33 research outputs found

    Fabrication of Octahedral Tantalum Cluster Film by Electrophoretic Deposition

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    The octahedral Ta6Br14.8H2O cluster, one of the [M6Li12La6]n- octahedrons (M= Nb, Ta; Li= halogen, La= halogen or chalcogen), exhibits interesting oxido-reduction properties in solution1. The application of the [Ta6Bri12]2+ cores has been potentially studied in biotechnologies2, optical devices3, photovoltaic cells4 and catalysis5. Originating from the expectation to block the UV and NIR light on low-emissivity window, the Ta6Br14.8H2O cluster thin film on ITO glass has been fabricated by electrophoretic deposition (EPD) process, a fairly rapid and low cost two-step process well-known for ceramic shaping, conductive surface coating and easily scalable to industrial level. The interesting characteristic has been recognized that the green [Ta6Bri12]2+ cores (adsorbing Ultra-Visible range) easily transfers to brown [Ta6Bri12]3+/4+ cores (absorbing near-infrared range) when dissolved in different solvents. Therefore, selecting the medium and optimizing the concentration of water in solvent to obtain the green homogeneous suspension with high dissolution is the main purpose of study. Considering the green color and transmittance of solution, as well as FE-SEM surface morphology of the green film, 0.02 mL H2O per mL acetone was selected as the optimal ratio to obtain the green transparent suspension and possibility to fabricate the green film by EPD process. However, the [Ta6Bri12]2+ green film has been essentially incorporated with poly vinyl pyrrolidone (PVP) in order to improve the dispersion of Ta6Br14.8H2O clusters inside the suspension and effectively prevent the performance of new [Ta6Bri12]3+/4+ clusters (brown-color) by oxidizing reactions. Reference [1] A. Vogler et al., Inorg. Chem., 1983, 23 (10), 1360. [2] J. Knablein et al., J. Mol. Biol., 1997, 270, 1. [3] S. Cordier et al., J. Inorg. Organomet. Polym., 2015, 25, 189. [4] A. Renaud et al., Chemistry Select., 2016, 1, 2284. [5] A. Barras et al., Appl. Catal. B: Environ., 2012, 123,

    A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells

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    Wepreviously reported the association of elevated levels of themultifunctional transcription factor, CCCTC binding factor (CTCF), in breast cancer cells with the specific anti-apoptotic function of CTCF. To understand the molecularmechanisms of this phenomenon, we investigated regulation of the human Bax gene by CTCF in breast and non-breast cells. Two CTCF binding sites (CTSs) within the Bax promoter were identified. In all cells, breast and non-breast, active histone modifications were present at these CTSs, DNA harboring this region was unmethylated, and levels of Bax mRNA and protein were similar. Nevertheless, up-regulation of Bax mRNA and protein and apoptotic cell deathwere observed only in breast cancer cells depleted of CTCF.We proposed that increased CTCF binding to the Bax promoter in breast cancer cells, by comparison with non-breast cells, may be mechanistically linked to the specific apoptotic phenotype in CTCF-depleted breast cancer cells. In this study, we show that CTCF binding was enriched at the Bax CTSs in breast cancer cells and tumors; in contrast, binding of other transcription factors (SP1,WT1, EGR1, and c-Myc) was generally increased in non- breast cells and normal breast tissues. Our findings suggest a novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells, whereby elevated levels of CTCF support preferential binding of CTCF to the Bax CTSs. In this context, CTCF functions as a transcriptional repressor counteracting influences of positive regulatory factors; depletion of breast cancer cells from CTCF therefore results in the activation of Bax and apoptosis. © 2013 Neoplasia Press, Inc

    Measurements of the Higgs boson production and decay rates and coupling strengths using pp collision data at √S=7 and 8 TeV in the ATLAS experiment

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    Combined analyses of the Higgs boson production and decay rates as well as its coupling strengths to vector bosons and fermions are presented. The combinations include the results of the analyses of the H -> gamma gamma, ZZ*, WW*, Z gamma, b (b) over bar, tau tau and mu mu decay modes, and the constraints on the associated production with a pair of top quarks and on the off-shell coupling strengths of the Higgs boson. The results are based on the LHC proton-proton collision datasets, with integrated luminosities of up to 4.7 fb(-1) at root s = 7 TeV and 20.3 fb(-1) at root s = 8 TeV, recorded by the ATLAS detector in 2011 and 2012. Combining all production modes and decay channels, the measured signal yield, normalised to the Standard Model expectation, is 1.18(-0.14)(+0.15). The observed Higgs boson production and decay rates are interpreted in a leading-order coupling framework, exploring a wide range of benchmark coupling models both with and without assumptions on the Higgs boson width and on the Standard Model particle content in loop processes. The data are found to be compatible with the Standard Model expectations for a Higgs boson at a mass of 125.36 GeV for all models considered

    Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8TeV\sqrt{s}=8\,\mathrm TeV{} with the ATLAS detector

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    ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider

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    Search for single production of vector-like quarks decaying into Wb in pp collisions at s=8\sqrt{s} = 8 TeV with the ATLAS detector

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    Measurements of top-quark pair differential cross-sections in the eμe\mu channel in pppp collisions at s=13\sqrt{s} = 13 TeV using the ATLAS detector

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    Measurement of the W boson polarisation in ttˉt\bar{t} events from pp collisions at s\sqrt{s} = 8 TeV in the lepton + jets channel with ATLAS

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    Measurement of the bbb\overline{b} dijet cross section in pp collisions at s=7\sqrt{s} = 7 TeV with the ATLAS detector

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