Can lung volumes and capacities be used as an outcome measure for phrenic nerve recovery after cardiac surgeries?

AbstractPhrenic nerve is the main nerve drive to the diaphragm and its injury is a well-known complication following cardiac surgeries. It results in diaphragmatic dysfunction with reduction in lung volumes and capacities. This study aimed to evaluate the objectivity of lung volumes and capacities as an outcome measure for the prognosis of phrenic nerve recovery after cardiac surgeries. In this prospective experimental study, patients were recruited from Cardio-Thoracic Surgery Department, Educational-Hospital of College of Medicine, Cairo University. They were 11 patients with right phrenic nerve injury and 14 patients with left injury. On the basis of receiving low-level laser irradiation, they were divided into irradiated group and non-irradiated group. Measures of phrenic nerve latency, lung volumes and capacities were taken pre and post-operative and at 3-months follow up. After 3months of low-level laser therapy, the irradiated group showed marked improvement in the phrenic nerve recovery. On the other hand, vital capacity and forced expiratory volume in the first second were the only lung capacity and volume that showed improvement consequent with the recovery of right phrenic nerve (P value <0.001 for both). Furthermore, forced vital capacity was the single lung capacity that showed significant statistical improvement in patients with recovered left phrenic nerve injury (P value <0.001). Study concluded that lung volumes and capacities cannot be used as an objective outcome measure for recovery of phrenic nerve injury after cardiac surgeries

Guideline for Groundwater Resource Management Using the GIS Tools in Arid to Semi Arid Climate Regions

International audienceFood security emerged as an issue in the first decade of the 21st Century, questioning the sustainability of thehuman race, which is inevitably related directly to the agricultural water management that has multifaceteddimensions and requires interdisciplinary expertise in order to be dealt with

MITIGATION OF CLIMATE CHANGE ADVERSE EFFECT BY ACCELERATING FENNEL GROWTH AND FLOWERING

The present experiment was conducted during 2014/2015 and 2015/2016 seasons in the Farm of Medicinal and Aromatic Plants Research Department in El Kanater El Khairia, Egypt to study the effect of ascorbic acid (AA) and citric acid (CA) individually and in combination on Foeniculum vulgare var. vulgare plants, in order to alleiviate climate change adverse effect by induce early flowering and to stimulate the growth and yield. Ascorbic acid and citric acid were sprayed at two rates 100 and 200 ppm. The following results were recorded: In general, Indian fennel plants were significantly responded to ascorbic and citric acid. Ascorbic acid at 100 and 200 ppm and citric acid at 200ppm increased the vegetative growth (plant height and number of branches/plant), number of umbels/plant, fruit yield/plant and essential oil production. Ascorbic and Citric acid each of them at 100 and 200 ppm decreased the time to flowering, this means that, the antioxidant ascorbic and citric acid stimulating fennel growth, shortening the juvenility stage and induce early flowering. The treated plants by the combination of ascorbic and citric acid at 200ppm gave the highest vegetative growth (plant height and number of branches/plant), number of umbels/plant, fruit yield/plant, essential oil production and accelerating flowering by 27 days in the 1st season and 22 day in the 2nd one in comparison with control. Ascorbic acid at 200 ppm plus CA at 200 ppm gave the highest anethole content and the lowest fenchone. Ascorbic acid at 200ppm with CA at 200 ppm produced the least time to flowering. The application of the combination of ascorbic and citric acid at the highest rate 200ppm had a promotion effect in growth traits and inducing early flowering, therefore accelerating fruiting of fennel plants before the sharp fluctuations of climate that occurred in the spring which in turn had a bad effect in fruiting of umbelliferous plants

Morphological variability of Mauritanian date-palm (Phoenix dactylifera L.) cultivars as revealed by vegetative traits

The aim of this study was to use morphological markers to characterize twelve Mauritanian date-palm ecotypes currently grown by farmers. Eighteen phenotypic traits describing the vegetative systems were measured in the field in Atar Oasis. The data set was analyzed by principal components analysis (PCA) and UPGMA clustering. PCA revealed a great variability among the cultivars. Fourteen out of the 18 characters studied showed a high discriminating power suggesting their possible uses in the establishment of a Mauritanian date-palm catalogue. UPGMA Clustering revealed association between cultivars with similar fruit characteristics indicating that these ecotypes are morphologically related. Results also showed that individuals belonging to the Ahmar cultivar were morphologically distinct, suggesting it is likely a polyclonal variety

The implication of ROS production on triflumuron-induced oxidative stress and genotoxicity in human colon carcinoma (HCT-116) cells

The aim of this study is to evaluate the cytotoxic and the genotoxic effects of triflumuron (TFM) on human colon carcinoma cells (HCT-116). Indeed, TFM is used to protect vegetables, fruits, and domestic animals against a large spectrum of parasites causing animal and human disorders. However, studies revealing its toxicity and its mode of action in mammalian systems remain very limited. We monitored our work with the cytotoxicity assay starting with the cell viability test, the ROS generation, the malondialdehyde (MDA) production, the DNA fragmentation, and the measurement of some antioxidant enzymes activities such as catalase, superoxide dismutase, and the glutathione S-transferase. Also, we measured the mitochondrial transmembrane potential. We showed that TFM induced a dose-dependent cell death. This decrease in cell viability was accompanied by a significant reduction in the mitochondrial membrane potential. We also have shown that TFM induced oxidative stress as revealed by the generation of reactive oxygen species, the increase of the MDA levels, and the activation of the antioxidant enzymes. Moreover, our results indicated that TFM induced DNA damage in HCT-116 cells as monitored by the comet assay. We demonstrate, for the first time, the cytotoxic and the genotoxic potentials of TFM on human cultured cells

ANALYSIS OF EGYPTIAN AGRICULTURAL FOREIGN TRADE WITH THE COUNTRIES OF THE EURO - ASIAN UNION

The study aims at identifying the analysis of the Egyptian agricultural foreign trade with the countries of the Euro-Asian Union. The  study problem , its objectives and the research method Where identified in the study. Where , there is a lack of information on the expected results or the role that the proposed free trade agreement between Egypt and the Euro-Asian Union could play and the requirements for maximizing the positive results and minimizing the negative consequences if this agreement is signed. Therefore, the research aims to identify the positive and negative results on the Egyptian economy under the proposed agreement, which contributes to reducing the negatives and supporting the positive factors to achieve effective decision-making. The study included four chapters. First, identifying the stages of economic integration. The second chapter was studying the economic interrelationships between the Russian Federation, Egypt, Belarus, Armenia and Kazakhstan, and the third chapter was the identification of commodity trade relations between Egypt and Eurasian countries during the period 2001-2017 through exports and imports  between Egypt and  the countries of the Euro-Asian Union The most important trading partner of Egypt among these countries is the Russian Federation, where the value of trade exchange between the two countries in 2017 to more than 4 billion dollars, including 3.6 billion imports to Egypt and 0.5 billion exports from Egypt to Russia, The fourth chapter was the use of trade indicators to reveal trade opportunities with the countries of the Euro-Asian Customs Union. Three indicators were used: 1- Conditions of trade, 2- Agricultural trade compatibility, 3- Price competitiveness, The tendency of the terms of exchange for Egypt in many commodities of vegetables and fruits in the studied markets and the most important Russian market and  it shows  the agricultural trade compatibility of these commodities and the advantage of some Egyptian commodities such as oranges, potatoes and grapes have a significant competitive advantage in the Russian market with great importance. The research included several recommendations, including the promotion of intraagricultural trade between Egypt and the EuroAsian countries through preferential agreements, especially with Russia, Armenia and Kazakhstan

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

GIS Based Multi-criteria Analysis for Flood Risk Assessment: Case of Manouba Essijoumi Basin, NE Tunisia

International audienc