North Korea and the Non-proliferation Regime

In this review of the implications of North Korea’s behaviour during 2009 on the Non-proliferation Regime, it is stressed that if North Korea cannot be deterred from its nuclear ambitions this will deliver a serious blow to the international non-proliferation regime. It will also damage the likelihood of a successful outcome at next year’s NPT Review Conference. The behaviour of North Korea so far, and especially during 2009, can be summarised as follows: failed satellite test in April, nuclear test in May, missile tests in July and additional tests of short-range missiles in October. This seems to imply that North Korea has now made its strategic choice between conciliation and hostility and that Pyongyang believes that its future security could be better preserved by maintaining a robust nuclear weapons programme. The implications of a nuclear North Korea range from diverse strategic concerns to serious humanitarian issues, while the US is faced with a number of different options, including engagement, deterrence, military pre-emption and regime change. However, all of these options have serious limitations and none promises to achieve the goal of a non-nuclear North Korea anytime soon

Corea del Norte y el nuevo paradigma de seguridad

Los últimos ensayos nucleares de Corea del Norte han provocado una nueva crisis en la península de Corea. La última detonación nuclear de Corea del Norte, sus ensayos con misiles balísticos y su provocadora retórica han causado una nueva crisis en la península de Corea. En vez de intentar obligar a este país a volver a la mesa de negociaciones a seis bandas para continuar con unas conversaciones que no llevan a ninguna parte, sería mucho mejor reconocer que el entorno de seguridad del noreste asiático ha cambiado radicalmente. Se precisa un nuevo paradigma de seguridad que haga hincapié en la disuasión y la contención y la importancia de las alianzas de EEUU

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue

Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations. At low concentrations, it has other effects, including induction of apoptosis. Many cellular effects of pneumolysin appear to be calcium dependent. Methods. Live imaging of primary mouse astroglia exposed to sublytic amounts of pneumolysin at various concentrations of extracellular calcium was used to measure changes in cellular permeability (as judged by lactate dehydrogenase release and propidium iodide chromatin staining). Individual pore properties were analyzed by conductance across artificial lipid bilayer. Tissue toxicity was studied in continuously oxygenated acute brain slices. Results. The reduction of extracellular calcium increased the lytic capacity of the toxin due to increased membrane binding. Reduction of calcium did not influence the conductance properties of individual toxin pores. In acute cortical brain slices, the reduction of extracellular calcium from 2 to 1 mM conferred lytic activity to pathophysiologically relevant nonlytic concentrations of pneumolysin. Conclusions. Reduction of extracellular calcium strongly enhanced the lytic capacity of pneumolysin due to increased membrane binding. Thus, extracellular calcium concentration should be considered as a factor of primary importance for the course of pneumococcal meningitis

Mirror Self Recognition and Self-Identification

That great apes are the only primates to recognise their reflections is often taken to show that they are self-aware – however, there has been much recent debate about whether the self-awareness in question is psychological or bodily self-awareness. This paper argues that whilst self-recognition does not require psychological self-awareness, to claim that it requires only bodily self-awareness would leave something out. That is that self-recognition requires ‘objective self-awareness’ – the capacity for first person thoughts like ‘that’s me’, which involve self-identification and so are vulnerable to error through misidentification. This objective self-awareness is distinct from bodily or psychological self-awareness, requires cognitive sophistication and provides the beginnings of a more conceptual self-representation which might play a role in planning, mental time travel and theory of mind.This work was supported by a research studentship from Peterhouse, University of Cambridge

From Expert Administration to Accountability Network: A New Paradigm for Comparative Administrative Law

Notwithstanding the radically changed landscape of contemporary administrative governance, the categories that guide comparative administrative law and that determine what will be compared remain similar to those used at the founding of the discipline in the late 1800s. These categories are rooted in confidence in an expert bureaucracy to accomplish public purposes and are mainly twofold - administrative organization and judicial review. This outdated model has limited the ability of comparative law to engage with contemporary debates on the administrative state, which instead display considerable skepticism of public administration and are premised on achieving the public good through a plural accountability network of public and private actors. This Article seeks to correct the anachronism by reframing comparative administrative law as an accountability network of rules and procedures designed to embed public administration and civil servants in their liberal democratic societies: accountability to elected officials, organized interests, the courts, and the general public. Based on this paradigm, the Article compares American and European administrative law in a global context. Among the many differences explored are parliamentary versus presidential political control, pluralist versus neo-corporatist forms of self-regulation and public-private collaboration, judicial review focused on fundamental rights versus policy rationality, and reliance on ombudsmen in lieu of courts. The Article concludes with a number of suggestions for how comparative law can speak to current debates on reforming administrative governance

Developing priority variables ("ecosystem Essential Ocean Variables" — eEOVs) for observing dynamics and change in Southern Ocean ecosystems

Reliable statements about variability and change in marine ecosystems and their underlying causes are needed to report on their status and to guide management. Here we use the Framework on Ocean Observing (FOO) to begin developing ecosystem Essential Ocean Variables (eEOVs) for the Southern Ocean Observing System (SOOS). An eEOV is a defined biological or ecological quantity, which is derived from field observations, and which contributes significantly to assessments of Southern Ocean ecosystems. Here, assessments are concerned with estimating status and trends in ecosystem properties, attribution of trends to causes, and predicting future trajectories. eEOVs should be feasible to collect at appropriate spatial and temporal scales and are useful to the extent that they contribute to direct estimation of trends and/or attribution, and/or development of ecological (statistical or simulation) models to support assessments. In this paper we outline the rationale, including establishing a set of criteria, for selecting eEOVs for the SOOS and develop a list of candidate eEOVs for further evaluation. Other than habitat variables, nine types of eEOVs for Southern Ocean taxa are identified within three classes: state (magnitude, genetic/species, size spectrum), predator–prey (diet, foraging range), and autecology (phenology, reproductive rate, individual growth rate, detritus). Most candidates for the suite of Southern Ocean taxa relate to state or diet. Candidate autecological eEOVs have not been developed other than for marine mammals and birds. We consider some of the spatial and temporal issues that will influence the adoption and use of eEOVs in an observing system in the Southern Ocean, noting that existing operations and platforms potentially provide coverage of the four main sectors of the region — the East and West Pacific, Atlantic and Indian. Lastly, we discuss the importance of simulation modelling in helping with the design of the observing system in the long term. Regional boundary: south of 30°S

The evolution of the cytoskeleton

The cytoskeleton is a system of intracellular filaments crucial for cell shape, division, and function in all three domains of life. The simple cytoskeletons of prokaryotes show surprising plasticity in composition, with none of the core filament-forming proteins conserved in all lineages. In contrast, eukaryotic cytoskeletal function has been hugely elaborated by the addition of accessory proteins and extensive gene duplication and specialization. Much of this complexity evolved before the last common ancestor of eukaryotes. The distribution of cytoskeletal filaments puts constraints on the likely prokaryotic line that made this leap of eukaryogenesis