College Student Development within the Context of Formalized Sport in American Higher Education

Those providing and managing sport in primary, secondary and post-secondary educational settings must be cognizant of the need for sport programs to enhance, rather than detract from, the educational environment. American post-secondary education provides an important context for inquiry in sport for two primary reasons. First, college enrollment marks a significant period of transition for individuals who are at a developmentally impressionable stage of their lives. Second, roughly 80% of all college students participate in some form of physical activity during their time on a college or university campus, with roughly half of them participating in formal sport. Two bodies of literature provide guidance for sport managers in US higher education: 1) sport development theory and 2) student development theory. This paper aims to provide a road map to facilitate the conversation between these two bodies of theory to unpack the potential contribution of sport to the individual development of sport participants at American colleges and universities. &nbsp

Fan Ties and Friendships: A Longitudinal Network Study of Division III Sports on Campus

The purpose of this longitudinal actor-based network study is to examine the evolution of sport fan ties and friendship ties on Division III campuses. Using two years of network data from a cohort of new students at a Division III institution, a SIENA model is developed to empirically test the co-evolution of fan ties and friendship ties. Grounded in student development, sport consumer behavior, and network theories, the overarching goal of this study is to explore the causal effect of fan ties on friendship ties among new students. To ascertain the value of Division III sports on campus, the authors explore the role of sports on campus in promoting friendships for new students based on the strong theoretical tradition from student development highlighting the salience of peer relationship in student success and retention. Accordingly, theoretical implications related to sport fan networks are considered within practical discussion of Division III sports and retention

Prevalence of Gestational Diabetes in Triplet Pregnancies: A Retrospective Cohort Study and Meta-Analysis

Background: Over the last decades, there has been a substantial increase in the incidence of higher-order multiple gestations. Twin pregnancies are associated with an increased risk of gestational diabetes mellitus (GDM). The literature on GDM rates in triplet pregnancies is scarce. Methods: A retrospective cohort study was performed to assess the prevalence of GDM in women with a triplet pregnancy. GDM was defined through an abnormal oral glucose tolerance test (OGTT). A meta-analysis of GDM prevalence was also carried out. Results: A cohort of 60 women was included in the analysis. Of these, 19 (31.7%) were diagnosed with GDM. There were no differences in pregnancy outcomes between women with and without GDM. In the meta-analysis of 12 studies, which used a sound GDM definition, an estimated pooled prevalence of 12.4% (95% confidence interval: 6.9–19.1%) was found. In a leave-one-out sensitivity analysis, the estimated GDM prevalence ranged from 10.7% to 14.1%. Conclusion: The rate of GDM seems increased in women with triplets compared to singleton pregnancies. However, GDM did not impact short-term pregnancy outcomes

Does anti-Mullerian hormone predict the outcome of further pregnancies in idiopathic recurrent miscarriage? : A retrospective cohort study

Purpose To evaluate whether anti-Mullerian hormone, basal follicle-stimulating hormone, luteinizing hormone, estradiol, and female age would predict future outcomes in women with idiopathic recurrent miscarriage. Methods One hundred and sixteen women with idiopathic recurrent miscarriage were retrospectively included. Luteal support with or without a combined treatment regimen for idiopathic recurrent miscarriage was applied in a tertiary-care center in Vienna. Occurrence and outcome of further pregnancies were analyzed. Results Within a median follow-up duration of 42.3 months, 94 women (81.0%) achieved one or more pregnancies. Further miscarriages occurred in 47 patients in whom only a higher number of previous miscarriages was predictive (OR 3.568, 95% CI 1.4578.738; p=0.005). Fifty-seven women had a live birth >23+0 gestational weeks. In a multivariate analysis, age (OR 0.920, 95% CI 0.8590.986; p=0.019) and the number of previous miscarriages (OR 0.403, 95% CI 0.1930.841; p=0.016), but not AMH (OR 1.191, 95% CI 0.9721.461; p=0.091) were significantly predictive. Conclusion AMH seems of either no or only minor relevance for the prediction of further miscarriages and live birth in women with idiopathic recurrent miscarriage.(VLID)363267

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

TDP-43 is an RNA/DNA-binding protein implicated in transcriptional repression and mRNA processing. Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis. Besides aggregation of TDP-43, loss of nuclear localization is observed in disease. To identify relevant targets of TDP-43, we performed expression profiling. Thereby, histone deacetylase 6 (HDAC6) downregulation was discovered on TDP-43 silencing and confirmed at the mRNA and protein level in human embryonic kidney HEK293E and neuronal SH-SY5Y cells. This was accompanied by accumulation of the major HDAC6 substrate, acetyl-tubulin. HDAC6 levels were restored by re-expression of TDP-43, dependent on RNA binding and the C-terminal protein interaction domains. Moreover, TDP-43 bound specifically to HDAC6 mRNA arguing for a direct functional interaction. Importantly, in vivo validation in TDP-43 knockout Drosophila melanogaster confirmed the specific downregulation of HDAC6. HDAC6 is necessary for protein aggregate formation and degradation. Indeed, HDAC6-dependent reduction of cellular aggregate formation and increased cytotoxicity of polyQ-expanded ataxin-3 were found in TDP-43 silenced cells. In conclusion, loss of functional TDP-43 causes HDAC6 downregulation and might thereby contribute to pathogenesis

A comparison of syringe disposal practices among injection drug users in a city with versus a city without needle and syringe programs

BACKGROUND: The United States (U.S.) approved use of federal funds for needle and syringe programs (NSPs) in December 2009. This study compares syringe disposal practices in a U.S. city with NSPs to a U.S. city without NSPs by examining the prevalence of improperly discarded syringes in public places and the self-reported syringe disposal practices of injection drug users (IDUs) in the two cities. METHODS: We conducted visual inspection walkthroughs in a random sample of the top-quartile of drug-affected neighborhoods in San Francisco, California (a city with NSPs) and Miami, Florida (a city without NSPs). We also conducted quantitative surveys of adult IDUs in San Francisco (N=602) and Miami (N=448). RESULTS: In the visual inspections, we found 44 syringes/1000 census blocks in San Francisco, and 371/1000 census blocks in Miami. Survey results showed that in San Francisco 13% of syringes IDUs reported using in the 30 days preceding the study interviews were disposed of improperly versus 95% of syringes by IDUs in Miami. In multivariable logistic regression analysis, IDUs in Miami had over 34 times the adjusted odds of public syringe disposal relative to IDUs in San Francisco (adjusted odds ratio=34.2, 95% CI = 21.92, 53.47). CONCLUSIONS: We found eight-fold more improperly disposed syringes on walkthroughs in the city without NSPs compared to the city with NSPs, which was corroborated by survey data. NSPs may help IDUs dispose of their syringes safely in cities with large numbers of IDUs

Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection

We examined interactions in a soluble tapasin (TPN)/HLA-B(*)0801 complex to gain mechanistic insights into the functions of TPN. Results show that TPN acts as a chaperone by increasing the ratio of active-to-inactive peptide-deficient HLA-B(*)0801 molecules in solution. TPN causes peptides to associate and dissociate faster owing to its effect on widening the binding groove of HLA-B(*)0801 molecules. Our data indicate that a TPN-assisted mechanism of peptide selection relies on disruption of conserved hydrogen bonds at the C-terminal end of the groove. Peptide sequence-dependent interactions along the entire length of the groove also play a role in this mechanism. We suggest that TPN influences presentation of antigenic peptides according to a mechanistically complicated process in which bound candidate peptides that are unable to conformationally disengage TPN from class I molecules are excluded from the repertoire. Overall, these studies unify our understanding of the functions of TPN