Evidências atuais acerca da terapia medicamentosa com Trastuzumab Deruxtecan em mulheres com Câncer de Mama Her2+: uma revisão de literatura: Current evidence on drug therapy with Trastuzumab Deruxtecan in women with Her2+ Breast Cancer: a literature review

Introdução: o câncer de mama foi a neoplasia mais incidente e de maior mortalidade em mulheres no Brasil em 2020, sendo o subtipo com fator de crescimento epidérmico humano 2 (HER-2) relacionado a um alto índice de recaída e morte por metástase da doença. Nenhum tratamento padrão foi definido até o momento após terapia com trastuzumab e emtansine (TDM1). Contudo, novos estudos e análises avaliam novas opções terapêuticas que podem levar a mudanças no tratamento atual preconizado. É o caso da medicação Trastuzumabe Deruxtecan (DS-8201). Metodologia: foi realizada uma busca na plataforma PUBMED, no período entre 2017 a 2021, com as palavras chaves “trastuzumab and deruxtecan, breast câncer, her2” para elaboração de uma revisão de literatura acerca das evidências atuais da terapia medicamentosa com Trastuzumab Deruxtecan em mulheres com câncer de mama Her 2+. Resultados e Discussão: A medicação DS-8201 apresentou resultados positivos para esse tipo de neoplasia, tanto em sobrevida livre de progressão quanto em mediana de meses de resposta ao Trastuzumabe Deruxtecan. Além disso, essa nova opção terapêutica apresentou atividade anticâncer em tumores refratários ao TDM1. Por fim, nota-se a possível utilização dessa nova droga contra tumores HER 2- . Conclusão: O uso da medicação DS-8201 mostrou resultados animadores em pacientes com câncer da mama HER-2 avançado e previamente tratado, contudo, complicações e efeitos adversos desses novos estudos e tratamento existem e requerem atenção e manejo cuidadoso

Análise comparativa dos estilos de aprendizagem de docentes e acadêmicos de um curso de Medicina: Comparative analysis of the learning styles of teachers and academics from a medicine course

Introdução: A teoria experiencial desenvolvida por Kolb afirma que a construção do conhecimento decorre dos modos de apreensão e transformação da experiência, e, que a combinação desses modos origina quatro estilos: assimilador, divergente, convergente e acomodador. Portanto, o processo de aprendizado é individual. Apesar disso, os docentes o fazem de acordo com seu próprio estilo, acarretando em uma possível diminuição do aprendizado para os discentes. Assim sendo, faz-se necessária uma análise desses estilos.  Objetivo: Determinar os estilos de aprendizagem dos professores e acadêmicos de um curso de medicina e avaliar as possíveis diferenças. Método: Estudo transversal realizado por aplicação de questionário baseado no Inventário de Estilo de Aprendizagem de Kolb. As associações entre variáveis categóricas foram avaliadas pelo teste Qui-quadrado e a comparação de médias/medianas entre os grupos, pelo teste de Kruskal-Wallis com comparações múltiplas pelo teste de Nemenyi. As análises foram realizadas no software R versão 4.0.3 e considerado nível de significância de 5%. Resultados: Foram avaliados 183 participantes, sendo 61 docentes, 61 alunos do 1º ano e 61 alunos do 5º ou 6º ano. 116 participantes eram mulheres. A média de idade foi de 30,3 anos. O estilo de aprendizagem mais frequente foi o assimilador com 49,2%. Houve diferença significativa entre o estilo de aprendizagem dos docentes e alunos (1º ano: p<0,001 e 5º/6º ano: p=0,001). Conclusão: A diferença entre os estilos de docentes e alunos demonstra que a maneira de ensinar deve ser compatível com os acadêmicos. Com isso, será possível melhorar a qualidade do ensino

Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV

Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated $\mathrm{t}\overline{\mathrm{t}}$ events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)

Evidence for the Higgs boson decay to a bottom quark–antiquark pair

info:eu-repo/semantics/publishe

Particle-flow reconstruction and global event description with the CMS detector

The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic tau decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8 TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions

Search for heavy resonances decaying to a top quark and a bottom quark in the lepton+jets final state in proton–proton collisions at 13 TeV

info:eu-repo/semantics/publishe

Pseudorapidity and transverse momentum dependence of flow harmonics in pPb and PbPb collisions

info:eu-repo/semantics/publishe

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Electroweak production of two jets in association with a Z boson in proton-proton collisions root s =13 TeV

A measurement of the electroweak (EW) production of two jets in association with a Z boson in proton-proton collisions at root s = 13 TeV is presented, based on data recorded in 2016 by the CMS experiment at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lljj final state with l including electrons and muons, and the jets j corresponding to the quarks produced in the hard interaction. The measured cross section in a kinematic region defined by invariant masses m(ll) > 50 GeV, m(jj) > 120 GeV, and transverse momenta P-Tj > 25 GeV is sigma(EW) (lljj) = 534 +/- 20 (stat) fb (syst) fb, in agreement with leading-order standard model predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. No evidence is found and limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are -2.6 <cwww/Lambda(2) <2.6 TeV-2 and -8.4 <cw/Lambda(2) <10.1 TeV-2. The additional jet activity of events in a signal-enriched region is also studied, and the measurements are in agreement with predictions.Peer reviewe