- Samira Laribi
- Samreen Ijaz
- Samuel Markowicz
- Sandra Bichoka
- Sandrine Couffin-Cadiergues
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Tubiana
- Saye Khoo
- SegolĂšne Greffe
- SeĂĄn Keating
- Shiranee Sriskandan
- Shona C Moore
- Simon Bessis
- Simon-Djamel Thiberville
- Soizic Mestre
- Sonja Hjellegjerde Brunvoll
- Sophie Halpin
- Sophie Letrou
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stephanie Kouba
- Stephanie Roberts
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphanie Cousse
- Stéphanie Fry
- Sue Smith
- Susanne Dudman
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie Kwedi
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- SĂ©bastien Preau
- SĂ©rgio GaiĂŁo
- SĂ©verine Ansart
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Drake
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomson David
- Thushan de Silva
- Tiffany Trouillon
- Timothy M Uyeki
- Tiphaine Goulenok
- Tom Fletcher
- Tom Solomon
- Tristan Gigante
- Trude Steinsvik
- Vadim Tieroshyn
- Valentine Campana
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- VĂ©ronique Lemee
- Waasila Jassat
- Walter Picard
- Wanjiru Citarella Barbara
- Wendy S Barclay
- White Nicole M
- William A Paxton
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Xavier Duval
- Yanay Gorelik
- Yash Doshi
- Yazdan Yazdanpanah
- Yoan Lavie-Badie
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yves Levy
- Zeno Bisoffi
- Publication venue
- Publication date
- 06/12/2023
- Field of study
in this study we aimed to characterize the type and prevalence of neurological symptoms related to neurological long-COVID-19 from a large international multicenter cohort of adults after discharge from hospital for acute COVID-19
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cåceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- AntolĂ Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés A.
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart MĂ©lodie
- Aubry Adeline
- Audiffred Laetitia
- Audureau Etienne
- Auger Christelle Nathalie
- Auguet Teresa
- Auregan Jean-Charles
- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
- Aytekin Selma Erol
- Azan Delphine
- Azemar Laurene
- Azot Axelle
- Azzouguen Billal
- Bachelet Delphine
- Badsi AĂŻda
- Baghdadi Jamila El
- Bahram Seiamak
- Bajolle Fanny
- Bakouboula Prissile
- Balcerowiak Coline
- Baldanti Fausto
- Balde Fanta
- Baldivia Elodie
- Baldolli Aurélie
- Ballester Maite
- Bangamingo Eliane-Flore
- Baptiste Amandine
- Baran-Marszak Fanny
- Barau Caroline
- Barget Nathalie
- Baris-Feldman Hagit
- Baronnet Flore
- Barrou Benoit
- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Baudel Jean-Luc
- Baudry Camille
- Baudry Elodie
- Bauters Fre
- Bax Diane
- Bayhan Gulsum Iclal
- Beaugerie Laurent
- Behilill Sylvie
- Behillil Sylvie
- Belamri Adel
- Belaube Nicolas
- Belilita Rhida
- Bellani Giacomo
- Bellassen Pierre
- Belmokhtar Rawan
- Belot Alexandre
- Belot Alexandre
- Beltran Isabel
- Beluze Marine
- Benainous Ruben
- Benallaoua Mourad
- Benamouzig Robert
- Benbara Amélie
- Benhida Jaouad
- Benkerrou Dehbia
- Benkhelouf Anis
- Benlagha Jihene
- Benmostafa Chahinez
- Benothmane Skander
- Bentifraouine Miassa
- Berard Laurence
- Beretta Ilaria
- Bergman Peter
- Berkell Matilda
- Bernier Quentin
- Bertholon Frédérique
- Berti Enora
- Bertier Astrid
- Berton Laure
- Bessis Simon
- Bettini Laura Rachele
- Beudel Martijn
- Beurton Alexandra
- Bezrodnik Liliana
- Bhavsar Krishna
- Bianco Celine
- Bianquis Clara
- Bidar Frank
- Biggs Catherine M.
- Bilbao Agurtzane
- Biondi Andrea
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanche Philippe
- Blanco Ignacio
- BlandiniĂšres Adeline
- Blayau Clarisse
- Bleibtreu Alexandre
- Bleibtreu Alexandre
- Blin Emmanuelle
- Bloch-Queyrat Coralie
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boissier Marie-Christophe
- Boisson Bertrand
- Boisson-Dupuis Stephanie
- Boland Anne
- Bolivar-Prados Mireia
- Bollens Diane
- Bolze Alexandre
- Bolzoni Marion
- Bomers Marije
- Bompard Rudy pierre
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondesan Simone
- Bonnet Nicolas
- Bonnouvrier Justine
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cedric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botha Shirmonecrystal
- Botta Michela
- Bouadma Lila
- Boucenna Wissam
- Bouchama Fatiha
- Bouchaud Olivier
- Bouchez Sabelline
- Bouchghoul Hanane
- Boudjebla Taoueslylia
- Boudjema Noel
- Bouffard Catherine
- Bougle Adrien
- Bouguerra Meriem
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bouras Leila
- Bourcier Agnes
- Bourgeon Marilou
- Bourrier Anne
- Bouscambert Maude
- Bouscarat Fabrice
- Bousfiha Ahmed A.
- Bousfiha Ahmed A.
- Bousquet Aurore
- Boutolleau David
- Bouvattier Claire
- Bouvry Diane
- Bouziri Nesrine
- Bouzrara Ons
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Bribier Sarah
- Briones M. Luisa
- Brodin Petter
- Brouwer Matthijs C.
- Brugier Delphine
- Bruneau LĂ©a
- Brunel Melanie
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bryceson Yenan T.
- Bueno Maria Rita P.
- Bugiani Marianna
- Bui Eida
- Buis David T. P.
- Buisson Anne
- Bukhari Huda
- Bukreyeva Iryna
- Bulle Esther
- Burdet Charles
- Bureau CĂŽme
- Bureau Serge
- Bustamante Carlos D.
- Bustamante Jacinta
- Bustos Ingrid G.
- Butte Manish J.
- Cabrera-Marante Oscar
- Cadranel Jacques
- Cailhol Johann
- Calin Ruxandra
- Canavaggio Pauline
- Cancella Marta
- Cantin Delphine
- Cao Albert
- Capra Ruggero
- Carapito Raphael
- Carbillon Lionel
- Carcel Sheila
- Carelli Valerio
- Carlier Nicolas
- Carrabba Maria
- Carrera Paola
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Cassard Clementine
- Castelle Martin
- Castelli Francesco
- Castor Guylaine
- Castro Mateus V.
- Catherinot Emilie
- Cauchy Marion
- Cazzaniga Marina
- Celik Jale Bengi
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Cha Olivier
- Chachoua Abla
- Chahine Abir
- Chaigne Benjamin
- Chair Anissa
- Chakravorty Samya
- Chaldebas Matthieu
- Challal Salima
- Chalumeau Martin
- Chalumeau Nathalie Costedoat
- Champion Karine
- Charbit Bruno
- Chariot Patrick
- Charpentier Charlotte
- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- ChaĂŻbi Khalil
- Chebbout Kamélia
- Cheng Matthew P.
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
- Choinier Pascaline
- Chommeloux Juliette
- Choquet Christophe
- Choupeaux Laure
- Chousterman Benjamin
- Christelle Kouakam
- Christodoulou John
- Ciocan Dragosmarius
- Citerio Giuseppe
- Clarke Ada
- Clavere Gaëlle
- Clavier Florian
- Clavé PÚre
- Clement Karine
- Clerc Sebastien
- Cloherty Osoul Chouchane Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Cohen Adrien
- Cohen Fleur
- Cohen Yves
- Cohen Yves
- Coilly Audrey
- Colboc Hester
- Colin Pauline
- Collet Magalie
- Colobran Roger
- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan N.
- Contro Ernesto
- Cooper Megan A.
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo G.
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- CoV-Contact Cohort [missing]
- COVID Clinicians [missing]
- COVID Human Genetic Effort [missing]
- COVID-STORM Clinicians [missing]
- COVIDeF Study Group [missing]
- Covill Laura E.
- CoĆkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
- Da Silveira CharlĂšne
- Dalgard Clifton L.
- Dalmau David
- Danielson Jeffrey J.
- Danion François
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- De Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- De Castro Nathalie
- De Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Diego Rebeca PĂ©rez
- De Farcy Pauline Mary
- de Jong Menno D.
- De Munter Paul
- de Pontual Loic
- de Rotte Maurits C. F. J.
- De Rycke Yann
- de Vera MartĂn Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Declercq Jozefien
- Deconinck Lauren
- Dehban Amin
- Del Pozo Lucie
- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
- Delay Mathieu
- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia M.
- Delphine Laëtitia
- Delplancq Geoffroy
- Demar Magalie
- Demare Noemie
- Demeret Sophie
- Demerville Lauren
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Demoule Alexandre
- Deniau Aurore
- Deplanque Dominique
- Deplanque Dominique
- Depret François
- Derolez Sophie
- Derradji Ouda
- Derridj Nawal
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Descamps Vincent
- Deschamps Lydia
- Desconclois Celine
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desnos Cyrielle
- Desongins Karine
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Dhote Robin
- Di Sabatino Antonio
- Diallo Alpha
- Diallo Benjamin
- Didier Morgane
- Diehl Jean-Luc
- Diemer Myriam
- Diez Stephane
- Dijkstra Mirjam
- Diouf Alphonsine
- Djadi-Prat Juliette
- Djebara Siham
- Djebra Naoual
- Djietcheu Minette
- Djillali Hadjer
- Djossou FĂ©lix
- Djouadi Nouara
- Dobbelaere Stephanie
- Dobbs Kerry
- DomĂnguez-Garrido Elena
- Dongelmans Dave A.
- Donneger Severine
- Dorival CĂ©line
- Dos Santos Catarina
- Dournon Nathalie
- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth A.
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein W. G.
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- DâAngioâ Mariella
- dâOrtenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- El Zein Loubna
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa H.
- Eloy Philippine
- Elrufaai Marwa Bachir
- Emiroglu Melike
- Endo Akifumi
- Enouf Vincent
- Enouf Vincent
- Erdeniz Emine Hafize
- Ernotte Gabriel
- Esling Anne
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Espérou HélÚne
- Etienne Manuel
- Etienne Martin
- Euvrard Romain
- Eyer Xavier
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fartoukh Muriel
- Fartoukh Muriel sarah
- Faure Morgane
- Fayali Takoua
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fermaut Marion
- Ferrer Ricard
- Ferreres Jose
- Fiorentino Alessio
- Fiorentino Arianna
- Fleuren Lucas
- Fliss Souha
- Flores Carlos
- Florkin Benoit
- Foti Giuseppe
- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-CĂ©line
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois HĂ©lĂšne
- French COVID Cohort Study Group [missing]
- Freynet Olivia
- Frezouls Wahiba
- Frigout Yvann
- Froidure Antoine
- Fromont Isaure
- Fuentes Axelle
- FumadĂł Victoria
- Fung Kitty S. C.
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
- Garnier Marc
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaubert Agnes
- Gaudry Stéphane
- Gaugain Samuel
- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
- Geromin Daniela
- Gervais Adrian
- Ghalayini Mohamed
- Ghaleh Bijan
- Ghezal Myriam
- Ghosn Jade
- Gibelin Aude
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilg Morgane
- Gimeno Linda
- Girard Benoit
- Girbes Armand
- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- Goas Carole L. E.
- GodĂnez Karen Alejandra Cifuentes
- Goffard Jean-Christophe
- Gomes Doryan
- Gomes-Pires Elisabete
- Gonzales Nacho
- Gonzalez-Granado Luis I.
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Gouge Anne
- Gouja Amel
- Goulet Helene
- Goupil Sylvain
- Gras Julien
- Greffe Segolene
- Gregersen Peter K.
- Grimaldi Lamiae
- Grobusch Martin P.
- Guedeney Paul
- Guedj Jérémie
- Guerder Antoine
- Guidet Bertrand
- Guillo Matthias
- Gulczynski Mariechristelle
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gysembergh-Houal Anne
- GĂ©rardin Patrick
- GĂŒlhan Belgin
- Hadjadj JĂ©rĂŽme
- Hadjam Tassadit
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Haguenauer Didier
- Halwani Rabih
- Hamann Jorg
- Hammal Soumeya
- Hammarström Lennart
- Hammoudi Nadjib
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hanon Olivier
- Hariyan Tetyana
- Harris Vanessa
- Harrois Anarole
- Hatipoglu Nevin
- HatipoÄlu Nevin
- Hausfater Pierre
- Hautem Coraline
- Heath James R.
- Heijmans Catherine
- Hekimian Guillaume
- Heming Nicholas
- Hemke Robert
- Hendou Samia
- Henrickson Sarah E.
- Heppekcan Deniz
- Hermine Olivier
- Hernandez-Brito Elisa
- Heunks Sabine M. Hermans Leo
- Ho Po-ki
- Ho Sylvie
- Hoctin Alexandre
- Hoffmann Isabelle
- Holanda-Peña MarĂa Soledad
- Hollmann Markus
- Horcajada Juan P.
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Houllier Marie
- Hovius Joppe W.
- Hraiech Sami
- Hsieh Elena W. Y.
- Hulot Jean-SĂ©bastien
- Humbert Linda
- Hung Ivan F. N.
- Huot Benjamin
- Hupalo Daniel N.
- Huscenot Tessa
- Husebye Eystein
- Iglesias Alejandro D.
- Ikherbane Ghilas
- Imai Kohsuke
- Imarazene Meriem
- Imberti Luisa
- Ingiliz Patrick
- Iratni Lina
- Itan Yuval
- Jaafoura Salma
- Jamme Matthieu
- Jarvis Erich D.
- Jaureguiberry Stephane
- Jean-Marc Jean-Francois
- Jeulin HĂ©lĂšne
- Jeyarajasingham Deleena
- Jimeno Marie-ThérÚse
- Jordan Iolanda
- Jouanguy Emmanuelle
- Jouany Pauline
- Jouis Veronique
- Jourdaine Clement
- Kaci Marc Ait
- Kafif Ouifiya
- Kafif Ouifiya
- Kafif Ouifiya
- Kaguelidou Florentia
- Kahn-Kirby Amanda
- Kali Sabrina
- Kallala Rim
- Kara Yalcin Burak
- Karahan Aydın
- Karamitros Timokratis
- Karbuz Adem
- Kasapcopur Ozgur
- Kashimada Kenichi
- Katsahian Sandrine
- Kayani Sandrine Dautheville Guibal El
- Keles Sevgi
- Kelesyan Lilit
- Keo Vixra
- Kermanach Nathalie Saidenberg
- Ketz Flora
- Khalifa Jihane El
- Khalil Antoine
- Khamis Warda
- Khan Coralie
- Khan Taj Ali
- Khelili Enfel
- Khellaf Mehdi
- Kido Yasutoshi
- Kılıç Ahmet Osman
- Kisand Kai
- Kizil Can
- Klocperk Adam
- Koning Rutger
- Kounis Ilias
- Koutsoukou Antonia
- Kpalma Gaelle
- Krause Jessica
- KrĂłl Zbigniew J.
- Ksouri Hatem
- Ku Cheng-Lung
- Kuentz Paul
- Kwan Arthur M. C.
- Kwan Yat Wah M.
- Kwok Janette S. Y.
- Kyheng ChristĂšle
- Labbe Vincent
- Lack Justin
- Lacombe Karine
- Lacorte Jean-Marc
- Lafont Anne Gaelle
- Lafont Emmanuel
- Lagha Lynda
- Lagier Jean-Christophe
- Laine Fabrice
- Lam David S. Y.
- Lamarre Yannie Cuvillier
- Lambrecht Bart
- Lamhaut Lionel
- Lampropoulou Vicky
- Lancelot Aymeric
- Landman Cecilia
- Lanternier Fanny
- Lanternier Fanny
- Laouénan Cédric
- Larcheveque Cecile
- Laribi Samira
- Larmurier Isabelle Nion
- Lasa Maria Pilar Etxart
- Lassel Ludovic
- Lau Yu-Lung
- Laverdant Benjamin
- Lavergne Christophe
- Lavillegrand Jean-RĂ©mi
- Laviolle Bruno
- Lazureanu Pompilia
- Le Bourgeois Fleur
- Le Guennec LoĂŻc
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Minh
- Leberre Lamia
- Leblanc Claire
- Leboyer Marion
- Lecomte Francois
- Lecorre Marine
- Leenhardt Romain
- Lefebvre Bénédicte
- Lefebvre Marylou
- Lefévre Benjamin
- Legendre Paul
- Leger Anne
- Legrand Karine
- Legros Laurence
- Legrosse Justyna
- Lehacaut Jonathan
- Lehuunghia SĂ©bastien
- Lemarec Julien
- Leo Yee-Sin
- Leon-Lopez Rafael
- Leporrier-Ext Jeremie
- Leprieur Bénédicte Giroux
- Lermine Alban
- Lescure François-Xavier
- Lesein Manon
- Lesur Hubert
- Letrou Sophie
- Letrou Sophie
- Leung Daniel
- Levin Michael
- Levy Albert
- Levy Michael
- Levy Vincent
- Levy Yves
- Li Zhi
- Lien Olivia Tran Dinh Thanh
- Lifton Richard P.
- Lilleri Daniele
- Lim Endry H. T.
- Lima Breno Melo
- Lima Edson Jose Adrian Bolanos
- Lina Bruno
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Linglart Agnes
- Llovich Alex Serra
- Lomazzi Sandra
- Lopes Amanda
- Lopes Edwige
- Lopez Rafael Leon
- Lopez Vanessa
- Lopinto Julien
- Lorenzo-Salazar José M.
- Lortholary Olivier
- Louadah Badr
- Louapre CĂ©line
- Loze Bénédicte
- Lubetzki Catherine
- Lucarelli Aude
- Lucas Carrie L.
- Lucas Marie-Laure
- Lucasamichi Axelle
- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
- Luong Liem Binh
- Luyt Charles-Edouard
- Lye David C.
- LĂ©vy Romain
- LĂłpez-Collazo Eduardo
- Magazimama-Ext Arouna
- Magnone Cinthia
- Maillot Adrien
- Maingret David
- Malhotra Surbi
- Malvy Denis
- Malvy Denis
- Mambert Marina
- Mameri Lakhdar
- Manchon Pauline
- Maniatis Tom
- Manivet Philippe
- Manry Jeremy
- Mansouri Cylia
- Mansouri Davood
- Marcault Estelle
- Marchal Astrid
- Marchioni Enrico
- Marey Jonathan
- Marin Nathalie
- Marioli Carola
- Marjani Majid
- Marois Clémence
- Marques Laura
- Martin Olivier
- Martin-Nalda Andrea
- Martineau Lou
- Martinez Antonio Morales
- Martinez-Lopez Cannelle
- Martinez-Picado Javier
- Martyniuck Pierre
- MartĂn-Nalda Andrea
- Marzana Iciar
- Marzouk Nessrine
- MarĂłdi LĂĄszlĂł
- Masmoudi Rafik
- Mata-MartĂnez Carmen
- Mathian Alexis
- Matos Larissa R. B.
- Matthews Gail V.
- Mattiaccio Alessandro
- Matuozzo Daniela
- Mayaux Julien
- McLaughlin-Garcia Raquel
- Mebazaa Alexandre
- Mechai Frédéric
- Mecozzi Fabio
- Medina Yeray Novoa
- Mediouni Chamseddine
- Meersseman Philippe
- Megarbane Bruno
- Meghadecha Mohamed
- Mejean Ălodie
- Mekinian Arsene
- Mekni Rania
- Mekontso-Dessap Armand
- Meliti Thinhinan Sabrina
- MeliĂĄn AbiĂĄn Montesdeoca
- Melki Isabelle
- Meloni Federica
- Meng Paris
- Mentre France
- Mentré France
- Merbah Soraya
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Messani Fadhila
- Messaoudi Yasmine
- Metin Akcan Ozge
- Meunier Alexandre
- Mewasing Baboo-Irwinsingh
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Meziane Lydia
- Mezidi Mehdi
- Michelot-Burger Carole
- Migaud Maria-Claire
- Migeotte Isabelle
- Mignot Françoise
- Milisavljevic Baptiste
- Milla Sonia Ayllon
- Millereux Maude
- Million Matthieu
- Milner Joshua D.
- Minka Fadi Hillary
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Miyara Makoto
- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
- Moine Pierre
- Mojoli Francesco
- Molina Jean-Michel
- Moncomble Elsa
- Monnory Fatima-Zohra Djamouri
- Montagne Samatha
- Montegnies-Boulet AnaĂŻs
- Monti Alexandra
- Montlahuc Claire
- Montout Anne-Lise
- Moores Alexandre
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
- Morio Tomohiro
- Mortelette Helene
- Mouly Stéphane
- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
- Muzaffar Rosita
- Muñoz-Barrera Adriån
- MĂšge Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Narvaez Rafael Usubillaga
- Nassarmadji Kladoum
- Natella Pierre
- Ndingamondze Sandrine
- Neant NadĂšge
- Nellen Jeaninne
- Neraal Stefan
- Neven Bénédicte
- Neves JoĂŁo Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- NâGuyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
- Ouelaa Wassila
- Oufella Hafid Ait
- Oukhedouma Anissa
- Oya Herve
- Ozcelik Tayfun
- Oziel Johanna
- Ozkaya-Parlakay Aslinur
- OâFarrelly Cliona
- Padilla Thomas
- Pagani Michele
- Paillaud Elena
- Paiva Solenne
- Palabiyik Figen
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Parfait Beatrice
- Paris Christophe
- Parize Perrine
- Parizot Christophe
- Parizot Christophe
- Parola Philippe
- Parrot Antoine
- Pascreau Tiffany
- Paul Christelle
- Paul Stéphane
- Paulus Frederique
- Pavot Arthur
- Payet Christine
- Paz-Artal Estela
- Peaudecerf Laetitia
- Pedraza Sigifredo
- Peiffer-Smadja Nathan
- Pellecer Nancy Carolina GonzĂĄlez
- Pellegrini Silvia
- Pene Frédéric
- Pepin Marion
- Pereira Jesus Marquez
- Pernet Julie
- Pernin Claire
- Perpoint Thomas
- Perreau Pauline
- Pesci Alberto
- Peters Edgar
- Petit MylĂšne
- Petrov-Sanchez Ventzislava
- Peyrony Olivier
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Pietri Marie-Pierre
- Pietri Olivia
- Pina-Fuentes Dan A. I.
- Pinson Michelle
- Pintado Claire
- Pippucci Tommaso
- Piquard Valentine
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pires Christine
- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
- Ploin Dominique
- Poirier Sandrine
- Poissy Julien
- Pomel Anne-Laure
- Poncelet GĂ©raldine
- Pons Stéphanie
- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
- Pourcher Valérie
- Pourshahnazari Persia
- Pouvaret Anne
- Prando Carolina
- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
- Prevost Margot
- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David MartĂnez
- Pujol Aurora
- Puéchal Oriane
- Pérez-Fernåndez Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quemeneur Cyril
- Quentric Paul
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Rabaud Christian
- Rafat CĂ©dric
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Rami Agathe
- Ramos Miquel Alfonso
- Ranque Brigitte
- Raoult Didier
- Raoult Violette
- Raphael Maurice
- Raphalen Jean Herle
- Rastoin Anna
- Raux Mathieu
- Rebai Amani
- Rebillat Anne-Sophie
- Reby Michael
- Redin Claire
- Regent Alexis
- Regrag Asma
- Reijnders Tom
- Renia Laurent
- Resche-Rigon Matthieu
- Resmini LĂ©a
- Resnick Igor
- Ressaire Quentin
- Reyes Luis Felipe
- Ricart Pilar
- Richard Christian
- Richard Jean-Christophe
- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin RaĂșl
- rivet Nadia
- RiviĂšre Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero AgustĂ
- RodrĂguez-Gallego Carlos
- Rohaut Benjamin
- Rojas Julian
- Rolland-Debord Camille
- Romero Carolina Soledad
- Ropers Jacques
- Roque-Afonso Anne-Marie
- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rosso Charlotte
- Rothenbuhler Anya
- Roufai Layidé
- Rousseaux MĂ©lanie
- Rousseaux Nabila
- Roux Damien
- Roux LorĂšne
- Roux Swasti
- Rouzaud Claire
- Rovere-Querini Patrizia
- Rovina Nikoletta
- Roy Carine
- Rozenberg Flore
- Rozes Antoine
- Rubenstein Emma
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabate Jean-Marc
- Sabater-Riera Joan
- Sabet Sheila
- Sacleux Sophie-Caroline
- Saied Wafa Ibn
- Saks Kai
- Salagianni Maria
- Saliba Faouzi
- Salmon Dominique
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Savale Laurent
- Savary Guillaume
- Sberro Rebecca
- Scemla Anne
- Schidlowski Laire
- Schinkel Michiel
- Schlemmer Frederic
- Schluter Agatha
- SchlĂŒter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke A. P.
- Schuetz Catharina
- Schultz Marcus J.
- Schuurmans Alex
- Schuurmans Jaap
- Schwartz Mathieu
- Schweitzer Cyril E.
- Scolari Francesco
- Sedfi SaĂŻd
- Sediva Anna
- Sediva Anna
- Seeleuthner Yoann
- Sefir-Kribel Samia
- Seijo Luis
- Seksik Philippe
- Sellier Pierre
- Selves Agathe
- Sembach Nicole
- Semerano Luca
- Seminario Analia Gisela
- Senat Marie-Victoire
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- SeppÀnen Mikko
- SeppÀnen Mikko R. J.
- Seri Marco
- Serris Alexandra
- Sese Lucile
- Sghiouar Naima
- Shahrooei Mohammad
- Shcherbina Anna
- Shcherbina Anna
- Sigaloff Kim
- Sigaux Johanna
- Siguier Martin
- Siguret Virginie
- Silvain Johanne
- Simon Noémie
- Simon Tabassome
- Siouti Eleni
- Skandri Lina Innes
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-PalacĂn Pere
- Soler-PalacĂn Pere
- Soliman Heithem
- Solis Blanca Garcia
- Soltani Nisrine
- Solé-Violån Jordi
- Sottini Alessandra
- Soyer Benjamin
- Sozeri Betul
- Spaan AndrĂĄs N.
- Steg Gabriel
- Stella Giulia Maria
- Stepanovskiy Yuriy
- Stijnis Cornelis S.
- Stilma Willemke
- Stoclin Annabelle
- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
- Sukumar Gauthaman
- Szwebel Tali-Anne
- SĂĄnchez-MontalvĂĄ AdriĂĄn
- SĂĄnchez-RamĂłn Silvia
- Sözeri BetĂŒl
- Taccone Fabio
- Tacconelli Evelina
- Taffame Kossi
- Talouarn Estelle
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tangye Stuart G.
- Tantet Claire
- Tardivon Coralie
- Tardy Bernard
- Tateo Mariagrazia
- Taupin Jean-Luc
- Tavernier Simon
- Tellier Marie-Capucine
- Tello Loreto Vidaur
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Theodose Igor
- Thiebaud Pierre clement
- Thiery Guillaume
- Thomas Caroline
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiercelet Kelly
- Timsit Jean-François
- Tipu Imran
- Tisserand Julie
- Tolstrup Martin
- Tomasoni Gabriele
- Tomczak Carole
- Tompkins Miranda F.
- Torelino Krystel
- Touam-Ext Fatima
- Toubiana Julie
- Toumi Lilia
- Toury Gustave
- Toy-Miou Mireille
- Trandinh Alexy
- Treluyer Jean-Marc
- Tresoldi Cristina
- Triantafyllia Vasiliki
- Trinque Baptiste
- Trouillet-Assant Sophie
- Troya Jesus
- Troya JesĂșs
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet HĂ©lĂšne
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel SĂ©bastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne AnaĂŻs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- YahĆi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- YĂŒksek Saliha Kanık
- YĂŒkselmiĆ Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli NaĂŻma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old