Measuring the 7Cs of Vaccination Readiness

Abstract. Although vaccines are among the most effective interventions used in fighting diseases, vaccination readiness varies substantially among individuals. Vaccination readiness is defined as a set of components that increase or decrease AN individual’s likelihood of getting vaccinated. Building on earlier work that distinguished five components of vaccination readiness (confidence, complacency, constraints, calculation, and collective responsibility), we revised the questionnaire used to measure these components to improve its psychometric properties, specifically criterion validity. In doing so, we also developed two new components of vaccination readiness: compliance and conspiracy. Compliance is the tendency to support monitoring to control adherence to regulations; conspiracy is the tendency to endorse conspiratorial beliefs about vaccination. The newly introduced 7C scale was initially piloted in a cascade of serial cross-sectional studies and then validated with N = 681 participants from the COVID-19 Snapshot Monitoring in Denmark. We report a bifactor measurement model, convergent validity with other questionnaires, and an explanation of 85% variance in the willingness to vaccinate against COVID-19. We also present a 7-item short version of the scale. The instrument is publicly available in several languages ( www.vaccination-readiness.com ), and we seek collaboration to provide translations of our instrument into other languages

Intra- and interchain interactions in (Cu1/2¬Au1/2)CN, (Ag1/2¬Au1/2)CN, and (Cu1/3Ag1/3Au1/3)CN and their effect on one-, two- and three-dimensional order

Mixed-metal cyanides, (Cu1/2Au1/2)CN, (Ag1/2Au1/2)CN and (Cu1/3Ag1/3Au1/3)CN, adopt an AuCN-type structure in which metal-cyanide chains pack on a hexagonal lattice with metal atoms arranged in sheets. The interactions between and within the metal-cyanide chains are investigated using density-functional-theory (DFT) calculations, 13C solid-state NMR (SSNMR) and X-ray pair distribution function (PDF) measurements. Long-range metal and cyanide order is found within the chains: (–Cu–NC–Au–CN–)∞, (–Ag–NC–Au–CN–)∞ and (–Cu–NC–Ag–NC–Au–CN–)∞. Although Bragg diffraction studies establish that there is no long-range order between chains, X-ray PDF results show that there is local order between chains. In (Cu1/2Au1/2)CN and (Ag1/2Au1/2)CN, there is a preference for unlike metal atoms occurring as nearest neighbours within the metal sheets. A general mathematical proof shows that the maximum average number of heterometallic nearest-neighbour interactions on a hexagonal lattice with two types of metal atom is four. Calculated energies of periodic structural models show that those with four unlike nearest neighbours are most favourable. Of these, models in space group Immm give the best fits to the X-ray PDF data out to 8 Å, providing good descriptions of the short- and medium-range structures. This result shows that interactions beyond those of nearest neighbours must be considered when determining the structures of these materials. Such interactions are also important in (Cu1/3Ag1/3Au1/3)CN, leading to the adoption of a structure in Pmm2 containing mixed Cu-Au and silver-only sheets arranged to maximise the numbers of CuˑˑˑAu nearest- and next-nearest-neighbour interactions

"Kategorisch unterschätzt und ausgeschlossen“ : Wahrnehmung von und Erfahrungen mit Diskriminierung an der Universität Bielefeld 2019/2020

Berghan W, Papendick M, Wenk E, et al. "Kategorisch unterschätzt und ausgeschlossen“ : Wahrnehmung von und Erfahrungen mit Diskriminierung an der Universität Bielefeld 2019/2020. Bielefeld: Universität Bielefeld, AG "Uni ohne Vorurteile"; 2020

Artificial auroral effects from a bare conducting tether

An electrically floating metallic bare tether in a low Earth orbit would be highly negative with respect to the ambient plasma over most of its length, and would be bombarded by ambient ions.This would liberates secondary electrons which after acceleration through the same voltage, would form a magnetically guided two-sided planar e beam,and result in auroral effects(ionization and light emission)upon impacto on the atmospheric E layer, at about 120-140 km altitude.This papere examines in a preliminary way the feasibility of using this effecet as an uppeart atmospheric probe. Ionization rate can reach up to 10 3 cm 3 S -1 if a tape, instead of a wire, is used as tether. Contrary to standard e beams,the beam from the tether is free of spacecrafct charging and plasma interaction problems and its energy flux varies across the crosss ection,w hich is quite large;this would make possible continuous observation from the satellite, with high resolution both spectral and vertical, of the induced optical emissions. Ground observation might be possible at latitudes around 40ø , for night, magnetically quiet conditions

The solar chromosphere at high resolution with IBIS. II. Acoustic shocks in the quiet internetwork and the role of magnetic fields

(Abridged) Aims: We characterize the dynamics of the quiet inter-network chromosphere by studying the occurrence of acoustic shocks and their relation with the concomitant photospheric structure and dynamics. Methods: We analyze a comprehensive data set that includes high resolution chromospheric and photospheric spectra obtained with the IBIS imaging spectrometer in two quiet-Sun regions. This is complemented by high-resolution sequences of MDI magnetograms of the same targets. From the chromospheric spectra we identify the spatio-temporal occurrence of the acoustic shocks. We compare it with the photospheric dynamics by means of both Fourier and wavelet analysis, and study the influence of magnetic structures. Results: Mid-chromospheric shocks occur as a response to underlying powerful photospheric motions at periodicities nearing the acoustic cut-off, consistent with 1-D hydrodynamical modeling. However, their spatial distribution within the supergranular cells is highly dependent on the local magnetic topology, both at the network and internetwork scale. Large portions of the internetwork regions undergo very few shocks, as "shadowed" by the horizontal component of the magnetic field. The latter is betrayed by the presence of chromospheric fibrils, observed in the core of the CaII line as slanted structures with distinct dynamical properties. The shadow mechanism appears to operate also on the very small scales of inter-network magnetic elements, and provides for a very pervasive influence of the magnetic field even in the quietest region analyzed.Comment: 18 pages, 16 figures (includes 1 Appendix). Accepted by A&A (16 October 2008). Minor changes from v1 after referee's comments. Higher quality figures available at http://www.arcetri.astro.it/~gcauzzi/papers_astroph/ibis.shocks.accepted.pd

Nanoparticle vesicle encoding for imaging and tracking cell populations.

For phenotypic behavior to be understood in the context of cell lineage and local environment, properties of individual cells must be measured relative to population-wide traits. However, the inability to accurately identify, track and measure thousands of single cells via high-throughput microscopy has impeded dynamic studies of cell populations. We demonstrate unique labeling of cells, driven by the heterogeneous random uptake of fluorescent nanoparticles of different emission colors. By sequentially exposing a cell population to different particles, we generated a large number of unique digital codes, which corresponded to the cell-specific number of nanoparticle-loaded vesicles and were visible within a given fluorescence channel. When three colors are used, the assay can self-generate over 17,000 individual codes identifiable using a typical fluorescence microscope. The color-codes provided immediate visualization of cell identity and allowed us to track human cells with a success rate of 78% across image frames separated by 8 h

Recommendation of short tandem repeat profiling for authenticating human cell lines, stem cells, and tissues

Cell misidentification and cross-contamination have plagued biomedical research for as long as cells have been employed as research tools. Examples of misidentified cell lines continue to surface to this day. Efforts to eradicate the problem by raising awareness of the issue and by asking scientists voluntarily to take appropriate actions have not been successful. Unambiguous cell authentication is an essential step in the scientific process and should be an inherent consideration during peer review of papers submitted for publication or during review of grants submitted for funding. In order to facilitate proper identity testing, accurate, reliable, inexpensive, and standardized methods for authentication of cells and cell lines must be made available. To this end, an international team of scientists is, at this time, preparing a consensus standard on the authentication of human cells using short tandem repeat (STR) profiling. This standard, which will be submitted for review and approval as an American National Standard by the American National Standards Institute, will provide investigators guidance on the use of STR profiling for authenticating human cell lines. Such guidance will include methodological detail on the preparation of the DNA sample, the appropriate numbers and types of loci to be evaluated, and the interpretation and quality control of the results. Associated with the standard itself will be the establishment and maintenance of a public STR profile database under the auspices of the National Center for Biotechnology Information. The consensus standard is anticipated to be adopted by granting agencies and scientific journals as appropriate methodology for authenticating human cell lines, stem cells, and tissues

Relative mobility determines the efficacy of MPAs in a two species mixed fishery with conflicting management objectives

Marine Protected Areas (MPAs) have been used to protect species in need of conservation and as a fisheries management tool. It has been suggested MPAs can benefit mobile stocks by protecting spawning grounds whilst also allowing yields to be maintained as mature fish move out of the protected areas. However, the robustness of this claim in mixed species fisheries has yet to be established. We use a simulation model to explore the efficacy of spatial closures and effort regulation when other forms of fishery control (e.g., Total Allowable Catches) are absent or non-enforced as ways of addressing management objectives that are difficult to reconcile due to the contrasting life-histories of a target and a bycatch, conservation species in a two-species fishery. The mobility of each stock in such a fishery affects the benefits conferred by an MPA. The differing management objectives of the two species can be partially met by effort regulations or closures when the species exhibit similar mobility. However, a more mobile conservation species prevents both sets of aims being met by either management tool. We use simulations to explore how spatial closures and effort regulation can be used to seek compromise between stakeholders when the mobility of one stock prevents conflicting management objectives to be fully met. Our results demonstrate that stock mobility is a key factor in considering whether an MPA can meet conflicting aims in a multispecies fishery compromised of stocks with differing life histories and mobilities