Crystal Spectroscopy for Kα X-rays from Silicon Bombarded with Protons and Alpha Particles

An automated Bragg spectrometer in which an organic electron multiplier is employed as an X-ray detector has been designed, and the Kₐ diagram and satellite X-rays from silicon bombarded with hydrogen and helium ions at MeV energies have been analyzed. The procedures of deriving the ionization cross sections from the satellite intensities are described. The multiple KL" ionization cross sections are compared with the theoretical binomial distribution, which means a statistical superposition of single ionizations

Developing a sustainable institutional repository : a Keio University case study

DRFIC2008 Session 2. Repository SustainabilityDRFIC2008 セッション2:持続可能なリポジトリの展開を目指して 事例報告

A case of unilateral adrenal medullary hyperplasia.

We report a case of unilateral hyperplasia of the adrenal medulla. The patient showed clinical features suggestive of pheochromocytoma. Removal of the hyperplastic adrenal gland resulted in complete disappearance of all prior symptoms, decrease of the plasma and urinary catecolamine levels and no high uptake in [133I] metaiodobenzylguanidine scintigraphy. A histological study revealed diffuse hyperplasia of the adrenal medulla. Up to now, there are relatively few reports of adrenal medullary hyperplasia in English literatures.</p

Routine Transurethral Biopsy of the Bladder is not Necessary to Evaluate the Response to Bacillus Calmette-guerin Therapy

We evaluated the need for transurethral biopsy at first follow-up after intravesical bacillus Calmette-Guerin (BCG) therapy for superficial bladder cancer. The records of 84 patients with superficial bladder cancer who received a 6- or 8-week course of BCG were reviewed. Pathological results before BCG, cystoscopic findings, urinary cytology, and biopsy results for evaluation of BCG therapy were reviewed. All 19 patients with positive urinary cytology had evidence of positive bladder biopsy results. Fifty-three of 54 patients (98.1%) with no visible recurrent tumor and negative urinary cytology demonstrated negative pathological results on bladder biopsy. When not found in conjunction with positive urinary cytology, erythematous mucosa on cystoscopy was not an indicator of tumor recurrence or residual cancer. In conclusion, routine transurethral biopsy of the bladder for evaluating the response to BCG intravesical therapy is not necessary in patients who have no visible tumor on cystoscopy and negative urinary cytology./</p

Introduction to Digital Fujikawa –History of Medicine in Japan–

[The 2019 International Image Interoperability Framework (IIIF) Conference] 2019/06/24-28, Göttingen, GermanyThe Fujikawa collection is a collection of old medical books that had been collected by Dr. Yu Fujikawa (1865-1940). Books in the collection are stored in multiple institutions including Kyoto University, Keio University, and the University of Tokyo. This presentation describes our project “Digital Fujikawa –History of Medicine in Japan–”, which has been jointly launched by Kyoto University Library Network and Keio University Media Center. The project intends to contribute to the development of the research in the history of medicine in Japan by providing the comprehensive view of the Fujikawa Collection that has been physically distributed over different institutions. On September 28, 2018, we launched a website (http://www.kulib.kyoto-u.ac.jp/rdl/digital_fujikawa/en/) that virtually brings together the holdings of different institutions in one place using IIIF protocols. As of February 22, 2019, the website delivers 5, 333 titles from three institutions. In the presentation, we look back on different implementations that we examined during the development of the website. In addition, we report the influence of the project on usage statistics of titles. In the future, we increase digital images available and participating institutions and develop new functions, in order to progress this project from the current trial phase to a full-scale phase by the end of academic year 2020/2021. Acknowledgements: the digitization of the Fujikawa collections has been supported by the following projects: (1) Project to build an international collaborative research network for pre-modern Japanese texts (NIJL-NW project) by the National Institute of Japanese Literature, (2) Grants for functional enhancements by the Ministry of Education, Culture, Sports, Science and Technology, (3) Kyoto University Open Access Promotion Project, and (4) Keio University Media Center (ordinary expenses)

Protective Microbiota: From Localized to Long-Reaching Co-Immunity

Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance localized within a microenvironment. This review shows that the protection against pathogens also involves the mitigation of pathogenic impact without eliminating the pathogens (i.e., “disease tolerance”) and the containment of microorganisms to prevent pathogenic spread. Protective microorganisms can have an impact beyond their niche, interfering with the entry, establishment, growth, and spread of pathogenic microorganisms. More fundamentally, we propose a series of conceptual clarifications in support of the idea of a “co-immunity,” where an organism is protected by both its own immune system and components of its microbiota

Intrinsic Promoter Activities of Primary DNA Sequences in the Human Genome

In order to understand an overview of promoter activities intrinsic to primary DNA sequences in the human genome within a particular cell type, we carried out systematic quantitative luciferase assays of DNA fragments corresponding to putative promoters for 472 human genes which are expressed in HEK (human embryonic kidney epithelial) 293 cells. We observed the promoter activities of them were distributed in a bimodal manner; putative promoters belonging to the first group (with strong promoter activities) were designated as P1 and the latter (with weak promoter activities) as P2. The frequencies of the TATA-boxes, the CpG islands, and the overall G + C-contents were significantly different between these two populations, indicating there are two separate groups of promoters. Interestingly, similar analysis using 251 randomly isolated genomic DNA fragments showed that P2-type promoter occasionally occurs within the human genome. Furthermore, 35 DNA fragments corresponding to putative promoters of non-protein-coding transcripts (ncRNAs) shared similar features with the P2 in both promoter activities and sequence compositions. At least, a part of ncRNAs, which have been massively identified by full-length cDNA projects with no functional relevance inferred, may have originated from those sporadic promoter activities of primary DNA sequences inherent to the human genome