61 research outputs found
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Redox-triggered buoyancy and size modulation of a dynamic covalent gel
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 24/04/2019
- Field of study
The development of stimuli-responsive materials capable of transducing external stimuli into mechanical and physical changes has always been an intriguing challenge and an inspiration for scientists. Several stimuli-responsive gels have been developed and applied to biomimetic actuators or artificial muscles. Redox active actuators in which the mechanical motion is driven chemically or electrochemically have attracted much interest and their actuation mechanism is based on the change in electrostatic repulsion and the loss or gain of counterions to balance newly formed charges. Actuation can also be promoted by changing the hydration state of the material leading to the release/adsorption of water molecules from the network, inducing a direct shrinking/swelling of the material respectively. A cationic crystalline dynamic covalent gel was obtained via the formation of imine bonds between 2,6-diformyl pyridine and triamino guanidinium chloride. The gel exhibits a reversible contraction/expansion behavior in response to base (oxidation, âH+, âeâ) and acid (reduction +H+, +eâ) respectively. The oxidation induces a color change and contraction of the gel with a concomitant increase in its strength. As synthesized, the cationic gel is denser than water and sinks when placed in water. Upon oxidation, the radical cationic gel expels water molecules rendering it less dense than water and the gel is propelled to the surface without any loss of its structural integrity. These results demonstrate that a careful choice of amine and aldehyde linkers can give rise to imine-linked materials capable of tolerating and resisting extreme acidic and basic conditions while performing work
Mutation screening of patients with Alzheimer disease identifies APP locus duplication in a Swedish patient
- Author
- A Goate
- A Lleo
- A Rovelet-Lecrux
- A Rovelet-Lecrux
- B Rumble
- C Forsell
- C Forsell
- C Nilsberth
- C Zekanowski
- Caroline Graff
- D Arango
- D Avramopoulos
- D McNaughton
- D Shinde
- E Levy-Lahad
- ES Blom
- G Raux
- GG Glenner
- HĂĽkan Thonberg
- I Guyant-Marechal
- Inger Nennesmo
- Jacqueline Schoumans
- Jenny BjĂśrkstrĂśm
- K Kasuga
- K Sleegers
- L Cabrejo
- L Keller
- M Mullan
- Marie FallstrĂśm
- R Clark
- R Sherrington
- RJ Ellis
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
BACKGROUND: Missense mutations in three different genes encoding amyloid-β precursor protein, presenilin 1 and presenilin 2 are recognized to cause familial early-onset Alzheimer disease. Also duplications of the amyloid precursor protein gene have been shown to cause the disease. At the Dept. of Geriatric Medicine, Karolinska University Hospital, Sweden, patients are referred for mutation screening for the identification of nucleotide variations and for determining copy-number of the APP locus.
METHODS: We combined the method of microsatellite marker genotyping with a quantitative real-time PCR analysis to detect duplications in patients with Alzheimer disease.
RESULTS: In 22 DNA samples from individuals diagnosed with clinical Alzheimer disease, we identified one patient carrying a duplication on chromosome 21 which included the APP locus. Further mapping of the chromosomal region by array-comparative genome hybridization showed that the duplication spanned a maximal region of 1.09 Mb.
CONCLUSIONS: This is the first report of an APP duplication in a Swedish Alzheimer patient and describes the use of quantitative real-time PCR as a tool for determining copy-number of the APP locus
Research trends in biomimetic medical materials for tissue engineering: commentary
- Author
- A Hurtado
- A Shekaran
- AJ Engler
- AJ Engler
- B Zhu
- CB Highley
- CD McCaig
- D Kai
- D Seliktar
- ES Place
- F Guilak
- G Shi
- GG Wallace
- H Ding
- H Onoe
- J He
- J Pelto
- JG Hardy
- JG Hardy
- JW Lee
- JY Lee
- JY Lee
- KM Park
- KM Park
- LK Povlich
- MC Cushing
- MK Nguyen
- MP Lutolf
- N Gomez
- N Huebsch
- NK Guimard
- RA Green
- S Han
- S Lv
- S Patel
- SH Lim
- SV Murphy
- TR Cox
- UP Shinde
- X Jiang
- YI Cho
- Z Ma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
- Baffioni S
- Bagby L
- Bagliesi G
- Bahk SY
- Bailleux D
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- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Baldin B
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- Xella S.
- Xie S
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- Zachariadou A
- Zalewski P
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- Zang SL
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- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
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- Zhukov V
- Zhukova V
- Ziebarth EB
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- Zilizi G
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines
- Author
- Adolfo GarcĂa-Sastre
- AE Fiore
- AJ Caton
- AL Vincent
- Balaji Manicassamy
- C Scholtissek
- C Scholtissek
- CC Dacso
- CF Basler
- Christopher F. Basler
- DE Wentworth
- DJ Sencer
- E Fodor
- Estanislao Nistal-VillĂĄn
- FS Dawood
- G Chowell
- G Neumann
- GF Rimmelzwaan
- GG Brownlee
- J Steel
- JC Gaydos
- JD Mathews
- JJ Skehel
- JK Taubenberger
- JS Peiris
- K Arnold
- K Hancock
- K Nakajima
- K Van Reeth
- KP Myers
- L Gillim-Ross
- L Hoyle
- LA Perrone
- M Enserink
- MH Bikour
- MH Bikour
- MI Nelson
- MR Sandbulte
- Muench Reed
- NJ Cox
- P Palese
- Peter Palese
- RA Bright
- Rafael A. Medina
- RB Belshe
- RG Webster
- RJ Garten
- Ron A. M. Fouchier
- Rong Hai
- SE Hensley
- Silke Stertz
- T Horimoto
- TM Tumpey
- TR Maines
- Tshidi Tsibane
- V Shinde
- VJ Munster
- WL DeLano
- X Yu
- Y Itoh
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The recent 2009 pandemic H1N1 virus infection in humans has resulted in nearly 5,000 deaths worldwide. Early epidemiological findings indicated a low level of infection in the older population (>65 years) with the pandemic virus, and a greater susceptibility in people younger than 35 years of age, a phenomenon correlated with the presence of cross-reactive immunity in the older population. It is unclear what virus(es) might be responsible for this apparent cross-protection against the 2009 pandemic H1N1 virus. We describe a mouse lethal challenge model for the 2009 pandemic H1N1 strain, used together with a panel of inactivated H1N1 virus vaccines and hemagglutinin (HA) monoclonal antibodies to dissect the possible humoral antigenic determinants of pre-existing immunity against this virus in the human population. By hemagglutinination inhibition (HI) assays and vaccination/challenge studies, we demonstrate that the 2009 pandemic H1N1 virus is antigenically similar to human H1N1 viruses that circulated from 1918â1943 and to classical swine H1N1 viruses. Antibodies elicited against 1918-like or classical swine H1N1 vaccines completely protect C57B/6 mice from lethal challenge with the influenza A/Netherlands/602/2009 virus isolate. In contrast, contemporary H1N1 vaccines afforded only partial protection. Passive immunization with cross-reactive monoclonal antibodies (mAbs) raised against either 1918 or A/California/04/2009 HA proteins offered full protection from death. Analysis of mAb antibody escape mutants, generated by selection of 2009 H1N1 virus with these mAbs, indicate that antigenic site Sa is one of the conserved cross-protective epitopes. Our findings in mice agree with serological data showing high prevalence of 2009 H1N1 cross-reactive antibodies only in the older population, indicating that prior infection with 1918-like viruses or vaccination against the 1976 swine H1N1 virus in the USA are likely to provide protection against the 2009 pandemic H1N1 virus. This data provides a mechanistic basis for the protection seen in the older population, and emphasizes a rationale for including vaccination of the younger, naĂŻve population. Our results also support the notion that pigs can act as an animal reservoir where influenza virus HAs become antigenically frozen for long periods of time, facilitating the generation of human pandemic viruses
Effects of biofertilizer containing N-fixer, P and K solubilizers and AM fungi on maize growth: A greenhouse trial.
- Author
- Adsul PB
- Affendy H
- Ahmad A
- Aiyelari OP
- Alagundagi SC
- Aminuddin M
- Amizi MA
- Assis K
- Attoe EE
- Azmy M
- Bagyalakshmi B
- Bahttacharyya R
- Bakker Pahm
- Balamurugan A
- Bhavalker US
- Bokhtiar SM
- Cao ZH
- Chaudhry AU
- Cheung KC
- Deshmukh AS
- Giri G
- Githiri SM
- Goletti F
- Gomez AA
- Gomez KA
- Gruhn P
- Gupta HS
- Hebsur NS
- Hossain A
- Islam MZ
- Ismail S
- Jayanthi R
- Jayathilake Pks
- Jisha MS
- Katyal JC
- Kirubi D
- Kishor P
- Kondapa-Naidu D
- Kundu S
- Lee KK
- Li ZG
- Linu MS
- Loon LC Van
- Maheswari J
- Majid MA
- Mansour Aem
- Mishra PK
- Morrissey JP
- Naseeb T
- Nawaz N
- Ngaboyisonga C
- Njoroge K
- Nwilene FE
- O'gara F
- Onasanya A
- Onasanya RO
- Oyelakin OO
- Pallavi RV
- Patil PL
- Paul GC
- Pieterse Cmj
- Ponmurugan P
- Prakash V
- Premkumar R
- Priya RS
- Radder BM
- Raha P
- Rahman Abmm
- Rahman MH
- Ramanjavenyulu AV
- Reddy IP
- Reddy KR
- Sangeetha SP
- Sarwar G
- Sarwar M
- Selvakumar G
- Shaaban EA
- Shah MJ
- Sharma PK
- Shinde GG
- Shivay YS
- Singh AP
- Singh CM
- Srihari D
- Stephen J
- Tamer AT
- Undie UL
- Uwah DF
- Verma R
- Walsh UF
- Wani SP
- Wong MH
- Wu SC
- Yassin Maged M.
- Yousaf M
- Yudelman M
- Publication venue
- orgz
- Publication date
- 01/01/2011
- Field of study
An in vitro study was undertaken to evaluate the compatibility of indigenous plant growth promoting rhizobacteria (PGPR) with commonly used inorganic and organic sources of fertilizers in tea plantations. The nitrogenous, phosphatic and potash fertilizers used for this study were urea, rock phosphate and muriate of potash, respectively. The organic sources of fertilizers neem cake, composted coir pith and vermicompost were also used. PGPRs such as nitrogen fixer; Azospirillum lipoferum, Phosphate Solubilizing Bacteria (PSB); Pseudomonas putida, Potassium Solubilizing Bacteria (KSB); Burkholderia cepacia and Pseudomonas putida were used for compatibility study. Results were indicated that PGPRs preferred the coir pith and they proved their higher colony establishment in the formulation except Azospirillum spp. that preferred vermicompost for their establishment. The optimum dose of neem cake powder
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
- Baffioni S
- Bagby L
- Bagliesi G
- Bahk SY
- Bailleux D
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Baldin B
- Ball AH
- Ball G
- Ballin J
- Bally SL
- Ban Y
- Bandurin D
- Banerjee S
- Banerjee S
- Banicz K
- Bansal S
- Banzuzi K
- Barashko V
- Barbagli G
- Barberis E
- Barbone L
- Barcala JM
- Barcellan L
- Bard R
- Bargassa P
- Baringer P
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Bartalini P
- Bartoloni A
- Bartz E
- Basegmez S
- Battilana C
- Baty C
- Baud A
- Bauer G
- Bauer J
- Bauerdick LAT
- Baur U
- Bawa HS
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaumont W
- Bechtel F
- Bedjidian M
- Bedoya CF
- Beetz CP
- Behrens U
- Bejar JC
- Belforte S
- Beliy N
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Benaglia A
- Bencze G
- Bendavid J
- Bender W
- Benedetti D
- Benelli G
- Benettoni M
- Beni N
- Benucci L
- Benussi L
- Benvenuti AC
- Berengueres JOL
- Beretvas A
- Bergauer H
- Bergauer T
- Beri SB
- Bernardini J
- Bernet C
- Berntzon L
- Berretta L
- Berry D
- Berry E
- Berryhill J
- Bertani M
- Bertl W
- Bertoldi M
- Berzano U
- Besancon M
- Besson A
- Betchart B
- Betev B
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Biallass P
- Bianchini L
- Bianco S
- Biasini M
- Biasotto M
- Biery K
- Biino C
- Bilei GM
- Bilki B
- Bilmis S
- Binkley M
- Bisello D
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- Blaha J
- Blekman F
- Bloch D
- Bloch I
- Bloch P
- Bloom K
- Bluj M
- Blum P
- Blumenfeld B
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- Boccali T
- Bocci A
- Bockelman B
- Bodek A
- Bodin D
- Boeriu O
- Boldini M
- Boldizsar L
- Bolla G
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- Bolton T
- Bona M
- Bonacorsi D
- Bonato A
- Bondar N
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- Boos E
- Borcherding F
- Borgia MA
- Bornheim A
- Borras K
- Borrello L
- Borsato E
- Bortoletto D
- Bos J
- Bose M
- Bose S
- Bose T
- Bosi F
- Bostock F
- Botta C
- Boudoul G
- Bouhali O
- Bourgeois N
- Bourilkov D
- Bourrel T
- Boutemeur M
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Brauer R
- Braunschweig W
- Breedon R
- Brett AM
- Breuker H
- Brew C
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- Briggs R
- Brigljevic V
- Broccolo G
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- Brown RM
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- Buege V
- Buehler M
- Bunin P
- Bunkowski K
- Bunn J
- Buontempo S
- Burkett K
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- Busson P
- Busza W
- Butler JN
- Butler PH
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- Butz E
- Bylsma B
- Caballero IG
- Cabrillo IJ
- Cafaro VD
- Cai J
- Caiazza SS
- Cakir A
- Calderon A
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- Calloni M
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- Calzolari F
- Camanzi B
- Caminada L
- Campagnari C
- Campbell A
- Campderros JD
- Campi D
- Camporesi T
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- Cano E
- Capiluppi P
- Caponeri B
- Cardaci M
- Carleton M
- Carlin R
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- Carroll R
- Cartiglia N
- Carvalho W
- Case M
- Cassel D
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- Castellani L
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- Caudron J
- Cavallari F
- Cavallo FR
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- Cavanaugh R
- Ceballos GG
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
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- Aguilar Benitez M
- Ahmad M
- Ahmad WH
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- Ahmed W
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- Aisa S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
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- Albayrak EA
- Alberdi J
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- Alexander J
- Alidra M
- Aliev T
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- Almeida N
- Altenhofer G
- Altsybeev I
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- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
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- Andreev V
- Andreev Y
- Anghel IM
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- Anh T. Vu
- Anisimov A
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- Asghar MI
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- Askew A
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- Atramentov O
- Auffray E
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
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- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zeiher AM
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu H
- Zirlik A
- Zizka J
- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aimsâ The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisinâkexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (âĽ1.8âmmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and resultsâ Median follow-up was 2.8âyears. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (nâ=â2) or Type 5 (nâ=â5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77â0.95; Pâ=â0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77â0.99; Pâ=â0.032) and Type 2 (0.77, 0.61â0.97; Pâ=â0.025), but not Type 4 MI. Conclusionâ After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Commissioning of the CMS high-level trigger with cosmic rays
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
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