1,031 research outputs found

    The Abandoned Spouse: Alimony and Support Actions, and the Maryland Long Arm Statute

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    Confirmation of out-of-State Arbitration Awards under Maryland\u27s Uniform Arbitration Act

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    This Article examines the difficulties inherent in the confirmation of out-of-state arbitration awards under the Maryland Uniform Arbitration Act. The author recommends that either the General Assembly amend the Act to provide expressly for such confirmations in Maryland courts, or the courts, in the absence of such legislation, nevertheless should allow confirmation of such awards

    A Roadmap through Malice, Actual or Implied: Punitive Damages in Torts Arising out of Contract in Maryland

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    The distinction between tort and tort arising out of contract is becoming blurred where awards of punitive damages are sought. The article analyzes torts arising out of contract and the present approach of the Maryland courts to malice, the key element governing the recovery of punitive damages. The author suggests that the conduct, and not the technical term of the wrongful act, should dictate whether a plaintiff may recover punitive damages

    Confirmation of out-of-State Arbitration Awards under Maryland\u27s Uniform Arbitration Act

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    This Article examines the difficulties inherent in the confirmation of out-of-state arbitration awards under the Maryland Uniform Arbitration Act. The author recommends that either the General Assembly amend the Act to provide expressly for such confirmations in Maryland courts, or the courts, in the absence of such legislation, nevertheless should allow confirmation of such awards

    Length, Protein-Protein Interactions, and Complexity

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    The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger number of distinct interactions due to their greater average surface area. Annotated protein sequences available from the SWISS-PROT database were analyzed for thirteen eukaryotes, eight bacteria, and two archaea species. The number of subcellular locations to which each protein is associated is used as a measure of the number of interactions to which a protein participates. Two databases of yeast protein-protein interactions were used as another measure of the number of interactions to which each \emph{S. cerevisiae} protein participates. Protein length is shown to correlate with both number of subcellular locations to which a protein is associated and number of interactions as measured by yeast two-hybrid experiments. Protein length is also shown to correlate with the probability that the protein is encoded by an essential gene. Interestingly, average protein length and number of subcellular locations are not significantly different between all human proteins and protein targets of known, marketed drugs. Increased protein length appears to be a significant mechanism by which the increasing complexity of protein-protein interaction networks is accommodated within the natural evolution of species. Consideration of protein length may be a valuable tool in drug design, one that predicts different strategies for inhibiting interactions in aberrant and normal pathways.Comment: 13 pages, 5 figures, 2 tables, to appear in Physica

    Cancer Molecular Analysis Project: Weaving a rich cancer research tapestry

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    AbstractThe Cancer Molecular Analysis Project (CMAP) of the NCI is integrating diverse cancer research data to elucidate fundamental etiologic processes, enable development of novel therapeutic approaches, and facilitate the bridging of basic and clinical science
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