New directions in sustainability science: promoting integration and cooperation

Since this journal was launched in 2006 to provide a platform for the pioneers of sustainability science (Komiyama and Takeuchi 2006), the science has matured in the development of theory and methodologies to address the potentially devastating consequences of the present development paradigm. The gains in research, however, do not mean that sustainability science in its present state will fulfill its promise of transformational change (Van der Leeuw et al. 2012). Hurdles remain, including insufficient engagement with stakeholder groups (Wiek et al. 2012), lack of robust communication and entrepreneurial skills on the part of scientists generally (Baron 2010; Brownell et al. 2013), the need for better support (structural and intellectual) within the academy to attract and maintain committed scholars to the field, and enhanced qualitative and quantitative meta-studies to make better use of experiences and evidence emerging from sustainability science research (Wiek et al. 2012). In sum, these challenges are symptomatic of a disconnect between the nascent science and society. If sustainability scientists are going to contribute to transformative change to achieve sustainable development, they must accept roles that go beyond traditional reflective scientist modes and that are outside of their professional comfort zones. It is clear that a higher level of knowledge integration and greater (tighter) cooperation between the generators and users of such knowledge are needed to overcome barriers to meeting these challenges. (Frodeman et al. 2010; Wiek et al. 2012; Komiyama 2014)

The CBD Post‐2020 biodiversity framework: People's place within the rest of nature

Recognizing two decades of failure to achieve global goals and targets, parties to the Convention on Biological Diversity are in the final phase of negotiating a Post-2020 Global Biodiversity Framework for the conservation, sustainable use and benefit sharing of biodiversity. The framework attempts to set out pathways, goals and targets for the next decade to achieve positive biodiversity change. This perspective intends to help that framework set people firmly as part of nature, not apart from it. Despite work done so far through four meetings, new thinking and focus is still needed on ‘what’ changes must be conceptualized and implemented, and ‘how’ those changes are to be delivered. To help achieve that new thinking, as a broad range of people, many with a focus on aquatic systems, we highlight six key foci that offer potential to strengthen delivery of the framework and break the ‘business as usual’ logjam. These foci are as follows: (i) a reframing of the narrative of ‘people's relationship with the rest of nature’ and emphasize the crucial role of Indigenous Peoples and Local Communities in delivering positive biodiversity change; (ii) moving beyond a focus on species and places by prioritizing ecosystem function and resilience; (iii) supporting a diversity of top-down and bottom-up governance processes; (iv) embracing new technologies to make and measure progress; (v) linking business more effectively with biodiversity and (vi) leveraging the power of international agencies and programmes. Given they are linked to a greater or lesser degree, implementing these six foci together will lead to a much-needed broadening of the framework, especially those of business and broader urban civil society, as well as those of Indigenous Peoples and Local Communities. Read the free Plain Language Summary for this article on the Journal blog

The IPBES Conceptual Framework - connecting nature and people

The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework. This conceptual and analytical tool, presented here in detail, will underpin all IPBES functions and provide structure and comparability to the syntheses that IPBES will produce at different spatial scales, on different themes, and in different regions. Salient innovative aspects of the IPBES Conceptual Framework are its transparent and participatory construction process and its explicit consideration of diverse scientific disciplines, stakeholders, and knowledge systems, including indigenous and local knowledge. Because the focus on co-construction of integrative knowledge is shared by an increasing number of initiatives worldwide, this framework should be useful beyond IPBES, for the wider research and knowledge-policy communities working on the links between nature and people, such as natural, social and engineering scientists, policy-makers at different levels, and decision-makers in different sectors of society

A Roadmap for Using the UN Decade of Ocean Science for Sustainable Development in Support of Science, Policy, and Action

The health of the ocean, central to human well-being, has now reached a critical point. Most fish stocks are overexploited, climate change and increased dissolved carbon dioxide are changing ocean chemistry and disrupting species throughout food webs, and the fundamental capacity of the ocean to regulate the climate has been altered. However, key technical, organizational, and conceptual scientific barriers have prevented the identification of policy levers for sustainability and transformative action. Here, we recommend key strategies to address these challenges, including (1) stronger integration of sciences and (2) ocean-observing systems, (3) improved science-policy interfaces, (4) new partnerships supported by (5) a new ocean-climate finance system, and (6) improved ocean literacy and education to modify social norms and behaviors. Adopting these strategies could help establish ocean science as a key foundation of broader sustainability transformations

Marine genetic resources: A review of scientific and commercial interest

Marine genetic resources both within and beyond national jurisdiction have been the focus of international negotiations in a range of forums in recent years. One recurrent theme throughout these discussions has been the absence of detailed information upon which policy responses to the emerging issue of the conservation and sustainable use of marine genetic resources (especially in areas beyond national jurisdiction) could be based. In an effort to address some of these knowledge gaps, this article examines the level and nature of scientific and commercial interest in marine genetic resources, including in areas beyond national jurisdiction. It also examines the changing perspectives of the scientific community in relation to the potential of marine genetic resources.Marine genetic resources Bioprospecting in areas beyond national jurisdiction Marine scientific research and commercial applications

Non invasive evaluation of endothelial function in patients with Anderson-Fabry disease

AIM: Fabry's disease is an X-linked recessive abnormality of glycosphingolipid metabolism. Increased levels of endothelial prothrombotic factors have recently been demonstrated in Fabry's disease, whereas endothelial function has not been studied using high resolution ultrasound. METHODS: We enrolled 6 patients (4 male, 2 female; mean age, 37 years) and 12 sex matched control subjects (mean age, 37 years). Patients' exclusion criteria included a prior history of cardiac disease, diabetes and treated or untreated hypertension. Patients underwent: anamnesis, physical examination, EKG, 2-dimensional echocardiography with tissue Doppler, measurement of body weight and height, blood pressure. Biochemistry variables were also considered: fasting blood sugar, total cholesterol, HDL-C, LDL-C, triglycerides, fibrinogen, C reactive protein and homocysteine. Using high resolution ultrasound, we assessed the brachial vasodilator response to reactive hyperemia (endothelium-dependent) and sublingual nitroglycerin (NTG) (endothelium-independent). Flow-mediated dilatation (FMD) was expressed as percentage change in post-stimulus diameter in comparison with the baseline. RESULTS: In baseline condition, there was no significant difference between patients and controls in the brachial artery diameter (3.5+/-0.55 vs 3.1+/-0.4). After reactive hyperemia, the FMD change was significantly higher in controls than in patients (16.5+/-6.3% vs 9.3+/-6.2%, P<0.05). After NTG, endothelium-independent vasodilation did not show a significant difference between cases and controls (15+/-7.7% vs 13.8+/-7.1%). CONCLUSIONS: Our study demonstrated the presence of endothelial dysfunction in patients with Fabry's disease in comparison to controls. We hypothesized that endothelial dysfunction may contribute to the pathogenesis of ischemic events in patients with Fabry's disease

In vitro neutralization of IL-17A sensitizes dendritic cells to vinblastine in Langerhans cell histiocytosis

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