The Relationship of Knowledge Management and Organizational Performance in Science and Technology Parks of Iran

Any effective and sustainable changes in an organization refers to three areas related with each other and play the best way in the humans, structure and technology fields. The Knowledge management by emphasizing the three areas with the axis of man and preparing him as a knowledge worker tries to achieve organizational goals.Purpose: The current study aims to investigate the existing relationship between knowledge management infrastructures, knowledge management process capabilities, creative organizational learning, and organizational performance.Originality/value: Previous researches did not appraise the effect of knowledge management and its capabilities on organizational performance, and the specific influence of creative organizational learning was disregarded. The present study demonstrates the mechanism of knowledge management effect on organizational performance and describes the comprehensive dimensions of knowledge management performance.Methodology: Statistical population includes executives of Knowledge based companies in Science and Technology Parks of Iran. The 336 questionnaire was distributed to the census, 248questionnaireswerecompletedcorrectly. The research data were analyzed by PLS software. The unit of analysis is a company that has adopted a KMS. Target population of the research consisted of 700 Top Managers of Knowledge based companies in Science and Technology Parks of Iran (N=700). Random sampling method applied in this study and 248Top Managers were considered as the statistical sample based on "Morgan Table". One standard 5-point Likert questionnaire adopted and distributed between Top managers in the park. 252 questionnaires were returned among which 248 ones were statistically investigated. The structural relations among variables were tested using the partial least squares (PLS) method.Findings: This study shows that the KM processes can mediate between creative organizational learning and factors in the KM infrastructure. The results of the study demonstrate that knowledge management process capabilities has the most crucial role in creative organizational learning. The results indicate that there is a significant influence of the infrastructure capabilities (Collaboration, Trust, Learning Culture, Decentralization, Top Management, Promotion, IT support) on the process capabilities, also the impacts of knowledge management process capabilities on creative organizational learning and the impacts of creative organizational learning on organizational performance was confirmed

Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017 : A systematic analysis for the global burden of disease study

Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-Adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs). Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care. © 2019 American Medical Association. All rights reserved.Peer reviewe

Diagnostic methods for Helicobacter pylori infection: ideals,options, and limitations

AbstractHelicobacter pylori (H. pylori) resides in the stomach, colonizes gastric epithelium, and causes several digestive system diseases.Several diagnostic methods utilizing invasive or non-invasive techniques with varying levels of sensitivity and specificity aredeveloped to detect H. pylori infection. Selection of one or more diagnostic tests will depend on the clinical conditions, theexperience of the clinician, cost, sensitivity, and specificity. Invasive methods require endoscopy with biopsies of gastric tissuesfor the histology, culture, and rapid urease test. Among non-invasive tests, urea breath test and fecal antigen tests are a quickdiagnostic procedure with comparable accuracy to biopsy-based techniques and are methods of choice in the test and treatmentsetting. Other techniques such as serological methods to detect immunoglobulin G antibodies to H. pylori can show highaccuracy as other non-invasive and invasive biopsies, but do not differentiate between current or past H. pylori infections.Polymerase chain reaction (PCR) is an emerging option that can be categorized as invasive and non-invasive tests. PCR methodis beneficial to detect H. pylori from gastric biopsies without the need for the cultures. There is no other chronic gastrointestinalinfection such as H. pylori with a set of comparable diagnostic methodologies. Despite the availability of multiple diagnosticmethods, it remains unclear on the choice of any one method as the gold standard for detecting H. pylori infection, especially inepidemiological studies. In this work, we review the principal diagnostic methods used to detect H. pylori infection and theiradvantages and disadvantages, and applications in clinical practice.Keywords Helicobacter pylori . Characteristics of infection . Diagnosis . Invasive tests . Non-invasive test

The eminence status of bacterial pigments under different aspects

Several bacteria such as Flavobacterium, Serratias, Chromobacterium and Streptomyces that produce different pigments are playing a significant role in various fields of sciences. Alternatively, current knowledge about bacterial pigments is limited to medical bacteriology, for instance their importance in virulence factors and protective features, however recently the investigators have revealed the supplementary consequence of pigments in food, textile and pharmaceutical aspects

Investigation of ATG5, ATG12 and LC3 Genes Expression Related to Autophagy in Colorectal Cancer

AbstractBackground: Colorectal cancer is the fourth leading cause of cancer deaths around the world. This type of cancer, like other cancers, is caused by the influence of environmental and genetic factors. One of the important mechanisms involved in cancer, especially colorectal cancer, is the autophagy mechanism. In this mechanism, important genes have been identified, including ATG12, ATG5, and LC3 genes.Method: To evaluate the gene expression level, thirty colorectal tumor samples and thirty adjacent normal samples were used for carrying out Real-Time PCR method.Results: We reported that there was no significant difference in the expression level of ATG12 and LC3 genes in tumor samples compared to normal samples (P>0.05), while the expression level of ATG5 gene with P Value=0.031 illustrated that this gene was reduced in colorectal tumor samples.Key Words: Colorectal cancer, Autophagy, Real Time-PCR, ATG12, ATG5, LC

The Relationship of Knowledge Management and Organizational Performance in Science and Technology Parks of Iran

Abstract Any effective and sustainable changes in an organization refers to three areas related with each other and play the best way in the humans, structure and technology fields. The Knowledge management by emphasizing the three areas with the axis of man and preparing him as a knowledge worker tries to achieve organizational goals. Purpose: The current study aims to investigate the existing relationship between knowledge management infrastructures, knowledge management process capabilities, creative organizational learning, and organizational performance. Originality/value: Previous researches did not appraise the effect of knowledge management and its capabilities on organizational performance, and the specific influence of creative organizational learning was disregarded. The present study demonstrates the mechanism of knowledge management effect on organizational performance and describes the comprehensive dimensions of knowledge management performance. Methodology: Statistical population includes executives of Knowledge based companies in Science and Technology Parks of Iran. The 336 questionnaire was distributed to the census, 248questionnaireswerecompletedcorrectly. The research data were analyzed by PLS software. The unit of analysis is a company that has adopted a KMS. Target population of the research consisted of 700 Top Managers of Knowledge based companies in Science and Technology Parks of Iran (N=700). Random sampling method applied in this study and 248Top Managers were considered as the statistical sample based on "Morgan Table". One standard 5-point Likert questionnaire adopted and distributed between Top managers in the park. 252 questionnaires were returned among which 248 ones were statistically investigated. The structural relations among variables were tested using the partial least squares (PLS) method. Findings: This study shows that the KM processes can mediate between creative organizational learning and factors in the KM infrastructure. The results of the study demonstrate that knowledge management process capabilities has the most crucial role in creative organizational learning. The results indicate that there is a significant influence of the infrastructure capabilities (Collaboration, Trust, Learning Culture, Decentralization, Top Management, Promotion, IT support) on the process capabilities, also the impacts of knowledge management process capabilities on creative organizational learning and the impacts of creative organizational learning on organizational performance was confirmed

An innovative Blockchain-based model to implement the 2030 Agenda in Italy

One of the most crucial collective efforts in history for improving the lives of billions of people is the Sustainable Development Goals (SDGs). The assessment of the implementation of the SDGs in Italy in 2019 demonstrates that, overall, Italian cities have achieved 53% of the implementation of the SDGs from 100 percent full achievement. In addition, in many regions, the investigation verifies the gap between the country's north and south. Given that the use of the transformational power of blockchain to achieve the SDGs looks promising, the goal of this study is to explore how blockchain may improve the implementation of the 2030 Agenda in Italy. In this research, a qualitative approach and the strategy of the systematic literature review and thematic analysis have been adopted. Our proposed model includes Big Data, Data Mining, Ethereum, and (IPFS), and NoSQL. The originality of the paper consists of developing an innovative blockchain model to adopt the potential of blockchain technology to implement the 2030 Agenda considering existing discussions in governance science, sustainability science, and data science. Consequentially, due to its comprehensive and structured nature, superior to existing approaches. The research findings offer insights to the policymakers and authorities at the regional and national levels on how to implement the 2030 Agenda through blockchain-based innovative solutions in Italy to reduce territorial inequalities between regions in Italy. and provides support knowledge to define Italy's sustainable development strategy toward achieving the 2030 Agenda in Italy

Developing a Blockchain-based Framework for Improving Customers' Loyalty to the Wine Brand: A Case Study

this paper focuses on the wine industry and explores how blockchain use cases, and blockchain-based applications including smart contracts, can improve the loyalty of customers to the wine brand. Starting from the strategies currently adopted in the wine industry to upgrade the customers’ loyalty towards the wine brands, the study aimsto propose potential applications of the BCT and smart contracts to make these strategies more effective and less expensive