144 research outputs found
Evaluation Methodologies for Visual Information Retrieval and Annotation
Die automatisierte Evaluation von Informations-Retrieval-Systemen erlaubt
Performanz und Qualität der Informationsgewinnung zu bewerten. Bereits in
den 60er Jahren wurden erste Methodologien für die system-basierte
Evaluation aufgestellt und in den Cranfield Experimenten überprüft.
Heutzutage gehören Evaluation, Test und Qualitätsbewertung zu einem aktiven
Forschungsfeld mit erfolgreichen Evaluationskampagnen und etablierten
Methoden. Evaluationsmethoden fanden zunächst in der Bewertung von
Textanalyse-Systemen Anwendung. Mit dem rasanten Voranschreiten der
Digitalisierung wurden diese Methoden sukzessive auf die Evaluation von
Multimediaanalyse-Systeme übertragen. Dies geschah häufig, ohne die
Evaluationsmethoden in Frage zu stellen oder sie an die veränderten
Gegebenheiten der Multimediaanalyse anzupassen. Diese Arbeit beschäftigt
sich mit der system-basierten Evaluation von Indizierungssystemen für
Bildkollektionen. Sie adressiert drei Problemstellungen der Evaluation von
Annotationen: Nutzeranforderungen für das Suchen und Verschlagworten von
Bildern, Evaluationsmaße für die Qualitätsbewertung von
Indizierungssystemen und Anforderungen an die Erstellung visueller
Testkollektionen. Am Beispiel der Evaluation automatisierter
Photo-Annotationsverfahren werden relevante Konzepte mit Bezug zu
Nutzeranforderungen diskutiert, Möglichkeiten zur Erstellung einer
zuverlässigen Ground Truth bei geringem Kosten- und Zeitaufwand vorgestellt
und Evaluationsmaße zur Qualitätsbewertung eingeführt, analysiert und
experimentell verglichen. Traditionelle Maße zur Ermittlung der Performanz
werden in vier Dimensionen klassifiziert. Evaluationsmaße vergeben
üblicherweise binäre Kosten für korrekte und falsche Annotationen. Diese
Annahme steht im Widerspruch zu der Natur von Bildkonzepten. Das gemeinsame
Auftreten von Bildkonzepten bestimmt ihren semantischen Zusammenhang und
von daher sollten diese auch im Zusammenhang auf ihre Richtigkeit hin
überprüft werden. In dieser Arbeit wird aufgezeigt, wie semantische
Ähnlichkeiten visueller Konzepte automatisiert abgeschätzt und in den
Evaluationsprozess eingebracht werden können. Die Ergebnisse der Arbeit
inkludieren ein Nutzermodell für die konzeptbasierte Suche von Bildern,
eine vollständig bewertete Testkollektion und neue Evaluationsmaße für die
anforderungsgerechte Qualitätsbeurteilung von Bildanalysesystemen.Performance assessment plays a major role in the research on Information
Retrieval (IR) systems. Starting with the Cranfield experiments in the
early 60ies, methodologies for the system-based performance assessment
emerged and established themselves, resulting in an active research field
with a number of successful benchmarking activities. With the rise of the
digital age, procedures of text retrieval evaluation were often transferred
to multimedia retrieval evaluation without questioning their direct
applicability. This thesis investigates the problem of system-based
performance assessment of annotation approaches in generic image
collections. It addresses three important parts of annotation evaluation,
namely user requirements for the retrieval of annotated visual media,
performance measures for multi-label evaluation, and visual test
collections. Using the example of multi-label image annotation evaluation,
I discuss which concepts to employ for indexing, how to obtain a reliable
ground truth to moderate costs, and which evaluation measures are
appropriate. This is accompanied by a thorough analysis of related work on
system-based performance assessment in Visual Information Retrieval (VIR).
Traditional performance measures are classified into four dimensions and
investigated according to their appropriateness for visual annotation
evaluation. One of the main ideas in this thesis adheres to the common
assumption on the binary nature of the score prediction dimension in
annotation evaluation. However, the predicted concepts and the set of true
indexed concepts interrelate with each other. This work will show how to
utilise these semantic relationships for a fine-grained evaluation
scenario. Outcomes of this thesis result in a user model for concept-based
image retrieval, a fully assessed image annotation test collection, and a
number of novel performance measures for image annotation evaluation
Evaluation Methodologies for Visual Information Retrieval and Annotation
Die automatisierte Evaluation von Informations-Retrieval-Systemen erlaubt
Performanz und Qualität der Informationsgewinnung zu bewerten. Bereits in
den 60er Jahren wurden erste Methodologien für die system-basierte
Evaluation aufgestellt und in den Cranfield Experimenten überprüft.
Heutzutage gehören Evaluation, Test und Qualitätsbewertung zu einem aktiven
Forschungsfeld mit erfolgreichen Evaluationskampagnen und etablierten
Methoden. Evaluationsmethoden fanden zunächst in der Bewertung von
Textanalyse-Systemen Anwendung. Mit dem rasanten Voranschreiten der
Digitalisierung wurden diese Methoden sukzessive auf die Evaluation von
Multimediaanalyse-Systeme übertragen. Dies geschah häufig, ohne die
Evaluationsmethoden in Frage zu stellen oder sie an die veränderten
Gegebenheiten der Multimediaanalyse anzupassen. Diese Arbeit beschäftigt
sich mit der system-basierten Evaluation von Indizierungssystemen für
Bildkollektionen. Sie adressiert drei Problemstellungen der Evaluation von
Annotationen: Nutzeranforderungen für das Suchen und Verschlagworten von
Bildern, Evaluationsmaße für die Qualitätsbewertung von
Indizierungssystemen und Anforderungen an die Erstellung visueller
Testkollektionen. Am Beispiel der Evaluation automatisierter
Photo-Annotationsverfahren werden relevante Konzepte mit Bezug zu
Nutzeranforderungen diskutiert, Möglichkeiten zur Erstellung einer
zuverlässigen Ground Truth bei geringem Kosten- und Zeitaufwand vorgestellt
und Evaluationsmaße zur Qualitätsbewertung eingeführt, analysiert und
experimentell verglichen. Traditionelle Maße zur Ermittlung der Performanz
werden in vier Dimensionen klassifiziert. Evaluationsmaße vergeben
üblicherweise binäre Kosten für korrekte und falsche Annotationen. Diese
Annahme steht im Widerspruch zu der Natur von Bildkonzepten. Das gemeinsame
Auftreten von Bildkonzepten bestimmt ihren semantischen Zusammenhang und
von daher sollten diese auch im Zusammenhang auf ihre Richtigkeit hin
überprüft werden. In dieser Arbeit wird aufgezeigt, wie semantische
Ähnlichkeiten visueller Konzepte automatisiert abgeschätzt und in den
Evaluationsprozess eingebracht werden können. Die Ergebnisse der Arbeit
inkludieren ein Nutzermodell für die konzeptbasierte Suche von Bildern,
eine vollständig bewertete Testkollektion und neue Evaluationsmaße für die
anforderungsgerechte Qualitätsbeurteilung von Bildanalysesystemen.Performance assessment plays a major role in the research on Information
Retrieval (IR) systems. Starting with the Cranfield experiments in the
early 60ies, methodologies for the system-based performance assessment
emerged and established themselves, resulting in an active research field
with a number of successful benchmarking activities. With the rise of the
digital age, procedures of text retrieval evaluation were often transferred
to multimedia retrieval evaluation without questioning their direct
applicability. This thesis investigates the problem of system-based
performance assessment of annotation approaches in generic image
collections. It addresses three important parts of annotation evaluation,
namely user requirements for the retrieval of annotated visual media,
performance measures for multi-label evaluation, and visual test
collections. Using the example of multi-label image annotation evaluation,
I discuss which concepts to employ for indexing, how to obtain a reliable
ground truth to moderate costs, and which evaluation measures are
appropriate. This is accompanied by a thorough analysis of related work on
system-based performance assessment in Visual Information Retrieval (VIR).
Traditional performance measures are classified into four dimensions and
investigated according to their appropriateness for visual annotation
evaluation. One of the main ideas in this thesis adheres to the common
assumption on the binary nature of the score prediction dimension in
annotation evaluation. However, the predicted concepts and the set of true
indexed concepts interrelate with each other. This work will show how to
utilise these semantic relationships for a fine-grained evaluation
scenario. Outcomes of this thesis result in a user model for concept-based
image retrieval, a fully assessed image annotation test collection, and a
number of novel performance measures for image annotation evaluation
How reliable are annotations via crowdsourcing? a study about inter-annotator agreement for multi-label image annotation
The creation of golden standard datasets is a costly business. Optimally more than one judgment per document is obtained to ensure a high quality on annotations. In this context, we explore how much annotations from experts differ from each other, how different sets of annotations influence the ranking of systems and if these annotations can be obtained with a crowdsourcing approach. This study is applied to annotations of images with multiple concepts. A subset of the images employed in the latest ImageCLEF Photo Annotation competition was manually annotated by expert annotators and non-experts with Mechanical Turk. The inter-annotator agreement is computed at an image-based and concept-based level using majority vote, accuracy and kappa statistics. Further, the Kendall τ and Kolmogorov-Smirnov correlation test is used to compare the ranking of systems regarding different ground-truths and different evaluation measures in a benchmark scenario. Results show that while the agreement between experts and non-experts varies depending on the measure used, its influence on the ranked lists of the systems is rather small. To sum up, the majority vote applied to generate one annotation set out of several opinions, is able to filter noisy judgments of non-experts to some extent. The resulting annotation set is of comparable quality to the annotations of experts
A sensitivity based optimization approach for aeroacoustic problems
This paper proposes an approach for the sensitivity computation of an aeroacoustic
problem via the solution of the continuous sensitivity equations. The equations are
derived by differentiating the coupled system (Navier-Stokes equations and the linearized
Euler equations) with respect to design parameters. The obtained acoustic sensitivity information
can be used to analyze the flow control variable’s influence on the acoustic field
or to calculate the gradient of an objective functional within aeroacoustic optimization
problems. The components of the coupled sensitivity solver are systematically verified
Developing and analysing a curriculum map in Occupational- and Environmental Medicine
Background: During the last 5 years a fundamental curriculum reform was realized at the medical school of the Ludwig Maximilians University. In contrast to those efforts, the learning objectives were not defined consistently for the curriculum and important questions concerning the curriculum could not be answered. This also applied to Occupational and Environmental Medicine where teachers of both courses were faced with additional problems such as the low number of students attending the lectures. The aims of the study were to develop and analyse a curriculum map for Occupational and Environmental Medicine based on learning objectives using a web-based database. Furthermore we aimed to evaluate student perception about the curricular structure. Methods: Using a web-based learning objectives database, a curriculum map for Occupational and Environmental Medicine was developed and analysed. Additionally online evaluations of students for each course were conducted. Results: The results show a discrepancy between the taught and the assessed curriculum. For both curricula, we identified that several learning objectives were not covered in the curriculum. There were overlaps with other content domains and redundancies within both curricula. 53% of the students in Occupational Medicine and 43% in Environmental Medicine stated that there is a lack of information regarding the learning objectives of the curriculum. Conclusions: The results of the curriculum mapping and the poor evaluation results for the courses suggest a need for re-structuring both curricula
Conception and pilot testing of a self-management health application for patients with pollen-related allergic rhinitis and allergic asthma-the APOLLO app
Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores
[Background]: Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome-wide significant risk loci, which explain less than 40% of nsCL/P heritability. Studies show that some of the hidden heritability is explained by rare penetrant variants.
[Methods]: To identify new candidate genes, we searched for highly penetrant de novo variants (DNVs) in 50 nsCL/P patient/parent-trios with a low polygenic risk for the phenotype (discovery). We prioritized DNV-carrying candidate genes from the discovery for resequencing in independent cohorts of 1010 nsCL/P patients of diverse ethnicities and 1574 population-matched controls (replication). Segregation analyses and rare variant association in the replication cohort, in combination with additional data (genome-wide association data, expression, protein–protein-interactions), were used for final prioritization.
[Conclusion]: In the discovery step, 60 DNVs were identified in 60 genes, including a variant in the established nsCL/P risk gene CDH1. Re-sequencing of 32 prioritized genes led to the identification of 373 rare, likely pathogenic variants. Finally, MDN1 and PAXIP1 were prioritized as top candidates. Our findings demonstrate that DNV detection, including polygenic risk score analysis, is a powerful tool for identifying nsCL/P candidate genes, which can also be applied to other multifactorial congenital malformations.The present study was supported by the German Research Foundation (DFG)-Grants BE 3828/8-1, LU 1944/2-1, MA 2546/5-1, and LU1944/3-1
Quantification of ETS exposure in hospitality workers who have never smoked
<p>Abstract</p> <p>Background</p> <p>Environmental Tobacco Smoke (ETS) was classified as human carcinogen (K1) by the German Research Council in 1998. According to epidemiological studies, the relative risk especially for lung cancer might be twice as high in persons who have never smoked but who are in the highest exposure category, for example hospitality workers. In order to implement these results in the German regulations on occupational illnesses, a valid method is needed to retrospectively assess the cumulative ETS exposure in the hospitality environment.</p> <p>Methods</p> <p>A literature-based review was carried out to locate a method that can be used for the German hospitality sector. Studies assessing ETS exposure using biological markers (for example urinary cotinine, DNA adducts) or questionnaires were excluded. Biological markers are not considered relevant as they assess exposure only over the last hours, weeks or months. Self-reported exposure based on questionnaires also does not seem adequate for medico-legal purposes. Therefore, retrospective exposure assessment should be based on mathematical models to approximate past exposure.</p> <p>Results</p> <p>For this purpose a validated model developed by Repace and Lowrey was considered appropriate. It offers the possibility of retrospectively assessing exposure with existing parameters (such as environmental dimensions, average number of smokers, ventilation characteristics and duration of exposure). The relative risk of lung cancer can then be estimated based on the individual cumulative exposure of the worker.</p> <p>Conclusion</p> <p>In conclusion, having adapted it to the German hospitality sector, an existing mathematical model appears to be capable of approximating the cumulative exposure. However, the level of uncertainty of these approximations has to be taken into account, especially for diseases with a long latency period such as lung cancer.</p
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
- …