Reflections on management's search for the Holy Grail: if it's not reengineering, what is it?

Text of an address given at the Annual Meeting of the Associated Drug and Chemical Industries of Missouri, April 29, 1997

An Exploratory Study of the Effects of Humor on Depression and Hopelessness of Incarcerated Males

The objective of this research was to explore the effects of humor, in the form of video-tapes of stand-up comedy performances, on the levels of depression and hopelessness of incarcerated males. The major finding was a significant decrease in baseline levels of depression and of hopelessness, as serially measured by the Beck Depression Inventory and Hopelessness Scale. The level of significance was p<.05. The total population of fifty males housed in a medium-sized detention center in Baltimore County, Maryland were placed in one of two treatment groups designated as the Aggressive-Humor (A-H) and the Non- Aggressive Humor (N-A H) Groups. Each group had twenty five members; subjects in the A-H Group saw two comedy tapes, one by Eddie Murphy and one by Richard Pryor. The N-A H Group members viewed a tape by Bill Cosby and one by Whoopi Goldberg. Although both groups appeared to be rather homogenous, the data revealed a substantial difference in the response to the comedy tapes: on average, subjects in the A-H Group laughed approximately twice the total recorded for the N-A H Group. Notwithstanding, the Cosby and Goldberg tapes significantly decreased the depression and hopelessness of the subjects in the N-A H Group. The responsibilities of the correctional system are broad and diverse. With crime on the rise, its obligations from either a detention or rehabilitation perspective will continue to grow. Correctional centers are charged with expanded control in monitoring behaviors of the incarcerated in groups as well as individually; the over-representation of the mentally ill who are incarcerated extends this responsibility to safe environment. By necessity, part of this goal is to decrease depression and feelings of hopelessness so prevalent among inmates. Humor emerged as an effective conduit for this objective

Rethinking place and the social work office in the delivery of children's social work services

Limited attention has been given to the concept of place in social work research and practice. This paper draws on the national evaluation of social work practices (SWPs) in England undertaken between 2009 and 2012. SWPs were pilot organisations providing independent social work services for children in out-of-home care in five sites. One factor distinguishing some of these pilots was their attention to place. The evaluation employed a mixed methods approach and we use data from interviews with 121 children and young people in out-of-home care, 19 birth parents and 31 interviews with SWP staff which explored their views and experiences of the SWP offices. Children and young people were alert to the stigma which could attach to social work premises and appreciated offices which were planned and furnished to appear less institutional and more ‘normal’. Daily interactions with staff which conveyed a sense of recognition and value to service users also contributed to a view of some SWP offices as accessible and welcoming places. Both children and parents appreciated offices that provided fun activities that positioned them as active rather than passive. Staff valued opportunities for influencing planning decisions about offices and place was seen to confer a value on them as well as on service users. However, not all the SWPs were able to achieve these aspects of place, and engaging children and families in place was less likely when the service user population was widely dispersed. Recognising the importance of place and how place is constructed through relationships between people as well as through the physical environment appeared to be key to creating offices that combated the stigma attached to out-of-home care. Those leading and managing children’s services should explore ways of involving local communities in planning social work offices and turn attention to making these offices accessible, welcoming, places

Suicidal students' use of and attitudes to primary care prevention services

Aim The aims of this study were to improve responses to students in distress and who are feeling suicidal, to help practitioners to increase their responsiveness to those at high risk of suicide and to develop effective responses to those affected by their deaths. The study sought to build a detailed picture of students’ patterns of service use. Background National suicide prevention strategies emphasise that suicide prevention requires the collaboration of a wide range of organisations. Among these, primary care services play a key role in relation to suicide prevention for young people in crisis. Methods This study, undertaken between 2004 and 2007, focused on 20 case studies of student suicide that took place in the United Kingdom between May 2000 and June 2005. It adopted a psychological autopsy approach to learn from a wide range of informants, including parents, friends, university staff and the records of coroners or procurator fiscals. Twenty families gave permission for their son’s or daughter’s death to be included in the study and agreed to participate in the study. Informants were interviewed in person and the data were analysed thematically. Analysis of the case study data suggested that in a number of cases students had failed to engage with services sufficiently early or in sufficient depth. Primary care practitioners need to be proactive in communicating concerns about vulnerable students to student support services. At local levels, collaboration between student support and National Health Service practitioners varied considerably and channels of communication need to be developed

Evidence for a mass-dependent AGN Eddington ratio distribution via the flat relationship between SFR and AGN luminosity

The lack of a strong correlation between AGN X-ray luminosity (L X ; a proxy for AGN power) and the star formation rate (SFR) of their host galaxies has recently been attributed to stochastic AGNvariability. Studies using population synthesis models have incorporated this by assuming a broad, universal (i.e. does not depend on the host galaxy properties) probability distribution for AGN specific X-ray luminosities (i.e. the ratio of L X to host stellar mass; a common proxy for Eddington ratio). However, recent studies have demonstrated that this universal Eddington ratio distribution fails to reproduce the observed X-ray luminosity functions beyond z ~ 1.2. Furthermore, empirical studies have recently shown that the Eddington ratio distribution may instead depend upon host galaxy properties, such as SFR and/or stellarmass. To investigate this further, we develop a population synthesis model in which the Eddington ratio distribution is different for star-forming and quiescent host galaxies. We showthat, although this model is able to reproduce the observed X-ray luminosity functions out to z ~ 2, it fails to simultaneously reproduce the observed flat relationship between SFR and X-ray luminosity. We can solve this, however, by incorporating a mass dependency in the AGN Eddington ratio distribution for starforming host galaxies. Overall, our models indicate that a relative suppression of low Eddington ratios (λ Edd < ~0.1) in lower mass galaxies (M * < ~10 10-11 M⊙) is required to reproduce both the observed X-ray luminosity functions and the observed flat SFR/X-ray relationship

The Quantity Theory of Money is Valid. The New Keynesians are Wrong!

We test the quantity theory of money (QTM) using a novel approach and a large new sample. We do not follow the usual approach of first differentiating the logarithm of the Cambridge equation to obtain an equation relating the growth rate of real GDP, the growth rate of money and inflation. These variables must then again be ‘integrated’ by averaging in order to obtain stable relationships. Instead we suggest a much simpler procedure for testing directly the stability of the coefficient of the Cambridge equation. For 125 countries and post-war data we find the coefficient to be surprisingly stable. We do not select for high inflation episodes as was done in most empirical studies; inflation rates do not even appear in our data set. Much work supporting the QTM has been done by economic historians and at the University of Chicago by Milton Friedman and his associates. The QTM was a foundation stone of the monetarist revolution. Subsequently belief in it waned. The currently dominant New Keynesian School, implicitly or explicitly denies the validity of the QTM. We survey this history and argue that the QTM is valid and New Keynesians are wrong

Multiple Folding Pathways of the SH3 domain

Experimental observations suggest that proteins follow different pathways under different environmental conditions. We perform molecular dynamics simulations of a model of the SH3 domain over a broad range of temperatures, and identify distinct pathways in the folding transition. We determine the kinetic partition temperature --the temperature for which the SH3 domain undergoes a rapid folding transition with minimal kinetic barriers-- and observe that below this temperature the model protein may undergo a folding transition via multiple folding pathways. The folding kinetics is characterized by slow and fast pathways and the presence of only one or two intermediates. Our findings suggest the hypothesis that the SH3 domain, a protein for which only two-state folding kinetics was observed in previous experiments, may exhibit intermediates states under extreme experimental conditions, such as very low temperatures. A very recent report (Viguera et al., Proc. Natl. Acad. Sci. USA, 100:5730--5735, 2003) of an intermediate in the folding transition of the Bergerac mutant of the alpha-spectrin SH3 domain protein supports this hypothesis.Comment: 16 pages, 4 figures To be published in the "Journal of Molecular Biology

Visualization of the <i>Serratia </i>type VI secretion system reveals unprovoked attacks and dynamic assembly

SummaryThe Type VI secretion system (T6SS) is a bacterial nanomachine that fires toxic proteins into target cells. Deployment of the T6SS represents an efficient and widespread means by which bacteria attack competitors or interact with host organisms and may be triggered by contact from an attacking neighbor cell as a defensive strategy. Here, we use the opportunist pathogen Serratia marcescens and functional fluorescent fusions of key components of the T6SS to observe different subassemblies of the machinery simultaneously and on multiple timescales in vivo. We report that the localization and dynamic behavior of each of the components examined is distinct, revealing a multi-stage and dynamic assembly process for the T6SS machinery. We also show that the T6SS can assemble and fire without needing a cell contact trigger, defining an aggressive strategy that broadens target range and suggesting that activation of the T6SS is tailored to survival in specific niches