58 research outputs found
Reification Fallacies and Inappropriate Totalities
As Russell's paradox of "the set of all sets that do not contain themselves" indicated long ago, matters go seriously amiss if one operates an ontology of unrestricted totalization. Some sort of restriction must be placed on such items as "the set of all sets that have the feature F' or "the conjunction of all truths that have the feature G." But generally, logicians here introduce such formalized and complex devices as the theory of types or the doctrine of impredictivity. The present paper argues for the informal and elementary idea that the items invoked in a proper identification have themselves already been identified. Even as an explanation is not satisfactory that proceeds in terms of items that themselves require prior explanation, so the same holds with identification. And heed of this elementary idea suffices to sideline those otherwise paradoxical perplexities
Structure of French expression of motion: Gesture-speech relation, between-language comparison and developmental perspective
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Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
Annexin A2, a calcium-, actin-, and lipid-binding protein involved in exocytosis, mediates the formation of lipid microdomains required for the structural and spatial organization of fusion sites at the plasma membrane. To understand how annexin A2 promotes this membrane remodeling, the involvement of cortical actin filaments in lipid domain organization was investigated. 3D electron tomography showed that cortical actin bundled by annexin A2 connected docked secretory granules to the plasma membrane and contributed to the formation of GM1-enriched lipid microdomains at the exocytotic sites in chromaffin cells. When an annexin A2 mutant with impaired actin filament-bundling activity was expressed, the formation of plasma membrane lipid microdomains and the number of exocytotic events were decreased and the fusion kinetics were slower, whereas the pharmacological activation of the intrinsic actin-bundling activity of endogenous annexin A2 had the opposite effects. Thus, annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites
Annexin A2–dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis
Elucidation of epithelial–mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis
Gene expression analysis by ESTs sequencing of the Brazilian frog Phyllomedusa nordestina skin glands
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