102 research outputs found
LED Lighting: Carbon Footprint Reduction and Energy Cost Savings at Prince George's County Parks and Recreational Facilities
Final project for ENSP400: Capstone Environmental Science and Policy (Fall 2021). University of Maryland, College Park.Through their work with the National Center for Smart Growth at the University of Maryland (UMD), the Maryland Department of Natural Resources (MDNR) commissioned this report from the university’s Partnership for Action Learning in Sustainability (PALS). PALS works with local jurisdictions throughout Maryland to identify projects and problems that can be taught through university courses where students focus on developing innovative, research-based solutions. The Prince George's Division of Maintenance and Development partnered with Environmental Science and Policy capstone students at the University of Maryland College Park to examine the cost and energy savings when LED lighting, and other energy-saving devices, are used at park system facilities. The facilities analysis allowed Prince George’s County Department of Parks and Recreation to uphold the values of a healthy lifestyle while still providing enriching leisure services.Prince George's County Department of Parks and Recreation (PGDPR
Kapsula
Selections from the 2015 Conference of the Contemporary Art, Design and New Media Art Histories Masters Progra
Kapsula
Selections from the 2015 Conference of the Contemporary Art, Design and New Media Art Histories Masters Progra
SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likely to uncover genetic factors that influence progression of disease. An alternative approach to identifying genetic risk for AD is the use of quantitative traits or endophenotypes. The use of endophenotypes has proven to be an effective strategy, implicating genetic risk factors in several diseases, including anemia, osteoporosis and heart disease. In this study we identify a genetic factor associated with the rate of decline in AD patients and present a methodology for identification of other such factors. We have used an established biomarker for AD, cerebrospinal fluid (CSF) tau phosphorylated at threonine 181 (ptau181) levels as an endophenotype for AD, identifying a SNP, rs1868402, in the gene encoding the regulatory sub-unit of protein phosphatase B, associated with CSF ptau181 levels in two independent CSF series . We show no association of rs1868402 with risk for AD or age at onset, but detected a very significant association with rate of progression of disease that is consistent in two independent series . Our analyses suggest that genetic variants associated with CSF ptau181 levels may have a greater impact on rate of progression, while genetic variants such as APOE4, that are associated with CSF Aβ42 levels influence risk and onset but not the rate of progression. Our results also suggest that drugs that inhibit or decrease tau phosphorylation may slow cognitive decline in individuals with very mild dementia or delay the appearance of memory problems in elderly individuals with low CSF Aβ42 levels. Finally, we believe genome-wide association studies of CSF tau/ptau181 levels should identify novel genetic variants which will likely influence rate of progression of AD
New genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
The Challenge of Evaluating Charter Schools: The Case of KIPP Charter Schools in North Carolina
This paper examines the success of the two KIPP charter schools in North Carolina that have been significantly more successful at raising minority test scores than most other charter schools in North Carolina. This paper asserts that parents with a higher degree of educational social capital are more likely to have children who make high scores on standardized tests. Using survey research this paper does not find significant evidence that parents at KIPP schools have a higher degree of social capital than the traditional public school surveyed
The Syntax of the EPP in Irish
In this paper, I will provide a detailed analysis of the EPP, a principle of theoretical syntax, in Modern Irish. I will document previous scholarship on this issue to give a comprehensive view of ways of reconciling the syntax with the language data, as language data is key to testing theoretical predictions. I will also provide my own model incorporating the EPP into Irish. First, I will provide necessary information about the background and development of the EPP and the Minimalist system in syntax, as well as a discussion of the Irish language and the features which make it relevant to the study of the EPP. Then, I will present the models of Irish and the considerations of the EPP which have shaped and influenced my own. These models include both instances of altering the definition of the EPP to increase its universal application and of adapting models of VSO languages to fit the prevailing definition of the EPP. Lastly, I will detail my own model for Irish sentence structure, which suggests an alternate subject position in the syntax which would allow for the EPP to adapt to fit VSO word order. An analysis of passive and the unaccusative constructions, as well as support from contemporary syntactic theory, will support this model. To complete my consideration of Irish and the EPP, I will also provide a discussion of whether of not pleonastic pronouns function in Irish and how they would be accounted for in my model
Identity Processes and Perceptions of the Attainment of Adulthood: A Model for Investigation
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