Psychological or physical prenatal stress differentially affects cognition behaviors

Introduction: Prenatal stress is proposed as a major risk factor in the development of cognitive impairments in the offspring. The objective of the current study was to evaluate the effect of prenatal physical or psychological stress on the motor and cognitive functions of male and female offspring. Methods: Adult female rats were stressed during their conception using a novel method to induced whether physical or psychological stress. Animal offspring were then kept until adulthood. Elevated plus maze (EPM) was used to evaluate their anxiety-like behavior. Rotarod and wire grip were used to evaluate muscle strength and balance function. Morris water maze (MWM) and passive avoidance (PA) learning and memory paradigm were used to evaluate the cognitive function of the offspring. Results: Female offspring of both physical and psychological stress had an increased anxiety-like behavior in the EPM test in comparison to female control rats. Balance function was impaired in physical stressed female offspring in comparison to the control and male offspring. Muscle strength was reduced in physical male and female offspring. Both male and female offspring groups that underwent prenatal physical and psychological stress had an impaired spatial learning and memory. PA learning and memory were impaired in both male and female offspring except for the psychological stress female offspring in PA learning. Conclusion: Results of our study revealed that prenatal physical or psychological stress have different effects on motor and cognitive functions of the offspring. Male and female offspring were differentially affected by prenatal stress. We suggest more studies to evaluate the role of sex hormones on the effects of prenatal physical or psychological stress on cognitive and motor functions of the offsprin

Psychological stress has a higher rate of developing addictive behaviors compared to physical stress in rat offspring

Prenatal stress could have great influence on development of offspring and might alter cognitive function and other physiological processes of children. The current study was conducted to study the effect of physical or psychological prenatal stress on addictive and anxiety-like behavior of male and female offspring during their adolescence period (postnatal day (PND) 40). Adult female rats were exposed to physical (swimming) or psychological (observing another female rat swimming) stress from day six of gestation for 10 days. Male and female offspring were assayed for anxiety-like behavior, motor and balance function and morphine conditioned place preference using the open field, elevated plus maze (EPM), rotarod and wire grip assay and conditioned place preference. Offspring in both physical and psychological prenatal stress groups demonstrated significant increase in anxiety-like behavior in EPM paradigm, but no alterations were observed in motor and balance function of animals. Offspring in the psychological prenatal stress group had an increased preference for morphine in comparison to control and physical prenatal stress groups. Results of the current study demonstrated that animals exposed to psychological stress during fetal development are at a higher risk of developing addictive behaviors. Further research might elucidate the exact mechanisms involved to provide better preventive and therapeutic interventions

Factors affecting burnout in Iranian health care workers during COVID-19: a systematic review

INTRODUCTION: Working through the COVID-19 pandemic has exposed Health Care Workers to physical and psychological risks that can result in a broad range of mental health problems, including burnout. The aim of the present study was to investigate factors affecting burnout in Iranian Health Care Workers during the COVID-19 pandemic. Identifying the principal factors affecting burnout will assist efforts to prepare for, and, prevent harm, to staff participating in future healthcare emergencies. MATERIAL AND METHODS: A systematic review of scientific literature using the PRISMA guideline was completed, and included literature published from January 2020 until December 2021. The articles related to burnout in Iranian Health Care Workers during COVID-19 were obtained through Google Scholar, SID, Magiran Scopus, PubMed, and Web of Science databases using related keywords. Thematic analysis was used to analyze the obtained data. RESULTS: 203 articles were identified through an initial search and finally, 14 studies were entered into the analysis. Based on the literature review, the principal factors affecting burnout were divided into 2 main themes and 4 subthemes. The themes included human factors, and organizational factors, and the sub-themes included individual characteristics, psychosocial factors, occupational conditions, and training. CONCLUSIONS: Individual and psychosocial characteristics have important effects on burnout among Health Care Workers and this can cause negative flow-on effects on the quality of life of these workers, and the quality of medical services. The prevalence of burnout is relatively higher among medical practitioners and nurses, and it is important to enhance coping resources and health education activities that support the resilience of these clinicians in the challenging and stressful context of a pandemic

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

The effect of eight weeks of strength training, strength and core stability on the Scoliosis deformity of 9 to 13- year-old female students

Objective: One of these anomalies that have a high prevalence is higher scoliosis. Higher scoliosis causes problems such as reduction in quality of life, disability, pain, appearance deformities, and in cases, respiratory problems, and increase in scoliosis angle in adulthood.  The objective of the study was to examine the effects of 8 weeks of stretching, strength and central stability exercises of female students aged 9 to 13 years. Methodology: this study was among the intervention and quasi-experimental studies and population of study included female students aged 9 to 13 years with scoliosis deformity, in which 60 female students who had dorsal scoliosis deformity were selected purposefully and they were randomly assigned  to 3 groups (each group containing 20 students)  (two experimental groups, the first group includes stretching exercises, second group includes strength and stretching and central stability exercises and one control group).  Exercises program included 8 weeks, 3 sessions per week, and each session lasted 25 to 40 minutes. The measurement of dorsal scoliosis was conducted using plaid plate and photogrammetry. Results: the results of post-test scores of scoliosis angle showed that corrective exercises program created significant difference among three groups so that, it caused significant reduction in scoliosis angle of subjects of both experimental groups compared to control group. It reduced more in the subjects of the second experimental group (stretching, strength and central stability exercises) compared to subjects of the first experimental group (stretching and strength exercises), while this difference was not significant. Conclusion: It seems that corrective eight-week exercise program with the emphasis on compound exercises (central stability) as a non-invasive method can have the desired effect in the treatment of scoliosis in students

Variances in the projections, resulting from CLIMEX, Boosted Regression Trees and Random Forests techniques

The aim of this study was to have a comparative investigation and evaluation of the capabilities of correlative and mechanistic modeling processes, applied to the projection of future distributions of date palm in novel environments and to establish a method of minimizing uncertainty in the projections of differing techniques. The location of this study on a global scale is in Middle Eastern Countries. We compared the mechanistic model CLIMEX (CL) with the correlative models MaxEnt (MX), Boosted Regression Trees (BRT), and Random Forests (RF) to project current and future distributions of date palm ('Phoenix dactylifera' L.). The Global Climate Model (GCM), the CSIRO-Mk3.0 (CS) using the A2 emissions scenario, was selected for making projections. Both indigenous and alien distribution data of the species were utilized in the modeling process. The common areas predicted by MX, BRT, RF, and CL from the CS GCM were extracted and compared to ascertain projection uncertainty levels of each individual technique. The common areas identified by all four modeling techniques were used to produce a map indicating suitable and unsuitable areas for date palm cultivation for Middle Eastern countries, for the present and the year 2100. The four different modeling approaches predict fairly different distributions. Projections from CL were more conservative than from MX. The BRT and RF were the most conservative methods in terms of projections for the current time. The combination of the final CL and MX projections for the present and 2100 provide higher certainty concerning those areas that will become highly suitable for future date palm cultivation. According to the four models, cold, hot, and wet stress, with differences on a regional basis, appears to be the major restrictions on future date palm distribution. The results demonstrate variances in the projections, resulting from different techniques. The assessment and interpretation of model projections requires reservations, especially in correlative models such as MX, BRT, and RF. Intersections between different techniques may decrease uncertainty in future distribution projections. However, readers should not miss the fact that the uncertainties are mostly because the future GHG emission scenarios are unknowable with sufficient precision. Suggestions towards methodology and processing for improving projections are included

The Impact of First and Second Languages on Azerbaijani EFL Learners’ Writing Ability

There has always been a debate whether or not the learners’ first language (L1) can facilitate the process of learning foreign language. Since foreign language writing (FL) is a complicated process, it seems that the role of the learners’ L1 and its effect on FL writing is of great importance in this regard. The present study aimed at investigating the role of Azerbaijani EFL learners’ L1 and L2 (Persian) on their FL writing. To meet the purposes of the study, 30 female EFL upper-intermediate students were selected (through running an OPT), who were native speakers of Azerbaijani, with Persian as their L2 and official language of Iranian context. The data were collected through running three writing sessions (in which the participants wrote three essays in each session using Azerbaijani as L1, Persian as L2, and direct writing) using the think-aloud protocol, through which they were asked to report their thoughts loudly to record using a tape recorder. In addition, a survey was used to ask their perceptions towards each writing task. The analysis of the data obtained from the evaluation of learners’ writings indicated that the mere use of their L1 or L2 in foreign language writing was by no means helpful for them and they performed better on direct writing task in comparison with the two other ones. It was also found that the majority of the learners (70%) had difficulty in generating their ideas using Azerbaijani as their L1. In addition, nearly 77% of them claimed that even in direct writing mode, they made use of their L2 (Persian) on the occasions they could not find a proper word or phrase in English. As the implications of the study, it seems that the present study can bring helpful insights for both FL teachers and learners about the roles that Azerbaijani and Persian languages play as the students’ L1 and L2 in FL writing. Keywords: Writing ability, first language, second language, foreign languag

The Impact of First and Second Languages on Azerbaijani EFL Learners’ Writing Ability

There has always been a debate whether or not the learners’ first language (L1) can facilitate the process of learning foreign language. Since foreign language writing (FL) is a complicated process, it seems that the role of the learners’ L1 and its effect on FL writing is of great importance in this regard. The present study aimed at investigating the role of Azerbaijani EFL learners’ L1 and L2 (Persian) on their FL writing. To meet the purposes of the study, 30 female EFL upper-intermediate students were selected (through running an OPT), who were native speakers of Azerbaijani, with Persian as their L2 and official language of Iranian context. The data were collected through running three writing sessions (in which the participants wrote three essays in each session using Azerbaijani as L1, Persian as L2, and direct writing) using the think-aloud protocol, through which they were asked to report their thoughts loudly to record using a tape recorder. In addition, a survey was used to ask their perceptions towards each writing task. The analysis of the data obtained from the evaluation of learners’ writings indicated that the mere use of their L1 or L2 in foreign language writing was by no means helpful for them and they performed better on direct writing task in comparison with the two other ones. It was also found that the majority of the learners (70%) had difficulty in generating their ideas using Azerbaijani as their L1. In addition, nearly 77% of them claimed that even in direct writing mode, they made use of their L2 (Persian) on the occasions they could not find a proper word or phrase in English. As the implications of the study, it seems that the present study can bring helpful insights for both FL teachers and learners about the roles that Azerbaijani and Persian languages play as the students’ L1 and L2 in FL writing.Keywords: Writing ability, first language, second language, foreign languag

A comparative modeling study on non-climatic and climatic risk assessment on Asian Tiger Mosquito (Aedes albopictus)

Aedes albopictus, the Asian Tiger Mosquito, vector of Chikungunya, Dengue Fever and Zika viruses, has proven its hardy adaptability in expansion from its natural Asian, forest edge, tree hole habitat on the back of international trade transportation, re-establishing in temperate urban surrounds, in a range of water receptacles and semi-enclosures of organic matter. Conventional aerial spray mosquito vector controls focus on wetland and stagnant water expanses, proven to miss the protected hollows and crevices favoured by Ae. albopictus. New control or eradication strategies are thus essential, particular in light of potential expansions in the southeastern and eastern USA. Successful regional vector control strategies require risk level analysis. Should strategies prioritize regions with non-climatic or climatic suitability parameters for Ae. albopictus? Our study used current Ae. albopictus distribution data to develop two independent models: (i) regions with suitable non-climatic factors, and (ii) regions with suitable climate for Ae. albopictus in southeastern USA. Non-climatic model processing used Evidential Belief Function (EBF), together with six geographical conditioning factors (raster data layers), to establish the probability index. Validation of the analysis results was estimated with area under the curve (AUC) using Ae. albopictus presence data. Climatic modeling was based on two General Circulation Models (GCMs), Miroc3.2 and CSIRO-MK30 running the RCP 8.5 scenario in MaxEnt software. EBF non-climatic model results achieved a 0.70 prediction rate and 0.73 success rate, confirming suitability of the study site regions for Ae. albopictus establishment. The climatic model results showed the best-fit model comprised Coldest Quarter Mean Temp, Precipitation of Wettest Quarter and Driest Quarter Precipitation factors with mean AUC value of 0.86. Both GCMs showed that the whole study site is highly suitable and will remain suitable climatically, according to the prediction for 2055, for Ae. albopictus expansion