The Metallicity Gradient of the Old Galactic Bulge Population

Understanding the structure, formation and evolution of the Galactic Bulge requires the proper determination of spatial metallicity gradients in both the radial and vertical directions. RR Lyrae pulsators, known to be excellent distance indicators, may hold the key to determining these gradients. Jurcsik & Kovacs (1996) has shown that RR Lyrae light curves and the phase difference of their Fourier decomposition, {\phi}31, can be used to estimate photometric metallicities. The existence of galactic bulge metallicity gradients is a currently debated topic that would help pinpoint the Galaxy's formation and evolution. A recent study of the OGLE-III Galactic Bulge RR Lyrae Population by Pietrukowicz et al. (2012) suggests that the spatial distribution is uniform. We investigate how small a gradient would be detectable within the current S/N levels of the present data set, given the random and systematic errors associated with the derivation of a photometric metallicity versus spatial position relationship.Comment: Proc. of the workshop "Asteroseismology of stellar populations in the Milky Way" (Sesto, 22-26 July 2013), Astrophysics and Space Science Proceedings, (eds. A. Miglio, L. Girardi, P. Eggenberger, J. Montalban

Common distribution patterns of marsupials related to physiographical diversity in Venezuela

The aim of this study is to identify significant biotic regions (groups of areas with similar biotas) and biotic elements (groups of taxa with similar distributions) for the marsupial fauna in a part of northern South America using physiographical areas as Operational Geographical Units (OGUs). We considered Venezuela a good model to elucidate this issue because of its high diversity in landscapes and the relatively vast amount of information available on the geographical distribution of marsupial species. Based on the presence-absence of 33 species in 15 physiographical sub-regions (OGUs) we identified Operational Biogeographical Units (OBUs) and chorotypes using a quantitative analysis that tested statistical significance of the resulting groups. Altitudinal and/or climatic trends in the OBUs and chorotypes were studied using a redundancy analysis. The classification method revealed four OBUs. Strong biotic boundaries separated: i) the xerophytic zone of the Continental coast (OBU I); ii) the sub-regions north of the Orinoco River (OBU III and IV); and those south to the river (OBU II). Eleven chorotypes were identified, four of which included a single species with a restricted geographic distribution. As for the other chorotypes, three main common distribution patterns have been inferred: i) species from the Llanos and/or distributed south of the Orinoco River; ii) species exclusively from the Andes; and iii) species that either occur exclusively north of the Orinoco River or that show a wide distribution throughout Venezuela. Mean altitude, evapotranspiration and precipitation of the driest month, and temperature range allowed us to characterize environmentally most of the OBUs and chorotypes obtained

Computing Accurate Probabilistic Estimates of One-D Entropy from Equiprobable Random Samples

We develop a simple Quantile Spacing (QS) method for accurate probabilistic estimation of one-dimensional entropy from equiprobable random samples, and compare it with the popular Bin-Counting (BC) method. In contrast to BC, which uses equal-width bins with varying probability mass, the QS method uses estimates of the quantiles that divide the support of the data generating probability density function (pdf) into equal-probability-mass intervals. Whereas BC requires optimal tuning of a bin-width hyper-parameter whose value varies with sample size and shape of the pdf, QS requires specification of the number of quantiles to be used. Results indicate, for the class of distributions tested, that the optimal number of quantile-spacings is a fixed fraction of the sample size (empirically determined to be ~0.25-0.35), and that this value is relatively insensitive to distributional form or sample size, providing a clear advantage over BC since hyperparameter tuning is not required. Bootstrapping is used to approximate the sampling variability distribution of the resulting entropy estimate, and is shown to accurately reflect the true uncertainty. For the four distributional forms studied (Gaussian, Log-Normal, Exponential and Bimodal Gaussian Mixture), expected estimation bias is less than 1% and uncertainty is relatively low even for very small sample sizes. We speculate that estimating quantile locations, rather than bin-probabilities, results in more efficient use of the information in the data to approximate the underlying shape of an unknown data generating pdf.Comment: 23 pages, 12 figure

Fragmento de biblia romanceada reutilizada como cubierta de un legajo procedente del Monasterio de Santa María de La Sisla

For centuries, the parchment bifolia of manuscripts that for one reason or another had ceased to be useful, were re-used as binding material. In Madrid’s Archivo Histórico Nacional, I have discovered one of these membra disiecta from a Romance Bible copied in the 15th century. It consists of a fragment from the translation from Hebrew to Castilian transmitted by Esc. I-I-3. In this paper I present a codicological analysis of this new testimony and I put forward a hypothesis about its origin. A paleographic transcription of the text completes the study.Durante siglos, los bifolios de pergamino de manuscritos que por una u otra razón habían dejado de ser útiles, fueron reaprovechados para encuadernaciones. En Madrid, en un fondo monástico sin catalogar del Archivo Histórico Nacional, he localizado uno de esos membra disiecta que procede de una biblia en romance copiada en el s. XV. Se trata de un fragmento de la traducción del hebreo al castellano transmitida por Esc. I-I-3. En este artículo presento un análisis codicológico de este nuevo testimonio y avanzo una hipótesis sobre su procedencia. El estudio se completa con una transcripción paleográfica del texto

Cardiovascular risk estimated after 13 years of follow-up in a low-incidence Mediterranean region with high-prevalence of cardiovascular risk factors

<p>Abstract</p> <p>Background</p> <p>Murcia (south-east Spain) shows increased cardiovascular (CV) morbimortality as compared to other Spanish regions. Our objective was to assess the CV risk associated with major risk factors (RF) among adult population of Murcia.</p> <p>Methods</p> <p>A cohort of 2314 subjects (18-70 years) with full biochemical and questionnaire data was followed-up for 13 years. Incident cases of ischemic heart disease and stroke were identified by record linkage, individual questionnaires and revision of medical records. Relative risks were obtained by multivariate Cox regression stratified by age and sex, and ischemic risk attributable to CVRF was calculated.</p> <p>Results</p> <p>After more than 26276 person-years of follow-up, 57 incident ischemic events (77% men) and 37 stroke cases (62% men) were identified. Independent risk factors of ischemic heart disease (IHD) and all CV events combined, with RR ranging from 1.6 to 2.6, were total serum cholesterol ≥ 240 mg/dl (HR = 2.6, 95%CI:1.3-5.1), blood pressure levels ≥ 140/90 mmHg (HR = 2.6, 95%CI:1.4-4.8), ever tobacco smoking (HR = 2.2; 95%CI:1.1-4.5), and diabetes (HR = 2.0; 95%CI: 1.0-3.8). No increased CV risk was detected for known participants under treatment who showed cholesterol and blood pressure values below the clinical risk threshold. Smoking was significantly associated with stroke. For all events combined, the major risk factors were hypercholesterolemia, hypertension and ever use of tobacco. Despite its high prevalence, obesity was not associated to CV risk. Most of the IHD cases were attributable to smoking (44%), hypertension (38%) and hypercholesterolemia (26%).</p> <p>Conclusions</p> <p>In the Region of Murcia, smoking accounted for the largest proportion of cardiovascular risk, whereas hypertension displaced hypercholesterolemia as the second leading cause of CV disease. Our study deepens in our understanding of the cardiovascular epidemiology in Spanish areas of Mediterranean Europe with relatively high cardiovascular morbimortality, that are poorly represented by the available risk equations.</p

HgGa2Se4 under high pressure: an optical absorption study

High-pressure optical absorption measurements have been performed in defect chalcopyrite HgGa2Se4 to investigate the influence of pressure on the bandgap energy and its relation with the pressure-induced order-disorder processes that occur in this ordered-vacancy compound. Two different experiments have been carried out in which the sample undergoes either a partial or a total pressure-induced disorder process at 15.4 and 30.8GPa, respectively. It has been found that the direct bandgap energies of the recovered samples at 1GPa were around 0.15 and 0.23eV smaller than that of the original sample, respectively, and that both recovered samples have different pressure coefficients of the direct bandgap than the original sample. A comprehensive explanation for these results on the basis of pressure-induced order-disorder processes is provided.This study was supported by the Spanish government MEC under Grants No: MAT2010-21270-C04-01/03/04 and MAT2013-46649-C4-1/2/3-P, by MALTA Consolider Ingenio 2010 project (CSD2007-00045), by Generalitat Valenciana (GVA-ACOMP-2013-1012 and GVA-ACOMP-2014-243), and by the Vicerrectorado de Investigacion y Desarrollo of the Universitat Politecnica de Valencia (UPV2011-0914 PAID-05-11 and UPV2011-0966 PAID-06-11). E. P.-G., J. L.-S., P. R.-H, and A. M. acknowledge computing time provided by Red Espanola de Supercomputacion (RES) and MALTA-Cluster. J.R.-F. thanks the Alexander von Humboldt foundation for a postdoctoral fellowship.Gomis, O.; Vilaplana Cerda, RI.; Manjón Herrera, FJ.; Ruiz-Fuertes, J.; Pérez-González, E.; López-Solano, J.; Bandiello, E.... (2015). HgGa2Se4 under high pressure: an optical absorption study. physica status solidi (b). 252(9):2043-2051. https://doi.org/10.1002/pssb.201451714S204320512529Bernard, J. E., & Zunger, A. (1988). Ordered-vacancy-compound semiconductors: PseudocubicCdIn2Se4. Physical Review B, 37(12), 6835-6856. doi:10.1103/physrevb.37.6835Jiang, X., & Lambrecht, W. R. L. (2004). Electronic band structure of ordered vacancy defect chalcopyrite compounds with formulaII−III2−VI4. Physical Review B, 69(3). doi:10.1103/physrevb.69.035201Burlakov, I. I., Raptis, Y., Ursaki, V. V., Anastassakis, E., & Tiginyanu, I. M. (1997). Order-disorder phase transition in CdAl2S4 under hydrostatic pressure. Solid State Communications, 101(5), 377-381. doi:10.1016/s0038-1098(96)00602-3Gonz�lez, J., Rico, R., Calder�n, E., Quintero, M., & Morocoima, M. (1999). Absorption Edge of MnGa2Se4 Single Crystals under Hydrostatic Pressure. physica status solidi (b), 211(1), 45-49. doi:10.1002/(sici)1521-3951(199901)211:13.0.co;2-8Ursaki, V. V., Burlakov, I. I., Tiginyanu, I. M., Raptis, Y. S., Anastassakis, E., & Anedda, A. (1999). Phase transitions in defect chalcopyrite compounds under hydrostatic pressure. Physical Review B, 59(1), 257-268. doi:10.1103/physrevb.59.257Grzechnik, A., Ursaki, V. V., Syassen, K., Loa, I., Tiginyanu, I. M., & Hanfland, M. (2001). Pressure-Induced Phase Transitions in Cadmium Thiogallate CdGa2Se4. Journal of Solid State Chemistry, 160(1), 205-211. doi:10.1006/jssc.2001.9224Mitani, T., Onari, S., Allakhverdiev, K., Gashimzade, F., & Kerimova, T. (2001). Raman Scattering in CdGa2S4 under Pressure. physica status solidi (b), 223(1), 287-291. doi:10.1002/1521-3951(200101)223:13.0.co;2-bTatsi, A., Lampakis, D., Liarokapis, E., Lopez, S. A., Martinez, L., & Giriat, W. (2002). Pressure Effects in Phonon Modes and Structure of A II B 2 III C 4 IV Compounds and Combinations. High Pressure Research, 22(1), 89-93. doi:10.1080/08957950211338Tiginyanu, I. M., Ursaki, V. V., Manjón, F. J., & Tezlevan, V. E. (2003). Raman scattering study of pressure-induced phase transitions in AIIB2IIIC4VI defect chalcopyrites and spinels. Journal of Physics and Chemistry of Solids, 64(9-10), 1603-1607. doi:10.1016/s0022-3697(03)00098-2Mitani, T., Naitou, T., Matsuishi, K., Onari, S., Allakhverdiev, K., Gashimzade, F., & Kerimova, T. (2003). Raman scattering in CdGa2Se4 under pressure. physica status solidi (b), 235(2), 321-325. doi:10.1002/pssb.200301579Allakhverdiev, K., Gashimzade, F., Kerimova, T., Mitani, T., Naitou, T., Matsuishi, K., & Onari, S. (2003). Raman scattering under pressure in ZnGa2Se4. Journal of Physics and Chemistry of Solids, 64(9-10), 1597-1601. doi:10.1016/s0022-3697(03)00077-5Marquina, J., Power, C., Grima, P., Morocoima, M., Quintero, M., Couzinet, B., … González, J. (2006). Crystallographic properties of the MnGa2Se4 compound under high pressure. Journal of Applied Physics, 100(9), 093513. doi:10.1063/1.2358826Meenakshi, S., Vijyakumar, V., Godwal, B. K., Eifler, A., Orgzall, I., Tkachev, S., & Hochheimer, H. D. (2006). High pressure X-ray diffraction study of CdAl2Se4 and Raman study of AAl2Se4 (A=Hg, Zn) and CdAl2X4 (X=Se, S). Journal of Physics and Chemistry of Solids, 67(8), 1660-1667. doi:10.1016/j.jpcs.2006.02.015Errandonea, D., Kumar, R. S., Manjón, F. J., Ursaki, V. V., & Tiginyanu, I. M. (2008). High-pressure x-ray diffraction study on the structure and phase transitions of the defect-stannite ZnGa2Se4 and defect-chalcopyrite CdGa2S4. Journal of Applied Physics, 104(6), 063524. doi:10.1063/1.2981089Meenakshi, S., Vijayakumar, V., Eifler, A., & Hochheimer, H. D. (2010). Pressure-induced phase transition in defect Chalcopyrites HgAl2Se4 and CdAl2S4. Journal of Physics and Chemistry of Solids, 71(5), 832-835. doi:10.1016/j.jpcs.2010.02.007Singh, P., Sharma, M., Verma, U. P., & Jensen, P. (2010). Pressure effects on energy gaps and phase transitions in ZnAl2Se4. Zeitschrift für Kristallographie, 225(11). doi:10.1524/zkri.2010.1301Manjón, F. J., Gomis, O., Rodríguez-Hernández, P., Pérez-González, E., Muñoz, A., Errandonea, D., … Ursaki, V. V. (2010). Nonlinear pressure dependence of the direct band gap in adamantine ordered-vacancy compounds. Physical Review B, 81(19). doi:10.1103/physrevb.81.195201Verma, U. P., Singh, P., & Jensen, P. (2011). A study of the electronic, optical and thermal properties for ZnAl2Se4 using the FP-LAPW method. physica status solidi (b), 248(7), 1682-1689. doi:10.1002/pssb.201046389Gomis, O., Vilaplana, R., Manjón, F. J., Pérez-González, E., López-Solano, J., Rodríguez-Hernández, P., … Ursaki, V. V. (2012). High-pressure optical and vibrational properties of CdGa2Se4: Order-disorder processes in adamantine compounds. Journal of Applied Physics, 111(1), 013518. doi:10.1063/1.3675162Gomis, O., Vilaplana, R., Manjón, F. J., Santamaría-Pérez, D., Errandonea, D., Pérez-González, E., … Ursaki, V. V. (2013). Crystal structure of HgGa2Se4 under compression. Materials Research Bulletin, 48(6), 2128-2133. doi:10.1016/j.materresbull.2013.02.037Gomis, O., Vilaplana, R., Manjón, F. J., Santamaría-Pérez, D., Errandonea, D., Pérez-González, E., … Ursaki, V. V. (2013). High-pressure study of the structural and elastic properties of defect-chalcopyrite HgGa2Se4. Journal of Applied Physics, 113(7), 073510. doi:10.1063/1.4792495Vilaplana, R., Robledillo, M., Gomis, O., Sans, J. A., Manjón, F. J., Pérez-González, E., … Ursaki, V. V. (2013). Vibrational study of HgGa2S4under high pressure. Journal of Applied Physics, 113(9), 093512. doi:10.1063/1.4794096Vilaplana, R., Gomis, O., Pérez-González, E., Ortiz, H. M., Manjón, F. J., Rodríguez-Hernández, P., … Tiginyanu, I. M. (2013). High-pressure Raman scattering study of defect chalcopyrite and defect stannite ZnGa2Se4. Journal of Applied Physics, 113(23), 233501. doi:10.1063/1.4810854Vilaplana, R., Gomis, O., Manjón, F. J., Ortiz, H. M., Pérez-González, E., López-Solano, J., … Tiginyanu, I. M. (2013). Lattice Dynamics Study of HgGa2Se4at High Pressures. The Journal of Physical Chemistry C, 117(30), 15773-15781. doi:10.1021/jp402493rGomis, O., Santamaría-Pérez, D., Vilaplana, R., Luna, R., Sans, J. A., Manjón, F. J., … Ursaki, V. V. (2014). Structural and elastic properties of defect chalcopyrite HgGa2S4 under high pressure. Journal of Alloys and Compounds, 583, 70-78. doi:10.1016/j.jallcom.2013.08.123Errandonea, D., Kumar, R. S., Gomis, O., Manjón, F. J., Ursaki, V. V., & Tiginyanu, I. M. (2013). X-ray diffraction study on pressure-induced phase transformations and the equation of state of ZnGa2Te4. Journal of Applied Physics, 114(23), 233507. doi:10.1063/1.4851735Sans, J. Á., Santamaría-Pérez, D., Popescu, C., Gomis, O., Manjón, F. J., Vilaplana, R., … Tiginyanu, I. M. (2014). Structural and Vibrational Properties of CdAl2S4under High Pressure: Experimental and Theoretical Approach. The Journal of Physical Chemistry C, 118(28), 15363-15374. doi:10.1021/jp5037926Manjón, F. J., & Vilaplana, R. I. (2014). $$\mathrm {AB}_{2}\text {S}_{4}$$ Ordered-Vacancy Compounds at High Pressures. Springer Series in Materials Science, 133-161. doi:10.1007/978-3-642-40367-5_5Gomis, Ó., & Manjón, F. J. (2014). $$\mathrm{AB}_{2} \text {Se}_{4}$$ Ordered-Vacancy Compounds at High Pressures. Springer Series in Materials Science, 163-184. doi:10.1007/978-3-642-40367-5_6Muñoz, A., & Fuentes-Cabrera, M. (2014). Theoretical Ab Initio Calculations in Ordered-Vacancy Compounds at High Pressures. Springer Series in Materials Science, 185-210. doi:10.1007/978-3-642-40367-5_7Santamaría-Pérez, D., Gomis, O., Pereira, A. L. J., Vilaplana, R., Popescu, C., Sans, J. A., … Tiginyanu, I. M. (2014). Structural and Vibrational Study of Pseudocubic CdIn2Se4under Compression. The Journal of Physical Chemistry C, 118(46), 26987-26999. doi:10.1021/jp5077565Letoullec, R., Pinceaux, J. P., & Loubeyre, P. (1988). The membrane diamond anvil cell: A new device for generating continuous pressure and temperature variations. High Pressure Research, 1(1), 77-90. doi:10.1080/08957958808202482Mao, H. K., Xu, J., & Bell, P. M. (1986). Calibration of the ruby pressure gauge to 800 kbar under quasi-hydrostatic conditions. Journal of Geophysical Research, 91(B5), 4673. doi:10.1029/jb091ib05p04673González-Leal, J.-M., Prieto-Alcón, R., Angel, J.-A., Minkov, D. A., & Márquez, E. (2002). Influence of substrate absorption on the optical and geometrical characterization of thin dielectric films. Applied Optics, 41(34), 7300. doi:10.1364/ao.41.007300Eggert, J. H., Xu, L., Che, R., Chen, L., & Wang, J. (1992). High pressure refractive index measurements of 4:1 methanol:ethanol. Journal of Applied Physics, 72(6), 2453-2461. doi:10.1063/1.351591Errandonea, D., Manj�n, F. J., Pellicer, J., Segura, A., & Mu�oz, V. (1999). Direct to Indirect Crossover in III-VI Layered Compounds and Alloys under Pressure. physica status solidi (b), 211(1), 33-38. doi:10.1002/(sici)1521-3951(199901)211:13.0.co;2-mManjón, F. J., Errandonea, D., Segura, A., Muñoz, V., Tobías, G., Ordejón, P., & Canadell, E. (2001). Experimental and theoretical study of band structure of InSe andIn1−xGaxSe(x3.0.co;2-2Rinco´n, C. (1992). Order-disorder transition in ternary chalcopyrite compounds and pseudobinary alloys. Physical Review B, 45(22), 12716-12719. doi:10.1103/physrevb.45.12716Manjón, F. J., Gomis, O., Vilaplana, R., Sans, J. A., & Ortiz, H. M. (2013). Order-disorder processes in adamantine ternary ordered-vacancy compounds. physica status solidi (b), 250(8), 1496-1504. doi:10.1002/pssb.201248596Cohen, M. L., & Bergstresser, T. K. (1966). Band Structures and Pseudopotential Form Factors for Fourteen Semiconductors of the Diamond and Zinc-blende Structures. Physical Review, 141(2), 789-796. doi:10.1103/physrev.141.789Reimann, K., Haselhoff, M., Rübenacke, S., & Steube, M. (1996). Determination of the Pressure Dependence of Band-Structure Parameters by Two-Photon Spectroscopy. physica status solidi (b), 198(1), 71-80. doi:10.1002/pssb.2221980110Wei, S.-H., & Zunger, A. (1999). Predicted band-gap pressure coefficients of all diamond and zinc-blende semiconductors: Chemical trends. Physical Review B, 60(8), 5404-5411. doi:10.1103/physrevb.60.5404González, J., & Rincón, C. (1989). Optical absorption and phase transitions in CuInSe2and CuInS2single crystals at high pressure. Journal of Applied Physics, 65(5), 2031-2034. doi:10.1063/1.342897Wei, S.-H., Ferreira, L. G., & Zunger, A. (1992). First-principles calculation of the order-disorder transition in chalcopyrite semiconductors. Physical Review B, 45(5), 2533-2536. doi:10.1103/physrevb.45.2533Lempert, R. J., Hass, K. C., & Ehrenreich, H. (1987). Molecular coherent-potential approximation for zinc-blende pseudobinary alloys. Physical Review B, 36(2), 1111-1129. doi:10.1103/physrevb.36.1111Wei, S. ‐H., & Zunger, A. (1990). Band‐gap narrowing in ordered and disordered semiconductor alloys. Applied Physics Letters, 56(7), 662-664. doi:10.1063/1.103307Iota, V., & Weinstein, B. A. (1999). Pitfalls of Using Pressure to Assign the Luminescence of Large-Lattice-Relaxation Defects. physica status solidi (b), 211(1), 91-104. doi:10.1002/(sici)1521-3951(199901)211:13.0.co;2-mHong, R.-D., Jenkins, D. W., Ren, S. Y., & Dow, J. D. (1988). Hydrostatic-pressure dependencies of deep impurity levels in zinc-blende semiconductors. Physical Review B, 38(17), 12549-12555. doi:10.1103/physrevb.38.1254

Structural and elastic properties of defect chalcopyrite HgGa2S4 under high pressure

In this work, we focus on the study of the structural and elastic properties of mercury digallium sulfide (HgGa2S4) at high pressures. This compound belongs to the family of AB(2)X(4) ordered-vacancy compounds and exhibits a tetragonal defect chalcopyrite structure. X-ray diffraction measurements at room temperature have been performed under compression up to 15.1 GPa in a diamond anvil cell. Our measurements have been complemented and compared with ab initio total energy calculations. The axial compressibility and the equation of state of the low-pressure phase of HgGa2S4 have been experimentally and theoretically determined and compared to other related ordered-vacancy compounds. The pressure dependence of the theoretical cation-anion and vacancy-anion distances and compressibilities in HgGa2S4 are reported and discussed in comparison to other related ordered-vacancy compounds. Finally, the pressure dependence of the theoretical elastic constants and elastic moduli of HgGa2S4 has been studied. Our calculations indicate that the low-pressure phase of HgGa2S4 becomes mechanically unstable above 13.8 GPa. (C) 2013 Elsevier B. V. All rights reserved.This study was supported by the Spanish government MEC under Grants No: MAT2010-21270-C04-01/03/04 and CTQ2009-14596-C02-01, by the Comunidad de Madrid and European Social Fund (S2009/PPQ-1551 4161893), by MALTA Consolider Ingenio 2010 Project (CSD2007-00045), by Generalitat Valenciana (GVA-ACOMP-2013-1012), and by the Vicerrectorado de Investigacion y Desarrollo of the Universidad Politecnica de Valencia (UPV2011-0914 PAID-05-11 and UPV2011-0966 PAID-06-11). E.P-G., A. M., and P.R-H. acknowledge computing time provided by Red Espa ola de Supercomputacion (RES) and MALTA-Cluster. J.A.S. acknowledges Juan de la Cierva fellowship program for financial support.Gomis Hilario, O.; Santamaría-Pérez, D.; Vilaplana Cerda, RI.; Luna Molina, R.; Sans, JA.; Manjón Herrera, FJ.; Errandonea, D.... (2014). Structural and elastic properties of defect chalcopyrite HgGa2S4 under high pressure. Journal of Alloys and Compounds. 583:70-78. https://doi.org/10.1016/j.jallcom.2013.08.123S707858

The circadian clock, metabolism and obesity

In the last decades, obesity has been on the rise becoming a burden for health care systems. The reasons behind this rise are most likely caused by lifestyle rather than by an increase in gene mutations, because manifestations of genetic alterations would take longer than just a few decades. Lifestyle has a great impact on the circadian system and therefore on the body internal organization of physiological and biochemical processes, regulating various aspects of behavior and metabolism. In the following, I will discuss recent studies delineating relationships between metabolic processes and the circadian system, how metabolites and nutrients regulate the circadian clock and how nuclear receptors can act as metabolic sensors and clock regulators. Finally, I will discuss how clock modulation and feeding patterns influence the development of obesity