667 research outputs found
Molecular mapping of leaf rust resistance gene Lr15 in bread wheat
- Author
- Publication venue
- Sydney University Press
- Publication date
- 01/01/2008
- Field of study
Forced vital capacity trajectories in patients with idiopathic pulmonary fibrosis: a secondary analysis of a multicentre, prospective, observational cohort
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 25/08/2022
- Field of study
BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease with a variable clinical trajectory. Decline in forced vital capacity (FVC) is the main indicator of progression; however, missingness prevents long-term analysis of patterns in lung function. We aimed to identify distinct clusters of lung function trajectory among patients with idiopathic pulmonary fibrosis using machine learning techniques. METHODS: We did a secondary analysis of longitudinal data on FVC collected from a cohort of patients with idiopathic pulmonary fibrosis from the PROFILE study; a multicentre, prospective, observational cohort study. We evaluated the imputation performance of conventional and machine learning techniques to impute missing data and then analysed the fully imputed dataset by unsupervised clustering using self-organising maps. We compared anthropometric features, genomic associations, serum biomarkers, and clinical outcomes between clusters. We also performed a replication of the analysis on data from a cohort of patients with idiopathic pulmonary fibrosis from an independent dataset, obtained from the Chicago Consortium. FINDINGS: 415 (71%) of 581 participants recruited into the PROFILE study were eligible for further analysis. An unsupervised machine learning algorithm had the lowest imputation error among tested methods, and self-organising maps identified four distinct clusters (1-4), which was confirmed by sensitivity analysis. Cluster 1 comprised 140 (34%) participants and was associated with a disease trajectory showing a linear decline in FVC over 3 years. Cluster 2 comprised 100 (24%) participants and was associated with a trajectory showing an initial improvement in FVC before subsequently decreasing. Cluster 3 comprised 113 (27%) participants and was associated with a trajectory showing an initial decline in FVC before subsequent stabilisation. Cluster 4 comprised 62 (15%) participants and was associated with a trajectory showing stable lung function. Median survival was shortest in cluster 1 (2·87 years [IQR 2·29-3·40]) and cluster 3 (2·23 years [1·75-3·84]), followed by cluster 2 (4·74 years [3·96-5·73]), and was longest in cluster 4 (5·56 years [5·18-6·62]). Baseline FEV1 to FVC ratio and concentrations of the biomarker SP-D were significantly higher in clusters 1 and 3. Similar lung function clusters with some shared anthropometric features were identified in the replication cohort. INTERPRETATION: Using a data-driven unsupervised approach, we identified four clusters of lung function trajectory with distinct clinical and biochemical features. Enriching or stratifying longitudinal spirometric data into clusters might optimise evaluation of intervention efficacy during clinical trials and patient management. FUNDING: National Institute for Health and Care Research, Medical Research Council, and GlaxoSmithKline
The Cosmological Constant
- Author
- A Albrecht
- A Albrecht
- A Dekel
- A Dekel
- A Einstein
- A Goobar
- A Kusenko
- A Lue
- A Masiero
- A Melchiorri
- A Sandage
- A Vilenkin
- A Vilenkin
- A Vilenkin
- A Vilenkin
- AA Starobinsky
- AD Dolgov
- AD Dolgov
- AD Lewis
- AD Linde
- AD Linde
- AD Linde
- AD Linde
- AD Linde
- AD Miller
- AG Cohen
- AG Riess
- AG Riess
- AG Riess
- AH Guth
- AN Aguirre
- AN Aguirre
- AN Aguirre
- AR Cooray
- AR Cooray
- AR Liddle
- AR Liddle
- AR Liddle
- B Ratra
- B Ratra
- B Ratra
- B Zumino
- BP Schmidt
- C Alcock
- C Kolda
- C Schmidhuber
- C Wetterich
- CH Lineweaver
- CJ Hogan
- CP Burgess
- CS Kochanek
- CT Hill
- D Branch
- D Huterer
- D Scott
- DE Holz
- DJ Eisenstein
- DJ Eisenstein
- DJ Fixsen
- DJ Heath
- DN Schramm
- DN Spergel
- E Cremmer
- E Witten
- E Witten
- E Witten
- EE Falco
- EI Guendelman
- EJ Copeland
- EJ Guerra
- EL Turner
- EP Hubble
- ET Tomboulis
- EW Kolb
- F Perrotta
- F Perrotta
- F Wilczek
- G Efstathiou
- G Efstathiou
- G Efstathiou
- G Efstathiou
- G Hooft ’t
- G Huey
- G Jungman
- G Jungman
- G Moore
- GA Tammann
- GF Smoot
- GN Felder
- GW Anderson
- H Martel
- HB Casimir
- HP Nilles
- HU Nørgaard-Nielsen
- I Antoniadis
- I Antoniadis
- I Antoniadis
- I Hachisu
- I Smail
- I Waga
- I Zlatev
- I Zlatev
- J García-Bellido
- J García-Bellido
- J Garriga
- J Garriga
- J-P Uzan
- JA Frieman
- JA Frieman
- JA Frieman
- JA Harvey
- JA Newman
- JA Peacock
- JC Charlton
- JD Barrow
- JD Cohn
- JD Lykken
- JD Lykken
- JE Carlstrom
- JE Felten
- JG Bartlett
- JG Polchinski
- JJ Mohr
- JM Overduin
- JP Ostriker
- JR Bond
- JR Bond
- JR Gott
- JR Mould
- JR Primack
- JR Primack
- JT Simonsen
- K Benakli
- K Choi
- K Coble
- K Freese
- KR Dienes
- KR Dienes
- L Amendola
- L Hui
- L Hui
- L Parker
- L Parker
- L Randall
- L Susskind
- L Wang
- LA Kofman
- LA Kofman
- LM Krauss
- LR Abramo
- M Bucher
- M Chiba
- M Dine
- M Dine
- M Fukugita
- M Fukugita
- M Giovannini
- M Gogberashvili
- M Hamuy
- M Kamionkowski
- M Tegmark
- M Tegmark
- M Tegmark
- M Visser
- M White
- M Zaldarriaga
- M Özer
- M Özer
- MB Green
- MC Bento
- MM Phillips
- MS Turner
- MS Turner
- MS Turner
- MS Turner
- MS Turner
- MS Turner
- MT Ressell
- N Arkani-Hamed
- N Bahcall
- N Turok
- N Weiss
- NA Bahcall
- NA Bahcall
- NA Bahcall
- NA Bahcall
- NC Tsamis
- NC Tsamis
- O Bertolami
- O Lahav
- P Binetruy
- P Binétruy
- P Brax
- P Hoflich
- P Horava
- P Kanti
- PA Popowski
- PG Ferreira
- PJ Steinhardt
- PJ Steinhardt
- PJE Peebles
- PJE Peebles
- PJE Peebles
- PJE Peebles
- PM Garnavich
- PM Garnavich
- PS Drell
- R Gambini
- R Horvat
- R Kantowski
- R Ritis de
- RA Battye
- RA Frewin
- RG Carlberg
- RG Carlberg
- RR Caldwell
- RR Caldwell
- S Burles
- S Coleman
- S Dodelson
- S Dodelson
- S Kachru
- S Perlmutter
- S Perlmutter
- S Perlmutter
- S Perlmutter
- S Phillips
- S Podariu
- S Weinberg
- S Weinberg
- S Weinberg
- SA Bludman
- SDM White
- SE Woosley
- SL Bridle
- SM Carroll
- SM Carroll
- SP Martin
- SW Hawking
- SW Hawking
- T Banks
- T Banks
- T Banks
- T Barreiro
- T Chiba
- T Chiba
- T Totani
- TD Saini
- U-L Pen
- V Sahni
- V Sahni
- V Sahni
- VA Rubakov
- W Hu
- W Hu
- W Hu
- W Hu
- W Hu
- W Unruh
- WD Garretson
- WE Ballinger
- WL Freedman
- X Wu
- Y Fujii
- Y Fujii
- Y Nomura
- Y Wang
- YB Zel’dovich
- YJ Ng
- YN Cheng
- Z Kakushadze
- Publication venue
- 'Living Reviews'
- Publication date
- 06/04/2000
- Field of study
This is a review of the physics and cosmology of the cosmological constant.
Focusing on recent developments, I present a pedagogical overview of cosmology
in the presence of a cosmological constant, observational constraints on its
magnitude, and the physics of a small (and potentially nonzero) vacuum energy.Comment: 50 pages. Submitted to Living Reviews in Relativity
(http://www.livingreviews.org/), December 199
Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 12/03/2015
- Field of study
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
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- Attikis A
- Auffray E
- Autermann C
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- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
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- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
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- Baden A
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- Baesso P
- Baffioni S
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- Baillon P
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- Bauerdick LAT
- Baumgartel D
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- CMS Collaboration
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- Yilmaz Y
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- Yumiceva F
- Yun JC
- Zabel J
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acosta MV
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- Wickramage N
- Widl E
- Wigmans R
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- Williams G
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- Willmott C
- Wimpenny S
- Winn D
- Winstrom L
- Wissing C
- Wittich P
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- Woehri HK
- Wolf M
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- Womersley WJ
- Won S
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- Wood JS
- Worm SD
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- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
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- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
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- Ahmad WH
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- Andreev Y
- Andrews W
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- Chang YH
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- Chang YW
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- Chao Y
- Charaf O
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- Chasco M
- Chatterjee A
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- Checchia P
- Chen GM
- Chen HS
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- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
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- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
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- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cushman P
- Cussans D
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silva WLP
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- Dallavalle GM
- Damgov J
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- Dammann D
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- Daubie E
- David A
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- de Barbaro P
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- de Cassagnac RG
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- De La Cruz B
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- De Roeck A
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- de Troconiz JF
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- Eugster J
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- Evangelou I
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- Wood JS
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- Wyslouch B
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- Yilmaz Y
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- Zanetti M
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- Zeuner WD
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- Ziebarth EB
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- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunovic Z
- Apanasevich L
- Appelt E
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
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- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zheng Y
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- Zhukov V
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Compressed representation of a partially defined integer function over multiple arguments
- Author
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- Abbiendi G
- Abbrescia M
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- Abdullin S
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Zachariadou A
- Zalewski P
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- Zanetti M
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- Zelepoukine S
- Zeuner WD
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
- …