Gamma-ray spectroscopy of positron annihilation in the Milky Way

T. Siegert, et al., “Gamma-ray spectroscopy of positron annihilation in the Milky Way”, Astronomy & Astrophysics, Vol. 586, January 2016, https://doi.org/10.1051/0004-6361/201527510. Reproduced with permission from Astronomy & Astrophysics, © ESO”.Context. The annihilation of positrons in the Galaxy's interstellar medium produces characteristic gamma-rays with a line at 511 keV. This gamma-ray emission has been observed with the spectrometer SPI on ESA's INTEGRAL observatory, confirming a puzzling morphology with bright emission from an extended bulge-like region, while emission from the disk is faint. Most known or plausible sources of positrons are, however, believed to be distributed throughout the disk of the Milky Way. Aims: We aim to constrain characteristic spectral shapes for different spatial components in the disk and bulge using data with an exposure that has doubled since earlier reports. Methods: We exploit high-resolution gamma-ray spectroscopy with SPI on INTEGRAL based on a new instrumental background method and detailed multi-component sky model fitting. Results: We confirm the detection of the main extended components of characteristic annihilation gamma-ray signatures, altogether at 58σ significance in the 511 keV line. The total Galactic 511 keV line intensity amounts to (2.74 ± 0.25) × 10-3 ph cm-2 s-1 for our assumed model of the spatial distribution. We derive spectra for the bulge and disk, and a central source modelled as point-like and at the position of Sgr A*, and discuss spectral differences. The bulge (56σ) shows a 511 keV line intensity of (0.96 ± 0.07) × 10-3 ph cm-2 s-1 together with ortho-positronium continuum equivalent to a positronium fraction of (1.080 ± 0.029). The two-dimensional Gaussian that represents the disk emission (12σ) has an extent of 60+10-5 degrees in longitude and a rather large latitudinal extent of 10.5+2.5-1.5 degrees; the line intensity is (1.66 ± 0.35) × 10-3 ph cm-2 s-1 with a marginal detection of the annihilation continuum and an overall diffuse Galactic continuum of (5.85 ± 1.05) × 10-5 ph cm-2 s-1 keV-1 at 511 keV. The disk shows no flux asymmetry between positive and negative longitudes, although spectral details differ. The flux ratio between bulge and disk is (0.58 ± 0.13). The central source (5σ) has an intensity of (0.80 ± 0.19) × 10-4 ph cm-2 s-1.Peer reviewe

Search for 511 keV Emission in Satellite Galaxies of the Milky Way with INTEGRAL/SPI

Reproduced with permission from Astronomy & Astrophysics. © 2018 ESO.The positron annihilation gamma-ray signal in the Milky Way (MW) shows a puzzling morphology: a very bright bulge and a very low surface-brightness disk. A coherent explanation of the positron origin, propagation through the Galaxy and subsequent annihilation in the interstellar medium has not yet been found. Tentative explanations involve positrons from radioactivity, X-ray binaries, and dark matter (DM). Dwarf satellite galaxies (DSGs) are believed to be DM-dominated and hence promising candidates in the search for 511 keV emission as a result of DM annihilation into electron-positron pairs. The goal of this study is to constrain possible 511 keV gamma-ray signals from 39 DSGs of the MW and to test the annihilating DM scenario. We use the spectrometer SPI on INTEGRAL to extract individual spectra for the studied objects. As the diffuse galactic emission dominates the signal, the large scale morphology of the MW has been modelled accordingly and was included in a maximum likelihood analysis. Alternatively, a distance-weighted stacked spectrum has been determined. Only Reticulum II (Ret II) shows a 3.1 sigma signal. Five other sources show tentative 2 sigma signals. The mass-to-511-keV-luminosity-ratio shows a marginal trend towards higher values for intrinsically brighter objects, opposite to the V band mass-to-light-ratio, which is generally used to uncover DM in DSGs. All derived flux values are above the level implied by a DM interpretation of the MW bulge signal. The signal from Ret II is unlikely to be related to a DM origin alone, otherwise, the MW bulge would be about 100 times brighter than what is seen. Ret II is exceptional considering the DSG sample, and rather points to enhanced recent star formation activity, if its origins are similar to processes in the MW. Understanding this emission may provide further clues regarding the origin of the annihilation emission in the MW.Peer reviewe

Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex

Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and plasticity. At synapses in the entorhinal cortex these receptors are tonically activated and provide a positive feedback modulation of the level of background excitation. NMDA receptor activation requires obligatory occupation of a co-agonist binding site, and in the present investigation we have examined whether this site on the presynaptic receptor is activated by endogenous glycine or d-serine. We used whole-cell patch clamp recordings of spontaneous AMPA receptor-mediated synaptic currents from rat entorhinal cortex neurones in vitro as a monitor of presynaptic glutamate release. Addition of exogenous glycine or d-serine had minimal effects on spontaneous release, suggesting that the co-agonist site was endogenously activated and likely to be saturated in our slices. This was supported by the observation that a co-agonist site antagonist reduced the frequency of spontaneous currents. Depletion of endogenous glycine by enzymatic breakdown with a bacterial glycine oxidase had little effect on glutamate release, whereas d-serine depletion with a yeast d-amino acid oxidase significantly reduced glutamate release, suggesting that d-serine is the endogenous agonist. Finally, the effects of d-serine depletion were mimicked by compromising astroglial cell function, and this was rescued by exogenous d-serine, indicating that astroglial cells are the provider of the d-serine that tonically activates the presynaptic NMDA receptor. We discuss the significance of these observations for the aetiology of epilepsy and possible targeting of the presynaptic NMDA receptor in anticonvulsant therapy. © 2014 Elsevier Ltd. All rights reserved

Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D

Computation of sensitivities for the invariant measure of a parameter dependent diffusion

International audienceWe consider the solution to a stochastic differential equation with a drift function which depends smoothly on some real parameter λ, and admitting a unique invariant measure for any value of λ around λ = 0. Our aim is to compute the derivative with respect to λ of averages with respect to the invariant measure, at λ = 0. We analyze a numerical method which consists in simulating the process at λ = 0 together with its derivative with respect to λ on long time horizon. We give sufficient conditions implying uniform-in-time square integrability of this derivative. This allows in particular to compute efficiently the derivative with respect to λ of the mean of an observable through Monte Carlo simulations

Effects of skin moisturization on various aspects of touch showing differences with age and skin site

International audienceThe human body is encompassed by a thin layer of tissue, the skin, which is heterogenous and highly specialized to protect the body and encode interactions with the external world. There is a fundamental scientific drive to understand its function, coupled with the need to preserve skin as we age, which impacts on our physiological and psychological well-being. In the present study, we aimed to define differences in touch perception between age groups and with skin cream application. We investigated touch on the finger, the forearm and cheek in younger (20–28 years, n = 22) and older (65–75 years, n = 22) females. We measured skin hydration, touch detection, finger spatial discrimination, forearm tactile pleasantness together with electrodermal activity, and perceptual ratings about cream use, skin dryness, and cosmetic habits. Glabrous finger skin became drier and touch performance was impaired with age, but these aspects were preserved in hairy skin. Skin moisturization immediately increased hydration levels, but did not significantly change touch perception. We also found that touch appreciation increased with age. We conclude that reduced finger capacity may impact self-evaluation of the skin and that long-term skin care strategies should focus on hydrating the hand to preserve touch capacities

Arabelle 1550 mwe units: 10 years of feedback experience in the EDF N4 nuclear power plants

The target of this paper is to describe the feed back experience of the main turbo-machines of the ARABELLETM technology after 10 years of operation in the EDF N4 Nuclear Power Plants. The main specificity of nuclear steam cycle is the low thermodynamic condition of the steam. Erosion due to steam condensation is one of the main maintenance issues for the steam turbine. After 10 years of operation, the inspection conducted on the LP modules revealed a satisfactory general condition with some non-uniform erosion on LP diaphragms. The article will highlight the repair solutions and the design evolutions to eliminate such local erosion on the new ARABELLE turbines (i.e. Flamanville 3). As for all the largest turbogenerators, armature windings of N4 generators are cooled by circulation of pure water in copper hollow conductors. The sensibility to copper corrosion of the stator bars hollow conductors has led Alstom to introduce stainless steel cooling tubes in the new products and for rewinding. The next more powerful turbo-machines in the N4 Turbine Island are the main turbine driven feedwater pumps. On the pump side, operating experience including impeller mechanical behaviour, erosion and gear coupling issues will be described with the corrections implemented

A reassessment of the budget of formic and acetic acids in the boundary layer at Dumont d'Urville (coastal Antarctica): The role of penguin emissions on the budget of several oxygenated volatile organic compounds

International audienceInitiated in 1997, the year-round study of formic and acetic acids was maintained until 2011 at the coastal Antarctic site of Dumont d'Urville. The records show that formic and acetic acids are rather abundant in summer with typical mixing ratios of 200 pptv and 700 pptv, respectively. With the aim to constrain their budget, investigations of their potential marine precursors like short-chain alkenes and acetaldehyde were initiated in 2011. Acetic acid levels in December 2010 were four times higher than those observed over summers back to 1997. These unusually high levels were accompanied by unusually high levels of ammonia, and by an enrichment of oxalate in aerosols. These observations suggest that the guano decomposition in the large penguin colonies present at the site was particularly strong under weather conditions encountered in spring 2010 (important snow storms followed by sunny days with mild temperatures). Although being dependent on environmental conditions, this process greatly impacts the local atmospheric budget of acetic acid, acetaldehyde, and acetone during the entire summer season. Present at levels as high as 500 pptv, acetaldehyde may represent the major precursor of acetic acid, alkene-ozone reactions remaining insignificant sources. Far less influenced by penguin emissions, the budget of formic acid remains not fully understood even if alkene-ozone reactions contribute significantly