4,543 research outputs found
Theory of mirror benchmarking and demonstration on a quantum computer
- Author
- Publication venue
- Publication date
- 01/06/2023
- Field of study
A new class of protocols called mirror benchmarking was recently proposed to
measure the system-level performance of quantum computers. These protocols
involve circuits with random sequences of gates followed by mirroring, that is,
inverting each gate in the sequence. We give a simple proof that mirror
benchmarking leads to an exponential decay of the survival probability with
sequence length, under the uniform noise assumption, provided the twirling
group forms a 2-design. The decay rate is determined by a quantity that is a
quadratic function of the error channel, and for certain types of errors is
equal to the unitarity. This result yields a new method for estimating the
coherence of noise. We present data from mirror benchmarking experiments run on
the Honeywell System Model H1. This data constitutes a set of performance
curves, indicating the success probability for random circuits as a function of
qubit number and circuit depth
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
- Author
- A Balbis
- A Bruzzaniti
- A Gschwind
- Angela Bruzzaniti
- BS Kochupurakkal
- Erin Crismore
- F Ciardiello
- G Bergers
- G Lorch
- GP Gupta
- J Foley
- J Sebastian
- J Yang
- JE Lee
- Jennifer L. Gilmore
- JL Gilmore
- JL Gilmore
- JM Roda
- John Foley
- JR Hens
- JT Price
- K Furugaki
- K Roepstorff
- KD Voduc
- Khalid S. Mohammad
- KJ Wilson
- KS Mohammad
- L Ciarloni
- L Qin
- L Qin
- LC Gerstenfeld
- LJ van 't Veer
- MA Ryan
- MJ Scandlyn
- MJ van de Vijver
- MR Allen
- N Bhagavathula
- NC Luetteke
- NE Davidson
- NE Willmarth
- NE Willmarth
- Nicole K. Nickerson
- P Berthon
- PA Kenny
- PD Bos
- Pranela Rameshwar
- RJ Thomas
- S Goswami
- SI Park
- SL Moulder
- T Sorlie
- T Voloshin
- TA Guise
- TA Guise
- Theresa A. Guise
- X Lu
- XR Yang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB family ligands, suggesting participation of these growth factors in autocrine and paracrine signaling within the bone microenvironment. EGFR ligand expression was profiled in the bone metastatic MDA-MB-231 cells (MDA-231), and agonist-induced signaling was examined in both breast cancer and osteoblast-like cells. Both paracrine and autocrine EGFR signaling were inhibited with a neutralizing amphiregulin antibody, PAR34, whereas shRNA to the EGFR was used to specifically block autocrine signaling in MDA-231 cells. The impact of these was evaluated with proliferation, migration and gene expression assays. Breast cancer metastasis to bone was modeled in female athymic nude mice with intratibial inoculation of MDA-231 cells, and cancer cell-bone marrow co-cultures. EGFR knockdown, but not PAR34 treatment, decreased osteoclasts formed in vitro (p<0.01), reduced osteolytic lesion tumor volume (p<0.01), increased survivorship in vivo (p<0.001), and resulted in decreased MDA-231 growth in the fat pad (p<0.01). Fat pad shEGFR-MDA-231 tumors produced in nude mice had increased necrotic areas and decreased CD31-positive vasculature. shEGFR-MDA-231 cells also produced decreased levels of the proangiogenic molecules macrophage colony stimulating factor-1 (MCSF-1) and matrix metalloproteinase 9 (MMP9), both of which were decreased by EGFR inhibitors in a panel of EGFR-positive breast cancer cells. Thus, inhibiting autocrine EGFR signaling in breast cancer cells may provide a means for reducing paracrine factor production that facilitates microenvironment support in the bone and mammary gland
Recommended from our members
A Search for Dark Higgs Bosons
- Author
- Acosta JG
- Adam N
- Adametz A.
- Adye T.
- Ahmed H.
- Akar S.
- Akchurin N
- Alagoz E
- Alam M. S.
- Albert J.
- Alver B
- Alverson G
- Anastassov A
- Anderson M
- Andreassen R.
- Angelini C.
- Antonelli L
- Anulli F.
- Appelt E
- Arenton MW
- Arnaud N.
- Asaadi J
- Asgeirsson D. J.
- Aston D.
- Atmacan H.
- Atramentov O
- Ayad R.
- Bachtis M
- Baden A
- Bailey D.
- Balazs M
- Baldini-Ferroli R.
- Band H. R.
- Banerjee Sw
- Barberis E
- Bard D. J.
- Barfuss AF
- Baringer P
- Barker A
- Barlow R. J.
- Barnes VE
- Barnett BA
- Bartoldus R.
- Batignani G.
- Bauer G
- Baumgartel D
- Baur U
- Bean A
- Behera P. K.
- Behn E.
- Bellinger JN
- Bellis M.
- Ben-Haim E.
- Bendavid J
- Benelli G
- Benitez J. F.
- Bernard D.
- Bernlochner F. U.
- Berry D
- Berry E
- Betchart B
- Bettarini S.
- Bettoni D.
- Bevan A. J.
- Bhatti A
- Bhuyan B.
- Bianchi F.
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- Biassoni P.
- Bingham I.
- Blinov V. E.
- Bloom K
- Bloom P. C.
- Blumenfeld B
- Bodek A
- Boeriu O
- Bolla G
- Bolton T
- Bomben M.
- Bonato A
- Bondioli M.
- Bonneaud G. R.
- Borrello L
- Bortoletto D
- Bose S
- Boulahouache C
- Boutemeur M
- Boutle S
- Bozzi C.
- Brau J.
- Briand H.
- Brown D. N.
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- Brownson E
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- Burchat P. R.
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- Campagnari C.
- Carlsmith D
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- Casarosa G.
- Cavoto G.
- Ceballos GG
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- Cerizza G
- Cervelli A.
- Chakaberia I
- Chan M
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- Cheaib R.
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- Chung YS
- Cibinetto G.
- Ciesielski R
- Claes DR
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- Cochran J.
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- Noonan D
- Nugent I. M.
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- Odell N
- Ofierzynski RA
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- Svintradze I
- Svyatkovskiy A
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- Toki W. H.
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- Touramanis C.
- Tran NV
- Tully C
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- Uwer U.
- Va'vra J.
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- Vargas JER
- Vasseur G.
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- Velkovska J
- Verderi M.
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- Vitale L.
- Vitug G. M.
- Volobouev I
- Voss C.
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- Wang W. F.
- Wayne M
- Weaver M.
- Weinberg M
- Weinberger M
- Wenger EA
- Werner JS
- West C. A.
- Whitbeck A
- White R. M.
- Wigmans R
- Williams G
- Wilson F. F.
- Wilson J. R.
- Wisniewski W. J.
- Wittgen M.
- Won S
- Wood D
- Wood JS
- Wormser G.
- Wray B. C.
- Wright D
- Wright D. H.
- Wright D. M.
- Wu S. L.tkin T
- Wulsin H. W.
- Xie S
- Yan M
- Yang M
- Yang ZC
- Yazgan E
- Yeche Ch
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
- Young C. C.
- Yushkov A. N.
- Zabel J
- Zablocki J
- Zallo A.
- Zanetti M
- Zatserklyaniy A
- Zhang J
- Zheng Y
- Zhukova V
- Ziegler J
- Ziegler V.
- Zielinski M
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
- Bargassa P
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bayshev I
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Beernaert K
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Belknap D
- Bell AJ
- Bell KW
- Bellan P
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- Bellinger JN
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
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- Beni N
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- Benvenuti AC
- Beranek S
- Beretvas A
- Bergauer T
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- Beri SB
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- Betchart B
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- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Bialas W
- Bialkowska H
- Bian JG
- Bianchi G
- Bianchini L
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bilinskas MJ
- Bilki B
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- Bitioukov S
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- Bloch I
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- Zang J
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acosta MV
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- Xiao H
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Adiguzel A
- Adler V
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- Aguilar-Benitez M
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- Brigliadori L
- Brigljevic V
- Broccolo G
- Brom JM
- Brona G
- Brooke JJ
- Broutin C
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- Brun H
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- Butler PH
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- Bylsma B
- Caballero IG
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- Cabrillo IJ
- Caebergs T
- Cakir A
- Calabria C
- Calderon A
- Cali IA
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- Caminada L
- Campagnari C
- Campbell A
- Campderros JD
- Camporesi T
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- Chang YH
- Chang YH
- Chang YW
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- Chao Y
- Charaf O
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- Chatterjee A
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- Chung J
- Chung YS
- Chwalek T
- Ciesielski R
- Cifuentes JAB
- Cihangir S
- Cimmino A
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
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- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Cole P
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- Collard C
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- Conetti S
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- Cooper SI
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- Costantini S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Creanza D
- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cushman P
- Cussans D
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silva WLP
- Dahmes B
- Dahms T
- Dallavalle GM
- Damgov J
- Damiao DD
- Dammann D
- Danielson T
- Darmenov N
- Das S
- Daskalakis G
- Dasu S
- Daubie E
- David A
- Davids M
- Davies G
- De Araujo FTD
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- De Filippis N
- De Gruttola M
- De Guio F
- De Jeneret JD
- De La Cruz B
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Palma M
- De Roeck A
- De Souza SF
- de Troconiz JF
- De Visscher S
- De Wolf EA
- Debreczeni G
- Deisher A
- Deiters K
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
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- Adiguzel A
- Adler V
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- Aguilar-Benitez M
- Aguilo E
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- Ahmad WH
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV
- Author
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- Álvarez Fernández A.
- Özçelik Ö.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 24/04/2020
- Field of study
The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8 TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum
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