166 research outputs found
The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome
- Author
- Araujo Daniela D
- Bitondi Marcia MG
- Carvalho Alex F
- Costa Maria CR
- Cunha Marco AV
- Dias-Neto Emmanuel
- Espindola Foued S
- Espreafico Enilza M
- Hartfelder Klaus
- Maia Rafaela M
- Martins Waleska K
- Monesi Nadia
- Nascimento Adriana M
- Nunes Francis MF
- Paco-Larson Maria L
- Peixoto Pablo MV
- Pinheiro Daniel G
- Ramos Ricardo GP
- Reis Luis FL
- Silva Maria FR
- Silva Wilson A
- Simoes Zila LP
- Simpson Andrew JG
- Soares Ademilson EE
- Sousa Josane F
- Souza Sandro J
- Valente Valeria
- Zago Marco A
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
BACKGROUND: The ongoing efforts to sequence the honey bee genome require additional initiatives to define its transcriptome. Towards this end, we employed the Open Reading frame ESTs (ORESTES) strategy to generate profiles for the life cycle of Apis mellifera workers. RESULTS: Of the 5,021 ORESTES, 35.2% matched with previously deposited Apis ESTs. The analysis of the remaining sequences defined a set of putative orthologs whose majority had their best-match hits with Anopheles and Drosophila genes. CAP3 assembly of the Apis ORESTES with the already existing 15,500 Apis ESTs generated 3,408 contigs. BLASTX comparison of these contigs with protein sets of organisms representing distinct phylogenetic clades revealed a total of 1,629 contigs that Apis mellifera shares with different taxa. Most (41%) represent genes that are in common to all taxa, another 21% are shared between metazoans (Bilateria), and 16% are shared only within the Insecta clade. A set of 23 putative genes presented a best match with human genes, many of which encode factors related to cell signaling/signal transduction. 1,779 contigs (52%) did not match any known sequence. Applying a correction factor deduced from a parallel analysis performed with Drosophila melanogaster ORESTES, we estimate that approximately half of these no-match ESTs contigs (22%) should represent Apis-specific genes. CONCLUSIONS: The versatile and cost-efficient ORESTES approach produced minilibraries for honey bee life cycle stages. Such information on central gene regions contributes to genome annotation and also lends itself to cross-transcriptome comparisons to reveal evolutionary trends in insect genomes
SOIL ORGANIC MATTER FRACTIONS IN PRESERVED AND DISTURBED WETLANDS OF THE CERRADO BIOME
- Author
- Bastida F
- Batlle-Bayer L
- Bayer C
- Bongiovanni MD
- Brady NC
- Burbridge PR
- Cambardella CA
- Canellas LP
- Cantarella H
- Carvalho JLN
- Cunha TJF
- Cunha TJF
- CĂcero CĂ©lio de Figueiredo
- Ebeling AG
- Eliana Paula Fernandes Brasil
- Elliott ET
- Figueiredo CC
- Figueiredo CC
- Franzluebbers AJ
- Gregorich EG
- Groffman PM
- GuimarĂŁes AJM
- GuimarĂŁes DV
- Guo LB
- Houlahan JE
- Islam KR
- Liu X
- Longo RM
- Loss A
- Machado PLOA
- Materechera SA
- Mendonça ES
- Neue HU
- Nortcliff S
- Pant HK
- Pulrolnik K
- Ramos DD
- Ramos MVV
- Ribeiro JF
- Ricardo Fernandes de Sousa
- Robertson GP
- Roscoe R
- Salton JC
- Santos VB
- Sigua GC
- Silva IR
- Sousa RF
- Stevenson FJ
- Von LĂŒtzow M
- Wantzen KM
- Wendling B
- Wilson Mozena Leandro
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury
- Author
- AA Aravin
- AA Camargo
- Andrew JG Simpson
- B Ewing
- B Ewing
- B Lemaitre
- C Castillejo-LĂłpez
- C Scherfer
- Daniela D Araujo
- E De Gregorio
- E De Gregorio
- E Dias Neto
- EM Reis
- Emmanuel Dias-Neto
- Enilza M Espreafico
- H Jiang
- H Tang
- I-H Jang
- J Ross
- J Sambrook
- JJ Perona
- Josane F Sousa
- JR Manak
- L Kalfayan
- M Hild
- M Stapleton
- M Stapleton
- M Yandell
- Marco A Zago
- Marco AV Cunha
- Maria L Paçó-Larson
- MC Sogayar
- MD Adams
- Nadia Monesi
- ND Rawlings
- Rafaela M Maia
- Ricardo GP Ramos
- S Misra
- Sandro J Souza
- SE Celniker
- SF Altschul
- SJ de Souza
- V Stolc
- Valeria Valente
- Wilson A Silva
- WR Pearson
- X Huang
- Z Kambris
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>The sequencing of the <it>D.melanogaster </it>genome revealed an unexpected small number of genes (~ 14,000) indicating that mechanisms acting on generation of transcript diversity must have played a major role in the evolution of complex metazoans. Among the most extensively used mechanisms that accounts for this diversity is alternative splicing. It is estimated that over 40% of <it>Drosophila </it>protein-coding genes contain one or more alternative exons. A recent transcription map of the <it>Drosophila </it>embryogenesis indicates that 30% of the transcribed regions are unannotated, and that 1/3 of this is estimated as missed or alternative exons of previously characterized protein-coding genes. Therefore, the identification of the variety of expressed transcripts depends on experimental data for its final validation and is continuously being performed using different approaches. We applied the Open Reading Frame Expressed Sequence Tags (ORESTES) methodology, which is capable of generating cDNA data from the central portion of rare transcripts, in order to investigate the presence of hitherto unnanotated regions of <it>Drosophila </it>transcriptome.</p> <p>Results</p> <p>Bioinformatic analysis of 1,303 <it>Drosophila </it>ORESTES clusters identified 68 sequences derived from unannotated regions in the current <it>Drosophila </it>genome version (4.3). Of these, a set of 38 was analysed by polyA<sup>+ </sup>northern blot hybridization, validating 17 (50%) new exons of low abundance transcripts. For one of these ESTs, we obtained the cDNA encompassing the complete coding sequence of a new serine protease, named SP212. The <it>SP212 </it>gene is part of a serine protease gene cluster located in the chromosome region 88A12-B1. This cluster includes the predicted genes CG9631, CG9649 and CG31326, which were previously identified as up-regulated after immune challenges in genomic-scale microarray analysis. In agreement with the proposal that this <it>locus </it>is co-regulated in response to microorganisms infection, we show here that SP212 is also up-regulated upon injury.</p> <p>Conclusion</p> <p>Using the ORESTES methodology we identified 17 novel exons from low abundance <it>Drosophila </it>transcripts, and through a PCR approach the complete CDS of one of these transcripts was defined. Our results show that the computational identification and manual inspection are not sufficient to annotate a genome in the absence of experimentally derived data.</p
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Aspell P
- Atakisi IO
- Atanassov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
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- Awan MIM
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- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
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- Bakas G
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- Bakirci MN
- Baldenegro Barrera C
- Ball AH
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- Banerjee S
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- Barbagli G
- Barberis E
- Bargassa P
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- Barnes VE
- Barney D
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- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
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- Beauceron S
- Beaudette F
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- Bedoya CF
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- Ălvarez FernĂĄndez A
- Ăsterberg K
- Ăzçelik Ă
- Ć irokĂœ J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of Ï Leptons in pp collisions at sqrt[s]=13ââTeV
- Author
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- Aarup Petersen H
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- Zorbilmez C
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- Zuo X
- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the Ï lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13ââTeV and corresponding to an integrated luminosity of 138ââfb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two Ï leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
- Author
- Aarrestad TK
- Aarup Petersen H
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- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
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- Chernyavskaya N
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- Civinini C
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- Cockerill DJA
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- Cornelis T
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
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- Wightman A
- Williams A
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer B
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf R
- Wolfe E
- Wong K
- Wong W
- Wood D
- Wozniak K
- Wozniewski S
- Wright D
- Wu H
- Wu Z
- Wuchterl S
- Wulz C
- Wunsch S
- Wyslouch B
- WĂŒrthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang S
- Yang U
- Yang Y
- Yao Y
- Yarar H
- Yates B
- Yazgan E
- Ye Z
- Yetkin E
- Yi K
- Yigitbasi E
- Yohay R
- Yoo H
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu G
- Yu I
- Yu P
- Yu S
- Yuan L
- Yuan S
- Yuldashev B
- Yumiceva F
- Yusli M
- Yzquierdo AP
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli A
- Zeinali M
- Zeuner W
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu D
- Zhu R
- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2022
- Field of study
- âŠ