Creativity in Distance Learning: Study Designing Art Furniture Based on Upcycling Concepts

The COVID-19 pandemic has lasted for over two years, revolutionizing offline learning in schools worldwide. Distance learning is one of the strategies employed by Indonesian schools and universities to ensure high-quality learning outcomes. However, apart from the technological issues associated with distance learning, there are challenges in implementing these learning outcomes effectively. Therefore, this study aims to examine how to respond to distance learning results. The study was conducted by Interior Architecture students through interior product design courses, utilizing post-use materials from residential homes or upcycling materials. Distance learning was conducted using a combination of synchronous and asynchronous techniques. The learning outcomes yielded 50 interior product concepts, predominantly based on regenerative design principles. These concepts include technical cycle items that can be assembled or incorporated into do-it-yourself (DIY) activities. The findings of this study have implications for fostering new forms of engagement and creativity by transforming waste materials derived from the production process into new art furniture designs. Kreativitas Pembelajaran Jarak Jauh: Studi Merancang Art Furniture Berdasarkan Konsep Upcycling Abstrak Pandemi COVID-19 yang telah berlangsung selama dua tahun lebih telah mengubah tatanan proses belajar mengajar di semua sekolah di seluruh dunia. Salah satu upaya yang dilakukan oleh sekolah/kampus adalah dengan memberlakukan strategi pembelajaran jarak jauh, baik langsung maupun tidak langsung. Strategi tersebut dilakukan demi memastikan tetap tercapainya tujuan pembelajaran dengan kualitas yang tetap optimal meski wabah covid masih melanda. Terlepas dari permasalahan teknis yang muncul terkait pembelajaran jarak jauh, muncul suatu pertanyaan tentang bagaimana dengan implementasi atas hasil pembelajaran yang telah dilaksanakan. Penelitian ini mencoba memberikan gambaran bagaimana merespons hasil pembelajaran jarak jauh yang dilakukan oleh mahasiswa prodi interior arsitektur melalui mata kuliah perancangan produk interior dengan studi berbasis material limbah padat rumah tangga atau material upcycling. Hasil dari pembelajaran perancangan menghasilkan 50 konsep produk interior yang sebagian besar merupakan desain regenerative yang secara khusus mengarah pada technical cycle product dengan dominasi pada jenis artefak art furniture. Implementasi hasil produk merujuk pada aktivitas swakriya atau do-it-yourself (DIY). Selain hasil akhir yang berwujud artefak desain, penelitian ini berimplikasi pada munculnya embrio entrepreneurial dalam bentuk interaksi antaranggota keluarga mahasiswa dalam mengembangkan serta menciptakan item baru melalui penggunaan sisa material limbah rumah tangga lain menjadi produk art furniture baru lainnya.

Marketing Capability: Antecedents and Implications for SME Marketing Performance in Surabaya, East Java, Indonesia

A marketing aspect in company�s company becomes a main concern for company leaders and practitioners and academic environment. This research aims to investigate the role of marketing capability as intervening variable and its implication to marketing performance. Marketing performance is a measure of improve corporate achievement. Small and Medium Enterprises (SMEs) located in Surabaya City have 50 business units, and all of are spread all over Surabaya. Partial Least Square (PLS) method, and Structural Equation Modeling (SEM) were used to examine the research hypothesis. The study found marketing capability acted as intervening variable linking the learning orientation and entrepreneurial orientation to marketing performance. Marketing capability have not mediated market orientation and marketing performanc

TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR gamma 2

TonEBP is a key transcription factor in cellular adaptation to hypertonic stress, and also in macrophage activation. Since TonEBP is involved in inflammatory diseases such as rheumatoid arthritis and atherosclerosis, we asked whether TonEBP played a role in adipogenesis and insulin resistance. Here we report that TonEBP suppresses adipogenesis and insulin signaling by inhibiting expression of the key transcription factor PPAR gamma 2. TonEBP binds to the PPAR gamma 2 promoter and blocks the epigenetic transition of the locus which is required for the activation of the promoter. When TonEBP expression is reduced, the epigenetic transition and PPAR gamma 2 expression are markedly increased leading to enhanced adipogenesis and insulin response while inflammation is reduced. Thus, TonEBP is an independent determinant of adipose insulin sensitivity and inflammation. TonEBP is an attractive therapeutic target for insulin resistance in lieu of PPAR gamma agonistsopen0

Viruses exacerbating chronic pulmonary disease: the role of immune modulation

Chronic pulmonary diseases are a major cause of morbidity and mortality and their impact is expected to increase in the future. Respiratory viruses are the most common cause of acute respiratory infections and it is increasingly recognized that respiratory viruses are a major cause of acute exacerbations of chronic pulmonary diseases such as asthma, chronic obstructive pulmonary disease and cystic fibrosis. There is now increasing evidence that the host response to virus infection is dysregulated in these diseases and a better understanding of the mechanisms of abnormal immune responses has the potential to lead to the development of new therapies for virus-induced exacerbations. The aim of this article is to review the current knowledge regarding the role of viruses and immune modulation in chronic pulmonary diseases and discuss avenues for future research and therapeutic implications

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

PENGARUH INOVASI PRODUK DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN MAISON NOB

Penelitian ini bertujuan untuk mengetahui apakah inovasi produk dan kualitas produk mempengaruhi keputusan pembelian pada konsumen Maison Nobl. Jenis penelitian adalah kuantitatif. Populasi dalam penelitian ini adalah konsumen Maison Nobl yang telah melakukan pembelian produk sebanyak 56 orang, teknik pengumpulan data menggunakan kuesioner. Analisis data menggunakan analisis regresi linear berganda, uji F, dan uji t. Berdasarkan hasil pengujian hipotesis secara parsial dapat disimpulkan bahwa variabel Inovasi produk dan variabel Kualitas produk mempunyai pengaruh signifikan terhadap Keputusan pembelian Maison Nobl. Hasil Pengujian statistik mengunakan analisis regresi berganda dapat disimpulkan bahwa variabel Inovasi produk (X1) dan Kualitas produk (X2) secara bersama-sama (simultan) berpengaruh signifikan terhadap Keputusan pembelian Maison Nobl

The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial

Contains fulltext : 117784.pdf (publisher's version ) (Open Access)BACKGROUND: Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy. METHODS AND FINDINGS: A household-based cluster-randomized, double-blind, placebo-controlled trial was conducted in an area in Indonesia endemic for STH. Using computer-aided block randomization, 481 households (2022 subjects) and 473 households (1982 subjects) were assigned to receive placebo and albendazole, respectively, every three months. The treatment code was concealed from trial investigators and participants. Malarial parasitemia and malaria-like symptoms were assessed in participants older than four years of age while skin prick test (SPT) to allergens as well as reported symptoms of allergy in children aged 5-15 years. The general impact of treatment on STH prevalence and body mass index (BMI) was evaluated. Primary outcomes were prevalence of malarial parasitemia and SPT to any allergen. Analysis was by intention to treat. At 9 and 21 months post-treatment 80.8% and 80.1% of the study subjects were retained, respectively. The intensive treatment regiment resulted in a reduction in the prevalence of STH by 48% in albendazole and 9% in placebo group. Albendazole treatment led to a transient increase in malarial parasitemia at 6 months post treatment (OR 4.16(1.35-12.80)) and no statistically significant increase in SPT reactivity (OR 1.18(0.74-1.86) at 9 months or 1.37 (0.93-2.01) 21 months). No effect of anthelminthic treatment was found on BMI, reported malaria-like- and allergy symptoms. No adverse effects were reported. CONCLUSIONS: The study indicates that intensive community treatment of 3 monthly albendazole administration for 21 months over two years leads to a reduction in STH. This degree of reduction appears safe without any increased risk of malaria or allergies. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN83830814