1,751 research outputs found
High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene.
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2010
- Field of study
Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder. This linkage is specific to multiplex pedigrees containing only male probands (MO) within the Autism Genetic Resource Exchange (AGRE). Earlier, Stone et al.(1) completed a high-density single nucleotide polymorphism association study of 13.7 Mb within this interval, but common variant association was not sufficient to account for the linkage signal. Here, we extend this single nucleotide polymorphism-based association study to complete the coverage of the two-LOD support interval around the chromosome 17q linkage peak by testing the majority of common alleles in 284 MO trios. Markers within an interval containing the gene, CACNA1G, were found to be associated with Autism Spectrum Disorder at a locally significant level (P=1.9 × 10(-5)). While establishing CACNA1G as a novel candidate gene for autism, these alleles do not contribute a sufficient genetic effect to explain the observed linkage, indicating that there is substantial genetic heterogeneity despite the clear linkage signal. The region thus likely harbors a combination of multiple common and rare alleles contributing to the genetic risk. These data, along with earlier studies of chromosomes 5 and 7q3, suggest few if any major common risk alleles account for Autism Spectrum Disorder risk under major linkage peaks in the AGRE sample. This provides important evidence for strategies to identify Autism Spectrum Disorder genes, suggesting that they should focus on identifying rare variants and common variants of small effect
The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex.
- Author
- A Chakraborty
- A Jain
- AE Kelly
- AG Larson
- AM Ainsztein
- AR Strom
- B Banerjee
- B Bolognesi
- BG Fuller
- BR Sabari
- E Niedzialkowska
- E Wang
- Enrico Gratton
- Ewa Niedzialkowska
- F Cardarelli
- F Sessa
- F Wang
- Francesco Palomba
- J Chen
- J Du
- JB Woodruff
- JG Ruppert
- K Jaqaman
- KM Sathyan
- KS Bloom
- L Scipioni
- M Delacour-Larose
- M Wachsmuth
- M Wühr
- Michelle A. Digman
- ML Hanley
- MS Wheelock
- P Trivedi
- P Trivedi
- P. Todd Stukenberg
- PDJ Moens
- Prasad Trivedi
- R Mahen
- RCC Hengeveld
- S Ambadipudi
- S Hauf
- S Hindriksen
- SC Sampath
- SE Rosasco-Nitcher
- SF Banani
- Shasha Chong
- SM Janicki
- SP Wheatley
- T Hirota
- T Tsukahara
- UR Klein
- VA Beardmore
- W Fischle
- X Liu
- Y Abe
- Y Shin
- Y Yamagishi
- Y Yamagishi
- Publication venue
- eScholarship, University of California
- Publication date
- 01/09/2019
- Field of study
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can resist microtubule pulling forces. The chromosomal passenger complex (CPC) is abundantly localized to the inner centromeres and it is unclear whether it is involved in non-kinase activities that contribute to the generation of these unique chromatin properties. We find that the borealin subunit of the CPC drives phase separation of the CPC in vitro at concentrations that are below those found on the inner centromere. We also provide strong evidence that the CPC exists in a phase-separated state at the inner centromere. CPC phase separation is required for its inner-centromere localization and function during mitosis. We suggest that the CPC combines phase separation, kinase and histone code-reading activities to enable the formation of a chromatin body with unique biochemical activities at the inner centromere
Immediate response of myocardium to pressure overload includes transient regulation of genes associated with mitochondrial bioenergetics and calcium availability
- Author
- Ana Carolina Deckmann
- Anisimov SV
- Barry SP
- Berni R
- Clerk A
- Cullingford TE
- Diamond JA
- Francisco Javier Medrano
- Glauser DA
- Goffart S
- Gonçalo Amarante Guimarães Pereira
- Gupta MP
- Kleber Gomes Franchini
- Krenz M
- Machackova J
- McKinsey TA
- Rimbaud S
- Spruill LS
- Stilli D
- Strom CC
- Thaís Holz Theizen
- van den Bosch BJ
- Weinberg EO
- Wilkins BJ
- Zhao M
- Publication venue
- Sociedade Brasileira de Genética
- Publication date
- 01/01/2010
- Field of study
Ventricular hypertrophy is one of the major myocardial responses to pressure overload (PO). Most studies on early myocardial response focus on the days or even weeks after induction of hypertrophic stimuli. Since mechanotransduction pathways are immediately activated in hearts undergoing increased work load, it is reasonable to infer that the myocardial gene program may be regulated in the first few hours. In the present study, we monitored the expression of some genes previously described in the context of myocardial hypertrophic growth by using the Northern blot technique, to estimate the mRNA content of selected genes in rat myocardium for the periods 1, 3, 6, 12 and 48 h after PO stimuli. Results revealed an immediate switch in the expression of genes encoding alpha and beta isoforms of myosin heavy chain, and up-regulation of the cardiac isoform of alpha actin. We also detected transitory gene regulation as the increase in mitochondrial cytochrome c oxidase 1 gene expression, parallel to down-regulation of genes encoding sarco(endo)plasmic reticulum Ca+2 ATPase and sodium-calcium exchanger. Taken together, these results indicate that initial myocardial responses to increased work load include alterations in the contractile properties of sarcomeres and transitory adjustment of mitochondrial bioenergetics and calcium availability
A review of elliptical and disc galaxy structure, and modern scaling laws
- Author
- A Boselli
- A Burkert
- A Friedmann
- A Marconi
- A Matković
- A Oemler Jr
- A Pellet
- A Popolo Del
- A Renzini
- A Rest
- A Sandage
- A Sandage
- A Sandage
- A Schurer
- A Wirth
- AC González-García
- AC Seth
- AH Gonzalez
- AH Maller
- AJ Barth
- AM Wolfe
- AS Bolton
- AS Reese
- ASG Robotham
- AV Filippenko
- AV Smith Castelli
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- AW Graham
- B Binggeli
- B Binggeli
- B Binggeli
- B Binggeli
- B Binggeli
- B Terzić
- B Terzić
- BG Elmegreen
- BJ Weiner
- BK Moorthy
- BT Draine
- BT Dullo
- BT Soifer
- C Babusiaux
- C Möllenhoff
- C Nipoti
- C Nipoti
- C Tonini
- C-W Chen
- CA Norman
- CA Tremonti
- CB Brook
- CC Popescu
- CC Popescu
- CJ Grillmair
- CJ Houten van
- CJ Peterson
- CJ Walcher
- CJ Webb
- CK Young
- CK Young
- CM Carollo
- CM Carollo
- CM Walmsley
- CP Wilson
- CS Kochanek
- CT Unterborn
- D Carter
- D Carter
- D Carter
- D Carter
- D Fisher
- D Gerbal
- D Kawata
- D Kereš
- D Krajnović
- D Merritt
- D Merritt
- D Merritt
- D Merritt
- D Merritt
- D Merritt
- D Pierini
- D Thomas
- DA Forbes
- DA Forbes
- DA Forbes
- DA Gadotti
- DA Gadotti
- DA Gadotti
- DB Fisher
- DB Fisher
- DC Morton
- DG York
- DJ Croton
- DN Spergel
- DT Hill
- E Athanassoula
- E Athanassoula
- E Athanassoula
- E Cameron
- E Daddi
- E D’Onghia
- E Emsellem
- E Hubble
- E Hubble
- E Hubble
- E Hubble
- E Hubble
- E Iodice
- E Iodice
- E Laurikainen
- E Laurikainen
- E Laurikainen
- E Tolstoy
- EA Evstigneeva
- EF Bell
- EJ Tollerud
- EK Grebel
- EM Malumuth
- EP Hubble
- EP Hubble
- EP Hubble
- EV Held
- F Bertola
- F Combes
- F Combes
- F Donato
- F Ferrari
- F Governato
- F Hohl
- F Hohl
- F Simien
- FD Barazza
- FG Pease
- FH Seares
- FS Liu
- FS Patterson
- G Bertin
- G Bertin
- G Cecil
- G Gavazzi
- G Gilmore
- G Gilmore
- G Kauffmann
- G Lemaitre
- G Lucia De
- G Reaves
- G Reaves
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- G Vaucouleurs de
- GA Mamon
- GB Lima Neto
- GD Bothun
- GD Bothun
- GL Pilbratt
- H Aceves
- H Jerjen
- H Knox Shaw
- H Kragh
- H Shapley
- H Spinrad
- H Wozniak
- H Zhao
- H-W Rix
- HC Ferguson
- HC Plummer
- HD Curtis
- HD Tran
- HG Khosroshahi
- HJ Rood
- HP Robertson
- HW Babcock
- HW Babcock
- I Chilingarian
- I Chilingarian
- I Damjanov
- I Marinova
- I Misgeld
- I Misgeld
- I Márquez
- I Trujillo
- I Trujillo
- I Trujillo
- I Trujillo
- IJ Barton
- IK Baldry
- IR King
- IR King
- IR King
- IR King
- IR King
- J Binney
- J Binney
- J Binney
- J Binney
- J Bland-Hawthorn
- J Bregman
- J Dabringhausen
- J Herschel
- J Hjorth
- J Jaan Einasto
- J Janz
- J Janz
- J Jeans
- J Koda
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Kormendy
- J Liske
- J Ma
- J Magorrian
- J Price
- J Stebbins
- J Tonry
- J Vennik
- J Wolf
- J-L Sérsic
- JA Sellwood
- JA Tyson
- JAL Aguerri
- JAL Aguerri
- JC Mihos
- JC Shields
- JE Greene
- JF Navarro
- JF Navarro
- JF Navarro
- JG Hoessel
- JH Barnes
- JH Knapen
- JH Reynolds
- JH Reynolds
- JH Reynolds
- JI Davies
- JL Sérsic
- JLE Dreyer
- JLE Dreyer
- JLE Dreyer
- JM Bardeen
- JM Schombert
- JP Brodie
- JP Emerson
- JP Ostriker
- K Bekki
- K Bekki
- K Bekki
- K Gebhardt
- K Kodaira
- K Lundmark
- K Ohta
- KC Freeman
- KC Freeman
- KL Masters
- KM Strom
- KR Stewart
- L Ciotti
- L Ciotti
- L Ciotti
- L Ferrarese
- L Ferrarese
- L Ferrarese
- L Glass
- L Hernquist
- L Hoffman
- LA MacArthur
- LA MacArthur
- LA MacArthur
- LP Bassino
- LVE Koopmans
- LVE Koopmans
- M Arnaboldi
- M Baes
- M Balcells
- M Balcells
- M Bernardi
- M Blanton
- M Boylan-Kolchin
- M Capaccioli
- M Capaccioli
- M D’Onofrio
- M D’Onofrio
- M Frankston
- M Geha
- M Gliozzi
- M Haşegan
- M Hilker
- M Hoskin
- M Humasson
- M Milosavljević
- M Persic
- M Prieto
- M Prieto
- M Rozas
- M Spano
- M Steinmetz
- M Stiavelli
- M Volonteri
- M Yoshizawa
- M Zoccali
- MA Norris
- MA Shaw
- MC Begelman
- MD Covington
- MG Haehnelt
- MH Liller
- MH Liller
- MJ Drinkwater
- MJ Duncan
- MJ Williams
- MR Blanton
- MS Clemens
- MS Seigar
- MS Seigar
- MW Auger
- MW Werner
- N Caldwell
- N Caldwell
- N Caon
- N Caon
- N Caon
- N Kaiser
- N Metcalfe
- NA Devereux
- NI Grant
- NM Ferrers
- P Crane
- P Côté
- P Côté
- P Erwin
- P Erwin
- P Goudfrooij
- P Goudfrooij
- P Heraudeau
- P Jablonka
- P Jonsson
- P Jonsson
- P Martin
- P Nair
- P Prugniel
- P Temi
- P Thakur
- PB Eskridge
- PC Kruit van der
- PC Kruit van der
- PC Kruit van der
- PC Kruit van der
- PD Allen
- PJ Humphre
- PJ Young
- PL Schechter
- PM Lugger
- PT Zeeuw de
- PW Hodge
- PW Hodge
- PW Hodge
- PW Hodge
- PW Hodge
- Q Guo
- R Bender
- R Domínguez-Tenreiro
- R Gavazzi
- R Genzel
- R Grijs de
- R Jong de
- R Launhardt
- R Mandelbaum
- R Michard
- R Michard
- R Minkowski
- R Schödel
- RAW Elson
- RB Larson
- RB Larson
- RB Larson
- RB Tully
- RB Tully
- RE Skelton
- RE White III
- RF Peletier
- RF Peletier
- RF Peletier
- RF Peletier
- RF Peletier
- RFG Wyse
- RFG Wyse
- RG Bower
- RG Carlberg
- RJ McLure
- RJ Trumpler
- RJ Trumpler
- RJ Wainscoat
- RJN Brown
- RL Davies
- RM Rich
- RS Jong de
- RT Farouki
- S Bergh van den
- S Bergh van den
- S Bergh van den
- S Bianchi
- S Cole
- S Djorgovski
- S Kent
- S Khochfar
- S Pellegrini
- S Ravindranath
- S Rijcke de
- S Smith
- S Zibetti
- S-I Ichikawa
- SA Cellone
- SC Ellis
- SJ Kannappan
- SJ Kautsch
- SJ Kautsch
- SJ Penny
- SM Faber
- SM Faber
- SM Faber
- SM Kent
- SP Driver
- SP Driver
- SP Driver
- SP Driver
- SP Driver
- T Böker
- T Ebisuzaki
- T Lisker
- T Lisker
- T Lisker
- T Lisker
- T Lisker
- T Matteo Di
- T Naab
- T Naab
- T Tal
- T Weinzirl
- T. R. Lauer
- TA Matthews
- TA McGlynn
- TG Hawarden
- TJ Davidge
- TR Lauer
- TR Lauer
- TR Lauer
- TR Lauer
- TR Lauer
- TS Albada van
- U Mebold
- U Schwarzkopf
- V Avila-Reese
- V Petrosian
- V Tsikoudi
- V. Trimble
- VC Rubin
- VE Karachentseva
- VF Cardone
- VM Slipher
- W Jaffe
- W McAlpine
- W Romanishin
- W Sitter de
- WB Sparks
- WC Keel
- WC Keel
- WC Saslaw
- WE Harris
- WW Morgan
- XY Dong
- Y Birnboim
- Y Qu
- Y Wadadekar
- Y-I Byun
- YC Andredakis
- YC Andredakis
- YP Jing
- Ž Ivezić
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/08/2011
- Field of study
A century ago, in 1911 and 1913, Plummer and then Reynolds introduced their
models to describe the radial distribution of stars in `nebulae'. This article
reviews the progress since then, providing both an historical perspective and a
contemporary review of the stellar structure of bulges, discs and elliptical
galaxies. The quantification of galaxy nuclei, such as central mass deficits
and excess nuclear light, plus the structure of dark matter halos and cD galaxy
envelopes, are discussed. Issues pertaining to spiral galaxies including dust,
bulge-to-disc ratios, bulgeless galaxies, bars and the identification of
pseudobulges are also reviewed. An array of modern scaling relations involving
sizes, luminosities, surface brightnesses and stellar concentrations are
presented, many of which are shown to be curved. These 'redshift zero'
relations not only quantify the behavior and nature of galaxies in the Universe
today, but are the modern benchmark for evolutionary studies of galaxies,
whether based on observations, N-body-simulations or semi-analytical modelling.
For example, it is shown that some of the recently discovered compact
elliptical galaxies at 1.5 < z < 2.5 may be the bulges of modern disc galaxies.Comment: Condensed version (due to Contract) of an invited review article to
appear in "Planets, Stars and Stellar
Systems"(www.springer.com/astronomy/book/978-90-481-8818-5). 500+ references
incl. many somewhat forgotten, pioneer papers. Original submission to
Springer: 07-June-201
Repeated measures study of weekly and daily cytomegalovirus shedding patterns in saliva and urine of healthy cytomegalovirus-seropositive children
- Author
- C Bello
- C Vauloup-Fellous
- Cynthia Stover
- D Scott Schmid
- Delaney Johnson
- EM Levinsohn
- ES Mocarski Jr
- G Nigro
- H Sung
- H Yan
- J Johnson
- J Strom
- JD Stowell
- Jennifer D Stowell
- Jing Guo
- JR Murph
- JR Murph
- Karen Mask
- Karen Wu
- KB Fowler
- M Barbi
- M Berntsson
- M Kharrazi
- Michael J Cannon
- Minal Amin
- MJ Cannon
- MJ Cannon
- MJ Cannon
- P Antoine
- PD Griffiths
- Philip R Dollard
- Rebekah Clark
- RF Pass
- S Stagno
- SA Staras
- SB Boppana
- SC Dollard
- Sheila C Dollard
- SP Adler
- SP Adler
- TB Hyde
- Will Hendley
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for Gravitational Waves from Primordial Black Hole Binary Coalescences in the Galactic Halo
- Author
- Abbott B
- Abbott R
- Adhikari R
- Ageev A
- Allen B
- Amin R
- Anderson SB
- Anderson WG
- Araya M
- Armandula H
- Ashley M
- Asiri F
- Aufmuth P
- Aulbert C
- Babak S
- Balasubramanian R
- Ballmer S
- Barish BC
- Barker C
- Barker D
- Barnes M
- Barr B.
- Barton MA
- Bayer K
- Beausoleil R
- Belczynski K
- Bennett R.
- Berukoff SJ
- Betzwieser J
- Bhawal B
- Bilenko IA
- Billingsley G
- Black E
- Blackburn K
- Blackburn L
- Bland B
- Bochner B
- Bogue L
- Bork R
- Bose S
- Brady PR
- Braginsky VB
- Brau JE
- Brown DA
- Bullington A
- Bunkowski A
- Buonanno A
- Burgess R
- Busby D
- Butler WE
- Byer RL
- Cadonati L
- Cagnoli G.
- Camp JB
- Cantley C.A.
- Cardenas L
- Carter K
- Casey M.M.
- Castiglione J
- Chandler A
- Chapsky J
- Charlton P
- Chatterji S
- Chelkowski S
- Chen Y
- Chickarmane V
- Chin D
- Christensen N
- Churches D
- Cokelaer T
- Colacino C
- Coldwell R
- Coles M
- Cook D
- Corbitt T
- Coyne D
- Creighton JDE
- Creighton TD
- Crooks D.R.M.
- Csatorday P
- Cusack BJ
- Cutler C
- DAmbrosio E
- Danzmann K
- Daw E
- DeBra D
- Delker T
- Dergachev V
- DeSalvo R
- Dhurandhar S
- Di Credico A
- Diaz M
- Ding H
- Drever RWP
- Dupuis R.J.
- Edlund JA
- Ehrens P
- Elliffe E.J.
- Etzel T
- Evans M
- Evans T
- Fairhurst S
- Fallnich C
- Farnham D
- Fejer MM
- Findley T
- Fine M
- Finn LS
- Franzen KY
- Freise A
- Frey R
- Fritschel P
- Frolov VV
- Fyffe M
- Ganezer KS
- Garofoli J
- Giaime JA
- Gillespie A
- Goda K
- Gonzalez G
- Gossler S
- Grandclement P
- Grant A.
- Gray C
- Gretarsson AM
- Grimmett D
- Grote H
- Grunewald S
- Guenther M
- Gustafson E
- Gustafson R
- Hamilton WO
- Hammond M
- Hanson J
- Hardham C
- Harms J
- Harry G
- Hartunian A
- Heefner J
- Hefetz Y
- Heinzel G
- Heng IS
- Hennessy M
- Hepler N
- Heptonstall A.
- Heurs M
- Hewitson M
- Hild S
- Hindman N
- Hoang P
- Hough J.
- Hrynevych M
- Hua W
- Ito M
- Itoh Y
- Ivanov A
- Jennrich O.
- Johnson B
- Johnson WW
- Johnston WR
- Jones DI
- Jones L
- Jungwirth D
- Kalogera V
- Katsavounidis E
- Kawabe K
- Kawamura S
- Kells W
- Kern J
- Khan A
- Killbourn S.
- Killow C.J.
- Kim C
- King C
- King P
- Klimenko S
- Koranda S
- Kotter K
- Kovalik J
- Kozak D
- Krishnan B
- Landry M
- Langdale J
- Lantz B
- Lawrence R
- Lazzarini A
- Lei M
- Leonor I
- Libbrecht K
- Libson A
- LIGO Sci Collaboration
- Lindquist P
- Liu S
- Logan J
- Lormand M
- Lubinski M
- Luck H
- Lyons TT
- Machenschalk B
- MacInnis M
- Mageswaran M
- Mailand K
- Majid W
- Malec M
- Mann F
- Marin A
- Marka S
- Maros E
- Mason J
- Mason K
- Matherny O
- Matone L
- Mavalvala N
- McCarthy R
- McClelland DE
- McHugh M
- McNabb JWC
- Mendell G
- Mercer RA
- Meshkov S
- Messaritaki E
- Messenger C
- Mitrofanov VP
- Mitselmakher G
- Mittleman R
- Miyakawa O
- Miyoki S
- Mohanty S
- Moreno G
- Mossavi K
- Mueller G
- Mukherjee S
- Murray P.
- Myers J
- Nagano S
- Nash T
- Nayak R
- Newton G.
- Nocera F
- Noel JS
- Nutzman P
- Olson T
- OReilly B
- Ottaway DJ
- Ottewill A
- Ouimette D
- Overmier H
- Owen BJ
- Pan Y
- Papa MA
- Parameshwaraiah V
- Parameswaran A
- Parameswariah C
- Pedraza M
- Penn S
- Pitkin M.
- Plissi M.
- Prix R
- Quetschke V
- Raab F
- Radkins H
- Rahkola R
- Rakhmanov M
- Rao SR
- Rawlins K
- Ray-Majumder S
- Re V
- Redding D
- Regehr MW
- Regimbau T
- Reid S.
- Reilly KT
- Reithmaier K
- Reitze DH
- Richman S
- Riesen R
- Riles K
- Rivera B
- Rizzi A
- Robertson D.I.
- Robertson N.A.
- Robison L
- Roddy S
- Rollins J
- Romano JD
- Romie J
- Rong H
- Rose D
- Rotthoff E
- Rowan S.
- Rudiger A
- Russell P
- Ryan K
- Salzman I
- Sandberg V
- Sanders GH
- Sannibale V
- Sathyaprakash B
- Saulson PR
- Savage R
- Sazonov A
- Schilling R
- Schlaufman K
- Schmidt V
- Schnabel R
- Schofield R
- Schutz BF
- Schwinberg P
- Scott SM
- Seader SE
- Searle AC
- Sears B
- Seel S
- Seifert F
- Sengupta AS
- Shapiro CA
- Shawhan P
- Shoemaker DH
- Shu QZ
- Sibley A
- Siemens X
- Sievers L
- Sigg D
- Sintes AM
- Smith JR
- Smith M
- Smith MR
- Sneddon P.H.
- Spero R
- Stapfer G
- Steussy D
- Strain K.A.
- Strom D
- Stuver A
- Summerscales T
- Sumner MC
- Sutton PJ
- Sylvestre J
- Takamori A
- Tanner DB
- Tariq H
- Taylor I
- Taylor R
- Thorne KA
- Thorne KS
- Tibbits M
- Tilav S
- Tinto M
- Tokmakov KV
- Torres C
- Torrie C
- Traylor G
- Tyler W
- Ugolini D
- Ungarelli C
- Vallisneri M
- van Putten M
- Vass S
- Vecchio A
- Veitch J.
- Vorvick C
- Vyachanin SP
- Wallace L
- Walther H
- Ward H.
- Ware B
- Watts K
- Webber D
- Weidner A
- Weiland U
- Weinstein A
- Weiss R
- Welling H
- Wen L
- Wen S
- Whelan JT
- Whitcomb SE
- Whiting BF
- Wiley S
- Wilkinson C
- Willems PA
- Williams PR
- Williams R
- Willke B
- Wilson A
- Winjum BJ
- Winkler W
- Wise S
- Wiseman AG
- Woan G.
- Woods D
- Wooley R
- Worden J
- Wu W
- Yakushin I
- Yamamoto H
- Yoshida S
- Zaleski KD
- Zanolin M
- Zawischa I
- Zhang L
- Zhu R
- Zotov N
- Zucker M
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2005
- Field of study
We use data from the second science run of the LIGO gravitational-wave
detectors to search for the gravitational waves from primordial black hole
(PBH) binary coalescence with component masses in the range 0.2--1.0M⊙.
The analysis requires a signal to be found in the data from both LIGO
observatories, according to a set of coincidence criteria. No inspiral signals
were found. Assuming a spherical halo with core radius 5 kpc extending to 50
kpc containing non-spinning black holes with masses in the range 0.2--1.0M⊙, we place an observational upper limit on the rate of PBH coalescence
of 63 per year per Milky Way halo (MWH) with 90% confidence.Comment: 7 pages, 4 figures, to be submitted to Phys. Rev.
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Siragusa G
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- Sivoklokov SY
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- Sjursen TB
- Skinnari LA
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- Slavicek T
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- Stekl I
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- Tsukerman II
- Tsulaia V
- Tsung J-W
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- Tua A
- Tudorache A
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- Tuggle JM
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- Urbaniec D
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- van Huysduynen LH
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- Van Vulpen I
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- Viehhauser GHA
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- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
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- Vokac P
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- von Radziewski H
- von Toerne E
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
- zur Nedden M
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- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
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- AbouZeid OS
- Abramowicz H
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- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes
- Author
- A Galli
- A Galli
- A Sigal
- A Sigal
- B Pardo
- B Pfander
- BD Rowland
- C Bauerschmidt
- C Richardson
- C Sjogren
- CB Bennett
- Dmitry A. Gordenin
- E Unal
- E Unal
- E Unal
- ED Strome
- EF Glynn
- EL Ivanov
- EP Mimitou
- F Cortes-Ledesma
- F Storici
- F Zhang
- G Lettier
- HT Tran
- I Onn
- J San Filippo
- J Westmoreland
- J Zhang
- JA Tischfield
- James E. Haber
- James W. Westmoreland
- JE Guidotti
- JL Argueso
- JS Kim
- K Han
- KS Ho
- L Strom
- L Strom
- LC Kadyk
- M Jasin
- MA Resnick
- MA Resnick
- MA Resnick
- MA Resnick
- Michael A. Resnick
- N Sugawara
- NJ Ganem
- O Date
- PS Lee
- S Ghaemmaghami
- Shay Covo
- SP Otto
- ST Durant
- ST Kim
- T Sutani
- TD Barber
- V Guacci
- W Gu
- Y Blat
- YH Jin
- Z Storchova
- Publication venue
- Public Library of Science
- Publication date
- 01/07/2010
- Field of study
Double-strand break (DSB) repair through homologous recombination (HR) is an evolutionarily conserved process that is generally error-free. The risk to genome stability posed by nonallelic recombination or loss-of-heterozygosity could be reduced by confining HR to sister chromatids, thereby preventing recombination between homologous chromosomes. Here we show that the sister chromatid cohesion complex (cohesin) is a limiting factor in the control of DSB repair and genome stability and that it suppresses DNA damage–induced interactions between homologues. We developed a gene dosage system in tetraploid yeast to address limitations on various essential components in DSB repair and HR. Unlike RAD50 and RAD51, which play a direct role in HR, a 4-fold reduction in the number of essential MCD1 sister chromatid cohesion subunit genes affected survival of gamma-irradiated G2/M cells. The decreased survival reflected a reduction in DSB repair. Importantly, HR between homologous chromosomes was strongly increased by ionizing radiation in G2/M cells with a single copy of MCD1 or SMC3 even at radiation doses where survival was high and DSB repair was efficient. The increased recombination also extended to nonlethal doses of UV, which did not induce DSBs. The DNA damage–induced recombinants in G2/M cells included crossovers. Thus, the cohesin complex has a dual role in protecting chromosome integrity: it promotes DSB repair and recombination between sister chromatids, and it suppresses damage-induced recombination between homologues. The effects of limited amounts of Mcd1and Smc3 indicate that small changes in cohesin levels may increase the risk of genome instability, which may lead to genetic diseases and cancer
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