125 research outputs found
BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions
- Author
- Publication venue
- Publication date
- 04/06/2014
- Field of study
Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural relationship between the aversive motivational state produced by drug withdrawal and the development of the drug-dependent state still remains elusive. It has been observed that chronic exposure to drugs of abuse increases brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. In particular, BDNF expression is dramatically increased during drug withdrawal, which would suggest a direct connection between the aversive state of withdrawal and BDNF-induced neuronal plasticity. Using lentivirus-mediated gene transfer to locally knock down the expression of the BDNF receptor tropomyosin-receptor-kinase type B in rats and mice, we observed that chronic opiate administration activates BDNF-related neuronal plasticity in the VTA that is necessary for both the establishment of an opiate-dependent state and aversive withdrawal motivation. Our findings highlight the importance of a bivalent, plastic mechanism that drives the negative reinforcement underlying addiction
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir Gökhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary N’tji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville Renée N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- D’Antuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- García-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
- Hare Stephanie
- Harijan Rajesh K.
- Haupt Larisa M.
- He Yuan
- Hedstrom Lizbeth
- Hedstrom Lizbeth
- Heifets Abraham
- Henriksen Niel
- Herdendorf Timothy J.
- Hermle Tobias
- Herr Andrew B.
- Hickey Robert J.
- Hildeman David A.
- Hirsch Anna K. H.
- Ho Gregory
- Hopkins Kevin M.
- Hoppe Heinrich
- Horstmann Nicola
- Hosfield David J.
- Hossain Sakib
- Houry Walid A.
- Hsiao Edward C.
- Hu Di
- Hu Yanmei
- Huang Chang
- Huimei Chen
- Hussain Muhammad Saddam
- Iglesias Pablo
- Ikegami Tetsuro
- Ilari Andrea
- Inde Zintis
- Ingoglia Filippo
- Iommarini Luisa
- Ip Philbert
- Jackson Michael R.
- Jafar-Nejad Hamed
- Jayasinghe Thilina D.
- Jo Eunji
- Johannsen Sandra
- John Ashley L. St.
- Jones Peter L.
- Jossart Jennifer N.
- Jung Hoyoung
- Kahler Charlene M.
- Kampourakis Thomas
- Kandror Olga
- Karan Charles
- Katyal Sachin
- Kee Jung-Min
- Kee Jung-Min
- Keedy Daniel A.
- Kejriwal Rishabh
- Keller Charles
- Kelm Robert J.
- Kemet Chinyere Maat
- Kenyon Victor
- Kerr William G.
- Khalaf Noureddine Ben
- Kilkenny Mairi Louise
- Kim Hyeong Jun
- Kim Kyu Kwang
- Kootstra Neeltje A.
- Koppisetti Rama K.
- Korotkov Konstantin V.
- Kotzé Timothy J.
- Kováts Benjámin
- Kratz Jadel Müller
- Krishnamurthy Durga
- Krist David T.
- Kroon Erna Geessien
- Kushnir Alexander
- Kwiatkowski Jacek
- Laggner Christian
- Lai Kent
- Lake Robert J.
- Lam Andrew
- Lama Eleonora
- Lan Tong
- Landfear Scott M.
- Lasarte Juan José
- Lawrence Daniel A.
- Lee Andreia H.
- Lee Donghan
- Lee Gyeongeun
- Lee Jiyoun
- Lee Kyung Hyeon
- Lee Pil H.
- Legare Scott
- Lehtiö Lari
- Lembo Gaia
- Lempicki Camille
- Lenci Elena
- Leng Fenfei
- Lescar Julien
- Leung Elisa
- Leuzzi Giuseppe
- Levin Michael
- Li Hai
- Li Shan
- Li Wei
- Li Yihe
- Li Yong
- Li Yunlong
- Liao Jiayu
- Liao Junzhuo
- Lieberman Howard B.
- Lin Jiabei
- Lin Jiusheng
- Liou Benjamin
- Lisabeth Erika Mathes
- Liu Chen
- Liu Koting
- Liu Pengda
- Liu Pengda
- Liu Zhongle
- Lobb Kevin A.
- Lolicato Marco
- Lolli Marco Lucio
- Longo Nicola
- Lotsaris Irina
- Lowther W. Todd
- Loy Cody A.
- Lu Xin
- Luh Frank
- Lukacs Gergely L.
- Luo Dahai
- Lussier Marc P.
- Lynn Edward G.
- Machaca Khaled
- Maciag Joseph J.
- Macias Maria J.
- MacKeigan Jeffrey P.
- Mahmoodi Niusha
- Maksimainen Mirko M.
- Malkas Linda H.
- Maltarollo Vinícius Gonçalves
- Mameli Eleonora
- Manor Danny
- Mantri Chinmay Kumar
- Maranda Vincent
- Martin Katie R.
- Martin-Malpartida Pau
- Maruta Shinsaku
- Marx Steven O.
- Mason Emily R.
- Matheeussen An
- Matovic Nick
- Mattevi Andrea
- Maurice Martin St.
- Mayer Gaétan
- Maynes Jason T.
- Mazitschek Ralph
- McCarthy Ronan R.
- McDowell Mary Ann
- McManus Kirk James
- Mehedi Masfique
- Mehlman Tamar
- Mellado Mario
- Mellor Paul
- Merrill Nathan M.
- Michlewski Gracjan
- Milosavljevic Julian
- Minakova Anna
- Miner Jaden
- Moharreri Ehsan
- Molyneaux Kathleen A.
- Montanaro Anna
- Moore Hannah P.
- Moore Richard G.
- Moreda Teresa Lozano
- Moreira David
- Moreira Paulo Otávio Lourenço
- Morisseau Christophe
- Morrison Adrian
- Morten Brianna C.
- Mostert Konrad J.
- Mota Bruno Eduardo Fernandes
- Motyl Anna A. L.
- Mousa Jarrod J.
- Mowat Michael
- Muli Christine S.
- Mungrue Imran N.
- Mushtaq Aisha
- Musta Kirsikka
- Müller Anna
- Müller Christa E.
- Myhr Courtney
- Mysinger Michael
- Mysore Venkatesh
- Nagai Maira Harume
- Nagamori Kiyo
- Namasivayam Vigneshwaran
- Nasburg Joshua Alexander
- Ng Ho Leung
- Ng James
- Ngo Lien
- Ngoi Peter
- Nguyen Kong
- Novina Carl D.
- null null
- Ogunwa Tomisin Happy
- Ojha Anil K.
- Ojo Kayode K.
- Olson Steven H.
- Ortiz Diana
- Oyarzabal Julen
- O’Brien Terrence E.
- O’Connell Patrick
- O’Dea Austin
- O’Donoghue Anthony J.
- O’Mara Megan L.
- O’Mara Tracy A.
- O’Meara Timothy R.
- O’Sullivan Ann Marie
- Pai Vaibhav P.
- Paige Mikell
- Palazzo Teresa
- Panganiban Antonito T.
- Paparella Ashleigh S.
- Parang Keykavous
- Parico Gian Carlo G.
- Park Soonju
- Partch Carrie L.
- Pascal John M.
- Pasquali Marzia
- Patel Amit K.
- Paulino Cristina
- Pederick Jordan L.
- Peltier Cheryl
- Pemberton Ryan P.
- Perry Benjamin
- Perry J. Jefferson P.
- Petretto Enrico
- Pérez-Pertejo Yolanda
- Phadke Sameer
- Pham Kien
- Pineda-Lucena Antonio
- Poirier Steve
- Popowicz Grzegorz Maria
- Porcelli Anna Maria
- PrasadPrasad Srimukh Veccham Krishna
- Presser Adam G.
- Pressly Brandon
- Prikler Gergely
- Prince Ashutosh
- Puchades-Carrasco Leonor
- Pusztai Lajos
- Qi Xin
- Qin Xingping
- Qureshi Insaf Ahmed
- Rabal Obdulia
- Radhakrishnan Senthil K.
- Ramachandran Rajesh
- Randall Lía M.
- Rangarajan Amith Vikram
- Rayman Joseph B.
- Reglero Clara
- Reguera Rosa Maria
- Reidenbach Andrew G.
- Reis Joana
- Ribeiro Beatriz Murta Rezende Moraes
- Richardson Timothy I.
- Riches David W. H.
- Rizzi Menico
- Robinson Victoria L.
- Rocha Rafael Eduardo Oliveira
- Rodriguez G. Marcela
- Rodríguez-Frade José Miguel
- Rohde Kyle H.
- Ronchi Virginia Paola
- Ronning Donald R.
- Rosnik Andreana
- Roti Giovanni
- Rouzbeh Nirvan
- Rowswell-Turner Rachael B.
- Rubin Eric J.
- Rucinski Gwennan
- Safo Martin K.
- Sainas Stefano
- Salas Brenda P. Medellin
- Samantha Ariela
- Samudio Ben
- Santiago César
- Sarangapani Krishna
- Sarilla Suryakala
- Sarosiek Kristopher
- Schneider Nicholas O.
- Schroedl Stefan
- Scoffone Viola Camilla
- Segers Vincent F. M.
- Seo Seung-Yong
- Serafim Mateus Sá Magalhães
- Shaqra Ala M.
- Shek Stefani
- Shelburne Samuel A.
- Shim Heesung
- Shorter James
- Shoue Douglas A.
- Shum David
- Shyng Show-Ling
- Siderovski David P.
- Sidorova Yulia A.
- Silva Elany Barbosa
- Silvennoinen Olli
- Singh Nathanael
- Singh Neeraj
- Singh Rakesh K.
- Siqueira-Neto Jair L.
- Sishtla Kamakshi
- Sistla Jyothi C.
- Skorodinsky Maxim
- Slotboom Dirk J.
- Smith David M.
- Smith Kristiana S.
- Smrcka Alan V.
- So Jonathan
- Sobrado Pablo
- Soellner Matthew B.
- Solano Roberto
- Sorenson Jon M.
- Stafford Kate
- Stahl Andreas
- Statsyuk Alexander V.
- Stec Natalia
- Stecula Adrian
- Stetefeld Joerg
- Strauss Erick
- Stuchbury Grant David
- Su Leila
- Su Tong
- Su Zhengchen
- Sugamori Kim S.
- Sun Ying
- Suterwala Shabbir
- Svensson Fredrik
- Sverzhinsky Aleksandr
- Swart Tarryn
- Taglialatela Angelo
- Tam Heng-Keat
- Tandon Vasudha
- Tang Weiping
- Tang Young
- Tanner John J.
- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed M.
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar B.
- Aji Budi
- Akalu Temesgen Y.
- Akinyemi Rufus O.
- Akinyemiju Tomi
- Akombi Blessing J.
- Akunna Chisom J.
- Al-Aly Ziyad
- Al-Mekhlaf Hesham M.
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad M.
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline E.
- Alema Niguse M.
- Alemu Biresaw W.
- Alemu Yihun M.
- Alhabib Khalid F.
- Alhassan Robert K.
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed M.
- Alla François
- Allebeck Peter
- Almadi Majid A.
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa K.
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amare Bekalu
- Amini Saeed
- Amini-Rarani Mostafa
- Aminorroaya Arya
- Amiri Fatemeh
- Amit Arianna M.
- Amugsi Dickson A.
- Amul Gianna G.
- Anbesu Etsay W.
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A.
- Andrei Catalina L.
- Andrei Tudorel
- Androudi Sofia
- Angus Colin
- Anjomshoa Mina
- Ansari Fereshteh
- Ansari Iman
- Ansari-Moghaddam Alireza
- Antonazzo Ippazio C.
- Antonio Carl A.
- Antony Catherine M.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth C.
- Arab-Zozani Morteza
- Arabloo Jalal
- Aravkin Aleksandr Y.
- Arba Aseb A.
- Aremu Olatunde
- Ariani Filippo
- Aripov Timur
- Armoon Bahram
- Arowosegbe Oluwaseyi O.
- Aryal Krishna K.
- Arzani Afsaneh
- Asaad Malke
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asgari Samaneh
- Asghari Jafarabadi Mohammad
- Asghari Babak
- Ashbaugh Charlie
- Assmus Michael
- Atafar Zahra
- Athari Seyyed S.
- Atnafu Desta D.
- Atout Maha M.
- Atre Sachin R.
- Atteraya Madhu
- Ausloos Floriane
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide Frinel G. Arthur
- Ayala Quintanilla Beatriz P.
- Ayano Getinet
- Ayanore Martin A.
- Aynalem Getie L.
- Aynalem Yared A.
- Ayza Muluken A.
- Azari Samad
- Azarian Ghasem
- Azene Zelalem N.
- Azhar Gulrez
- Azzopardi Peter
- B Darshan B.
- Babaee Ebrahim
- Badawi Alaa
- Badiye Ashish D.
- Bagherzadeh Mojtaba
- Bagli Eleni
- Bahrami Mohammad A.
- Baig Atif A.
- Bairwa Mohan
- Bakhshaei Mohammad H.
- Bakhtiari Ahad
- Bakkannavar Shankar M.
- Balachandran Arun
- Balakrishnan Senthilkumar
- Balalla Shivanthi
- Balassyano Shelly
- Baldasseroni Alberto
- Bali Ahmed O.
- Ball Kylie
- Ballew Shoshana
- Balzi Daniela
- Banach Maciej
- Banerjee Srikanta K.
- Banik Palash C.
- Bannick Marlena S.
- Bante Agegnehu B.
- Bante Simachew A.
- Baraki Adhanom G.
- Barboza Miguel A.
- Barker-Collo Suzanne L.
- Barrero Lope H.
- Barthelemy Celine M.
- Barua Lingkan
- Barzegar Akbar
- Basaleem Huda B.
- Bassat Quique
- Basu Sanjay
- Baune Bernhard T.
- Bayati Mohsen
- Baye Bayisa A.
- Bazmandegan Gholamreza
- Becker Jacob S.
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Bekuma Tariku T.
- Bell Michelle L.
- Bello Aminu K.
- Bender Rose G.
- Bennett Derrick A.
- Bennitt Fiona B.
- Bensenor Isabela M.
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- Plana-Ripoll Oleguer
- Plass Dietrich
- Pletche Martin
- Pokhrel Khem N.
- Polibin Roman V.
- Polinder Suzanne
- Polkinghorne Kevan R.
- Pond Constance D.
- Postma Maarten J.
- Pottoo Faheem H.
- Pourjafar Hadi
- Pourmalek Farshad
- Pourmirza Kalhori Reza
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas R.
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
- Regassa Lemma D.
- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad Mashhour
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline Elizabeth
- Alema Niguse Meles
- Alemu Biresaw Wassihun
- Alemu Yihun Mulugeta
- Alhabib Khalid F.
- Alhassan Robert Kaba
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
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- Allebeck Peter
- Almadi Majid Abdulrahman Hamad
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- Altirkawi Khalid A.
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- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
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- Amini Saeed
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- Aminorroaya Arya
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- Ancuceanu Robert
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- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Jurisson Mikk
- Kabir Ali
- Kabir Zubair
- Kafil Hossein Samadi
- Kalan Mohammad Ebrahimi
- Kalani Hamed
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- Kalankesh Leila R.
- Kalhor Rohollah
- Kalhori Reza Pourmirza
- Kamath Aruna M.
- Kamiab Zahra
- Kanchan Tanuj
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- Karanikolos Marina
- Karch Andre
- Karim Mohd Anisul
- Karimi Salah Eddin
- Karimi Seyed Asaad
- Karimi Seyed M.
- Karyani Ali Kazemi
- Kasa Ayele Semachew
- Kassa Getachew Mullu
- Kassebaum Nicholas J.
- Katikireddi Srinivasa Vittal
- Kawakami Norito
- Kayode Gbenga A.
- Keddie Suzanne H.
- Keiyoro Peter Njenga
- Keller Cathleen
- Kemmer Laura
- Kendrick Parkes J.
- Kereselidze Maia
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khalid Nauman
- Khammarnia Mohammad
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khan Maseer
- Khaneghah Amin Mousavi
- Khang Young-Ho
- Khatab Khaled
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- Khater Mona M.
- Khatib Mahalaqua Nazli
- Khayamzadeh Maryam
- Khazaei Salman
- Khazaie Habibolah
- Khodayari Mohammad Taghi
- Khoja Abdullah T.
- Khubchandani Jagdish
- Khundkar Roba
- Kianipour Neda
- Kieling Christian
- Kim Cho-Il
- Kim Daniel
- Kim Young-Eun
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- Kimokoti Ruth W.
- Kinfu Yohannes
- Kisa Adnan
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- Kissimova-Skarbek Katarzyna
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- Moazen Babak
- Moghadam Telma Zahirian
- Moghadaszadeh Masoud
- Moghaddam Sahar Saeedi
- Mohajer Bahram
- Mohamad Osama
- Mohamadi Efat
- Mohammad Dara K.
- Mohammad Yousef
- Mohammadbeigi Abolfazl
- Mohammadian-Hafshejani Abdollah
- Mohammadifard Noushin
- Mohammadpourhodki Reza
- Mohammed Ammas Siraj
- Mohammed Hussen
- Mohammed Jemal Abdu
- Mohammed Shafiu
- Mohebi Farnam
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- Molokhia Mariam
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- Moradi Ghobad
- Moradi Masoud
- Moradi-Joo Mohammad
- Moradi-Lakeh Maziar
- Moradzadeh Rahmatollah
- Moraga Paula
- Morales Linda
- Morawska Lidia
- Morgado-da-Costa Joana
- Morrison Shane Douglas
- Mosapour Abbas
- Mosser Jonathan F.
- Motlagh Soraya Nouraei
- Mouodi Simin
- Mousavi Seyyed Meysam
- Mueller Ulrich Otto
- Mukhopadhyay Satinath
- Mullany Erin C.
- Mumford John Everett
- Munro Sandra B.
- Muriithi Moses K.
- Murray Christopher J. L.
- Musa Kamarul Imran
- Mustafa Ghulam
- Muthupandian Saravanan
- Nabavizadeh Behnam
- Nabhan Ashraf F.
- Naderi Mehdi
- Nagaraja Sharath Burugina
- Nagarajan Ahamarshan Jayaraman
- Nagel Gabriele
- Naghavi Mohsen
- Naghshtabrizi Behshad
- Naik Gurudatta
- Naimzada Mukhammad David
- Nair Sanjeev
- Najafi Farid
- Naldi Luigi
- Nandakumar Vishnu
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- Nangia Vinay
- Nansseu Jobert Richie
- Nasab Entezar Mehrabi
- Naserbakht Morteza
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- Nazari Javad
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- Ndwandwe Duduzile Edith
- Negoi Ionut
- Negoi Ruxandra Irina
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- Ngari Kiirithio N.
- Nguefack-Tsague Georges
- Ngunjiri Josephine W.
- Nguyen Cuong Tat
- Nguyen Diep Ngoc
- Nguyen Huong Lan Thi
- Nguyen Jason
- Nguyen Michele
- Nguyen Ming
- Nguyen Trang Huyen
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- Nigatu Dabere
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- Nikbakhsh Rajan
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- Nnaji Chukwudi A.
- Nomura Shuhei
- Norheim Ole F.
- Norrving Bo
- Noubiap Jean Jacques
- Nowak Christoph
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- Oancea Bogdan
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- Ogbo Felix Akpojene
- Oghenetega Onome Bright
- Oh In-Hwan
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- Okunga Emmanuel Wandera
- Oladnabi Morteza
- Olagunju Andrew T.
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Oluwasanu Mojisola Morenike
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- Oren Eyal
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- Osarenotor Osayomwanbo
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- Otstavnov Nikita
- Otstavnov Stanislav S.
- Overland Simon
- Owolabi Mayowa O.
- Padubidri Jagadish Rao
- Pakhale Smita
- Pakhare Abhijit P.
- Pakshir Keyvan
- Palladino Raffaele
- Pana Adrian
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pangaribuan Helena Ullyartha
- Park Eun-Kee
- Park James
- Parmar Priya G. Kumari
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- Pasovic Maja
- Pasupula Deepak Kumar
- Patel Jenil R.
- Patel Sangram Kishor
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- Pathak Ashish
- Pathak Mona
- Patten Scott B.
- Patton George C.
- Paudel Deepak
- Paudel Sagun
- Paulson Katherine R.
- Pease Spencer A.
- Peden Amy E.
- Pennini Alyssa
- Pepito Veincent Christian Filipino
- Peprah Emmanuel K.
- Pereira Alexandre
- Pereira David M.
- Pereira Jeevan
- Perico Norberto
- Pescarini Julia Moreira
- Pesudovs Konrad
- Pham Hai Quang
- Phillips Michael R.
- Piccinelli Cristiano
- Pierce Maxwell
- Pigott David M.
- Pilgrim Thomas
- Pilz Tessa M.
- Pinheiro Marina
- Piradov Michael A.
- Pirsaheb Meghdad
- Pishgar Farhad
- Plana-Ripoll Oleguer
- Plass Dietrich
- Pletcher Martin
- Pokhrel Khem Narayan
- Polibin Roman V.
- Polinder Suzanne
- Polkinghorne Kevan R.
- Pond Constance Dimity
- Postma Maarten J.
- Pottoo Faheem Hyder
- Pourjafar Hadi
- Pourmalek Farshad
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas Ria Angga
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Quintanilla Beatriz Paulina Ayala
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad Hifz Ur
- Rahman Muhammad Aziz
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem Muhammad
- Ranabhat Chhabi Lal
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura Kishor
- Rathi Priya
- Rawaf David Laith
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Regassa Lemma Demissie
- Reiner Robert C., Jr.
- Reinig Nickolas
- Reitsma Marissa Bettay
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N.
- Resnikoff Serge
- Rezaei Negar
- Rezaei Nima
- Rezai Mohammad Sadegh
- Rezapour Aziz
- Rhinehart Phoebe-Anne
- Riahi Seyed Mohammad
- Ribeiro Antonio Luiz P.
- Ribeiro Daniel Cury
- Ribeiro Daniela
- Rickard Jennifer
- Rincon Julio Cesar Campuzano
- Rivera Juan A.
- Robalik Toshana
- Roberts Nicholas L. S.
- Roberts Shaun
- Robinson Stephen R.
- Rodriguez-Ramirez Sonia
- Roever Leonardo
- Rolfe Sam
- Romoli Michele
- Ronfani Luca
- Room Robin
- Roshandel Gholamreza
- Rostamian Morteza
- Roth Gregory A.
- Rothenbacher Dietrich
- Rubagotti Enrico
- Rumisha Susan Fred
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- Saadatagah Seyedmohammad
- Sabour Siamak
- Sachdev Perminder S.
- Saddik Basema
- Sadeghi Ehsan
- Sadeghi Masoumeh
- Saeedi Reza
- Saeidi Shahram
- Safari Yahya
- Safi Sare
- Safiri Saeid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi S. Mohammad
- Salahshoor Mohammad Reza
- Salam Nasir
- Salama Joseph S.
- Salamati Payman
- Salem Hosni
- Salem Marwa R.
- Salimi Yahya
- Salimzadeh Hamideh
- Salman Omar Mukhtar
- Salomon Joshua A.
- Salz Inbal
- Samad Zainab
- Sambala Evanson Zondani
- Samy Abdallah M.
- Sanabria Juan
- Sanchez-Pimienta Tania G.
- Santomauro Damian Francesco
- Santos Itamar S.
- Santos Joao Vasco
- Santric-Milicevic Milena M.
- Saraswathy Sivan Yegnanarayana Iyer
- Sarmiento-Suarez Rodrigo
- Sarrafzadegan Nizal
- Sartorius Benn
- Sarveazad Arash
- Sathian Brijesh
- Sathish Thirunavukkarasu
- Sattin Davide
- Savic Miloje
- Sawyer Susan M.
- Saxena Deepak
- Saxena Sonia
- Saylan Mete
- Sbarra Alyssa N.
- Schaeffer Lauren E.
- Schiavolin Silvia
- Schlaich Markus P.
- Schmidt Maria Ines
- Schutte Aletta Elisabeth
- Schwebel David C.
- Schwendicke Falk
- Section Mahesh P. A.
- Seedat Soraya
- Sekerija Mario
- Senbeta Anbissa Muleta
- Senthilkumaran Subramanian
- Sepanlou Sadaf G.
- Serdar Berrin
- Serre Marc L.
- Servan-Mori Edson
- Sha Feng
- Shabani Mahsima
- Shackelford Katya Anne
- Shadid Jamileh
- Shafaat Omid
- Shahabi Saeed
- Shahbaz Mohammad
- Shaheen Amira A.
- Shaikh Masood Ali
- Shaji K. S.
- Shalash Ali S.
- Shams-Beyranvand Mehran
- Shamsi MohammadBagher
- Shamsizadeh Morteza
- Shannawaz Mohammed
- Sharafi Kiomars
- Sharafi Zeinab
- Sharan Subodh
- Sharara Fablina
- Sharifi Hamid
- Sharma Rajesh
- Shaw David H.
- Sheena Brittney S.
- Sheikh Aziz
- Sheikhtaheri Abbas
- Shetty B. Suresh Kumar
- Shetty Ranjitha S.
- Shibuya Kenji
- Shield Kevin David
- Shiferaw Wondimeneh Shibabaw
- Shigematsu Mika
- Shin Min-Jeong
- Shiri Rahman
- Shirkoohi Reza
- Shivakumar K. M.
- Shrime Mark G.
- Shuval Kerem
- Siabani Soraya
- Sierpinski Radoslaw
- Sigfusdottir Inga Dora
- Sigurvinsdottir Rannveig
- Silva Diego Augusto Santos
- Silva Joao Pedro
- Simonetti Biagio
- Simpson Kyle E.
- Singh Ambrish
- Singh Jasvinder A.
- Singh Pushpendra
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Skou Soren T.
- Skryabin Valentin Yurievich
- Sliwa Karen
- Smith Amanda
- Smith Emma U. R.
- Sobngwi Eugene
- Soheili Amin
- Sokhan Anton
- Soltani Shahin
- Somefun Oluwaseyi Dolapo
- Soofi Moslem
- Sorensen Reed J. D.
- Soriano Joan B.
- Sorrie Muluken Bekele
- Soshnikov Sergey
- Soyiri Ireneous N.
- Spencer Cory N.
- Spotin Adel
- Spurlock Emma Elizabeth
- Sreeramareddy Chandrashekhar T.
- Srinivasan Vinay
- Sripada Kam
- Stanaway Jeffrey D.
- Stark Benjamin A.
- Steel Nicholas
- Stefan Simona Catalina
- Stein Caroline
- Stein Dan J.
- Steiner Caitlyn
- Steiner Timothy J.
- Steuben Krista M.
- Stockfelt Leo
- Stokes Mark A.
- Stovner Lars Jacob
- Straif Kurt
- Stranges Saverio
- Stubbs Jacob L.
- Suchdev Parminder S.
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Suleria Hafiz Ansar Rasul
- Sulo Gerhard
- Sultan Iyad
- Swope Carolyn B.
- Sykes Bryan L.
- Sylte Dillon O.
- Szocska Miklos
- Szumowski Lukasz
- Tabares-Seisdedos Rafael
- Tabb Karen M.
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Taddele Biruk Wogayehu
- Tadesse Degena Bahrey
- Taherkhani Amir
- Tahir Zarfishan
- Tajdini Masih
- Takahashi Ken
- Takala Jukka S.
- Tamiru Animut Tagele
- Tang Muming
- Tanser Frank C.
- Tareque Md Ismail
- Tarigan Ingan Ukur
- Taveira Nuno
- Taylor Heather Jean
- Teagle Whitney L.
- Teame Hirut
- Tediosi Fabrizio
- Tefera Yonas Getaye
- Tehrani-Banihashemi Arash
- Teklehaimanot Berhane Fseha
- Tela Freweini Gebrearegay
- Temsah Mohamad-Hani
- Terrason Sonyah
- Tesema Getayeneh Antehunegn
- Tessema Zemenu Tadesse
- Thakur Bhaskar
- Thankappan Kavumpurathu Raman
- Thapar Rekha
- Thomas Nihal
- Thomson Azalea M.
- Thrift Amanda G.
- Thurston George D.
- Titova Mariya Vladimirovna
- Tlou Boikhutso
- Tohidinik Hamid Reza
- Tonelli Marcello
- Topor-Madry Roman
- Topouzis Fotis
- Toroudi Hamidreza Pazoki
- Torre Anna E.
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Bach Xuan
- Travillian Ravensara
- Trias-Llimos Sergi
- Troeger Christopher E.
- Truelsen Thomas Clement
- Tsai Alexander C.
- Tsatsakis Aristidis
- Tyrovolas Stefanos
- Uddin Riaz
- Ullah Irfan
- Ullah Saif
- Umeokonkwo Chukwuma David
- Undurraga Eduardo A.
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Uthman Olalekan A.
- Vacante Marco
- Vaicekonyte Regina
- Vakilian Alireza
- Valdez Pascual R.
- Valli Alessandro
- Van Donkelaar Aaron
- Vardavas Constantine
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasconcelos Ana Maria Nogales
- Vasseghian Yasser
- Veisani Yousef
- Velasquez Ilais Moreno
- Venketasubramanian Narayanaswamy
- Vidale Simone
- Violante Francesco S.
- Vlassov Vasily
- Vollset Stein Emil
- Vongpradith Avina
- Vos Theo
- Vu Giang Thu
- Vujcic Isidora S.
- Vukovic Ana
- Vukovic Rade
- Waheed Yasir
- Wallin Mitchell Taylor
- Walters Magdalene K.
- Wamai Richard G.
- Wang Fang
- Wang Haidong
- Wang Hongbo
- Wang Jiayu
- Wang Yafeng
- Wang Yanzhong
- Wang Yuan-Pang
- Ward Joseph L.
- Watson Alexandrea
- Watson Stefanie
- Wei Jingkai
- Wei Melissa Y. Wei
- Weintraub Robert G.
- Weiss Daniel J.
- Weiss Jordan
- Welay Fissaha Tekulu
- Weldesamuel Girmay Teklay
- Werdecker Andrea
- West J. Jason
- Westerman Ronny
- Whisnant Joanna L.
- Whiteford Harvey A.
- Wiangkham Taweewat
- Wickramasinghe Nuwan Darshana
- Wiens Kirsten E.
- Wijeratne Tissa
- Wilner Lauren B.
- Wilson Shadrach
- Wiysonge Charles Shey
- Wojtyniak Bogdan
- Woldu Gebremariam
- Wolfe Charles D. A.
- Wondmeneh Temesgen Gebeyehu
- Wondmieneh Adam Belay
- Wool Eve E.
- Wozniak Sarah S.
- Wu Ai-Min
- Wu Chenkai
- Wu Junjie
- Wunrow Han Yong
- Xie Yang
- Xu Gelin
- Xu Rixing
- Yadgir Simon
- Yamada Tomohide
- Yamagishi Kazumasa
- Yaminfirooz Mousa
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yearwood Jamal A.
- Yeheyis Tomas Y.
- Yeshitila Yordanos Gizachew
- Yilgwan Christopher Sabo
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- York Hunter W.
- Younis Mustafa Z.
- Younker Theodore Patrick
- Yousefi Bahman
- Yousefi Zabihollah
- Yousefifard Mahmoud
- Yousefinezhadi Taraneh
- Yousuf Abdilahi Yousuf
- Yu Chuanhua
- Yu Yong
- Yuan Chun-Wei
- Yuce Deniz
- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019
- Author
- Abady Gdiom Gebreheat
- Abbas Jaffar
- Abbasi-Kangevari Mohsen
- Abbastabar Hedayat
- Abd-Allah Foad
- Abd-Elsalam Sherief M.
- Abdoli Amir
- Abdulkader Rizwan Suliankatchi
- Abedi Aidin
- Abolhassani Hassan
- Abreu Lucas Guimaraes
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen M. E.
- Abushouk Abdelrahman
- Adamu Aishatu L.
- Adebayo Oladimeji M.
- Adegbosin Adeyinka Emmanuel
- Adekanmbi Victor
- Adetokunboh Olatunji O.
- Adeyinka Daniel Adedayo
- Adsuar Jose C.
- Afshari Khashayar
- Aghaali Mohammad
- Agudelo-Botero Marcela
- Ahinkorah Bright Opoku
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Yonas
- Akinyemi Oluwaseun Oladapo
- Aklilu Addis
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alam Khurshid
- Alam Tahiya
- Alanezi Fahad Mashhour
- Alanzi Turki M.
- Alcalde-Rabanal Jacqueline Elizabeth
- Ali Tilahun
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa Khalid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Ameyaw Edward Kwabena
- Amini Saeed
- Amini-Rarani Mostafa
- Amit Arianna Maever L.
- Amugsi Dickson A.
- Ancuceanu Robert
- Anderlini Deanna
- Andrei Catalina Liliana
- Ansari Fereshteh
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- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Aripov Timur
- Arnlov Johan
- Artanti Kurnia Dwi
- Arzani Afsaneh
- Asaad Malke
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Athari Seyyed Shamsadin
- Athari Seyyede Masoume
- Atnafu Desta Debalkie
- Atreya Alok
- Atteraya Madhu Sudhan
- Ausloos Marcel
- Awan Asma Tahir
- Ayano Getinet
- Ayanore Martin Amogre
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- Azari Samad
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- Birihane Binyam Minuye
- Biswas Raaj Kishore
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- Breusov Alexey
- Brunoni Andre R.
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- Castaldelli-Maia Joao Mauricio
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- Charan Jaykaran
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- Tessema Zemenu Tadesse
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- Thapar Rekha
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- Tovani-Palone Marcos Roberto
- Traini Eugenio
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- Tsatsakis Aristidis
- Uddin Riaz
- Ullah Anayat
- Umeokonkwo Chukwuma David
- Unim Brigid
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Usman Muhammad Shariq
- Vacante Marco
- Vaezi Maryam
- Valdez Pascual R.
- Vasankari Tommi Juhani
- Venketasubramanian Narayanaswamy
- Verma Madhur
- Violante Francesco S.
- Vlassov Vasily
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- Vu Giang Thu
- Wado Yohannes Dibaba
- Waheed Yasir
- Wamai Richard G.
- Wang Haidong
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- Wang Yanzhong
- Wang Yuan-Pang
- Ward Paul
- Werdecker Andrea
- Westerman Ronny
- Wickramasinghe Nuwan Darshana
- Wilner Lauren B.
- Wiysonge Charles Shey
- Wu Ai-Min
- Wu Chenkai
- Xie Yang
- Yamagishi Kazumasa
- Yandrapalli Srikanth
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Younis Mustafa Z.
- Yousefi Zabihollah
- Yousefinezhadi Taraneh
- Yu Chuanhua
- Yusuf Sifat Shahana
- Zaidi Syed Saoud
- Zamani Mohammad
- Zamanian Maryam
- Zastrozhin Mikhail Sergeevich
- Zastrozhina Anasthasia
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Xiu-Ju George
- Ziapour Arash
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/01/2021
- Field of study
Background Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival. Methods We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (USMR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index. Findings Global U5MR decreased from 71.2 deaths per 1000 livebirths (95% uncertainty interval WI] 68.3-74-0) in 2000 to 37.1 (33.2-41.7) in 2019 while global NMR correspondingly declined more slowly from 28.0 deaths per 1000 live births (26.8-29-5) in 2000 to 17.9 (16.3-19-8) in 2019. In 2019,136 (67%) of 204 countries had a USMR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030,154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9.65 million (95% UI 9.05-10.30) in 2000 and 5.05 million (4.27-6.02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3.76 million 95% UI 3.53-4.021) in 2000 to 48% (2.42 million; 2.06-2.86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0.80 (95% UI 0.71-0.86) deaths per 1000 livebirths and U5MR to 1.44 (95% UI 1-27-1.58) deaths per 1000 livebirths, and in 2019, there were as many as 1.87 million (95% UI 1-35-2.58; 37% 95% UI 32-43]) of 5.05 million more deaths of children younger than 5 years than the survival potential frontier. Interpretation Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve USMR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd
Search for new phenomena in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in s= 13 pp collisions with the ATLAS detector
- Author
- Aad Georges
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Abeloos Baptiste
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adachi Shunsuke
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allen Benjamin W
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah Aziz
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel Jos
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Araujo Ferraz Victor
- Arce Ayana
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Armitage Lewis Jame
- Arnaez Olivier
- Arnold Hannah
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- Arslan Ozan
- Artamonov Andrei
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- Wanotayaroj Chaowaroj
- Warburton Andreas
- Ward Patricia
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- Washbrook Andrew
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- Waugh Ben
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- Weber Michele
- Weber Stefan Wol
- Weber Stephen
- Webster Jordan S
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weiser Christian
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- Wells Phillippa
- Wenaus Torre
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- Wiik-Fuchs Liv Antje
- Wildauer Andreas
- Wilk Fabian
- Wilkens Henric Geo
- Williams Hugh
- Williams Sarah
- Willis Christophe
- Willocq Stephane
- Wilson John
- Wingerter-Seez Isabelle
- Winklmeier Frank
- Winston Oliver Jam
- Winter Benedict T
- Wittgen Matthias
- Wobisch Markus
- Wolf Tim Michae
- Wolff Robert
- Wolter Marcin Wla
- Wolters Helmut
- Worm Steven D
- Wosiek Barbara
- Wotschack Jorg
- Woudstra Martin
- Wozniak Krzysztof
- Wu Mengqing
- Wu Miles
- Wu Sau Lan
- Wu Xin
- Wu Yusheng
- Wyatt Terry Rich
- Wynne Benjamin
- Xella Stefania
- Xi Zhaoxu
- Xu Da
- Xu Lailin
- Yabsley Bruce
- Yacoob Sahal
- Yamaguchi Daiki
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamauchi Katsuya
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee Chinn
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven Henr
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yildirim Eda
- Yorita Kohei
- Yoshida Rikutaro
- Yoshihara Keisuke
- Young Charles
- Young Christophe
- Youssef Saul
- Yu David Ren-
- Yu Jaehoon
- Yu Jie
- Yuan Li
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis George
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zeng Jian Cong
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/03/2017
- Field of study
Measurement of jet fragmentation in Pb+Pb and pp collisions at sNN=2.76 TeV with the ATLAS detector at the LHC
- Author
- Aad Georges
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed Haide
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allen Benjamin W
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah Aziz
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel Jos
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose Elisa
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Armitage Lewis Jame
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baas Alessandra
- Baca Matthew Jo
- Bachacou Henri
- Bachas Konstantin
- Backes Moritz
- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver Kei
- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Balunas William Ke
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Ste
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Loui
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros do Vale Maria Alin
- Bartoldus Rainer
- Barton Adam Edwar
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago J
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder S
- Beacham James
- Beattie Michael Da
- Beau Tristan
- Beauchemin Pierre-Hug
- Bechtle Philip
- Beck Hans~Peter
- Becker Kathrin
- Becker Maurice
- Beckingham Matthew
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christophe
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna Kath
- Bell Andrew Stu
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimilia
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Bendtz Katarina
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- Bessidskaia Bylund Olga
- Bessner Martin Flo
- Besson Nathalie
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- Bethani Agni
- Bethke Siegfried
- Bevan Adrian Joh
- Bianchi Riccardo-M
- Bianco Michele
- Biebel Otmar
- Biedermann Dustin
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- Borissov Guennadi
- Bortfeldt Jonathan
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- Bos Kors
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan D
- Boudreau Joseph
- Bouffard Julian
- Bouhova-Thacker Evelina Va
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- Carlino Gianpaolo
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- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German D
- Carvalho João
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- Chisholm Andrew
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- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur Ren
- Chouridou Sofia
- Chow Bonnie Kar
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- Chromek-Burckhart Doris
- Chu Ming Chung
- Chudoba Jiri
- Chuinard Annabelle
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- Clark Brian Lee
- Clark Michael
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- Da Cunha Sargedas De Sousa Mario Jose
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- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Dang Nguyen Phu
- Daniells Andrew Chr
- Dann Nicholas S
- Danninger Matthias
- Dano Hoffmann Maria
- Dao Valerio
- Darbo Giovanni
- Darmora Smita
- Dassoulas James
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- Daubney Thomas
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- de Asmundis Riccardo
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- De Vasconcelos Corga Kevin
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- De Kaushik
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- Ellajosyula Venugopal
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- Flick Tobias
- Flierl Bernhard M
- Flores Castillo Luis
- Flowerdew Michael
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- Ganguly Sanmay
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- Garay Walls Francisca
- Garcia-Sciveres Maurice
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- Gardner Robert
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- Gilles Geoffrey
- Gingrich Douglas
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- Giordani MarioPaolo
- Giorgi Filippo Ma
- Giraud Pierre-Fra
- Giromini Paolo
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- Gjelsten Børge Kil
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- Gomes Agostinho
- Goncalves Gama Rafael
- Goncalves Pinto Firmino Da Costa Joao
- Gonella Giulia
- Gonella Laura
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- Gonzalez-Sevilla Sergio
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- Gonçalo Ricardo
- Goossens Luc
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- Gorišek Andrej
- Goshaw Alfred
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- Goudet Christophe
- Goujdami Driss
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- Govender Nicolin
- Gozani Eitan
- Graber Lars
- Grabowska-Bold Iwona
- Gradin Per Olov J
- Gramling Johanna
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- Grenier Philippe
- Grevtsov Kirill
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
- Grinstein Sebastian
- Gris Philippe L
- Grivaz Jean-Franc
- Groh Sabrina
- Gross Eilam
- Grosse-Knetter Joern
- Grossi Giulio Cor
- Grout Zara Jane
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- Gutierrez Phillip
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- Guyot Claude
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- Gwilliam Carl
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- Haddad Nacim
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- Hasegawa Yoji
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- Hawkings Richard Jo
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- Hays Jonathan M
- Hayward Helen
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- Henrot-Versille Sophie
- Herbert Geoffrey H
- Herde Hannah
- Herget Verena
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- Herten Gregor
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- Herwig Theodor Ch
- Hesketh Gavin Gran
- Hessey Nigel
- Hetherly Jeffrey Wa
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- Hill John
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- Hobbs John
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- Homann Michael
- Honda Shunsuke
- Honda Takuya
- Hong Tae Min
- Hooberman Benjamin H
- Hopkins Walter
- Horii Yasuyuki
- Horton Arthur Jam
- Hostachy Jean-Yves
- Hou Suen
- Hoummada Abdeslam
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- Huth John
- Iacobucci Giuseppe
- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Idrissi Zineb
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- Iizawa Tomoya
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- Iturbe Ponce Julia Mari
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- Johns Kenneth
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- Jon-And Kerstin
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- Jones Samuel Dav
- Jones Sarah
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- Kamenshchikov Andrey
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- Kaplan Laser Seym
- Kar Deepak
- Karakostas Konstantin
- Karastathis Nikolaos
- Kareem Mohammad J
- Karentzos Efstathios
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- Kasahara Kota
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- Kay Ellis
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- Kehoe Robert
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- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
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- Zhang Ruiqi
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- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/06/2017
- Field of study
Ventral Tegmental Area GABAA Receptors Mediate the Change from a Drug-naive to an Opiate- or Ethanol-deprived Motivational State
- Author
- Publication venue
- Publication date
- 31/08/2012
- Field of study
A crucial question in drug addiction research concerns whether the varying reports of dopamine-independent and dopamine-dependent motivation can be integrated. According to one theory, the prior drug history of a subject — that is to say, whether they have received minimal or chronic drug exposure — determines whether opiate motivation is dependent upon the brainstem tegmental pedunculopontine nucleus (TPP) or dopamine neurotransmission. The biological analogue of this change is thought to be a switch in the signalling properties (from hyperpolarizing to depolarizing) of ventral tegmental area (VTA) gamma-aminobutyric acid subtype-A (GABAA) receptors. In this thesis, I demonstrate that the mechanisms underlying opiate motivation can be selected artificially by manipulating the signalling properties of VTA GABAA receptors, irrespective of the past drug history of the subject. Furthermore, I suggest that these same VTA GABAA receptors also play a similar role in controlling ethanol motivation. Indeed, the mechanisms underlying ethanol motivation can be doubly dissociated in a manner similar to that observed with opiates. However, whereas opiate motivation is TPP-dependent in the drug-naive state, I found that ethanol motivation was dependent on dopamine neurotransmission (via the D2 receptor) in drug-naive animals. Conversely, ethanol motivation was TPP-dependent in ethanol-deprived mice (as opposed to opiate motivation being dopamine-dependent in opiate-deprived animals). These effects are consistent with a VTA GABAA receptor switching mechanism identical to the one seen in the case of opiate motivation.Ph
Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation
- Author
- Publication venue
- Publication date
- 21/12/2012
- Field of study
Recent work has shown that infusion of brain-derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine-independent to a dopamine-dependent pathway. Here we showed that a single infusion of intra-VTA BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from a dopamine-dependent to a dopamine-independent pathway (exactly opposite to that seen with morphine). We suggest that intra-VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug-naive, non-deprived state to a drug-deprived state. The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non-deprived animals is consistent with their proposed actions on VTA GABAA receptors
Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versus core
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
- …