Implementasi Web-Service dan Aplikasi Seluler pada Sistem Pemantauan Proses Penjernihan Air Perusahaan Daerah Air Minum

Clean water is a water that can be used for many household need. To produce a high quality water a supervision on its production needs to be done by pdam on a regular basis in order to qualify for the requirements such as physic, microbiology, chemistry, radioactive. This days reporting process that is on time and accurate has yet to be done, beside that there is potential of mistake from this reporting due to its conventional preparation process was still high. The purpose from this was to implement web service using RESTfull method server that are integrated with cellular app in smartphone with android platform so that the data reporting process can be done at the exact same time with serving it on the data sample in a graphic and table form. The data gathering technique that are being used in this research was observation technique, interview, documentation, literature review, and questionnaire. The method that are being used in this research was the Global extreme programming method (GXP). This research produce a supervision on water cleansing based on cellular app based on web service to support the data reporting that are done real time, so the possibility of mistake in the water processing process In PDAM Tirta Wijaya can be known as soon as possibl

Analisa Pengaruh Kemampuan Kerja Pegawai dan Komunikasi Antar Pribadi terhadap Kualitas Pelayanan Perusahaan PT. Indosat Tbk

Answering the challenges of the business world of telecommunications services with the sharpening of competition, Indosat need to do to improve the quality of service. For that we need a sober assessment of the factors that have an influence on the quality of the service itself. Suspected of employees working ability and interpersonal communication can affect the quality of service at the company experiment was conducted with the aim of proving allegations that an employee working ability and interpersonal communication together affect the quality of care in Indosat. From the results of data processing can be in the know that individually and the two independent variables have a relationshipand influence equally strong on the quality of service (r X1 = 0.621 and r x2 = 0.670) Collectively variable Job Skills Employees and Communication Between Personal Associated very strong with quality service on (R = 0.853) and by the coefficient of determination of 72.8% affect test results significantly with T test and F test proved significant at 95% confidence level, it can be concluded that: Alleged ability Employee Work and Inter-Personal Communication together effect on the quality of service at PT Indosat Tbk. Positive and significant effect can be received

Developing Learning Media of Cirebonese Language

This study employs the research and development model of Borg & Gall and Dick & Carey involving students of SMPN 4 Kota Cirebon. This study aims to develop Cirebonese language learning media for the junior high school of the eleventh-grade students. To find out the results of the content of media, instructional design and instructional media experts validation were conducted. In addition, individual, group, and field try out were conducted.The data regarding the quality of the product were collected through questionnaire then analyzed by using descriptive analysis of qualitative and quantitative descriptive analysis. The try-out process involved the experts of Cirebonese language media and instructional design. It also involved six students an individual (one to one) try out, fifteen students for group and thirty-four students for the field try out.The results showed, first, because t, 3,0569E-18 or = 3.0569 x 10-18 or = .000000000000030596 smaller than t table at a significance level (α) amounted to 2.034515 0.05, then it rejects Ho and accepts Ha. It can be concluded that the Cirebonese language learning using developed instructional media is effective in improving students' learning outcomes. Second, the mean scores after using the media of Cirebonese language learning showed higher (better) than before using learning media of Cirebonese language. It is shown in the table Paired Sample Statistics, where the mean score before using media language learning Cirebon amounted 50.44117647 while the mean score after using learning media of Cirebonese language amounted 65.88235294. This means that learning media of Cirebonese language has a positive effect. Third, because the learning media of Cirebonese language had a positive influence, so that the decision to develop a program learning media Cirebonese language ensures to have practical significanc

Strategi Pengembangan BUMDesa yang Berdaya Saing di Era Digitalisasi Melalui Pemanfaatan Teknologi Informasi

BUMDesa must improve rural welfare in line with the digital era. Data collection, administration, and outreach are still carried out manually in many villages, as well as the lack of cooperation between related parties which causes the welfare of the villagers to not be optimal. The method used is lecture, simulation and question and answer. The result of this activity is that people's awareness and understanding of technological developments increases and with the completion of the activity it is hoped that the community can utilize technology in carrying out their daily activities in managing their business

The structures underpinning vulnerability: examining landscape-society interactions in a smallholder coffee agroforestry system

Smallholder farmers dependent on rain-fed agriculture are particularly vulnerable to extreme climate events and, therefore, it is necessary to identify adaptive measures that would increase farmer resilience to these shocks. The management options in a low-input system, like forest coffee (Coffea arabica), are limited and there are several factors out of farmers' control driving their vulnerability to changing climatic conditions. These can relate to social structures and landscape factors, which can interact to reduce farmers' adaptive capacity, creating a state of contextual vulnerability. We explored the potential synergies of this interaction across elevation, patch area and shade management gradients for smallholder coffee farms around the UNESCO Yayu Coffee Forest Biosphere Reserve in Ethiopia before, during and immediately following the 2015/16 El Niño. We documented a dramatic collapse in coffee yields across all farms, resulting in coffee incomes 29.5 ± 18.0 % and 19.5 ± 10.0 % of 2014 incomes in 2015 and 2016, respectively. We identified farms at elevations between 1500-1600 m with canopy openness between 40-45 % as being consistently low yielding over our study period. We found these farmers had the highest rates of income diversification and, therefore, were already exhibiting adaptive capacity. Farmers with the largest income losses were spatially concentrated between 1600-1700 m, located in larger patch areas with lower canopy openness. Farmers at this elevation have access to poor infrastructure, restrictions on shade management and reported higher dependence on income from coffee, indicating an interaction of biotic and social factors exacerbating their vulnerability. Unfortunately, due to a nationally declared state of emergency, we were unable to survey farmers on the adaptive measures they undertook; therefore, we are limited in assessing their resilience. However, we do show the importance of considering both biotically and socially-mediated influences for assessing smallholder vulnerability, particularly barriers to diversifying incomes

A Comparative Molecular Dynamics Study of Methylation State Specificity of JMJD2A

Histone modifications have great importance in epigenetic regulation. JMJD2A is a histone demethylase which is selective for di- and trimethyl forms of residues Lys9 and Lys36 of Histone 3 tail (H3K9 and H3K36). We present a molecular dynamics simulations of mono-, di- and trimethylated histone tails in complex with JMJD2A catalytic domain to gain insight into how JMJD2A discriminates between the methylation states of H3K9. The methyl groups are located at specific distances and orientations with respect to Fe(II) in methylammonium binding pocket. For the trimethyllysine the mechanism which provides the effectual orientation of methyl groups is the symmetry, whereas for the dimethyllysine case the determining factors are the interactions between methyllysine head and its environment and subsequently the restriction on angular motion. The occurrence frequency of methyl groups in a certain proximity of Fe(II) comes out as the explanation of the enzyme activity difference on di- and tri-methylated peptides. Energy analysis suggests that recognition is mostly driven by van der Waals and followed by Coulombic interactions in the enzyme-substrate interface. The number (mono, di or tri) and orientations of methyl groups and water molecules significantly affect the extent of van der Waals interaction strengths. Hydrogen bonding analysis suggests that the interaction between JMJD2A and its substrates mainly comes from main chain-side chain interactions. Binding free energy analysis points out Arg8 as an important residue forming an intra-substrate hydrogen bond with tri and dimethylated Lys9 of the H3 chain. Our study provides new insights into how JMJD2A discriminates between its substrates from both a structural and dynamical point of view

The inflammatory microenvironment in colorectal neoplasia

Peer reviewedPublisher PD

Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered

<p>Abstract</p> <p>Background</p> <p>High dose of corticosteroids has been previously shown to protect against controlled mechanical ventilation (CMV)-induced diaphragmatic dysfunction while inhibiting calpain activation. Because literature suggests that the calpain inhibiting effect of corticosteroid depends on the dose administered, we determined whether lower doses of corticosteroids would also provide protection of the diaphragm during CMV. This may be important for patients undergoing mechanical ventilation and receiving corticosteroids.</p> <p>Methods</p> <p>Rats were assigned to controls or to 24 hours of CMV while being treated at the start of mechanical ventilation with a single intramuscular administration of either saline, or 5 mg/kg (low MP) or 30 mg/kg (high MP) of methylprednisolone.</p> <p>Results</p> <p>Diaphragmatic force was decreased after CMV and this was exacerbated in the low MP group while high MP rescued this diaphragmatic dysfunction. Atrophy was more severe in the low MP group than after CMV while no atrophy was observed in the high MP group. A significant and similar increase in calpain activity was observed in both the low MP and CMV groups whereas the high dose prevented calpain activation. Expression of calpastatin, the endogenous inhibitor of calpain, was decreased in the CMV and low MP groups but its level was preserved to controls in the high MP group. Caspase-3 activity increased in all CMV groups but to a lesser extent in the low and high MP groups. The 20S proteasome activity was increased in CMV only.</p> <p>Conclusions</p> <p>Administration of 30 mg/kg methylprednisolone during CMV protected against CMV-induced diaphragm dysfunction while 5 mg/kg was more deleterious. The protective effect is due mainly to an inhibition of the calpain system through preservation of calpastatin levels and to a lesser extent to a caspase-3 inhibition.</p

Observation of two new Ξb−\Xi_b^- baryon resonances

Two structures are observed close to the kinematic threshold in the $\Xi_b^0 \pi^-$ mass spectrum in a sample of proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ recorded by the LHCb experiment. In the quark model, two baryonic resonances with quark content $bds$ are expected in this mass region: the spin-parity $J^P = \frac{1}{2}^+$ and $J^P=\frac{3}{2}^+$ states, denoted $\Xi_b^{\prime -}$ and $\Xi_b^{*-}$. Interpreting the structures as these resonances, we measure the mass differences and the width of the heavier state to be $m(\Xi_b^{\prime -}) - m(\Xi_b^0) - m(\pi^{-}) = 3.653 \pm 0.018 \pm 0.006$ MeV$/c^2$, $m(\Xi_b^{*-}) - m(\Xi_b^0) - m(\pi^{-}) = 23.96 \pm 0.12 \pm 0.06$ MeV$/c^2$, $\Gamma(\Xi_b^{*-}) = 1.65 \pm 0.31 \pm 0.10$ MeV, where the first and second uncertainties are statistical and systematic, respectively. The width of the lighter state is consistent with zero, and we place an upper limit of $\Gamma(\Xi_b^{\prime -}) < 0.08$ MeV at 95% confidence level. Relative production rates of these states are also reported.Comment: 17 pages, 2 figure

Search for CP violation in D+→ϕπ+ and D+s→K0Sπ+ decays

A search for CP violation in D + → ϕπ + decays is performed using data collected in 2011 by the LHCb experiment corresponding to an integrated luminosity of 1.0 fb−1 at a centre of mass energy of 7 TeV. The CP -violating asymmetry is measured to be (−0.04 ± 0.14 ± 0.14)% for candidates with K − K + mass within 20 MeV/c 2 of the ϕ meson mass. A search for a CP -violating asymmetry that varies across the ϕ mass region of the D + → K − K + π + Dalitz plot is also performed, and no evidence for CP violation is found. In addition, the CP asymmetry in the D+s→K0Sπ+ decay is measured to be (0.61 ± 0.83 ± 0.14)%